Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: A multi-centre case-control study

Molecular Neurodegeneration

Volumn 6, Issue 1, 2011, Pages

  Carrasquillo, Minerva M ^a   Belbin, Olivia ^a,b,h   Hunter, Talisha A ^a   Ma, Li ^a   Bisceglio, Gina D ^a   Zou, Fanggeng ^a   Crook, Julia E ^a   Pankratz, V ^c   Sando, Sigrid B ^d,e   Aasly, Jan O ^d,e   Barcikowska, Maria ^f   Wszolek, Zbigniew K ^a   Dickson, Dennis W ^a   Graff Radford, Neill R ^a   Petersen, Ronald C ^c   Passmore, Peter ^g   Morgan, Kevin ^b   Younkin, Steven G ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c MAYO CLINIC   (United States)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^e NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^f MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^g QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^h HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CD2 ASSOCIATED PROTEIN; CD33 ANTIGEN; EPHRIN RECEPTOR A1;

ALZHEIMER DISEASE; ARTICLE; AT RICH INTERACTIVE DOMAIN 5B GENE; EUROPE; FOLLOW UP; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; UNITED STATES;

EID: 79960654507     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-6-54     Document Type: Article

References (25)

1. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Saunders AM Strittmatter WJ, Schmechel D George-Hyslop PH, Pericak-Vance MA Joo SH, Rosi BL Gusella JF, Crapper-MacLachlan DR Alberts MJ, Hulette C Crain B, Goldgaber D Roses AD, Neurology 1993 43 1467 1472 8350998 (Pubitemid 23230526)
2. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Harold D Abraham R, Hollingworth P Sims R, Gerrish A Hamshere ML, Pahwa JS Moskvina V, Dowzell K Williams A, Jones N Thomas C, Stretton A Morgan AR, Lovestone S Powell J, Proitsi P Lupton MK, Brayne C Rubinsztein DC, Gill M Lawlor B, Lynch A Morgan K, Brown KS Passmore PA, Craig D McGuinness B, Todd S Holmes C, Mann D Smith AD, Love S Kehoe PG, Hardy J Mead S, Fox N Rossor M, Collinge J Maier W, Jessen F Schürmann B, van den Bussche H Heuser I, Kornhuber J Wiltfang J, Dichgans M Frölich L, Hampel H Hüll M, Rujescu D Goate AM, Kauwe JS Cruchaga C, Nowotny P Morris JC, Mayo K Sleegers K, Bettens K Engelborghs S, De Deyn PP Van Broeckhoven C, Livingston G Bass NJ, Gurling H McQuillin A, Gwilliam R Deloukas P, Al-Chalabi A Shaw CE, Tsolaki M Singleton AB, Guerreiro R Mühleisen TW, Nöthen MM Moebus S, Jöckel KH Klopp N, Wichmann HE Carrasquillo MM, Pankratz VS Younkin SG, Holmans PA O'Donovan M, Owen MJ Williams J, Nat Genet 2009 41 1088 1093 10.1038/ng.440 19734902
3. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Lambert JC Heath S Even G Campion D, Sleegers K Hiltunen M, Combarros O Zelenika D, Bullido MJ Tavernier B, Letenneur L Bettens K, Berr C Pasquier F, Fiévet N Barberger-Gateau P, Engelborghs S De Deyn P, Mateo I Franck A, Helisalmi S Porcellini E, Hanon O European Alzheimer's Disease Initiative Investigators, de Pancorbo MM Lendon C, Dufouil C Jaillard C, Leveillard T Alvarez V, Bosco P Mancuso M, Panza F Nacmias B, Boss P Piccardi P, Annoni G Seripa D, Galimberti D Hannequin D, Licastro F Soininen H, Ritchie K Blanché H, Dartigues JF Tzourio C, Gut I Van Broeckhoven C, Alpérovitch A Lathrop M, Amouyel P,, Nat Genet 2009 41 1094 1099 10.1038/ng.439 19734903
4. Genome-wide analysis of genetic loci associated with Alzheimer disease. Seshadri S Fitzpatrick AL, Ikram MA DeStefano AL, Gudnason V Boada M, Bis JC Smith AV, Carrasquillo MM Lambert JC, Harold D Schrijvers EM, Ramirez-Lorca R Debette S, Longstreth WT Jr Janssens AC, Pankratz VS Dartigues JF, Hollingworth P Aspelund T, Hernandez I Beiser A, Kuller LH Koudstaal PJ, Dickson DW Tzourio C, Abraham R Antunez C, Du Y Rotter JI, Aulchenko YS Harris TB, Petersen RC Berr C, Owen MJ Lopez-Arrieta J, Varadarajan BN Becker JT, Rivadeneira F Nalls MA, Graff-Radford NR Campion D, Auerbach S Rice K, Hofman A Jonsson PV, Schmidt H Lathrop M, Mosley TH Au R, Psaty BM Uitterlinden AG, Farrer LA Lumley T, Ruiz A Williams J, Amouyel P Younkin SG, Wolf PA Launer LJ, Lopez OL van Duijn CM, Breteler MM CHARGE Consortium, GERAD1 ConsortiumEADI1 Consortium, JAMA 2010 303 1832 1840 10.1001/jama.2010.574 20460622
5. Replication of CLU, CR1, and PICALM associations with alzheimer disease. Carrasquillo MM Belbin O Hunter TA Ma L, Bisceglio GD Zou F, Crook JE Pankratz VS, Dickson DW Graff-Radford NR, Petersen RC Morgan K, Younkin SG,, Arch Neurol 2010 67 961 964 10.1001/archneurol.2010.147 20554627
6. Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease. Zhang Q Yu JT Zhu QX Zhang W, Wu ZC Miao D, Tan L,, Brain Res 2010 1348 216 221 20558149
7. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Corneveaux JJ Myers AJ, Allen AN Pruzin JJ, Ramirez M Engel A, Nalls MA Chen K, Lee W Chewning K, Villa SE Meechoovet HB, Gerber JD Frost D, Benson HL O'Reilly S, Chibnik LB Shulman JM, Singleton AB Craig DW, Van Keuren-Jensen KR Dunckley T, Bennett DA De Jager PL, Heward C Hardy J, Reiman EM Huentelman MJ, Hum Mol Genet 2010 19 3295 3301 10.1093/hmg/ddq221 20534741
8. Association of CLU and PICALM variants with Alzheimer's disease. Kamboh MI Minster RL Demirci FY Ganguli M, Dekosky ST Lopez OL, Barmada MM,, Neurobiol Aging advance online publication: 4 Jun 2010
9. Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease. Yu JT Li L, Zhu QX Zhang Q, Zhang W Wu ZC, Guan J Tan L, Clin Chim Acta 2010 411 1516 1519 10.1016/j.cca.2010.06.013 20599866
10. Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes. Jun G Naj AC Beecham GW Wang LS, Buros J Gallins PJ, Buxbaum JD Ertekin-Taner N, Fallin MD Friedland R, Inzelberg R Kramer P, Rogaeva E St George-Hyslop P, Alzheimer's Disease Genetics Consortium Cantwell LB, Dombroski BA Saykin AJ, Reiman EM Bennett DA, Morris JC Lunetta KL, Martin ER Montine TJ, Goate AM Blacker D, Tsuang DW Beekly D, Cupples LA Hakonarson H, Kukull W Foroud TM, Haines J Mayeux R, Farrer LA Pericak-Vance MA, Schellenberg GD,, Arch Neurol 2010 67 1473 1484 10.1001/archneurol.2010.201 20697030
11. Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese. Yu JT Song JH Ma T Zhang W, Yu NN Xuan SY, Tan L,, J Neurol Sci 2011 300 78 80 10.1016/j.jns.2010.09.027 20951388
12. The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Schjeide BM Schnack C, Lambert JC Lill CM, Kirchheiner J Tumani H, Otto M Tanzi RE, Lehrach H Amouyel P, von Arnim CA Bertram L, Arch Gen Psychiatry 2011 68 207 213 10.1001/archgenpsychiatry.2010.196 21300948
13. Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Brouwers N Van Cauwenberghe C, Engelborghs S Lambert JC, Bettens K Le Bastard N, Pasquier F Montoya AG, Peeters K Mattheijssens M, Vandenberghe R De Deyn PP, Cruts M Amouyel P, Sleegers K Van Broeckhoven C, Mol Psychiatry advance online publication: 15 March 2011
14. Identification of Novel Loci for Alzheimer Disease and Replication of CLU and BIN1 in Caribbean Hispanic Individuals. Lee JH Cheng R, Barral S Reitz C, Medrano M Lantigua R, Jimenez-Velazquez IZ Rogaeva E, St George-Hyslop PH Mayeux R, Arch Neurol 2011 68 320 328 10.1001/archneurol.2010.292 21059989
15. Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations. Lambert JC Zelenika D Hiltunen M Chouraki V, Combarros O Bullido MJ, Tognoni G Fiévet N, Boland A Arosio B, Coto E Del Zompo M, Mateo I Frank-Garcia A, Helisalmi S Porcellini E, Pilotto A Forti P, Ferri R Delepine M, Scarpini E Siciliano G, Solfrizzi V Sorbi S, Spalletta G Ravaglia G, Valdivieso F Alvarez V, Bosco P Mancuso M, Panza F Nacmias B, Boss P Piccardi P, Annoni G Seripa D, Galimberti D Licastro F, Lathrop M Soininen H, Amouyel P,, Neurobiol Aging 2011 32 756.e11 756.e15
16. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. Wijsman EM Pankratz ND Choi Y Rothstein JH, Faber KM Cheng R, Lee JH Bird TD, Bennett DA Diaz-Arrastia R, Goate AM Farlow M, Ghetti B Sweet RA, Foroud TM Mayeux R, NIA-LOAD/NCRAD Family Study Group,, PLoS Genet 2011 7 1001308 10.1371/journal.pgen.1001308 21379329
17. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Naj AC Jun G Beecham GW Wang LS, Vardarajan BN Buros J, Gallins PJ Buxbaum JD, Jarvik GP Crane PK, Larson EB Bird TD, Boeve BF Graff-Radford NR, De Jager PL Evans D, Schneider JA Carrasquillo MM, Ertekin-Taner N Younkin SG, Cruchaga C Kauwe JS, Nowotny P Kramer P, Hardy J Huentelman MJ, Myers AJ Barmada MM, Demirci FY Baldwin CT, Green RC Rogaeva E, St George-Hyslop P Arnold SE, Barber R Beach T, Bigio EH Bowen JD, Boxer A Burke JR, Cairns NJ Carlson CS, Carney RM Carroll SL, Chui HC Clark DG, Corneveaux J Cotman CW, Cummings JL DeCarli C, DeKosky ST Diaz-Arrastia R, Dick M Dickson DW, Ellis WG Faber KM, Fallon KB Farlow MR, Ferris S Frosch MP, Galasko DR Ganguli M, Gearing M Geschwind DH, Ghetti B Gilbert JR, Gilman S Giordani B, Glass JD Growdon JH, Hamilton RL Harrell LE, Head E Honig LS, Hulette CM Hyman BT, Jicha GA Jin LW, Johnson N Karlawish J, Karydas A Kaye JA, Kim R Koo EH, Kowall NW Lah JJ, Levey AI Lieberman AP, Lopez OL Mack WJ, Marson DC Martiniuk F, Mash DC Masliah E, McCormick WC McCurry SM, McDavid AN McKee AC, Mesulam M Miller BL, Miller CA Miller JW, Parisi JE Perl DP, Peskind E Petersen RC, Poon WW Quinn JF, Rajbhandary RA Raskind M, Reisberg B Ringman JM, Roberson ED Rosenberg RN, Sano M Schneider LS, Seeley W Shelanski ML, Slifer MA Smith CD, Sonnen JA Spina S, Stern RA Tanzi RE, Trojanowski JQ Troncoso JC, Van Deerlin VM Vinters HV, Vonsattel JP Weintraub S, Welsh-Bohmer KA Williamson J, Woltjer RL Cantwell LB, Dombroski BA Beekly D, Lunetta KL Martin ER, Kamboh MI Saykin AJ, Reiman EM Bennett DA, Morris JC Montine TJ, Goate AM Blacker D, Tsuang DW Hakonarson H, Kukull WA Foroud TM, Haines JL Mayeux R, Pericak-Vance MA Farrer LA, Schellenberg GD,, Nat Genet 2011 43 436 441 10.1038/ng.801 21460841
18. Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions. Carrasquillo MM Belbin O Hunter TA Ma L, Bisceglio GD Zou F, Crook JE Pankratz VS, Sando SB Aasly JO, Barcikowska M Wszolek ZK, Dickson DW Graff-Radford NR, Petersen RC Morgan K, Younkin SG,, J Alzheimers Dis advance online publication: 14 Feb 2011
19. Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease. Hu X Pickering E, Liu YC Hall S, Fournier H Katz E, Dechairo B John S, Van Eerdewegh P Soares H, PloS one 2011 6 16616 10.1371/journal.pone.0016616 21390209
20. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Hollingworth P Harold D Sims R Gerrish A, Lambert JC Carrasquillo MM, Abraham R Hamshere ML, Pahwa JS Moskvina V, Dowzell K Jones N, Stretton A Thomas C, Richards A Ivanov D, Widdowson C Chapman J, Lovestone S Powell J, Proitsi P Lupton MK, Brayne C Rubinsztein DC, Gill M Lawlor B, Lynch A Brown KS, Passmore PA Craig D, McGuinness B Todd S, Holmes C Mann D, Smith AD Beaumont H, Warden D Wilcock G, Love S Kehoe PG, Hooper NM Vardy ER, Hardy J Mead S, Fox NC Rossor M, Collinge J Maier W, Jessen F Rüther E, Schürmann B Heun R, Kölsch H van den Bussche H, Heuser I Kornhuber J, Wiltfang J Dichgans M, Frölich L Hampel H, Gallacher J Hüll M, Rujescu D Giegling I, Goate AM Kauwe JS, Cruchaga C Nowotny P, Morris JC Mayo K, Sleegers K Bettens K, Engelborghs S De Deyn PP, Van Broeckhoven C Livingston G, Bass NJ Gurling H, McQuillin A Gwilliam R, Deloukas P Al-Chalabi A, Shaw CE Tsolaki M, Singleton AB Guerreiro R, Mühleisen TW Nöthen MM, Moebus S Jöckel KH, Klopp N Wichmann HE, Pankratz VS Sando SB, Aasly JO Barcikowska M, Wszolek ZK Dickson DW, Graff-Radford NR Petersen RC, Alzheimer's Disease Neuroimaging Initiative van Duijn CM, Breteler MM Ikram MA, DeStefano AL Fitzpatrick AL, Lopez O Launer LJ, Seshadri S CHARGE consortium, Berr C Campion D, Epelbaum J Dartigues JF, Tzourio C Alpérovitch A, Lathrop M EADI1 consortium, Feulner TM Friedrich P, Riehle C Krawczak M, Schreiber S Mayhaus M, Nicolhaus S Wagenpfeil S, Steinberg S Stefansson H, Stefansson K Snaedal J, Björnsson S Jonsson PV, Chouraki V Genier-Boley B, Hiltunen M Soininen H, Combarros O Zelenika D, Delepine M Bullido MJ, Pasquier F Mateo I, Frank-Garcia A Porcellini E, Hanon O Coto E, Alvarez V Bosco P, Siciliano G Mancuso M, Panza F Solfrizzi V, Nacmias B Sorbi S, Boss P Piccardi P, Arosio B Annoni G, Seripa D Pilotto A, Scarpini E Galimberti D, Brice A Hannequin D, Licastro F Jones L, Holmans PA Jonsson T, Riemenschneider M Morgan K, Younkin SG Owen MJ, O'Donovan M Amouyel P, Williams J,, Nat Genet 2011 43 429 435 10.1038/ng.803 21460840
21. Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease. Belbin O Carrasquillo MM, Crump M Culley OJ, Hunter TA Ma L, Bisceglio G Zou F, Allen M Dickson DW, Graff-Radford NR Petersen RC, Morgan K Younkin SG, Hum Genet 2011 129 273 282 10.1007/s00439-010-0924-2 21132329
22. APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway. Sando SB Melquist S Cannon A Hutton ML, Sletvold O Saltvedt I, White LR Lydersen S, Aasly JO,, BMC Neurol 2008 8 9 10.1186/1471-2377-8-9 18416843
23. Interleukin-1 gene -511 CT polymorphism and the risk of Alzheimer's disease in a Polish population. Klimkowicz-Mrowiec A Marona M Wolkow P Maruszak A, Styczynska M Barcikowska M, Zekanowski C Szczudlik A, Slowik A,, Dement Geriatr Cogn Disord 2009 28 461 464 10.1159/000259460 19940477
24. Meta-analysis in clinical trials. DerSimonian R Laird N, Control Clin Trials 1986 7 177 188 10.1016/0197-2456(86)90046-2 3802833 (Pubitemid 17189972)
25. PLINK: a tool set for whole-genome association and population-based linkage analyses. Purcell S Neale B, Todd-Brown K Thomas L, Ferreira MA Bender D, Maller J Sklar P, de Bakker PI Daly MJ, Sham PC, Am J Hum Genet 2007 81 559 575 10.1086/519795 17701901 (Pubitemid 47330214)