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Volumn 12, Issue 5, 2013, Pages 371-387

Platforms for antibiotic discovery

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; AVIBACTAM; BEDAQUILINE; BETA LACTAM ANTIBIOTIC; CASPOFUNGIN; CERULENIN; CHLORAMPHENICOL; CHLORTETRACYCLINE; CIPROFLOXACIN; CLAVULANIC ACID; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; ERYTHROMYCIN; ETHAMBUTOL; ISONIAZID; METRONIDAZOLE; MIKAMYCIN B; NALIDIXIC ACID; NATURAL PRODUCT; PLATENSIMYCIN; PRODRUG; PYRAZINAMIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; STREPTOMYCIN; SULFAMIDOCHRYSOIDINE; THIOLACTOMYCIN; UNINDEXED DRUG;

EID: 84877279350     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3975     Document Type: Review
Times cited : (1077)

References (124)
  • 1
    • 84964134387 scopus 로고
    • Streptomycin a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria
    • Schatz, A., Bugie, E. & Waksman, S. A. Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. Proc. Soc. Exp. Biol. Med. 55, 66-69 (1944)
    • (1944) Proc. Soc. Exp. Biol. Med. , vol.55 , pp. 66-69
    • Schatz, A.1    Bugie, E.2    Waksman, S.A.3
  • 2
    • 84877298064 scopus 로고
    • Responsibilities and opportunities of the private practitioner in preventive medicine
    • Fleming, A. G. Responsibilities and opportunities of the private practitioner in preventive medicine. Can. Med. Assoc. J. 20, 11-13 (1929).
    • (1929) Can. Med. Assoc. J. , vol.20 , pp. 11-13
    • Fleming, A.G.1
  • 3
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nature Rev. Drug Discov. 6, 29-40 (2007).
    • (2007) Nature Rev. Drug Discov. , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 4
    • 0022469992 scopus 로고
    • In vitro and in vivo activity of LY, 146032, a new cyclic lipopeptide antibiotic
    • Eliopoulos, G. M. et al. In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibiotic. Antimicrob. Agents Chemother. 30, 532-535 (1986).
    • (1986) Antimicrob. Agents Chemother. , vol.30 , pp. 532-535
    • Eliopoulos, G.M.1
  • 5
    • 0024832298 scopus 로고
    • Susceptibility of anaerobic bacteria to the new streptogramin RP 59500 in vitro
    • Nord, C. E., Lindmark, A. & Persson, I. Susceptibility of anaerobic bacteria to the new streptogramin RP 59500 in vitro. Eur. J. Clin. Microbiol. Infect. Dis. 8, 1064-1067 (1989).
    • (1989) Eur. J. Clin. Microbiol. Infect. Dis. , vol.8 , pp. 1064-1067
    • Nord, C.E.1    Lindmark, A.2    Persson, I.3
  • 8
    • 0036150240 scopus 로고    scopus 로고
    • Evolution of drug resistance in Mycobacterium tuberculosis: Clinical and molecular perspective
    • Gillespie, S. H. Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective. Antimicrob. Agents Chemother. 46, 267-274 (2002).
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 267-274
    • Gillespie, S.H.1
  • 9
    • 79958784137 scopus 로고    scopus 로고
    • Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: Classical and new drugs
    • Almeida Da Silva, P. E. & Palomino, J. C. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs. J. Antimicrob. Chemother. 66, 1417-1430 (2011).
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1417-1430
    • Almeida Da Silva, P.E.1    Palomino, J.C.2
  • 10
    • 0028156861 scopus 로고
    • InhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
    • Banerjee, A. et al. InhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263, 227-230 (1994).
    • (1994) Science , vol.263 , pp. 227-230
    • Banerjee, A.1
  • 11
    • 0345306174 scopus 로고    scopus 로고
    • EthA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates
    • Morlock, G. P., Metchock, B., Sikes, D., Crawford, J. T. & Cooksey, R. C. ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob. Agents Chemother. 47, 3799-3805 (2003).
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 3799-3805
    • Morlock, G.P.1    Metchock, B.2    Sikes, D.3    Crawford, J.T.4    Cooksey, R.C.5
  • 12
    • 81155160151 scopus 로고    scopus 로고
    • Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis
    • Shi, W. et al. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science 333, 1630-1632 (2011)
    • (2011) Science , vol.333 , pp. 1630-1632
    • Shi, W.1
  • 14
    • 19944429772 scopus 로고    scopus 로고
    • A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
    • Andries, K. et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307, 223-227 (2005).
    • (2005) Science , vol.307 , pp. 223-227
    • Andries, K.1
  • 15
    • 0024431530 scopus 로고
    • Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis
    • Takayama, K. & Kilburn, J. O. Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis. Antimicrob. Agents Chemother. 33, 1493-1499 (1989).
    • (1989) Antimicrob. Agents Chemother. , vol.33 , pp. 1493-1499
    • Takayama, K.1    Kilburn, J.O.2
  • 16
    • 66649090346 scopus 로고    scopus 로고
    • The diarylquinoline TMC207 for multidrug-resistant tuberculosis
    • Diacon, A. H. et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 360, 2397-2405 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2397-2405
    • Diacon, A.H.1
  • 17
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • Fischbach, M. A. & Walsh, C. T. Antibiotics for emerging pathogens. Science 325, 1089-1093 (2009).
    • (2009) Science , vol.325 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 18
    • 77949393654 scopus 로고    scopus 로고
    • Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    • Larsen, N. et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PloS ONE 5, e9085 (2010).
    • (2010) PloS ONE , vol.5
    • Larsen, N.1
  • 19
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh, P. J. et al. A core gut microbiome in obese and lean twins. Nature 457, 480-484 (2009).
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1
  • 20
    • 79959201412 scopus 로고    scopus 로고
    • Human nutrition, the gut microbiome and the immune system
    • Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L. & Gordon, J. I. Human nutrition, the gut microbiome and the immune system. Nature 474, 327-336 (2011).
    • (2011) Nature , vol.474 , pp. 327-336
    • Kau, A.L.1    Ahern, P.P.2    Griffin, N.W.3    Goodman, A.L.4    Gordon, J.I.5
  • 21
    • 79551713705 scopus 로고    scopus 로고
    • Reduced anxiety-like behavior and central neurochemical change in germ-free mice
    • Neufeld, K. M., Kang, N., Bienenstock, J. & Foster, J. A. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol. Motil. 23, 255-e119 (2011).
    • (2011) Neurogastroenterol. Motil. , vol.23
    • Neufeld, K.M.1    Kang, N.2    Bienenstock, J.3    Foster, J.A.4
  • 22
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • Dethlefsen, L. & Relman, D. A. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4554-4561 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.SUPPL. 1 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 23
    • 84877306061 scopus 로고    scopus 로고
    • Phage-based platforms for the clinical detection of human bacterial pathogens
    • Schofield, D. A., Sharp, N. J. & Westwater, C. Phage-based platforms for the clinical detection of human bacterial pathogens. Bacteriophage 2, 105-121 (2012).
    • (2012) Bacteriophage , vol.2 , pp. 105-121
    • Schofield, D.A.1    Sharp, N.J.2    Westwater, C.3
  • 24
    • 0344717988 scopus 로고    scopus 로고
    • Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin
    • Renau, T. E. et al. Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin. J. Med. Chem. 42, 4928-4931 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 4928-4931
    • Renau, T.E.1
  • 25
    • 0035162640 scopus 로고    scopus 로고
    • Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: Novel agents for combination therapy
    • Lomovskaya, O. et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob. Agents Chemother. 45, 105-116 (2001).
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 105-116
    • Lomovskaya, O.1
  • 26
    • 0037057652 scopus 로고    scopus 로고
    • Crystal structure of bacterial multidrug efflux transporter AcrB
    • Murakami, S., Nakashima, R., Yamashita, E. & Yamaguchi, A. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419, 587-593 (2002).
    • (2002) Nature , vol.419 , pp. 587-593
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Yamaguchi, A.4
  • 27
    • 0038670226 scopus 로고    scopus 로고
    • Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
    • Yu, E. W., McDermott, G., Zgurskaya, H. I., Nikaido, H. & Koshland, D. E. Jr. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 300, 976-980 (2003).
    • (2003) Science , vol.300 , pp. 976-980
    • Yu, E.W.1    McDermott, G.2    Zgurskaya, H.I.3    Nikaido, H.4    Koshland Jr., D.E.5
  • 28
  • 29
    • 84355166442 scopus 로고    scopus 로고
    • Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
    • Nakashima, R., Sakurai, K., Yamasaki, S., Nishino, K. & Yamaguchi, A. Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature 480, 565-569 (2011).
    • (2011) Nature , vol.480 , pp. 565-569
    • Nakashima, R.1    Sakurai, K.2    Yamasaki, S.3    Nishino, K.4    Yamaguchi, A.5
  • 31
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46, 3-26 (2001).
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 33
    • 0034652383 scopus 로고    scopus 로고
    • Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5-methoxyhydnocarpin, a multidrug pump inhibitor
    • Stermitz, F. R., Lorenz, P., Tawara, J. N., Zenewicz, L. A. & Lewis, K. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5-methoxyhydnocarpin, a multidrug pump inhibitor. Proc. Natl Acad. Sci. USA 97, 1433-1437 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 1433-1437
    • Stermitz, F.R.1    Lorenz, P.2    Tawara, J.N.3    Zenewicz, L.A.4    Lewis, K.5
  • 34
    • 33845711756 scopus 로고    scopus 로고
    • Prospects for plant-derived antimicrobials
    • Lewis, K. & Ausubel, F. M. Prospects for plant-derived antimicrobials. Nature Biotech. 24, 1504-1507 (2006).
    • (2006) Nature Biotech. , vol.24 , pp. 1504-1507
    • Lewis, K.1    Ausubel, F.M.2
  • 35
    • 43949129098 scopus 로고    scopus 로고
    • Physicochemical properties of antibacterial compounds: Implications for drug discovery
    • O'Shea, R. & Moser, H. E. Physicochemical properties of antibacterial compounds: implications for drug discovery. J. Med. Chem. 51, 2871-2878 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 2871-2878
    • O'Shea, R.1    Moser, H.E.2
  • 36
    • 44649092678 scopus 로고    scopus 로고
    • Are natural products still the best source for antibacterial discovery? the bacterial entry factor
    • Silver, L. L. Are natural products still the best source for antibacterial discovery? The bacterial entry factor. Expert Opin. Drug Discov. 3, 487-500 (2008).
    • (2008) Expert Opin. Drug Discov. , vol.3 , pp. 487-500
    • Silver, L.L.1
  • 37
    • 34250799619 scopus 로고    scopus 로고
    • An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site
    • Rock, F. L. et al. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 316, 1759-1761 (2007).
    • (2007) Science , vol.316 , pp. 1759-1761
    • Rock, F.L.1
  • 38
    • 0242628703 scopus 로고
    • Ein beitrag zur chemotherapie der bakteriellen infektionen
    • German
    • Domagk, G. Ein beitrag zur chemotherapie der bakteriellen infektionen. Deutsche Medizinische Wochenschrift 61, 250-253 (in German) (1935).
    • (1935) Deutsche Medizinische Wochenschrift , vol.61 , pp. 250-253
    • Domagk, G.1
  • 39
    • 33745912507 scopus 로고    scopus 로고
    • Identification of novel antimicrobials using a live-animal infection model
    • Moy, T. I. et al. Identification of novel antimicrobials using a live-animal infection model. Proc. Natl Acad. Sci. USA 103, 10414-10419 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 10414-10419
    • Moy, T.I.1
  • 40
    • 66849097241 scopus 로고    scopus 로고
    • Whole-animal high-throughput screens: The C. elegans model
    • O'Rourke, E. J., Conery, A. L. & Moy, T. I. Whole-animal high-throughput screens: the C. elegans model. Methods Mol. Biol. 486, 57-75 (2009).
    • (2009) Methods Mol. Biol. , vol.486 , pp. 57-75
    • O'Rourke, E.J.1    Conery, A.L.2    Moy, T.I.3
  • 41
    • 33845708150 scopus 로고    scopus 로고
    • New antibiotics from bacterial natural products
    • Clardy, J., Fischbach, M. A. & Walsh, C. T. New antibiotics from bacterial natural products. Nature Biotech. 24, 1541-1550 (2006).
    • (2006) Nature Biotech. , vol.24 , pp. 1541-1550
    • Clardy, J.1    Fischbach, M.A.2    Walsh, C.T.3
  • 42
    • 0036213075 scopus 로고    scopus 로고
    • Prescription for an ailing pharmaceutical industry
    • Demain, A. L. Prescription for an ailing pharmaceutical industry. Nature Biotech. 20, 331 (2002).
    • (2002) Nature Biotech. , vol.20 , pp. 331
    • Demain, A.L.1
  • 43
    • 3342969325 scopus 로고    scopus 로고
    • Prediction of mechanisms of action of antibacterial compounds by gene expression profiling
    • Hutter, B. et al. Prediction of mechanisms of action of antibacterial compounds by gene expression profiling. Antimicrob. Agents Chemother. 48, 2838-2844 (2004).
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2838-2844
    • Hutter, B.1
  • 44
    • 33744994317 scopus 로고    scopus 로고
    • Platensimycin is a selective FabF inhibitor with potent antibiotic properties
    • Wang, J. et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441, 358-361 (2006).
    • (2006) Nature , vol.441 , pp. 358-361
    • Wang, J.1
  • 45
    • 33646568438 scopus 로고    scopus 로고
    • Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): Unique resources for biological research
    • Kitagawa, M. et al. Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research. DNA Res. 12, 291-299 (2005).
    • (2005) DNA Res. , vol.12 , pp. 291-299
    • Kitagawa, M.1
  • 46
    • 0028876538 scopus 로고
    • Effect of polymyxin B nonapeptide on daptomycin permeability and cell surface properties in Pseudomonas aeruginosa Escherichia coli and Pasteurella multocida
    • Morris, C. M., George, A., Wilson, W. W. & Champlin, F. R. Effect of polymyxin B nonapeptide on daptomycin permeability and cell surface properties in Pseudomonas aeruginosa, Escherichia coli, and Pasteurella multocida. J. Antibiot. 48, 67-72 (1995).
    • (1995) J. Antibiot. , vol.48 , pp. 67-72
    • Morris, C.M.1    George, A.2    Wilson, W.W.3    Champlin, F.R.4
  • 47
    • 33744536067 scopus 로고    scopus 로고
    • Antibiotics from actinomycetes: Will a renaissance follow the decline and fall?
    • Baltz, R. H. Antibiotics from actinomycetes: will a renaissance follow the decline and fall? SIM News 55, 186-196 (2005).
    • (2005) SIM News , vol.55 , pp. 186-196
    • Baltz, R.H.1
  • 48
    • 31944450795 scopus 로고    scopus 로고
    • Discovery of FabH/FabF inhibitors from natural products
    • Young, K. et al. Discovery of FabH/FabF inhibitors from natural products. Antimicrob. Agents Chemother. 50, 519-526 (2006).
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 519-526
    • Young, K.1
  • 49
    • 29844440702 scopus 로고    scopus 로고
    • Sporolides A and B: Structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica
    • Buchanan, G. O. et al. Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. Org. Lett. 7, 2731-2734 (2005).
    • (2005) Org. Lett. , vol.7 , pp. 2731-2734
    • Buchanan, G.O.1
  • 50
    • 0037046560 scopus 로고    scopus 로고
    • Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    • Bentley, S. D. et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417, 141-147 (2002).
    • (2002) Nature , vol.417 , pp. 141-147
    • Bentley, S.D.1
  • 51
    • 0038561132 scopus 로고    scopus 로고
    • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    • Ikeda, H. et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nature Biotech. 21, 526-531 (2003).
    • (2003) Nature Biotech. , vol.21 , pp. 526-531
    • Ikeda, H.1
  • 52
    • 0037318402 scopus 로고    scopus 로고
    • A genomics-guided approach for discovering and expressing cryptic metabolic pathways
    • Zazopoulos, E. et al. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotech. 21, 187-190 (2003).
    • (2003) Nature Biotech. , vol.21 , pp. 187-190
    • Zazopoulos, E.1
  • 53
    • 0014144988 scopus 로고
    • The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini
    • Khokhlov, A. S. et al. The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini. Dokl. Akad. Nauk SSSR 177, 232-235 (1967).
    • (1967) Dokl. Akad. Nauk SSSR , vol.177 , pp. 232-235
    • Khokhlov, A.S.1
  • 54
    • 0032847109 scopus 로고    scopus 로고
    • The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: Identification of a target gene of the A-factor receptor
    • Ohnishi, Y., Kameyama, S., Onaka, H. & Horinouchi, S. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol. Microbiol. 34, 102-111 (1999).
    • (1999) Mol. Microbiol. , vol.34 , pp. 102-111
    • Ohnishi, Y.1    Kameyama, S.2    Onaka, H.3    Horinouchi, S.4
  • 55
    • 0036778196 scopus 로고    scopus 로고
    • A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus
    • Horinouchi, S. A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Front. Biosci. 7, 2045-2057 (2002)
    • (2002) Front. Biosci. , vol.7 , pp. 2045-2057
    • Horinouchi, S.1
  • 56
    • 77956468890 scopus 로고    scopus 로고
    • Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters
    • Baltz, R. H. Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters. J. Ind. Microbiol. Biotechnol. 37, 759-772 (2010).
    • (2010) J. Ind. Microbiol. Biotechnol. , vol.37 , pp. 759-772
    • Baltz, R.H.1
  • 57
    • 79951846247 scopus 로고    scopus 로고
    • Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters
    • Gomez-Escribano, J. P. & Bibb, M. J. Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. Microb. Biotechnol. 4, 207-215 (2011).
    • (2011) Microb. Biotechnol. , vol.4 , pp. 207-215
    • Gomez-Escribano, J.P.1    Bibb, M.J.2
  • 58
    • 77249153701 scopus 로고    scopus 로고
    • Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
    • Komatsu, M., Uchiyama, T., Omura, S., Cane, D. E. & Ikeda, H. Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc. Natl Acad. Sci. USA 107, 2646-2651 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2646-2651
    • Komatsu, M.1    Uchiyama, T.2    Omura, S.3    Cane, D.E.4    Ikeda, H.5
  • 59
    • 80051671943 scopus 로고    scopus 로고
    • Strain improvement in actinomycetes in the postgenomic era
    • Baltz, R. H. Strain improvement in actinomycetes in the postgenomic era. J. Ind. Microbiol. Biotechnol. 38, 657-666 (2011).
    • (2011) J. Ind. Microbiol. Biotechnol. , vol.38 , pp. 657-666
    • Baltz, R.H.1
  • 62
    • 0030690924 scopus 로고    scopus 로고
    • A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms
    • Seow, K. T. et al. A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms. J. Bacteriol. 179, 7360-7368 (1997).
    • (1997) J. Bacteriol. , vol.179 , pp. 7360-7368
    • Seow, K.T.1
  • 63
    • 0036727242 scopus 로고    scopus 로고
    • Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA
    • Gillespie, D. E. et al. Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA. Appl. Environ. Microbiol. 68, 4301-4306 (2002).
    • (2002) Appl. Environ. Microbiol. , vol.68 , pp. 4301-4306
    • Gillespie, D.E.1
  • 64
    • 0037052320 scopus 로고    scopus 로고
    • Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment
    • Kaeberlein, T., Lewis, K. & Epstein, S. S. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment. Science 296, 1127-1129 (2002).
    • (2002) Science , vol.296 , pp. 1127-1129
    • Kaeberlein, T.1    Lewis, K.2    Epstein, S.S.3
  • 65
    • 39749129635 scopus 로고    scopus 로고
    • A trap for in situ cultivation of filamentous actinobacteria
    • Gavrish, E., Bollmann, A., Epstein, S. & Lewis, K. A trap for in situ cultivation of filamentous actinobacteria. J. Microbiol. Methods 72, 257-262 (2008).
    • (2008) J. Microbiol. Methods , vol.72 , pp. 257-262
    • Gavrish, E.1    Bollmann, A.2    Epstein, S.3    Lewis, K.4
  • 66
    • 77950560416 scopus 로고    scopus 로고
    • Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species
    • Nichols, D. et al. Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species. Appl. Environ. Microbiol. 76, 2445-2450 (2010).
    • (2010) Appl. Environ. Microbiol. , vol.76 , pp. 2445-2450
    • Nichols, D.1
  • 67
    • 77949545789 scopus 로고    scopus 로고
    • Siderophores from neighboring organisms promote the growth of uncultured bacteria
    • D'Onofrio, A. et al. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem. Biol. 17, 254-264 (2010).
    • (2010) Chem. Biol. , vol.17 , pp. 254-264
    • D'Onofrio, A.1
  • 68
    • 35448948699 scopus 로고    scopus 로고
    • Incubation of environmental samples in a diffusion chamber increases the diversity of recovered isolates
    • Bollmann, A., Lewis, K. & Epstein, S. S. Incubation of environmental samples in a diffusion chamber increases the diversity of recovered isolates. Appl. Environ. Microbiol. 73, 6386-6390 (2007).
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 6386-6390
    • Bollmann, A.1    Lewis, K.2    Epstein, S.S.3
  • 69
    • 0028149474 scopus 로고
    • Increased antifungal activity of L-733, 560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis
    • Kurtz, M. B. et al. Increased antifungal activity of L-733, 560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis. Antimicrob. Agents Chemother. 38, 2750-2757 (1994).
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 2750-2757
    • Kurtz, M.B.1
  • 70
    • 0018939225 scopus 로고
    • Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
    • Alberts, A. W. et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl Acad. Sci. USA 77, 73957-3961 (1980).
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 73957-73961
    • Alberts, A.W.1
  • 71
    • 0017157814 scopus 로고
    • Biological effects of cyclosporin A: A new antilymphocytic agent
    • Borel, J. F., Feurer, C., Gubler, H. U. & Stahelin, H. Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Act. 6, 468-475 (1976).
    • (1976) Agents Act. , vol.6 , pp. 468-475
    • Borel, J.F.1    Feurer, C.2    Gubler, H.U.3    Stahelin, H.4
  • 72
    • 0016724057 scopus 로고
    • Rapamycin (AY-22, 989), a new antifungal antibiotic. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina, C., Kudelski, A. & Sehgal, S. N. Rapamycin (AY-22, 989), a new antifungal antibiotic. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28, 721-726 (1975).
    • (1975) J. Antibiot. , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 73
    • 84856554767 scopus 로고    scopus 로고
    • A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma
    • Pacey, S. et al. A Phase II trial of 17-allylamino, 17- demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma. Invest. New Drugs 30, 341-349 (2012).
    • (2012) Invest. New Drugs , vol.30 , pp. 341-349
    • Pacey, S.1
  • 74
  • 76
    • 80052937334 scopus 로고    scopus 로고
    • Artemisinin: Discovery from the Chinese herbal garden
    • Miller, L. H. & Su, X. Artemisinin: discovery from the Chinese herbal garden. Cell 146, 855-858 (2011).
    • (2011) Cell , vol.146 , pp. 855-858
    • Miller, L.H.1    Su, X.2
  • 77
    • 0035859039 scopus 로고    scopus 로고
    • Natural products and plant disease resistance
    • Dixon, R. A. Natural products and plant disease resistance. Nature 4 11, 843-847 (2001).
    • (2001) Nature , vol.4 , Issue.11 , pp. 843-847
    • Dixon, R.A.1
  • 78
    • 0017043747 scopus 로고
    • Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase
    • Gellert, M., O'Dea, M. H., Itoh, T. & Tomizawa, J. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc. Natl Acad. Sci. USA 73, 4474-4478 (1976).
    • (1976) Proc. Natl Acad. Sci. USA , vol.73 , pp. 4474-4478
    • Gellert, M.1    O'Dea, M.H.2    Itoh, T.3    Tomizawa, J.4
  • 79
    • 77952382039 scopus 로고    scopus 로고
    • That was then but this is now: Malaria research in the time of an eradication agenda
    • Kappe, S. H. I., Vaughan, A. M., Boddey, J. A. & Cowman, A. F. That was then but this is now: malaria research in the time of an eradication agenda. Science 328, 862-866 (2010).
    • (2010) Science , vol.328 , pp. 862-866
    • Kappe, S.H.I.1    Vaughan, A.M.2    Boddey, J.A.3    Cowman, A.F.4
  • 80
    • 1942502195 scopus 로고    scopus 로고
    • Anti-staphylococcal plant natural products
    • Gibbons, S. Anti-staphylococcal plant natural products. Nat. Prod. Rep. 21, 263-277 (2004).
    • (2004) Nat. Prod. Rep. , vol.21 , pp. 263-277
    • Gibbons, S.1
  • 82
    • 77953584054 scopus 로고    scopus 로고
    • Creation of a bacterial cell controlled by a chemically synthesized genome
    • Gibson, D. G. et al. Creation of a bacterial cell controlled by a chemically synthesized genome. Science 329, 52-56 (2010).
    • (2010) Science , vol.329 , pp. 52-56
    • Gibson, D.G.1
  • 83
    • 57749107808 scopus 로고    scopus 로고
    • Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America
    • Boucher, H. W. et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin. Infect. Dis. 48, 1-12 (2009).
    • (2009) Clin. Infect. Dis. , vol.48 , pp. 1-12
    • Boucher, H.W.1
  • 86
    • 33947260230 scopus 로고    scopus 로고
    • Molecular mechanisms of antibacterial multidrug resistance
    • Alekshun, M. N. & Levy, S. B. Molecular mechanisms of antibacterial multidrug resistance. Cell 128, 1037-1050 (2007).
    • (2007) Cell , vol.128 , pp. 1037-1050
    • Alekshun, M.N.1    Levy, S.B.2
  • 87
    • 33845607284 scopus 로고    scopus 로고
    • Persister cells, dormancy and infectious disease
    • Lewis, K. Persister cells, dormancy and infectious disease. Nature Rev. Microbiol. 5, 48-56 (2007).
    • (2007) Nature Rev. Microbiol. , vol.5 , pp. 48-56
    • Lewis, K.1
  • 88
    • 77955628762 scopus 로고    scopus 로고
    • Persister cells
    • Lewis, K. Persister cells. Annu. Rev. Microbiol. 64, 357-372 (2010).
    • (2010) Annu. Rev. Microbiol. , vol.64 , pp. 357-372
    • Lewis, K.1
  • 91
    • 33747436591 scopus 로고    scopus 로고
    • Persisters: A distinct physiological state of E. coli
    • Shah, D. et al. Persisters: A distinct physiological state of E. coli. BMC Microbiol. 6, 53-61 (2006).
    • (2006) BMC Microbiol. , vol.6 , pp. 53-61
    • Shah, D.1
  • 92
    • 77649174212 scopus 로고    scopus 로고
    • Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli
    • Dorr, T., Vulic, M. & Lewis, K. Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol. 8, e1000317 (2010).
    • (2010) PLoS Biol. , vol.8
    • Dorr, T.1    Vulic, M.2    Lewis, K.3
  • 93
    • 10044266575 scopus 로고    scopus 로고
    • Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli
    • Keren, I., Shah, D., Spoering, A., Kaldalu, N. & Lewis, K. Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J. Bacteriol. 186, 8172-8180 (2004).
    • (2004) J. Bacteriol. , vol.186 , pp. 8172-8180
    • Keren, I.1    Shah, D.2    Spoering, A.3    Kaldalu, N.4    Lewis, K.5
  • 94
    • 58449087611 scopus 로고    scopus 로고
    • Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB
    • Schumacher, M. A. et al. Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science 323, 396-401 (2009).
    • (2009) Science , vol.323 , pp. 396-401
    • Schumacher, M.A.1
  • 96
    • 48749089081 scopus 로고    scopus 로고
    • The role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli
    • Hansen, S., Lewis, K. & Vulic, M. The role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrob. Agents Chemother. 52, 2718-2726 (2008).
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 2718-2726
    • Hansen, S.1    Lewis, K.2    Vulic, M.3
  • 97
    • 73849102829 scopus 로고    scopus 로고
    • Patients with long-term oral carriage harbor high-persister mutants of Candida albicans
    • LaFleur, M. D., Qi, Q. & Lewis, K. Patients with long-term oral carriage harbor high-persister mutants of Candida albicans. Antimicrob. Agents Chemother. 54, 39-44 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 39-44
    • Lafleur, M.D.1    Qi, Q.2    Lewis, K.3
  • 98
    • 77957947243 scopus 로고    scopus 로고
    • Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis
    • Mulcahy, L. R., Burns, J. L., Lory, S. & Lewis, K. Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J. Bacteriol. 192, 6191-6199 (2010).
    • (2010) J. Bacteriol. , vol.192 , pp. 6191-6199
    • Mulcahy, L.R.1    Burns, J.L.2    Lory, S.3    Lewis, K.4
  • 99
    • 33745189789 scopus 로고    scopus 로고
    • Non-inherited antibiotic resistance
    • Levin, B. R. & Rozen, D. E. Non-inherited antibiotic resistance. Nature Rev. Microbiol. 4, 556-562 (2006).
    • (2006) Nature Rev. Microbiol. , vol.4 , pp. 556-562
    • Levin, B.R.1    Rozen, D.E.2
  • 100
    • 0036834373 scopus 로고    scopus 로고
    • The future challenges facing the development of new antimicrobial drugs
    • Coates, A. et al. The future challenges facing the development of new antimicrobial drugs. Nature Rev. Drug Discov. 1, 895-910 (2002).
    • (2002) Nature Rev. Drug Discov. , vol.1 , pp. 895-910
    • Coates, A.1
  • 101
    • 84877304193 scopus 로고
    • Some properties of penicillin-resistant staphylococci
    • Bellamy, W. D. & Klimek, J. W. Some properties of penicillin-resistant staphylococci. J. Bacteriol. 55, 153-160 (1948).
    • (1948) J. Bacteriol. , vol.55 , pp. 153-160
    • Bellamy, W.D.1    Klimek, J.W.2
  • 102
    • 0017074284 scopus 로고
    • Naturally-occurring beta-lactamase inhibitors with antibacterial activity
    • Brown, A. G. et al. Naturally-occurring beta-lactamase inhibitors with antibacterial activity. J. Antibiot. 29, 668-669 (1976).
    • (1976) J. Antibiot. , vol.29 , pp. 668-669
    • Brown, A.G.1
  • 103
    • 33747179934 scopus 로고    scopus 로고
    • The beta-lactamase threat in Enterobacteriaceae Pseudomonas and Acinetobacter
    • Livermore, D. M. & Woodford, N. The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter. Trends Microbiol. 14, 413-420 (2006).
    • (2006) Trends Microbiol. , vol.14 , pp. 413-420
    • Livermore, D.M.1    Woodford, N.2
  • 104
    • 37049005385 scopus 로고    scopus 로고
    • Metallo-beta-lactamase IMP-18 is located in a class 1 integron (In96) in a clinical isolate of Pseudomonas aeruginosa from Mexico
    • Garza-Ramos, U. et al. Metallo-beta-lactamase IMP-18 is located in a class 1 integron (In96) in a clinical isolate of Pseudomonas aeruginosa from Mexico. Int. J. Antimicrob. Agents 31, 78-80 (2008).
    • (2008) Int. J. Antimicrob. Agents , vol.31 , pp. 78-80
    • Garza-Ramos, U.1
  • 105
    • 78649683457 scopus 로고    scopus 로고
    • Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor
    • Stachyra, T. et al. Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. Antimicrob. Agents Chemother. 54, 5132-5138 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 5132-5138
    • Stachyra, T.1
  • 107
    • 77955917495 scopus 로고    scopus 로고
    • Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: A molecular, biological, and epidemiological study
    • Kumarasamy, K. K. et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10, 597-602 (2010).
    • (2010) Lancet Infect. Dis. , vol.10 , pp. 597-602
    • Kumarasamy, K.K.1
  • 108
    • 0026686805 scopus 로고
    • Emr an Escherichia coli locus for multidrug resistance
    • Lomovskaya, O. & Lewis, K. Emr, an Escherichia coli locus for multidrug resistance. Proc. Natl Acad. Sci. USA 89, 8938-8942 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 8938-8942
    • Lomovskaya, O.1    Lewis, K.2
  • 109
    • 0442307441 scopus 로고    scopus 로고
    • Efflux-mediated drug resistance in bacteria
    • Li, X. Z. & Nikaido, H. Efflux-mediated drug resistance in bacteria. Drugs 64, 159-204 (2004).
    • (2004) Drugs , vol.64 , pp. 159-204
    • Li, X.Z.1    Nikaido, H.2
  • 110
    • 13844312649 scopus 로고    scopus 로고
    • ZINC - A free database of commercially available compounds for virtual screening
    • Irwin, J. J Shoichet B. K.
    • Irwin, J. J. & Shoichet, B. K. ZINC-a free database of commercially available compounds for virtual screening. J. Chem. Inf. Model. 45, 177-182 (2005).
    • (2005) J. Chem. Inf. Model. , vol.45 , pp. 177-182
  • 111
    • 57549100233 scopus 로고    scopus 로고
    • Using ZINC to acquire a virtual screening library
    • Irwin, J. J., Ch. 14, Unit 14.6
    • Irwin, J. J. Using ZINC to acquire a virtual screening library. Curr. Protoc. Bioinformatics Ch. 14, Unit 14.6 (2008).
    • (2008) Curr. Protoc. Bioinformatics
  • 112
    • 0030039619 scopus 로고    scopus 로고
    • The art and practice of structure-based drug design: A molecular modeling perspective
    • Bohacek, R. S., McMartin, C. & Guida, W. C. The art and practice of structure-based drug design: a molecular modeling perspective. Med. Res. Rev. 16, 3-50 (1996).
    • (1996) Med. Res. Rev. , vol.16 , pp. 3-50
    • Bohacek, R.S.1    McMartin, C.2    Guida, W.C.3
  • 113
    • 84874238564 scopus 로고    scopus 로고
    • A comprehensive regulatory framework to address the unmet need for new antibacterial treatments
    • Rex, J. H. et al. A comprehensive regulatory framework to address the unmet need for new antibacterial treatments. Lancet Infect. Dis. 13, 269-275 (2013).
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 269-275
    • Rex, J.H.1
  • 114
    • 74849098405 scopus 로고    scopus 로고
    • Treatment with monoclonal antibodies against Clostridium difficile toxins
    • Lowy, I. et al. Treatment with monoclonal antibodies against Clostridium difficile toxins. N. Engl. J. Med. 362, 197-205 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 197-205
    • Lowy, I.1
  • 115
    • 27344443267 scopus 로고    scopus 로고
    • Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization
    • Hung, D. T., Shakhnovich, E. A., Pierson, E. & Mekalanos, J. J. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science 310, 670-674 (2005).
    • (2005) Science , vol.310 , pp. 670-674
    • Hung, D.T.1    Shakhnovich, E.A.2    Pierson, E.3    Mekalanos, J.J.4
  • 116
    • 77952741849 scopus 로고    scopus 로고
    • Therapeutic effect of (Z)-3-(2, 5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile (DMMA) against Staphylococcus aureus infection in a murine model
    • Oh, K. B. et al. Therapeutic effect of (Z)-3-(2, 5-dimethoxyphenyl)-2-(4- methoxyphenyl) acrylonitrile (DMMA) against Staphylococcus aureus infection in a murine model. Biochem. Biophys. Res. Commun. 396, 440-444 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.396 , pp. 440-444
    • Oh, K.B.1
  • 118
    • 0031782954 scopus 로고    scopus 로고
    • Lantibiotics: Biosynthesis and biological activities of uniquely modified peptides from Gram-positive bacteria
    • Sahl, H. G. & Bierbaum, G. Lantibiotics: biosynthesis and biological activities of uniquely modified peptides from Gram-positive bacteria. Annu. Rev. Microbiol. 52, 41-79 (1998).
    • (1998) Annu. Rev. Microbiol. , vol.52 , pp. 41-79
    • Sahl, H.G.1    Bierbaum, G.2
  • 119
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 415, 389-395 (2002).
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 120
    • 79151470498 scopus 로고    scopus 로고
    • In vitro management of hospital Pseudomonas aeruginosa biofilm using indigenous T7-like lytic phage
    • Ahiwale, S. et al. In vitro management of hospital Pseudomonas aeruginosa biofilm using indigenous T7-like lytic phage. Curr. Microbiol. 62, 335-340 (2011).
    • (2011) Curr. Microbiol. , vol.62 , pp. 335-340
    • Ahiwale, S.1
  • 121
    • 0031737099 scopus 로고    scopus 로고
    • Biofilm susceptibility to bacteriophage attack: The role of phage-borne polysaccharide depolymerase
    • Hughes, K. A., Sutherland, I. W. & Jones, M. V. Biofilm susceptibility to bacteriophage attack: the role of phage-borne polysaccharide depolymerase. Microbiol. 144, 3039-3047 (1998).
    • (1998) Microbiol. , vol.144 , pp. 3039-3047
    • Hughes, K.A.1    Sutherland, I.W.2    Jones, M.V.3
  • 123
    • 0742305687 scopus 로고    scopus 로고
    • Phage-inspired antibiotics?
    • Projan, S. Phage-inspired antibiotics? Nature Biotech. 22, 167-168 (2004).
    • (2004) Nature Biotech. , vol.22 , pp. 167-168
    • Projan, S.1
  • 124
    • 68349154135 scopus 로고    scopus 로고
    • A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; A preliminary report of efficacy
    • Wright, A., Hawkins, C. H., Anggard, E. E. & Harper, D. R. A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin. Otolaryngol. 34, 349-357 (2009).
    • (2009) Clin. Otolaryngol. , vol.34 , pp. 349-357
    • Wright, A.1    Hawkins, C.H.2    Anggard, E.E.3    Harper, D.R.4


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