-
1
-
-
67649388045
-
Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells
-
Autelli, R., Ullio, C., Prigione, E., Crepaldi, S., Schiavone, N., Brunk, U.T., Capaccioli, S., Baccino, F.M., Bonelli, G., Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells. Biochim. Biophys. Acta 1793 (2009), 1182–1190.
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 1182-1190
-
-
Autelli, R.1
Ullio, C.2
Prigione, E.3
Crepaldi, S.4
Schiavone, N.5
Brunk, U.T.6
Capaccioli, S.7
Baccino, F.M.8
Bonelli, G.9
-
2
-
-
84975247161
-
Mitochondrial dysfunction remodels one-carbon metabolism in human cells
-
Bao, X.R., Ong, S.E., Goldberger, O., Peng, J., Sharma, R., Thompson, D.A., Vafai, S.B., Cox, A.G., Marutani, E., Ichinose, F., et al. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. eLife, 5, 2016, e10575.
-
(2016)
eLife
, vol.5
, pp. e10575
-
-
Bao, X.R.1
Ong, S.E.2
Goldberger, O.3
Peng, J.4
Sharma, R.5
Thompson, D.A.6
Vafai, S.B.7
Cox, A.G.8
Marutani, E.9
Ichinose, F.10
-
3
-
-
85013066207
-
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective
-
Celardo, I., Lehmann, S., Costa, A.C., Loh, S.H., Miguel Martins, L., dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective. Cell Death Differ. 24 (2017), 638–648.
-
(2017)
Cell Death Differ.
, vol.24
, pp. 638-648
-
-
Celardo, I.1
Lehmann, S.2
Costa, A.C.3
Loh, S.H.4
Miguel Martins, L.5
-
4
-
-
0014887484
-
Two enzymes of serine metabolism in rat liver and hepatomas
-
Davis, J.L., Fallon, H.J., Morris, H.P., Two enzymes of serine metabolism in rat liver and hepatomas. Cancer Res. 30 (1970), 2917–2920.
-
(1970)
Cancer Res.
, vol.30
, pp. 2917-2920
-
-
Davis, J.L.1
Fallon, H.J.2
Morris, H.P.3
-
5
-
-
0942265677
-
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor
-
Davis, S.R., Stacpoole, P.W., Williamson, J., Kick, L.S., Quinlivan, E.P., Coats, B.S., Shane, B., Bailey, L.B., Gregory, J.F. 3rd, Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am. J. Physiol. Endocrinol. Metab. 286 (2004), E272–E279.
-
(2004)
Am. J. Physiol. Endocrinol. Metab.
, vol.286
, pp. E272-E279
-
-
Davis, S.R.1
Stacpoole, P.W.2
Williamson, J.3
Kick, L.S.4
Quinlivan, E.P.5
Coats, B.S.6
Shane, B.7
Bailey, L.B.8
Gregory, J.F.9
-
6
-
-
0038075441
-
L-serine in disease and development
-
de Koning, T.J., Snell, K., Duran, M., Berger, R., Poll-The, B.T., Surtees, R., L-serine in disease and development. Biochem. J. 371 (2003), 653–661.
-
(2003)
Biochem. J.
, vol.371
, pp. 653-661
-
-
de Koning, T.J.1
Snell, K.2
Duran, M.3
Berger, R.4
Poll-The, B.T.5
Surtees, R.6
-
7
-
-
84947704464
-
Cancer's fuel choice: new flavors for a picky eater
-
DeNicola, G.M., Cantley, L.C., Cancer's fuel choice: new flavors for a picky eater. Mol. Cell 60 (2015), 514–523.
-
(2015)
Mol. Cell
, vol.60
, pp. 514-523
-
-
DeNicola, G.M.1
Cantley, L.C.2
-
8
-
-
84994772445
-
One-carbon metabolism in health and disease
-
Ducker, G.S., Rabinowitz, J.D., One-carbon metabolism in health and disease. Cell Metab. 25 (2017), 27–42.
-
(2017)
Cell Metab.
, vol.25
, pp. 27-42
-
-
Ducker, G.S.1
Rabinowitz, J.D.2
-
9
-
-
84975455372
-
Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway
-
Ducker, G.S., Chen, L., Morscher, R.J., Ghergurovich, J.M., Esposito, M., Teng, X., Kang, Y., Rabinowitz, J.D., Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab. 23 (2016), 1140–1153.
-
(2016)
Cell Metab.
, vol.23
, pp. 1140-1153
-
-
Ducker, G.S.1
Chen, L.2
Morscher, R.J.3
Ghergurovich, J.M.4
Esposito, M.5
Teng, X.6
Kang, Y.7
Rabinowitz, J.D.8
-
10
-
-
84902332213
-
Quantitative flux analysis reveals folate-dependent NADPH production
-
Fan, J., Ye, J., Kamphorst, J.J., Shlomi, T., Thompson, C.B., Rabinowitz, J.D., Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510 (2014), 298–302.
-
(2014)
Nature
, vol.510
, pp. 298-302
-
-
Fan, J.1
Ye, J.2
Kamphorst, J.J.3
Shlomi, T.4
Thompson, C.B.5
Rabinowitz, J.D.6
-
11
-
-
84918586438
-
Serine deprivation enhances antineoplastic activity of biguanides
-
Gravel, S.P., Hulea, L., Toban, N., Birman, E., Blouin, M.J., Zakikhani, M., Zhao, Y., Topisirovic, I., St-Pierre, J., Pollak, M., Serine deprivation enhances antineoplastic activity of biguanides. Cancer Res. 74 (2014), 7521–7533.
-
(2014)
Cancer Res.
, vol.74
, pp. 7521-7533
-
-
Gravel, S.P.1
Hulea, L.2
Toban, N.3
Birman, E.4
Blouin, M.J.5
Zakikhani, M.6
Zhao, Y.7
Topisirovic, I.8
St-Pierre, J.9
Pollak, M.10
-
12
-
-
85039950381
-
Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells
-
Hwang, S., Gustafsson, H.T., O'Sullivan, C., Bisceglia, G., Huang, X., Klose, C., Schevchenko, A., Dickson, R.C., Cavaliere, P., Dephoure, N., Torres, E.M., Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells. Cell Rep. 21 (2017), 3807–3818.
-
(2017)
Cell Rep.
, vol.21
, pp. 3807-3818
-
-
Hwang, S.1
Gustafsson, H.T.2
O'Sullivan, C.3
Bisceglia, G.4
Huang, X.5
Klose, C.6
Schevchenko, A.7
Dickson, R.C.8
Cavaliere, P.9
Dephoure, N.10
Torres, E.M.11
-
13
-
-
84873692057
-
Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
-
Jiang, W., Ogretmen, B., Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Autophagy 9 (2013), 258–259.
-
(2013)
Autophagy
, vol.9
, pp. 258-259
-
-
Jiang, W.1
Ogretmen, B.2
-
14
-
-
33749846225
-
Role of Bax and Bak in mitochondrial morphogenesis
-
Karbowski, M., Norris, K.L., Cleland, M.M., Jeong, S.Y., Youle, R.J., Role of Bax and Bak in mitochondrial morphogenesis. Nature 443 (2006), 658–662.
-
(2006)
Nature
, vol.443
, pp. 658-662
-
-
Karbowski, M.1
Norris, K.L.2
Cleland, M.M.3
Jeong, S.Y.4
Youle, R.J.5
-
15
-
-
84996554610
-
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
-
Kottakis, F., Nicolay, B.N., Roumane, A., Karnik, R., Gu, H., Nagle, J.M., Boukhali, M., Hayward, M.C., Li, Y.Y., Chen, T., et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 (2016), 390–395.
-
(2016)
Nature
, vol.539
, pp. 390-395
-
-
Kottakis, F.1
Nicolay, B.N.2
Roumane, A.3
Karnik, R.4
Gu, H.5
Nagle, J.M.6
Boukhali, M.7
Hayward, M.C.8
Li, Y.Y.9
Chen, T.10
-
16
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
Koves, T.R., Ussher, J.R., Noland, R.C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J.R., Newgard, C.B., et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7 (2008), 45–56.
-
(2008)
Cell Metab.
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
Slentz, D.4
Mosedale, M.5
Ilkayeva, O.6
Bain, J.7
Stevens, R.8
Dyck, J.R.9
Newgard, C.B.10
-
17
-
-
84901263663
-
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
-
Labuschagne, C.F., van den Broek, N.J., Mackay, G.M., Vousden, K.H., Maddocks, O.D., Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep. 7 (2014), 1248–1258.
-
(2014)
Cell Rep.
, vol.7
, pp. 1248-1258
-
-
Labuschagne, C.F.1
van den Broek, N.J.2
Mackay, G.M.3
Vousden, K.H.4
Maddocks, O.D.5
-
18
-
-
84904504373
-
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
-
Lewis, C.A., Parker, S.J., Fiske, B.P., McCloskey, D., Gui, D.Y., Green, C.R., Vokes, N.I., Feist, A.M., Vander Heiden, M.G., Metallo, C.M., Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol. Cell 55 (2014), 253–263.
-
(2014)
Mol. Cell
, vol.55
, pp. 253-263
-
-
Lewis, C.A.1
Parker, S.J.2
Fiske, B.P.3
McCloskey, D.4
Gui, D.Y.5
Green, C.R.6
Vokes, N.I.7
Feist, A.M.8
Vander Heiden, M.G.9
Metallo, C.M.10
-
19
-
-
84930440744
-
High-resolution metabolomics with acyl-CoA profiling reveals widespread remodeling in response to diet
-
Liu, X., Sadhukhan, S., Sun, S., Wagner, G.R., Hirschey, M.D., Qi, L., Lin, H., Locasale, J.W., High-resolution metabolomics with acyl-CoA profiling reveals widespread remodeling in response to diet. Mol. Cell. Proteomics 14 (2015), 1489–1500.
-
(2015)
Mol. Cell. Proteomics
, vol.14
, pp. 1489-1500
-
-
Liu, X.1
Sadhukhan, S.2
Sun, S.3
Wagner, G.R.4
Hirschey, M.D.5
Qi, L.6
Lin, H.7
Locasale, J.W.8
-
20
-
-
84881177291
-
Serine, glycine and one-carbon units: cancer metabolism in full circle
-
Locasale, J.W., Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 13 (2013), 572–583.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 572-583
-
-
Locasale, J.W.1
-
21
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale, J.W., Grassian, A.R., Melman, T., Lyssiotis, C.A., Mattaini, K.R., Bass, A.J., Heffron, G., Metallo, C.M., Muranen, T., Sharfi, H., et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43 (2011), 869–874.
-
(2011)
Nat. Genet.
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lyssiotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
Heffron, G.7
Metallo, C.M.8
Muranen, T.9
Sharfi, H.10
-
22
-
-
74949133862
-
Myocardial fatty acid metabolism in health and disease
-
Lopaschuk, G.D., Ussher, J.R., Folmes, C.D., Jaswal, J.S., Stanley, W.C., Myocardial fatty acid metabolism in health and disease. Physiol. Rev. 90 (2010), 207–258.
-
(2010)
Physiol. Rev.
, vol.90
, pp. 207-258
-
-
Lopaschuk, G.D.1
Ussher, J.R.2
Folmes, C.D.3
Jaswal, J.S.4
Stanley, W.C.5
-
23
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
Maddocks, O.D., Berkers, C.R., Mason, S.M., Zheng, L., Blyth, K., Gottlieb, E., Vousden, K.H., Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493 (2013), 542–546.
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
Vousden, K.H.7
-
24
-
-
84957427247
-
Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells
-
Maddocks, O.D., Labuschagne, C.F., Adams, P.D., Vousden, K.H., Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells. Mol. Cell 61 (2016), 210–221.
-
(2016)
Mol. Cell
, vol.61
, pp. 210-221
-
-
Maddocks, O.D.1
Labuschagne, C.F.2
Adams, P.D.3
Vousden, K.H.4
-
25
-
-
85018159283
-
Modulating the therapeutic response of tumours to dietary serine and glycine starvation
-
Maddocks, O.D.K., Athineos, D., Cheung, E.C., Lee, P., Zhang, T., van den Broek, N.J.F., Mackay, G.M., Labuschagne, C.F., Gay, D., Kruiswijk, F., et al. Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature 544 (2017), 372–376.
-
(2017)
Nature
, vol.544
, pp. 372-376
-
-
Maddocks, O.D.K.1
Athineos, D.2
Cheung, E.C.3
Lee, P.4
Zhang, T.5
van den Broek, N.J.F.6
Mackay, G.M.7
Labuschagne, C.F.8
Gay, D.9
Kruiswijk, F.10
-
26
-
-
84980041497
-
The importance of serine metabolism in cancer
-
Mattaini, K.R., Sullivan, M.R., Vander Heiden, M.G., The importance of serine metabolism in cancer. J. Cell Biol. 214 (2016), 249–257.
-
(2016)
J. Cell Biol.
, vol.214
, pp. 249-257
-
-
Mattaini, K.R.1
Sullivan, M.R.2
Vander Heiden, M.G.3
-
27
-
-
84912139448
-
Characterization of the usage of the serine metabolic network in human cancer
-
Mehrmohamadi, M., Liu, X., Shestov, A.A., Locasale, J.W., Characterization of the usage of the serine metabolic network in human cancer. Cell Rep. 9 (2014), 1507–1519.
-
(2014)
Cell Rep.
, vol.9
, pp. 1507-1519
-
-
Mehrmohamadi, M.1
Liu, X.2
Shestov, A.A.3
Locasale, J.W.4
-
28
-
-
85006051826
-
Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism
-
Mehrmohamadi, M., Mentch, L.K., Clark, A.G., Locasale, J.W., Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism. Nat. Commun., 7, 2016, 13666.
-
(2016)
Nat. Commun.
, vol.7
, pp. 13666
-
-
Mehrmohamadi, M.1
Mentch, L.K.2
Clark, A.G.3
Locasale, J.W.4
-
29
-
-
85041012891
-
Serine one-carbon catabolism with formate overflow
-
Meiser, J., Tumanov, S., Maddocks, O., Labuschagne, C.F., Athineos, D., Van Den Broek, N., Mackay, G.M., Gottlieb, E., Blyth, K., Vousden, K., et al. Serine one-carbon catabolism with formate overflow. Sci. Adv., 2, 2016, e1601273.
-
(2016)
Sci. Adv.
, vol.2
, pp. e1601273
-
-
Meiser, J.1
Tumanov, S.2
Maddocks, O.3
Labuschagne, C.F.4
Athineos, D.5
Van Den Broek, N.6
Mackay, G.M.7
Gottlieb, E.8
Blyth, K.9
Vousden, K.10
-
30
-
-
84948412126
-
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
-
Mentch, S.J., Mehrmohamadi, M., Huang, L., Liu, X., Gupta, D., Mattocks, D., Gómez Padilla, P., Ables, G., Bamman, M.M., Thalacker-Mercer, A.E., et al. Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metab. 22 (2015), 861–873.
-
(2015)
Cell Metab.
, vol.22
, pp. 861-873
-
-
Mentch, S.J.1
Mehrmohamadi, M.2
Huang, L.3
Liu, X.4
Gupta, D.5
Mattocks, D.6
Gómez Padilla, P.7
Ables, G.8
Bamman, M.M.9
Thalacker-Mercer, A.E.10
-
31
-
-
85020450794
-
Serine and Functional Metabolites in Cancer
-
Newman, A.C., Maddocks, O.D.K., Serine and Functional Metabolites in Cancer. Trends Cell Biol. 27 (2017), 645–657.
-
(2017)
Trends Cell Biol.
, vol.27
, pp. 645-657
-
-
Newman, A.C.1
Maddocks, O.D.K.2
-
32
-
-
84959141435
-
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism
-
Nikkanen, J., Forsström, S., Euro, L., Paetau, I., Kohnz, R.A., Wang, L., Chilov, D., Viinamäki, J., Roivainen, A., Marjamäki, P., et al. Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism. Cell Metab. 23 (2016), 635–648.
-
(2016)
Cell Metab.
, vol.23
, pp. 635-648
-
-
Nikkanen, J.1
Forsström, S.2
Euro, L.3
Paetau, I.4
Kohnz, R.A.5
Wang, L.6
Chilov, D.7
Viinamäki, J.8
Roivainen, A.9
Marjamäki, P.10
-
33
-
-
84897414311
-
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
-
Nilsson, R., Jain, M., Madhusudhan, N., Sheppard, N.G., Strittmatter, L., Kampf, C., Huang, J., Asplund, A., Mootha, V.K., Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat. Commun., 5, 2014, 3128.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3128
-
-
Nilsson, R.1
Jain, M.2
Madhusudhan, N.3
Sheppard, N.G.4
Strittmatter, L.5
Kampf, C.6
Huang, J.7
Asplund, A.8
Mootha, V.K.9
-
34
-
-
84930226005
-
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling
-
Norris, K.L., Hao, R., Chen, L.F., Lai, C.H., Kapur, M., Shaughnessy, P.J., Chou, D., Yan, J., Taylor, J.P., Engelender, S., et al. Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. J. Biol. Chem. 290 (2015), 13862–13874.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 13862-13874
-
-
Norris, K.L.1
Hao, R.2
Chen, L.F.3
Lai, C.H.4
Kapur, M.5
Shaughnessy, P.J.6
Chou, D.7
Yan, J.8
Taylor, J.P.9
Engelender, S.10
-
35
-
-
84955326448
-
The Emerging Hallmarks of Cancer Metabolism
-
Pavlova, N.N., Thompson, C.B., The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 23 (2016), 27–47.
-
(2016)
Cell Metab.
, vol.23
, pp. 27-47
-
-
Pavlova, N.N.1
Thompson, C.B.2
-
36
-
-
84902455654
-
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway
-
Pennanen, C., Parra, V., López-Crisosto, C., Morales, P.E., Del Campo, A., Gutierrez, T., Rivera-Mejías, P., Kuzmicic, J., Chiong, M., Zorzano, A., et al. Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway. J. Cell Sci. 127 (2014), 2659–2671.
-
(2014)
J. Cell Sci.
, vol.127
, pp. 2659-2671
-
-
Pennanen, C.1
Parra, V.2
López-Crisosto, C.3
Morales, P.E.4
Del Campo, A.5
Gutierrez, T.6
Rivera-Mejías, P.7
Kuzmicic, J.8
Chiong, M.9
Zorzano, A.10
-
37
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R., Marks, K.M., Shaul, Y.D., Pacold, M.E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.K., Jang, H.G., Jha, A.K., et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476 (2011), 346–350.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
-
38
-
-
84870302121
-
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
-
Sentelle, R.D., Senkal, C.E., Jiang, W., Ponnusamy, S., Gencer, S., Selvam, S.P., Ramshesh, V.K., Peterson, Y.K., Lemasters, J.J., Szulc, Z.M., et al. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat. Chem. Biol. 8 (2012), 831–838.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 831-838
-
-
Sentelle, R.D.1
Senkal, C.E.2
Jiang, W.3
Ponnusamy, S.4
Gencer, S.5
Selvam, S.P.6
Ramshesh, V.K.7
Peterson, Y.K.8
Lemasters, J.J.9
Szulc, Z.M.10
-
39
-
-
84974735979
-
Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow
-
Ser, Z., Gao, X., Johnson, C., Mehrmohamadi, M., Liu, X., Li, S., Locasale, J.W., Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow. Cell Rep. 15 (2016), 2367–2376.
-
(2016)
Cell Rep.
, vol.15
, pp. 2367-2376
-
-
Ser, Z.1
Gao, X.2
Johnson, C.3
Mehrmohamadi, M.4
Liu, X.5
Li, S.6
Locasale, J.W.7
-
40
-
-
26444453262
-
Mitochondrial ceramide and the induction of apoptosis
-
Siskind, L.J., Mitochondrial ceramide and the induction of apoptosis. J. Bioenerg. Biomembr. 37 (2005), 143–153.
-
(2005)
J. Bioenerg. Biomembr.
, vol.37
, pp. 143-153
-
-
Siskind, L.J.1
-
41
-
-
0022643088
-
Enzymic imbalance in serine metabolism in rat hepatomas
-
Snell, K., Weber, G., Enzymic imbalance in serine metabolism in rat hepatomas. Biochem. J. 233 (1986), 617–620.
-
(1986)
Biochem. J.
, vol.233
, pp. 617-620
-
-
Snell, K.1
Weber, G.2
-
42
-
-
0023829928
-
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma
-
Snell, K., Natsumeda, Y., Eble, J.N., Glover, J.L., Weber, G., Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Br. J. Cancer 57 (1988), 87–90.
-
(1988)
Br. J. Cancer
, vol.57
, pp. 87-90
-
-
Snell, K.1
Natsumeda, Y.2
Eble, J.N.3
Glover, J.L.4
Weber, G.5
-
43
-
-
84890872873
-
Mitochondrial lipid trafficking
-
Tatsuta, T., Scharwey, M., Langer, T., Mitochondrial lipid trafficking. Trends Cell Biol. 24 (2014), 44–52.
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 44-52
-
-
Tatsuta, T.1
Scharwey, M.2
Langer, T.3
-
44
-
-
84887444816
-
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
-
Tedeschi, P.M., Markert, E.K., Gounder, M., Lin, H., Dvorzhinski, D., Dolfi, S.C., Chan, L.L., Qiu, J., DiPaola, R.S., Hirshfield, K.M., et al. Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis., 4, 2013, e877.
-
(2013)
Cell Death Dis.
, vol.4
, pp. e877
-
-
Tedeschi, P.M.1
Markert, E.K.2
Gounder, M.3
Lin, H.4
Dvorzhinski, D.5
Dolfi, S.C.6
Chan, L.L.7
Qiu, J.8
DiPaola, R.S.9
Hirshfield, K.M.10
-
45
-
-
77955616558
-
Compartmentalization of Mammalian folate-mediated one-carbon metabolism
-
Tibbetts, A.S., Appling, D.R., Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annu. Rev. Nutr. 30 (2010), 57–81.
-
(2010)
Annu. Rev. Nutr.
, vol.30
, pp. 57-81
-
-
Tibbetts, A.S.1
Appling, D.R.2
-
46
-
-
78649413837
-
Mitochondrial fusion and fission in cell life and death
-
Westermann, B., Mitochondrial fusion and fission in cell life and death. Nat. Rev. Mol. Cell Biol. 11 (2010), 872–884.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 872-884
-
-
Westermann, B.1
-
47
-
-
84988431514
-
Serine and one-carbon metabolism in cancer
-
Yang, M., Vousden, K.H., Serine and one-carbon metabolism in cancer. Nat. Rev. Cancer 16 (2016), 650–662.
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 650-662
-
-
Yang, M.1
Vousden, K.H.2
-
48
-
-
84860793042
-
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
-
Ye, J., Mancuso, A., Tong, X., Ward, P.S., Fan, J., Rabinowitz, J.D., Thompson, C.B., Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc. Natl. Acad. Sci. USA 109 (2012), 6904–6909.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 6904-6909
-
-
Ye, J.1
Mancuso, A.2
Tong, X.3
Ward, P.S.4
Fan, J.5
Rabinowitz, J.D.6
Thompson, C.B.7
-
49
-
-
50349092706
-
Kinetic flux profiling for quantitation of cellular metabolic fluxes
-
Yuan, J., Bennett, B.D., Rabinowitz, J.D., Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nat. Protoc. 3 (2008), 1328–1340.
-
(2008)
Nat. Protoc.
, vol.3
, pp. 1328-1340
-
-
Yuan, J.1
Bennett, B.D.2
Rabinowitz, J.D.3
|