Cracking the regulatory code of biosynthetic gene clusters as a strategy for natural product discovery

Biochemical Pharmacology

Volumn 153, Issue , 2018, Pages 24-34

  Rigali, Sébastien ^a   Anderssen, Sinaeda ^a   Naômé, Aymeric ^a   van Wezel, Gilles P ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Actinobacteria; Antibiotics; Cryptic metabolite; Regulatory network; Streptomyces

Indexed keywords

CIS ACTING ELEMENT; NATURAL PRODUCT; ANTIINFECTIVE AGENT; BIOLOGICAL PRODUCT;

ANTIBIOTIC RESISTANCE; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; GENE ACTIVATION; GENE CLUSTER; GENE REPRESSION; GENETIC CODE; GENETIC REGULATION; HUMAN; METABOLITE; METHODOLOGY; PRIORITY JOURNAL; REVIEW; ANIMAL; BIOLOGY; DRUG DEVELOPMENT; DRUG EFFECT; METABOLISM; METABOLOMICS; MULTIGENE FAMILY; PHYSIOLOGY; PROCEDURES; SYNTHESIS; TRENDS;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL PRODUCTS; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; HUMANS; METABOLOMICS; MULTIGENE FAMILY;

EID: 85040253654     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2018.01.007     Document Type: Review

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