Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions

Science

Volumn 350, Issue 6260, 2015, Pages

  Jiang, Jiansen ^a   Chan, Henry ^a   Cash, Darian D ^a   Miracco, Edward J ^a,d   Loo, Rachel R Ogorzalek ^b   Upton, Heather E ^c   Cascio, Duilio ^a   Johnson, Reid O'Brien ^a   Collins, Kathleen ^c   Loo, Joseph A ^a,b   Zhou, Z Hong ^a   Feigon, Juli ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MODERNA THERAPEUTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HOLOENZYME; MULTIENZYME COMPLEX; PROTEIN P19; PROTEIN P75; PROTOZOAL PROTEIN; REPLICATION FACTOR A; SINGLE STRANDED DNA; TELOMERASE; PROTEIN BINDING; PROTEIN SUBUNIT; RNA; TELOMERASE RNA; TELOMERE BINDING PROTEIN;

CATALYSIS; DNA; ENZYME ACTIVITY; PROTEIN; RNA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; DNA REPAIR; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; HUMAN; IMAGE PROCESSING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TELOMERE; TELOMERE HOMEOSTASIS; TETRAHYMENA; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; PROTEIN CONFORMATION; PROTEIN SUBUNIT; X RAY CRYSTALLOGRAPHY;

TETRAHYMENA;

CATALYTIC DOMAIN; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; DNA, SINGLE-STRANDED; HOLOENZYMES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SUBUNITS; REPLICATION PROTEIN A; RNA; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE-BINDING PROTEINS; TETRAHYMENA;

EID: 84945574353     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab4070     Document Type: Article

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