Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Ohgidani, Masahiro ^a   Kato, Takahiro A ^a,b   Setoyama, Daiki ^b   Sagata, Noriaki ^a   Hashimoto, Ryota ^c   Shigenobu, Kazue ^d   Yoshida, Tetsuhiko ^c   Hayakawa, Kohei ^a   Shimokawa, Norihiro ^a   Miura, Daisuke ^b   Utsumi, Hideo ^b   Kanba, Shigenobu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d Asakayama General Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CYTOKINE; MEMBRANE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TYROBP PROTEIN, HUMAN;

CELL DIFFERENTIATION; CHONDRODYSPLASIA; CYTOLOGY; DRUG EFFECTS; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOPHENOTYPING; LIPODYSTROPHY; METABOLISM; MICROGLIA; MIDDLE AGED; MONOCYTE; PATHOLOGY; RNA INTERFERENCE; SUBACUTE SCLEROSING PANENCEPHALITIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL DIFFERENTIATION; CYTOKINES; FEMALE; HUMANS; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; LIPODYSTROPHY; MEMBRANE PROTEINS; MICROGLIA; MIDDLE AGED; MONOCYTES; OSTEOCHONDRODYSPLASIAS; RNA INTERFERENCE; SUBACUTE SCLEROSING PANENCEPHALITIS;

EID: 84901044935     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04957     Document Type: Article

References (35)

1. Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845 (2010).
2. Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005). (Pubitemid 40746128)
3. Kettenmann, H., Hanisch, U. K., Noda, M. & Verkhratsky, A. Physiology of microglia. Physiol Rev 91, 461-553 (2011).
4. Ransohoff, R. M. & Perry, V. H. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 27, 119-145 (2009).
5. Graeber, M. B. Changing face of microglia. Science 330, 783-788 (2010).
6. Block, M. L., Zecca, L. &Hong, J. S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8, 57-69 (2007). (Pubitemid 46011999)
7. Hanisch, U. K. & Kettenmann, H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10, 1387-1394 (2007). (Pubitemid 350014685)
8. Kato, T. A. et al. Neurotransmitters, psychotropic drugs and microglia: clinical implications for psychiatry. Curr Med Chem 20, 331-344 (2013).
9. Hakola, H. P. Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia. Acta Psychiatr Scand Suppl 232, 1-173 (1972).
10. Nasu, T., Tsukahara, Y. & Terayama, K. A lipid metabolic disease-''membranous lipodystrophy''-an autopsy case demonstrating numerous peculiar membranestructures composed of compound lipid in bone and bone marrow and various adipose tissues. Acta Pathol Jpn 23, 539-558 (1973).
11. Kaneko, M., Sano, K., Nakayama, J. & Amano, N. Nasu-Hakola disease: The first case reported by Nasu and review. Neuropathology 30, 463-470 (2010).
12. Paloneva, J. et al. CNS manifestations of Nasu-Hakola disease: a frontal dementia with bone cysts. Neurology 56, 1552-1558 (2001). (Pubitemid 32532269)
13. Paloneva, J. et al. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nat Genet 25, 357-361 (2000). (Pubitemid 30437329)
14. Paloneva, J. et al. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am J Hum Genet 71, 656-662 (2002). (Pubitemid 34970138)
15. Roumier, A. et al. Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J Neurosci 24, 11421-11428 (2004). (Pubitemid 39658277)
16. Satoh, J. et al. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology 31, 363-375 (2011).
17. Mattis, V. B. & Svendsen, C. N. Induced pluripotent stem cells: a new revolution for clinical neurology? Lancet Neurol 10, 383-394 (2011).
18. Dimos, J. T. et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321, 1218-1221 (2008).
19. Pfisterer, U. et al. Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A 108, 10343-10348 (2011).
20. Qiang, L. et al. Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons. Cell 146, 359-371 (2011).
21. Pang, Z. P. et al. Induction of human neuronal cells by defined transcription factors. Nature 476, 220-223 (2011).
22. Wang, Y. et al. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol 13, 753-760 (2012).
23. Aloisi, F., De Simone, R., Columba-Cabezas, S., Penna, G. & Adorini, L. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells. J Immunol 164, 1705-1712 (2000). (Pubitemid 30108719)
24. Erblich, B., Zhu, L., Etgen, A. M., Dobrenis, K. & Pollard, J. W. Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS One 6, e26317 (2011).
25. Nandi, S. et al. The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Dev Biol 367, 100-113 (2012).
26. Sedgwick, J. D. et al. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci U S A 88, 7438-7442 (1991). (Pubitemid 21915167)
27. Melief, J. et al. Phenotyping primary human microglia: tight regulation of LPS responsiveness. Glia 60, 1506-1517 (2012).
28. Mizutani, M. et al. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J Immunol 188, 29-36 (2012).
29. Hinze, A. et al. Microglia differentiation using a culture system for the expansion of mice non-dadherent bone marrow stem cells. J Inflamm 9, 12 (2012).
30. Noto, D. et al. Development of a culture system to induce microglia-like cells from haematopoitic cells. Neuropathol Appl Neurobiol. Doi10. 1111/nan. 12086. (2013).
31. Guilemini, G. et al. Granulocyte macrophage colony stimulating factor stimulates in vitro proliferation of astrocytes derived from simian mature brains. Glia 16, 71-80 (1996).
32. Gomez-Nicola, D. et al. Regulation of microglial proliferation during chronic neurodegeneration. J Neurosci 33, 2481-2493 (2013).
33. Schwarz, J. M. & Bilbo, S. D. Sex, glia, and development: interactions in health and disease. Horm Behgav 62, 243-253 (2012).
34. Paradowska-Gorycka, A. & Jurkowska, M. Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12. Hum Immunol 74, 730-737 (2013).
35. Hamerman, J. A., Tchao, N. K., Lowell, C. A. & Lanier, L. L. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 6, 579-586 (2005). (Pubitemid 41710728)