Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow

Cell Reports

Volumn 15, Issue 11, 2016, Pages 2367-2376

  Ser, Zheng ^a   Gao, Xia ^b   Johnson, Christelle ^c   Mehrmohamadi, Mahya ^b,d   Liu, Xiaojing ^b   Li, Siqi ^b   Locasale, Jason W ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b DUKE CANCER INSTITUTE   (United States)

^c Cornell University   (United States)

^d Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; DEOXYURIDINE; FLUOROURACIL; THYMIDYLATE SYNTHASE; URACIL; CARBON; NUCLEOTIDE; PYRIMIDINE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL LINE; CARBON METABOLISM; COLORECTAL TUMOR; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; EXTRACELLULAR SPACE; IC50; MALE; METABOLITE; METABOLOMICS; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE TRANSPORT; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; ANIMAL; DRUG EFFECTS; HOMEOSTASIS; METABOLISM; METABOLOME; NONOBESE DIABETIC MOUSE; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CARBON; CELL LINE, TUMOR; FLUOROURACIL; HOMEOSTASIS; MALE; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MICE, INBRED NOD; MICE, SCID; NUCLEOTIDES; PYRIMIDINES;

EID: 84974735979     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.05.035     Document Type: Article

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