PIK3CA and APC mutations are synergistic in the development of intestinal cancers

Oncogene

Volumn 33, Issue 17, 2014, Pages 2245-2254

  Deming, D A ^a   Leystra, A A ^b   Nettekoven, L ^a   Sievers, C ^a   Miller, D ^a   Middlebrooks, M ^a   Clipson, L ^b   Albrecht, D ^a   Bacher, J ^c   Washington, M K ^d   Weichert, J ^b   Halberg, R B ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c PROMEGA CORPORATION   (United States)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

APC; colon cancer; mouse models; PI3K; PIK3CA

Indexed keywords

BETA CATENIN;

ADENOMATOUS POLYPOSIS COLI GENE; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON; CONTROLLED STUDY; DOWNSTREAM PROCESSING; GENE; GENE ACTIVITY; GENE EXPRESSION; HUMAN; INTESTINE CANCER; MALE; MICROSATELLITE MARKER; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHOSPHATIDYLINOSITOL 3 KINASE GENE; PRIORITY JOURNAL; SMALL INTESTINE; TUMOR VOLUME;

MAMMALIA; MURINAE; MUS;

ADENOCARCINOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BETA CATENIN; CELL NUCLEUS; COLORECTAL NEOPLASMS; CYCLIN D1; DISEASE MODELS, ANIMAL; EPISTASIS, GENETIC; FEMALE; GENE EXPRESSION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSATELLITE INSTABILITY; PHOSPHATIDYLINOSITOL 3-KINASES; TUMOR BURDEN; WNT SIGNALING PATHWAY;

EID: 84899645301     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.167     Document Type: Article

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