A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

Science Translational Medicine

Volumn 9, Issue 421, 2017, Pages

  Ryan, Katie J ^a,b,c   White, Charles C ^a,c   Patel, Kruti ^a,b,c   Xu, Jishu ^a,c   Olah, Marta ^c,d   Replogle, Joseph M ^a,b,c,g   Frangieh, Michael ^a,c   Cimpean, Maria ^a,c,h   Winn, Phoebe ^a,c   McHenry, Allison ^a,c   Kaskow, Belinda J ^a,b,c   Chan, Gail ^a,b,c   Cuerdon, Nicole ^a,b,c   Bennett, David A ^e   Boyd, Justin D ^a,b   Imitola, Jaime ^f   Elyaman, Wassim ^c,d   De Jager, Philip L ^c,d   Bradshaw, Elizabeth M ^c,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

^f THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALZHEIMER DISEASE; ARTICLE; CD33 GENE; CELL DIFFERENTIATION; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; GENE; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; LRRK2 GENE; MALE; METTL21B GENE; MICROGLIA; MONOCYTE; MULTIPLE SCLEROSIS; NORMAL HUMAN; NUP160 GENE; PARKINSON DISEASE; PHAGOCYTOSIS; PHENOTYPE; PILRB GENE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RGS1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; BIOLOGICAL MODEL; CELL POLARITY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; METABOLISM; NERVE DEGENERATION; PATHOLOGY;

CD33 ANTIGEN; ISOPROTEIN;

CELL POLARITY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MICROGLIA; MODELS, BIOLOGICAL; MONOCYTES; NERVE DEGENERATION; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN ISOFORMS; QUANTITATIVE TRAIT LOCI; SIALIC ACID BINDING IG-LIKE LECTIN 3;

EID: 85039165213     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aai7635     Document Type: Article

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