Waking up streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors

Methods in Enzymology

Volumn 517, Issue , 2012, Pages 343-366

  Aigle, Bertrand ^a   Corre, Christophe ^b  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Microbial engineering; Natural products; Pathway specific; Strain improvement; Streptomyces; Transcriptional regulation

Indexed keywords

APRAMYCIN; AVERMECTIN; GELDANAMYCIN; GENOMIC DNA; KANAMYCIN; KINAMYCIN; METHYLENOMYCIN A; METHYLENOMYCIN B; NATURAL PRODUCT; SPIRAMYCIN; TETRACYCLINE;

ARTICLE; BACTERIAL METABOLISM; BACTERIUM CULTURE; BIOASSAY; CARBOXY TERMINAL SEQUENCE; CODON; CRYSTAL STRUCTURE; DNA BINDING; DNA EXTRACTION; DNA SEQUENCE; DRUG MANUFACTURE; DRUG PURIFICATION; DRUG SCREENING; DRUG STRUCTURE; FUNGAL STRAIN; GENE AMPLIFICATION; GENE CLUSTER; GENE DISRUPTION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE STRUCTURE; GENETIC ENGINEERING; GENETIC MANIPULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REPRESSOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; STREPTOMYCES; TRANSCRIPTION REGULATION; X RAY ANALYSIS;

EID: 84867629258     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-404634-4.00017-6     Document Type: Chapter

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