Simple "on-demand" production of bioactive natural products

ChemBioChem

Volumn 16, Issue 7, 2015, Pages 1115-1119

  Bode, Edna ^a   Brachmann, Alexander O ^a   Kegler, Carsten ^a   Simsek, Rukayye ^a   Dauth, Christina ^a   Zhou, Qiuqin ^a   Kaiser, Marcel ^b   Klemmt, Petra ^a   Bode, Helge B ^a  

^a GOETHE UNIVERSITY   (Germany)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

"silent" gene cluster; biosynthesis; natural products; overproduction; promoter exchange approach

Indexed keywords

ANTIBIOTIC AGENT; ARABINOSE; BENZNIDAZOLE; CHLOROQUINE; INDIGOIDINE; MELARSOPROL; MEVALAGMAPEPTIDE A; MEVALAGMAPEPTIDE B; NATURAL PRODUCT; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG; XENOAMICIN C; XENORHABDIN 2; XENORHABDIN 5; BIOLOGICAL PRODUCT;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENTOMOPATHOGENIC BACTERIUM; GENE ACTIVATION; GENE CLUSTER; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IC50; NONHUMAN; PHOTORHABDUS LUMINESCENS; PRIORITY JOURNAL; PROMOTER REGION; SILENT GENE; XENORHABDUS; XENORHABDUS DOUCETIAE; ANIMAL; CELL LINE; DRUG EFFECTS; GENETIC ENGINEERING; GENETICS; METABOLISM; MULTIGENE FAMILY; PHOTORHABDUS; PLASMID; PROCEDURES; RAT;

ANIMALS; ARABINOSE; BIOLOGICAL PRODUCTS; CELL LINE; GENETIC ENGINEERING; MULTIGENE FAMILY; PHOTORHABDUS; PLASMIDS; PROMOTER REGIONS, GENETIC; RATS; XENORHABDUS;

EID: 84928391757     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201500094     Document Type: Article

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