Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

Cell Death and Disease

Volumn 4, Issue 10, 2013, Pages

  Tedeschi, P M ^a   Markert, E K ^a   Gounder, M ^a   Lin, H ^a   Dvorzhinski, D ^a   Dolfi, S C ^a   Chan, L L Y ^b   Qiu, J ^b   DiPaola, R S ^a   Hirshfield, K M ^a   Boros, L G ^c   Bertino, J R ^a   Oltvai, Z N ^d   Vazquez, A ^a  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b Nexcelom Bioscience LLC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer metabolism; Glycine metabolism; One carbon metabolism; Proliferation; Serine metabolism; Targeted tracer fate association study

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; FATTY ACID SYNTHASE; FOLIC ACID; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; METHIONINE; METHIONINE SYNTHASE; METHOTREXATE; MYC PROTEIN; PURINE; PURINE DERIVATIVE; PYRUVATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBONUCLEOTIDE; SERINE; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

AMINO ACID METABOLISM; ARTICLE; BIOSYNTHESIS; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER PROGNOSIS; CELL METABOLISM; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; FATTY ACID SYNTHESIS; FOLATE METABOLISM; HUMAN; HUMAN CELL; MALE; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; PROTEIN TARGETING; PURINE SYNTHESIS; UPREGULATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID OXIDOREDUCTASES; ANIMALS; CARRIER PROTEINS; CELL LINE, TUMOR; EMBRYONIC STEM CELLS; ENERGY METABOLISM; FATTY ACIDS; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCINE; HUMANS; MALE; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; METHOTREXATE; MICE; MULTIENZYME COMPLEXES; NADP; NEOPLASMS; PROTEIN BIOSYNTHESIS; PURINES; SERINE; TRANSFERASES;

EID: 84887444816     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.393     Document Type: Article

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