-
1
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer׳s disease and related disorders
-
Ballatore, C., Lee, V.M., Trojanowski, J.Q., Tau-mediated neurodegeneration in Alzheimer׳s disease and related disorders. Nat. Rev. Neurosci. 8 (2007), 663–672.
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
2
-
-
78649232442
-
Genetics of Alzheimer disease
-
Bekris, L.M., Yu, C.E., Bird, T.D., Tsuang, D.W., Genetics of Alzheimer disease. J. Geriatr. Psychiatry Neurol. 23 (2010), 213–227.
-
(2010)
J. Geriatr. Psychiatry Neurol.
, vol.23
, pp. 213-227
-
-
Bekris, L.M.1
Yu, C.E.2
Bird, T.D.3
Tsuang, D.W.4
-
3
-
-
84924721164
-
3rd, Gage F.H., Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
-
Brennand, K., Savas, J.N., Kim, Y., Tran, N., Simone, A., Hashimoto-Torii, K., Beaumont, K.G., Kim, H.J., Topol, A., Ladran, I., Abdelrahim, M., Matikainen-Ankney, B., Chao, S.H., MrSich, M., Rakic, P., Fang, G., Zhang, B., Yates, J.R., 3rd, Gage F.H., Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Mol. Psychiatry 3 (2015), 361–368.
-
(2015)
Mol. Psychiatry
, vol.3
, pp. 361-368
-
-
Brennand, K.1
Savas, J.N.2
Kim, Y.3
Tran, N.4
Simone, A.5
Hashimoto-Torii, K.6
Beaumont, K.G.7
Kim, H.J.8
Topol, A.9
Ladran, I.10
Abdelrahim, M.11
Matikainen-Ankney, B.12
Chao, S.H.13
MrSich, M.14
Rakic, P.15
Fang, G.16
Zhang, B.17
Yates, J.R.18
-
4
-
-
55049142500
-
Genome-wide association analysis reveals putative Alzheimer׳s disease susceptibility loci in addition to APOE
-
Bertram, L., Lange, C., Mullin, K., Parkinson, M., Hsiao, M., Hogan, M.F., Schjeide, B.M., Hooli, B., Divito, J., Ionita, I., Jiang, H., Laird, N., Moscarillo, T., Ohlsen, K.L., Elliott, K., Wang, X., Hu-Lince, D., Ryder, M., Murphy, A., Wagner, S.L., Blacker, D., Becker, K.D., Tanzi, R.E., Genome-wide association analysis reveals putative Alzheimer׳s disease susceptibility loci in addition to APOE. Am. J. Hum. Genet. 83 (2008), 623–632.
-
(2008)
Am. J. Hum. Genet.
, vol.83
, pp. 623-632
-
-
Bertram, L.1
Lange, C.2
Mullin, K.3
Parkinson, M.4
Hsiao, M.5
Hogan, M.F.6
Schjeide, B.M.7
Hooli, B.8
Divito, J.9
Ionita, I.10
Jiang, H.11
Laird, N.12
Moscarillo, T.13
Ohlsen, K.L.14
Elliott, K.15
Wang, X.16
Hu-Lince, D.17
Ryder, M.18
Murphy, A.19
Wagner, S.L.20
Blacker, D.21
Becker, K.D.22
Tanzi, R.E.23
more..
-
5
-
-
77955908261
-
Generation of microglial cells from mouse embryonic stem cells
-
Beutner, C., Roy, K., Linnartz, B., Napoli, I., Neumann, H., Generation of microglial cells from mouse embryonic stem cells. Nat. Protoc. 5 (2010), 1481–1494.
-
(2010)
Nat. Protoc.
, vol.5
, pp. 1481-1494
-
-
Beutner, C.1
Roy, K.2
Linnartz, B.3
Napoli, I.4
Neumann, H.5
-
6
-
-
84896699997
-
Modulation of inflammation in transgenic models of Alzheimer׳s disease
-
Birch, A.M., Katsouri, L., Sastre, M., Modulation of inflammation in transgenic models of Alzheimer׳s disease. J. Neuroinflamm., 11, 2014, 25.
-
(2014)
J. Neuroinflamm.
, vol.11
, pp. 25
-
-
Birch, A.M.1
Katsouri, L.2
Sastre, M.3
-
7
-
-
79955411486
-
The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells
-
Bissonnette, C.J., Lyass, L., Bhattacharyya, B.J., Belmadani, A., Miller, R.J., Kessler, J.A., The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells. Stem Cells 29 (2011), 802–811.
-
(2011)
Stem Cells
, vol.29
, pp. 802-811
-
-
Bissonnette, C.J.1
Lyass, L.2
Bhattacharyya, B.J.3
Belmadani, A.4
Miller, R.J.5
Kessler, J.A.6
-
8
-
-
84891403855
-
The specification of telencephalic glutamatergic neurons from human pluripotent stem cells
-
Boisvert, E.M., Denton, K., Lei, L., Li, X.J., The specification of telencephalic glutamatergic neurons from human pluripotent stem cells. J. Vis. Exp., 2013, 74.
-
(2013)
J. Vis. Exp.
, pp. 74
-
-
Boisvert, E.M.1
Denton, K.2
Lei, L.3
Li, X.J.4
-
9
-
-
84891706947
-
CD33 Alzheimer׳s disease locus: altered monocyte function and amyloid biology
-
Bradshaw, E.M., Chibnik, L.B., Keenan, B.T., Ottoboni, L., Raj, T., Tang, A., Rosenkrantz, L.L., Imboywa, S., Lee, M., Von Korff, A., Morris, M.C., Evans, D.A., Johnson, K., Sperling, R.A., Schneider, J.A., Bennett, D.A., De Jager, P.L., CD33 Alzheimer׳s disease locus: altered monocyte function and amyloid biology. Nat. Neurosci. 16 (2013), 848–850.
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 848-850
-
-
Bradshaw, E.M.1
Chibnik, L.B.2
Keenan, B.T.3
Ottoboni, L.4
Raj, T.5
Tang, A.6
Rosenkrantz, L.L.7
Imboywa, S.8
Lee, M.9
Von Korff, A.10
Morris, M.C.11
Evans, D.A.12
Johnson, K.13
Sperling, R.A.14
Schneider, J.A.15
Bennett, D.A.16
De Jager, P.L.17
-
10
-
-
84920829978
-
Direct conversion of fibroblasts into functional astrocytes by defined transcription factors
-
Caiazzo, M., Giannelli, S., Valente, P., Lignani, G., Carissimo, A., Sessa, A., Colasante, G., Bartolomeo, R., Massimino, L., Ferroni, S., Settembre, C., Benfenati, F., Broccoli, V., Direct conversion of fibroblasts into functional astrocytes by defined transcription factors. Stem Cell Rep. 4 (2015), 25–36.
-
(2015)
Stem Cell Rep.
, vol.4
, pp. 25-36
-
-
Caiazzo, M.1
Giannelli, S.2
Valente, P.3
Lignani, G.4
Carissimo, A.5
Sessa, A.6
Colasante, G.7
Bartolomeo, R.8
Massimino, L.9
Ferroni, S.10
Settembre, C.11
Benfenati, F.12
Broccoli, V.13
-
11
-
-
84909578705
-
Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
-
Campos, P.B., Paulsen, B.S., Rehen, S.K., Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species. Front Aging Neurosci., 6, 2014, 292.
-
(2014)
Front Aging Neurosci.
, vol.6
, pp. 292
-
-
Campos, P.B.1
Paulsen, B.S.2
Rehen, S.K.3
-
12
-
-
0033869715
-
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer׳s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
-
Cataldo, A.M., Peterhoff, C.M., Troncoso, J.C., Gomez-Isla, T., Hyman, B.T., Nixon, R.A., Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer׳s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am. J. Pathol. 157 (2000), 277–286.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 277-286
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Troncoso, J.C.3
Gomez-Isla, T.4
Hyman, B.T.5
Nixon, R.A.6
-
13
-
-
4644319713
-
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
-
Cataldo, A.M., Petanceska, S., Terio, N.B., Peterhoff, C.M., Durham, R., Mercken, M., Mehta, P.D., Buxbaum, J., Haroutunian, V., Nixon, R.A., Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol. Aging 25 (2004), 1263–1272.
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
Mercken, M.6
Mehta, P.D.7
Buxbaum, J.8
Haroutunian, V.9
Nixon, R.A.10
-
14
-
-
62149125434
-
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
-
Chambers, S.M., Fasano, C.A., Papapetrou, E.P., Tomishima, M., Sadelain, M., Studer, L., Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27 (2009), 275–280.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 275-280
-
-
Chambers, S.M.1
Fasano, C.A.2
Papapetrou, E.P.3
Tomishima, M.4
Sadelain, M.5
Studer, L.6
-
15
-
-
84912064761
-
A three-dimensional human neural cell culture model of Alzheimer׳s disease
-
Choi, S.H., Kim, Y.H., Hebisch, M., Sliwinski, C., Lee, S., D׳Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J.B., Zhang, C., Wainger, B.J., Peitz, M., Kovacs, D.M., Woolf, C.J., Wagner, S.L., Tanzi, R.E., Kim, D.Y., A three-dimensional human neural cell culture model of Alzheimer׳s disease. Nature 515 (2014), 274–278.
-
(2014)
Nature
, vol.515
, pp. 274-278
-
-
Choi, S.H.1
Kim, Y.H.2
Hebisch, M.3
Sliwinski, C.4
Lee, S.5
D׳Avanzo, C.6
Chen, H.7
Hooli, B.8
Asselin, C.9
Muffat, J.10
Klee, J.B.11
Zhang, C.12
Wainger, B.J.13
Peitz, M.14
Kovacs, D.M.15
Woolf, C.J.16
Wagner, S.L.17
Tanzi, R.E.18
Kim, D.Y.19
-
16
-
-
84922639322
-
hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice
-
Cunningham, M., Cho, J.H., Leung, A., Savvidis, G., Ahn, S., Moon, M., Lee, P.K., Han, J.J., Azimi, N., Kim, K.S., Bolshakov, V.Y., Chung, S., hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 15 (2014), 559–573.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 559-573
-
-
Cunningham, M.1
Cho, J.H.2
Leung, A.3
Savvidis, G.4
Ahn, S.5
Moon, M.6
Lee, P.K.7
Han, J.J.8
Azimi, N.9
Kim, K.S.10
Bolshakov, V.Y.11
Chung, S.12
-
17
-
-
84892188499
-
Stem cell derived basal forebrain cholinergic neurons from Alzheimer׳s disease patients are more susceptible to cell death
-
Duan, L., Bhattacharyya, B.J., Belmadani, A., Pan, L., Miller, R.J., Kessler, J.A., Stem cell derived basal forebrain cholinergic neurons from Alzheimer׳s disease patients are more susceptible to cell death. Mol. Neurodegener., 9, 2014, 3.
-
(2014)
Mol. Neurodegener.
, vol.9
, pp. 3
-
-
Duan, L.1
Bhattacharyya, B.J.2
Belmadani, A.3
Pan, L.4
Miller, R.J.5
Kessler, J.A.6
-
18
-
-
54949102049
-
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals
-
Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., Sasai, Y., Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 3 (2008), 519–532.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 519-532
-
-
Eiraku, M.1
Watanabe, K.2
Matsuo-Takasaki, M.3
Kawada, M.4
Yonemura, S.5
Matsumura, M.6
Wataya, T.7
Nishiyama, A.8
Muguruma, K.9
Sasai, Y.10
-
19
-
-
84856694078
-
Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes
-
Emdad, L., D׳Souza, S.L., Kothari, H.P., Qadeer, Z.A., Germano, I.M., Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Stem Cells Dev. 21 (2012), 404–410.
-
(2012)
Stem Cells Dev.
, vol.21
, pp. 404-410
-
-
Emdad, L.1
D׳Souza, S.L.2
Kothari, H.P.3
Qadeer, Z.A.4
Germano, I.M.5
-
20
-
-
84904752371
-
Successful therapies for Alzheimer׳s disease: why so many in animal models and none in humans?
-
Franco, R., Cedazo-Minguez, A., Successful therapies for Alzheimer׳s disease: why so many in animal models and none in humans?. Front. Pharmacol., 5, 2014, 146.
-
(2014)
Front. Pharmacol.
, vol.5
, pp. 146
-
-
Franco, R.1
Cedazo-Minguez, A.2
-
21
-
-
84878433339
-
Alzheimer׳s disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc, A., Serrano-Pozo, A., Parrado, A.R., Lesinski, A.N., Asselin, C.N., Mullin, K., Hooli, B., Choi, S.H., Hyman, B.T., Tanzi, R.E., Alzheimer׳s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78 (2013), 631–643.
-
(2013)
Neuron
, vol.78
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozo, A.2
Parrado, A.R.3
Lesinski, A.N.4
Asselin, C.N.5
Mullin, K.6
Hooli, B.7
Choi, S.H.8
Hyman, B.T.9
Tanzi, R.E.10
-
22
-
-
84872057940
-
TREM2 variants in Alzheimer׳s disease
-
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J.S., Younkin, S., Hazrati, L., Collinge, J., Pocock, J., Lashley, T., Williams, J., Lambert, J.C., Amouyel, P., Goate, A., Rademakers, R., Morgan, K., Powell, J., St George-Hyslop, P., Singleton, A., Hardy, J., TREM2 variants in Alzheimer׳s disease. N. Engl. J. Med. 368 (2013), 117–127.
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 117-127
-
-
Guerreiro, R.1
Wojtas, A.2
Bras, J.3
Carrasquillo, M.4
Rogaeva, E.5
Majounie, E.6
Cruchaga, C.7
Sassi, C.8
Kauwe, J.S.9
Younkin, S.10
Hazrati, L.11
Collinge, J.12
Pocock, J.13
Lashley, T.14
Williams, J.15
Lambert, J.C.16
Amouyel, P.17
Goate, A.18
Rademakers, R.19
Morgan, K.20
Powell, J.21
St George-Hyslop, P.22
Singleton, A.23
Hardy, J.24
more..
-
23
-
-
0037135111
-
The amyloid hypothesis of Alzheimer׳s disease: progress and problems on the road to therapeutics
-
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer׳s disease: progress and problems on the road to therapeutics. Science 297 (2002), 353–356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
24
-
-
84869998396
-
Genome-wide association study of Alzheimer׳s disease with psychotic symptoms
-
Hollingworth, P., Sweet, R., Sims, R., Harold, D., Russo, G., Abraham, R., Stretton, A., Jones, N., Gerrish, A., Chapman, J., Ivanov, D., Moskvina, V., Lovestone, S., Priotsi, P., Lupton, M., Brayne, C., Gill, M., Lawlor, B., Lynch, A., Craig, D., McGuinness, B., Johnston, J., Holmes, C., Livingston, G., Bass, N.J., Gurling, H., McQuillin, A., Holmans, P., Jones, L., Devlin, B., Klei, L., Barmada, M.M., Demirci, F.Y., DeKosky, S.T., Lopez, O.L., Passmore, P., Owen, M.J., O׳Donovan, M.C., Mayeux, R., Kamboh, M.I., Williams, J., Genome-wide association study of Alzheimer׳s disease with psychotic symptoms. Mol. Psychiatry 17 (2012), 1316–1327.
-
(2012)
Mol. Psychiatry
, vol.17
, pp. 1316-1327
-
-
Hollingworth, P.1
Sweet, R.2
Sims, R.3
Harold, D.4
Russo, G.5
Abraham, R.6
Stretton, A.7
Jones, N.8
Gerrish, A.9
Chapman, J.10
Ivanov, D.11
Moskvina, V.12
Lovestone, S.13
Priotsi, P.14
Lupton, M.15
Brayne, C.16
Gill, M.17
Lawlor, B.18
Lynch, A.19
Craig, D.20
McGuinness, B.21
Johnston, J.22
Holmes, C.23
Livingston, G.24
Bass, N.J.25
Gurling, H.26
McQuillin, A.27
Holmans, P.28
Jones, L.29
Devlin, B.30
Klei, L.31
Barmada, M.M.32
Demirci, F.Y.33
DeKosky, S.T.34
Lopez, O.L.35
Passmore, P.36
Owen, M.J.37
O׳Donovan, M.C.38
Mayeux, R.39
Kamboh, M.I.40
Williams, J.41
more..
-
25
-
-
84856956771
-
Probing sporadic and familial Alzheimer׳s disease using induced pluripotent stem cells
-
Israel, M.A., Yuan, S.H., Bardy, C., Reyna, S.M., Mu, Y., Herrera, C., Hefferan, M.P., Van Gorp, S., Nazor, K.L., Boscolo, F.S., Carson, C.T., Laurent, L.C., Marsala, M., Gage, F.H., Remes, A.M., Koo, E.H., Goldstein, L.S., Probing sporadic and familial Alzheimer׳s disease using induced pluripotent stem cells. Nature 482 (2012), 216–220.
-
(2012)
Nature
, vol.482
, pp. 216-220
-
-
Israel, M.A.1
Yuan, S.H.2
Bardy, C.3
Reyna, S.M.4
Mu, Y.5
Herrera, C.6
Hefferan, M.P.7
Van Gorp, S.8
Nazor, K.L.9
Boscolo, F.S.10
Carson, C.T.11
Laurent, L.C.12
Marsala, M.13
Gage, F.H.14
Remes, A.M.15
Koo, E.H.16
Goldstein, L.S.17
-
26
-
-
84880923645
-
TREM2 in Alzheimer׳s disease
-
Jiang, T., Yu, J.T., Zhu, X.C., Tan, L., TREM2 in Alzheimer׳s disease. Mol. Neurobiol. 48 (2013), 180–185.
-
(2013)
Mol. Neurobiol.
, vol.48
, pp. 180-185
-
-
Jiang, T.1
Yu, J.T.2
Zhu, X.C.3
Tan, L.4
-
27
-
-
84861589603
-
Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of gamma-secretase activity in endogenous amyloid-beta generation
-
Koch, P., Tamboli, I.Y., Mertens, J., Wunderlich, P., Ladewig, J., Stuber, K., Esselmann, H., Wiltfang, J., Brustle, O., Walter, J., Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of gamma-secretase activity in endogenous amyloid-beta generation. Am. J. Pathol. 180 (2012), 2404–2416.
-
(2012)
Am. J. Pathol.
, vol.180
, pp. 2404-2416
-
-
Koch, P.1
Tamboli, I.Y.2
Mertens, J.3
Wunderlich, P.4
Ladewig, J.5
Stuber, K.6
Esselmann, H.7
Wiltfang, J.8
Brustle, O.9
Walter, J.10
-
28
-
-
84875916922
-
Modeling Alzheimer׳s disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness
-
Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., Takahashi, K., Asaka, I., Aoi, T., Watanabe, A., Watanabe, K., Kadoya, C., Nakano, R., Watanabe, D., Maruyama, K., Hori, O., Hibino, S., Choshi, T., Nakahata, T., Hioki, H., Kaneko, T., Naitoh, M., Yoshikawa, K., Yamawaki, S., Suzuki, S., Hata, R., Ueno, S., Seki, T., Kobayashi, K., Toda, T., Murakami, K., Irie, K., Klein, W.L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H., Modeling Alzheimer׳s disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness. Cell Stem Cell 12 (2013), 487–496.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 487-496
-
-
Kondo, T.1
Asai, M.2
Tsukita, K.3
Kutoku, Y.4
Ohsawa, Y.5
Sunada, Y.6
Imamura, K.7
Egawa, N.8
Yahata, N.9
Okita, K.10
Takahashi, K.11
Asaka, I.12
Aoi, T.13
Watanabe, A.14
Watanabe, K.15
Kadoya, C.16
Nakano, R.17
Watanabe, D.18
Maruyama, K.19
Hori, O.20
Hibino, S.21
Choshi, T.22
Nakahata, T.23
Hioki, H.24
Kaneko, T.25
Naitoh, M.26
Yoshikawa, K.27
Yamawaki, S.28
Suzuki, S.29
Hata, R.30
Ueno, S.31
Seki, T.32
Kobayashi, K.33
Toda, T.34
Murakami, K.35
Irie, K.36
Klein, W.L.37
Mori, H.38
Asada, T.39
Takahashi, R.40
Iwata, N.41
Yamanaka, S.42
Inoue, H.43
more..
-
29
-
-
80054798510
-
Directed differentiation of functional astroglial subtypes from human pluripotent stem cells
-
Krencik, R., Zhang, S.C., Directed differentiation of functional astroglial subtypes from human pluripotent stem cells. Nat. Protoc. 6 (2011), 1710–1717.
-
(2011)
Nat. Protoc.
, vol.6
, pp. 1710-1717
-
-
Krencik, R.1
Zhang, S.C.2
-
30
-
-
84884414984
-
Cerebral organoids model human brain development and microcephaly
-
Lancaster, M.A., Renner, M., Martin, C.A., Wenzel, D., Bicknell, L.S., Hurles, M.E., Homfray, T., Penninger, J.M., Jackson, A.P., Knoblich, J.A., Cerebral organoids model human brain development and microcephaly. Nature 501 (2013), 373–379.
-
(2013)
Nature
, vol.501
, pp. 373-379
-
-
Lancaster, M.A.1
Renner, M.2
Martin, C.A.3
Wenzel, D.4
Bicknell, L.S.5
Hurles, M.E.6
Homfray, T.7
Penninger, J.M.8
Jackson, A.P.9
Knoblich, J.A.10
-
31
-
-
84892673266
-
Genetic correction using engineered nucleases for gene therapy applications
-
Li, H.L., Nakano, T., Hotta, A., Genetic correction using engineered nucleases for gene therapy applications. Dev. Growth Differ. 56 (2014), 63–77.
-
(2014)
Dev. Growth Differ.
, vol.56
, pp. 63-77
-
-
Li, H.L.1
Nakano, T.2
Hotta, A.3
-
32
-
-
84918522964
-
Effect of potent gamma-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers
-
Liu, Q., Waltz, S., Woodruff, G., Ouyang, J., Israel, M.A., Herrera, C., Sarsoza, F., Tanzi, R.E., Koo, E.H., Ringman, J.M., Goldstein, L.S., Wagner, S.L., Yuan, S.H., Effect of potent gamma-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 71 (2014), 1481–1489.
-
(2014)
JAMA Neurol.
, vol.71
, pp. 1481-1489
-
-
Liu, Q.1
Waltz, S.2
Woodruff, G.3
Ouyang, J.4
Israel, M.A.5
Herrera, C.6
Sarsoza, F.7
Tanzi, R.E.8
Koo, E.H.9
Ringman, J.M.10
Goldstein, L.S.11
Wagner, S.L.12
Yuan, S.H.13
-
33
-
-
84916882571
-
Induced pluripotent stem cells from familial Alzheimer׳s disease patients differentiate into mature neurons with amyloidogenic properties
-
Mahairaki, V., Ryu, J., Peters, A., Chang, Q., Li, T., Park, T.S., Burridge, P.W., Talbot, C.C. Jr., Asnaghi, L., Martin, L.J., Zambidis, E.T., Koliatsos, V.E., Induced pluripotent stem cells from familial Alzheimer׳s disease patients differentiate into mature neurons with amyloidogenic properties. Stem Cells Dev. 23 (2014), 2996–3010.
-
(2014)
Stem Cells Dev.
, vol.23
, pp. 2996-3010
-
-
Mahairaki, V.1
Ryu, J.2
Peters, A.3
Chang, Q.4
Li, T.5
Park, T.S.6
Burridge, P.W.7
Talbot, C.C.8
Asnaghi, L.9
Martin, L.J.10
Zambidis, E.T.11
Koliatsos, V.E.12
-
34
-
-
84890109489
-
Human iPSC-based modeling of late-onset disease via progerin-induced aging
-
Miller, J.D., Ganat, Y.M., Kishinevsky, S., Bowman, R.L., Liu, B., Tu, E.Y., Mandal, P.K., Vera, E., Shim, J.W., Kriks, S., Taldone, T., Fusaki, N., Tomishima, M.J., Krainc, D., Milner, T.A., Rossi, D.J., Studer, L., Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell Stem Cell. 13 (2013), 691–705.
-
(2013)
Cell Stem Cell.
, vol.13
, pp. 691-705
-
-
Miller, J.D.1
Ganat, Y.M.2
Kishinevsky, S.3
Bowman, R.L.4
Liu, B.5
Tu, E.Y.6
Mandal, P.K.7
Vera, E.8
Shim, J.W.9
Kriks, S.10
Taldone, T.11
Fusaki, N.12
Tomishima, M.J.13
Krainc, D.14
Milner, T.A.15
Rossi, D.J.16
Studer, L.17
-
35
-
-
84933677790
-
APP metabolism regulates tau proteostasis in human cerebral cortex neurons
-
Moore, S., Evans, L.D., Andersson, T., Portelius, E., Smith, J., Dias, T.B., Saurat, N., McGlade, A., Kirwan, P., Blennow, K., Hardy, J., Zetterberg, H., Livesey, F.J., APP metabolism regulates tau proteostasis in human cerebral cortex neurons. Cell Rep. 11 (2015), 689–696.
-
(2015)
Cell Rep.
, vol.11
, pp. 689-696
-
-
Moore, S.1
Evans, L.D.2
Andersson, T.3
Portelius, E.4
Smith, J.5
Dias, T.B.6
Saurat, N.7
McGlade, A.8
Kirwan, P.9
Blennow, K.10
Hardy, J.11
Zetterberg, H.12
Livesey, F.J.13
-
36
-
-
84897954445
-
Microglial dysfunction in brain aging and Alzheimer׳s disease
-
Mosher, K.I., Wyss-Coray, T., Microglial dysfunction in brain aging and Alzheimer׳s disease. Biochem. Pharmacol. 88 (2014), 594–604.
-
(2014)
Biochem. Pharmacol.
, vol.88
, pp. 594-604
-
-
Mosher, K.I.1
Wyss-Coray, T.2
-
37
-
-
84902303124
-
The familial Alzheimer׳s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
-
Muratore, C.R., Rice, H.C., Srikanth, P., Callahan, D.G., Shin, T., Benjamin, L.N., Walsh, D.M., Selkoe, D.J., Young-Pearse, T.L., The familial Alzheimer׳s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum. Mol. Genet. 23 (2014), 3523–3536.
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 3523-3536
-
-
Muratore, C.R.1
Rice, H.C.2
Srikanth, P.3
Callahan, D.G.4
Shin, T.5
Benjamin, L.N.6
Walsh, D.M.7
Selkoe, D.J.8
Young-Pearse, T.L.9
-
38
-
-
84877301288
-
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
-
Nicholas, C.R., Chen, J., Tang, Y., Southwell, D.G., Chalmers, N., Vogt, D., Arnold, C.M., Chen, Y.J., Stanley, E.G., Elefanty, A.G., Sasai, Y., Alvarez-Buylla, A., Rubenstein, J.L., Kriegstein, A.R., Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell 12 (2013), 573–586.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 573-586
-
-
Nicholas, C.R.1
Chen, J.2
Tang, Y.3
Southwell, D.G.4
Chalmers, N.5
Vogt, D.6
Arnold, C.M.7
Chen, Y.J.8
Stanley, E.G.9
Elefanty, A.G.10
Sasai, Y.11
Alvarez-Buylla, A.12
Rubenstein, J.L.13
Kriegstein, A.R.14
-
39
-
-
17944368176
-
The ‘Arctic’ APP mutation (E693G) causes Alzheimer׳s disease by enhanced Abeta protofibril formation
-
Nilsberth, C., Westlind-Danielsson, A., Eckman, C.B., Condron, M.M., Axelman, K., Forsell, C., Stenh, C., Luthman, J., Teplow, D.B., Younkin, S.G., Naslund, J., Lannfelt, L., The ‘Arctic’ APP mutation (E693G) causes Alzheimer׳s disease by enhanced Abeta protofibril formation. Nat. Neurosci. 4 (2001), 887–893.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
Forsell, C.6
Stenh, C.7
Luthman, J.8
Teplow, D.B.9
Younkin, S.G.10
Naslund, J.11
Lannfelt, L.12
-
40
-
-
78149435065
-
The myeloid cells of the central nervous system parenchyma
-
Ransohoff, R.M., Cardona, A.E., The myeloid cells of the central nervous system parenchyma. Nature 468 (2010), 253–262.
-
(2010)
Nature
, vol.468
, pp. 253-262
-
-
Ransohoff, R.M.1
Cardona, A.E.2
-
41
-
-
84877780026
-
Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein
-
Rice, H.C., Young-Pearse, T.L., Selkoe, D.J., Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry 52 (2013), 3264–3277.
-
(2013)
Biochemistry
, vol.52
, pp. 3264-3277
-
-
Rice, H.C.1
Young-Pearse, T.L.2
Selkoe, D.J.3
-
42
-
-
84865468329
-
The genetics and neuropathology of Alzheimer׳s disease
-
Schellenberg, G.D., Montine, T.J., The genetics and neuropathology of Alzheimer׳s disease. Acta Neuropathol. 124 (2012), 305–323.
-
(2012)
Acta Neuropathol.
, vol.124
, pp. 305-323
-
-
Schellenberg, G.D.1
Montine, T.J.2
-
43
-
-
0035066332
-
Alzheimer׳s disease: genes, proteins, and therapy
-
Selkoe, D.J., Alzheimer׳s disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001), 741–766.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
44
-
-
84863229339
-
A human stem cell model of early Alzheimer׳s disease pathology in Down syndrome
-
Shi, Y., Kirwan, P., Smith, J., MacLean, G., Orkin, S.H., Livesey, F.J., A human stem cell model of early Alzheimer׳s disease pathology in Down syndrome. Sci. Transl. Med., 4, 2012, 124ra29.
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 124ra29
-
-
Shi, Y.1
Kirwan, P.2
Smith, J.3
MacLean, G.4
Orkin, S.H.5
Livesey, F.J.6
-
45
-
-
84870156157
-
Medicine: iPSC disease modeling
-
Soldner, F., Jaenisch, R., Medicine: iPSC disease modeling. Science 338 (2012), 1155–1156.
-
(2012)
Science
, vol.338
, pp. 1155-1156
-
-
Soldner, F.1
Jaenisch, R.2
-
46
-
-
84877906835
-
Tau pathology and neurodegeneration
-
Spillantini, M.G., Goedert, M., Tau pathology and neurodegeneration. Lancet Neurol. 12 (2013), 609–622.
-
(2013)
Lancet Neurol.
, vol.12
, pp. 609-622
-
-
Spillantini, M.G.1
Goedert, M.2
-
47
-
-
84897136184
-
Characterization and molecular profiling of PSEN1 familial Alzheimer׳s disease iPSC-derived neural progenitors
-
Sproul, A.A., Jacob, S., Pre, D., Kim, S.H., Nestor, M.W., Navarro-Sobrino, M., Santa-Maria, I., Zimmer, M., Aubry, S., Steele, J.W., Kahler, D.J., Dranovsky, A., Arancio, O., Crary, J.F., Gandy, S., Noggle, S.A., Characterization and molecular profiling of PSEN1 familial Alzheimer׳s disease iPSC-derived neural progenitors. PLoS One, 9, 2014, e84547.
-
(2014)
PLoS One
, vol.9
, pp. e84547
-
-
Sproul, A.A.1
Jacob, S.2
Pre, D.3
Kim, S.H.4
Nestor, M.W.5
Navarro-Sobrino, M.6
Santa-Maria, I.7
Zimmer, M.8
Aubry, S.9
Steele, J.W.10
Kahler, D.J.11
Dranovsky, A.12
Arancio, O.13
Crary, J.F.14
Gandy, S.15
Noggle, S.A.16
-
48
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007), 861–872.
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
Yamanaka, S.7
-
49
-
-
84875354777
-
2013 Alzheimer׳s disease facts and figures
-
Thies, W., Bleiler, L., 2013 Alzheimer׳s disease facts and figures. Alzheimers Dement. 9 (2013), 208–245.
-
(2013)
Alzheimers Dement.
, vol.9
, pp. 208-245
-
-
Thies, W.1
Bleiler, L.2
-
50
-
-
84884935465
-
Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer׳s disease
-
Vazin, T., Ball, K.A., Lu, H., Park, H., Ataeijannati, Y., Head-Gordon, T., Poo, M.M., Schaffer, D.V., Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer׳s disease. Neurobiol Dis. 62 (2014), 62–72.
-
(2014)
Neurobiol Dis.
, vol.62
, pp. 62-72
-
-
Vazin, T.1
Ball, K.A.2
Lu, H.3
Park, H.4
Ataeijannati, Y.5
Head-Gordon, T.6
Poo, M.M.7
Schaffer, D.V.8
-
51
-
-
3543128746
-
The many faces of Aβ: strucures and activity
-
Walsh, D.M., Hartley, D.M., Selkoe, D.J., The many faces of Aβ: strucures and activity. Curr. Med. Chem. – Immunol. Endocr. Metab. Agents 3 (2003), 277–291.
-
(2003)
Curr. Med. Chem. – Immunol. Endocr. Metab. Agents
, vol.3
, pp. 277-291
-
-
Walsh, D.M.1
Hartley, D.M.2
Selkoe, D.J.3
-
52
-
-
78650786023
-
Beta-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons
-
Wicklund, L., Leao, R.N., Stromberg, A.M., Mousavi, M., Hovatta, O., Nordberg, A., Marutle, A., Beta-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons. PLoS One, 5, 2010, e15600.
-
(2010)
PLoS One
, vol.5
, pp. e15600
-
-
Wicklund, L.1
Leao, R.N.2
Stromberg, A.M.3
Mousavi, M.4
Hovatta, O.5
Nordberg, A.6
Marutle, A.7
-
53
-
-
84876391906
-
Alzheimer׳s disease modeling: ups, downs, and perspectives for human induced pluripotent stem cells
-
Wojda, U., Kuznicki, J., Alzheimer׳s disease modeling: ups, downs, and perspectives for human induced pluripotent stem cells. J. Alzheimers Dis. 34 (2013), 563–588.
-
(2013)
J. Alzheimers Dis.
, vol.34
, pp. 563-588
-
-
Wojda, U.1
Kuznicki, J.2
-
54
-
-
77955944764
-
Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases
-
Wolfe, M.S., Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases. Biol. Chem. 391 (2010), 839–847.
-
(2010)
Biol. Chem.
, vol.391
, pp. 839-847
-
-
Wolfe, M.S.1
-
55
-
-
84888433312
-
The presenilin-1 DeltaE9 mutation results in reduced gamma-secretase activity, but not total loss of PS1 function, in isogenic human stem cells
-
Woodruff, G., Young, J.E., Martinez, F.J., Buen, F., Gore, A., Kinaga, J., Li, Z., Yuan, S.H., Zhang, K., Goldstein, L.S., The presenilin-1 DeltaE9 mutation results in reduced gamma-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep. 5 (2013), 974–985.
-
(2013)
Cell Rep.
, vol.5
, pp. 974-985
-
-
Woodruff, G.1
Young, J.E.2
Martinez, F.J.3
Buen, F.4
Gore, A.5
Kinaga, J.6
Li, Z.7
Yuan, S.H.8
Zhang, K.9
Goldstein, L.S.10
-
56
-
-
84872171503
-
Prevention of beta-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of cyclin-dependent kinases and associated cell cycle events
-
Xu, X., Lei, Y., Luo, J., Wang, J., Zhang, S., Yang, X.J., Sun, M., Nuwaysir, E., Fan, G., Zhao, J., Lei, L., Zhong, Z., Prevention of beta-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of cyclin-dependent kinases and associated cell cycle events. Stem Cell Res. 10 (2013), 213–227.
-
(2013)
Stem Cell Res.
, vol.10
, pp. 213-227
-
-
Xu, X.1
Lei, Y.2
Luo, J.3
Wang, J.4
Zhang, S.5
Yang, X.J.6
Sun, M.7
Nuwaysir, E.8
Fan, G.9
Zhao, J.10
Lei, L.11
Zhong, Z.12
-
57
-
-
81255169342
-
Modeling familial Alzheimer׳s disease with induced pluripotent stem cells
-
Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H., Suzuki, N., Modeling familial Alzheimer׳s disease with induced pluripotent stem cells. Hum. Mol. Genet. 20 (2011), 4530–4539.
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 4530-4539
-
-
Yagi, T.1
Ito, D.2
Okada, Y.3
Akamatsu, W.4
Nihei, Y.5
Yoshizaki, T.6
Yamanaka, S.7
Okano, H.8
Suzuki, N.9
-
58
-
-
80053604531
-
Anti-Abeta drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer׳s disease
-
Yahata, N., Asai, M., Kitaoka, S., Takahashi, K., Asaka, I., Hioki, H., Kaneko, T., Maruyama, K., Saido, T.C., Nakahata, T., Asada, T., Yamanaka, S., Iwata, N., Inoue, H., Anti-Abeta drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer׳s disease. PLoS One, 6, 2011, e25788.
-
(2011)
PLoS One
, vol.6
, pp. e25788
-
-
Yahata, N.1
Asai, M.2
Kitaoka, S.3
Takahashi, K.4
Asaka, I.5
Hioki, H.6
Kaneko, T.7
Maruyama, K.8
Saido, T.C.9
Nakahata, T.10
Asada, T.11
Yamanaka, S.12
Iwata, N.13
Inoue, H.14
-
59
-
-
84886528116
-
Efficient and rapid derivation of primitive neural stem cells and generation of brain subtype neurons from human pluripotent stem cells
-
Yan, Y., Shin, S., Jha, B.S., Liu, Q., Sheng, J., Li, F., Zhan, M., Davis, J., Bharti, K., Zeng, X., Rao, M., Malik, N., Vemuri, M.C., Efficient and rapid derivation of primitive neural stem cells and generation of brain subtype neurons from human pluripotent stem cells. Stem Cells Transl. Med. 2 (2013), 862–870.
-
(2013)
Stem Cells Transl. Med.
, vol.2
, pp. 862-870
-
-
Yan, Y.1
Shin, S.2
Jha, B.S.3
Liu, Q.4
Sheng, J.5
Li, F.6
Zhan, M.7
Davis, J.8
Bharti, K.9
Zeng, X.10
Rao, M.11
Malik, N.12
Vemuri, M.C.13
-
60
-
-
84926222043
-
Elucidating molecular phenotypes caused by the SORL1 Alzheimer׳s disease genetic risk factor using human induced pluripotent stem cells
-
Young, J.E., Boulanger-Weill, J., Williams, D.A., Woodruff, G., Buen, F., Revilla, A.C., Herrera, C., Israel, M.A., Yuan, S.H., Edland, S.D., Goldstein, L.S., Elucidating molecular phenotypes caused by the SORL1 Alzheimer׳s disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell 16 (2015), 373–385.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 373-385
-
-
Young, J.E.1
Boulanger-Weill, J.2
Williams, D.A.3
Woodruff, G.4
Buen, F.5
Revilla, A.C.6
Herrera, C.7
Israel, M.A.8
Yuan, S.H.9
Edland, S.D.10
Goldstein, L.S.11
-
61
-
-
79952292990
-
Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells
-
Yuan, S.H., Martin, J., Elia, J., Flippin, J., Paramban, R.I., Hefferan, M.P., Vidal, J.G., Mu, Y., Killian, R.L., Israel, M.A., Emre, N., Marsala, S., Marsala, M., Gage, F.H., Goldstein, L.S., Carson, C.T., Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One, 6, 2011, e17540.
-
(2011)
PLoS One
, vol.6
, pp. e17540
-
-
Yuan, S.H.1
Martin, J.2
Elia, J.3
Flippin, J.4
Paramban, R.I.5
Hefferan, M.P.6
Vidal, J.G.7
Mu, Y.8
Killian, R.L.9
Israel, M.A.10
Emre, N.11
Marsala, S.12
Marsala, M.13
Gage, F.H.14
Goldstein, L.S.15
Carson, C.T.16
-
62
-
-
77955641542
-
Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells
-
Zeng, H., Guo, M., Martins-Taylor, K., Wang, X., Zhang, Z., Park, J.W., Zhan, S., Kronenberg, M.S., Lichtler, A., Liu, H.X., Chen, F.P., Yue, L., Li, X.J., Xu, R.H., Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One, 5, 2010, e11853.
-
(2010)
PLoS One
, vol.5
, pp. e11853
-
-
Zeng, H.1
Guo, M.2
Martins-Taylor, K.3
Wang, X.4
Zhang, Z.5
Park, J.W.6
Zhan, S.7
Kronenberg, M.S.8
Lichtler, A.9
Liu, H.X.10
Chen, F.P.11
Yue, L.12
Li, X.J.13
Xu, R.H.14
-
63
-
-
84878849645
-
Rapid single-step induction of functional neurons from human pluripotent stem cells
-
Zhang, Y., Pak, C., Han, Y., Ahlenius, H., Zhang, Z., Chanda, S., Marro, S., Patzke, C., Acuna, C., Covy, J., Xu, W., Yang, N., Danko, T., Chen, L., Wernig, M., Sudhof, T.C., Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron 78 (2013), 785–798.
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(2013)
Neuron
, vol.78
, pp. 785-798
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Zhang, Y.1
Pak, C.2
Han, Y.3
Ahlenius, H.4
Zhang, Z.5
Chanda, S.6
Marro, S.7
Patzke, C.8
Acuna, C.9
Covy, J.10
Xu, W.11
Yang, N.12
Danko, T.13
Chen, L.14
Wernig, M.15
Sudhof, T.C.16
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