Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

Science Signaling

Volumn 8, Issue 381, 2015, Pages ra58-

  Panneer Selvam, Shanmugam ^a,b   De Palma, Ryan M ^a,b   Oaks, Joshua J ^a,b   Oleinik, Natalia ^a,b   Peterson, Yuri K ^b   Stahelin, Robert V ^c,d   Skordalakes, Emmanuel ^e   Ponnusamy, Suriyan ^a,b   Garrett Mayer, Elizabeth ^b   Smith, Charles D ^b   Ogretmen, Besim ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NOTRE DAME   (United States)

^e WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYL GROUP; LAMIN B; MAKORIN RING FINGER PROTEIN 1; RING FINGER PROTEIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 2; TELOMERASE REVERSE TRANSCRIPTASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; LYSOPHOSPHOLIPID; PROTEIN BINDING; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; TELOMERASE; TERT PROTEIN, HUMAN; TUMOR PROTEIN;

A549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STABILITY; FIBROBLAST; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; LEWIS LUNG CARCINOMA CELL; LUNG CANCER; MOLECULAR DOCKING; MOUSE; MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENESCENCE; TELOMERE HOMEOSTASIS; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; UBIQUITINATION; WILD TYPE; ALLOSTERISM; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL NUCLEUS; GENETICS; KNOCKOUT MOUSE; LEWIS CARCINOMA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SCID MOUSE; TUMOR CELL LINE;

MURINAE; MUS;

ALLOSTERIC REGULATION; ANIMALS; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; CELL NUCLEUS; HUMANS; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; MICE, SCID; MOLECULAR DOCKING SIMULATION; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; SPHINGOSINE; TELOMERASE;

EID: 84931085758     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aaa4998     Document Type: Article

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