A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression

Nature Protocols

Volumn 13, Issue 2, 2018, Pages 235-247

  Fumagalli, Arianna ^a,b   Suijkerbuijk, Saskia J E ^a,b   Begthel, Harry ^a   Beerling, Evelyne ^a,b   Oost, Koen C ^a   Snippert, Hugo J ^a   Van Rheenen, Jacco ^a,b   Drost, Jarno ^c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c University Medical Center Utrecht Princess Máxima Center for Pediatric Oncology   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CECUM EPITHELIUM; CIRCULATION; COLORECTAL CANCER; CONTROLLED STUDY; DISTANT METASTASIS; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INFANT; INTESTINE; INTRAVITAL MICROSCOPY; MALE; MOUSE; NONHUMAN; ORGANOID; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANIMAL; CELL TRANSFORMATION; COLON TUMOR; COLONOSCOPY; COLORECTAL TUMOR; CRISPR CAS SYSTEM; DISEASE MODEL; DRUG SCREENING; GENE EDITING; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; NONOBESE DIABETIC MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; TRANSPLANTATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; COLONOSCOPY; COLORECTAL NEOPLASMS; CRISPR-CAS SYSTEMS; DISEASE MODELS, ANIMAL; GENE EDITING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED NOD; ORGANOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85041112645     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2017.137     Document Type: Article

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