메뉴 건너뛰기




Volumn 53, Issue 7, 2016, Pages 4931-4938

Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility

Author keywords

Alzheimer s disease; Genome wide association study; Parkinson s disease; rs75932628; TREM2

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN;

EID: 84941366394     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9416-7     Document Type: Article
Times cited : (46)

References (31)
  • 2
    • 84952631227 scopus 로고    scopus 로고
    • The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
    • Lill CM, Rengmark A, Pihlstrom L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T et al (2015) The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease. Alzheimers Dement
    • (2015) Alzheimers Dement
    • Lill, C.M.1    Rengmark, A.2    Pihlstrom, L.3    Fogh, I.4    Shatunov, A.5    Sleiman, P.M.6    Wang, L.S.7    Liu, T.8
  • 3
    • 84879113935 scopus 로고    scopus 로고
    • TREM2 in neurodegeneration: evidence for association of the p.R47h variant with frontotemporal dementia and Parkinson's disease
    • COI: 1:CAS:528:DC%2BC3sXhtVyhtLfF, PID: 23800361
    • Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C et al (2013) TREM2 in neurodegeneration: evidence for association of the p.R47h variant with frontotemporal dementia and Parkinson's disease. Mol Neurodegener 8:19
    • (2013) Mol Neurodegener , vol.8 , pp. 19
    • Rayaprolu, S.1    Mullen, B.2    Baker, M.3    Lynch, T.4    Finger, E.5    Seeley, W.W.6    Hatanpaa, K.J.7    Lomen-Hoerth, C.8
  • 4
    • 84885821412 scopus 로고    scopus 로고
    • TREM2 and neurodegenerative disease
    • PID: 24131187
    • Benitez BA, Cruchaga C (2013) TREM2 and neurodegenerative disease. N Engl J Med 369:1567–1568
    • (2013) N Engl J Med , vol.369 , pp. 1567-1568
    • Benitez, B.A.1    Cruchaga, C.2
  • 5
    • 84885828745 scopus 로고    scopus 로고
    • TREM2 and neurodegenerative disease
    • COI: 1:CAS:528:DC%2BC3sXhs1CgsbjE, PID: 24131183
    • Jonsson T, Stefansson K (2013) TREM2 and neurodegenerative disease. N Engl J Med 369:1568–1569
    • (2013) N Engl J Med , vol.369 , pp. 1568-1569
    • Jonsson, T.1    Stefansson, K.2
  • 6
    • 11844302840 scopus 로고    scopus 로고
    • Treating individuals 2. Subgroup analysis in randomised controlled trials: importance, indications, and interpretation
    • PID: 15639301
    • Rothwell PM (2005) Treating individuals 2. Subgroup analysis in randomised controlled trials: importance, indications, and interpretation. Lancet 365:176–186
    • (2005) Lancet , vol.365 , pp. 176-186
    • Rothwell, P.M.1
  • 7
    • 84896417597 scopus 로고    scopus 로고
    • Analyzing large-scale samples confirms the association between the abca7 rs3764650 polymorphism and alzheimer's disease susceptibility
    • Liu G, Li F, Zhang S, Jiang Y, Ma G, Shang H, Liu J, Feng R et al. Analyzing large-scale samples confirms the association between the abca7 rs3764650 polymorphism and alzheimer's disease susceptibility. Mol Neurobiol 2014
    • (2014) Mol Neurobiol
    • Liu, G.1    Li, F.2    Zhang, S.3    Jiang, Y.4    Ma, G.5    Shang, H.6    Liu, J.7    Feng, R.8
  • 8
    • 85018091239 scopus 로고    scopus 로고
    • Analyzing 54,936 samples supports the association between cd2ap rs9349407 polymorphism and Alzheimer's disease susceptibility
    • Chen H, Wu G, Jiang Y, Feng R, Liao M, Zhang L, Ma G, Chen Z et al (2014) Analyzing 54,936 samples supports the association between cd2ap rs9349407 polymorphism and Alzheimer's disease susceptibility. Mol Neurobiol
    • (2014) Mol Neurobiol
    • Chen, H.1    Wu, G.2    Jiang, Y.3    Feng, R.4    Liao, M.5    Zhang, L.6    Ma, G.7    Chen, Z.8
  • 9
    • 84877762031 scopus 로고    scopus 로고
    • PICALM gene rs3851179 polymorphism contributes to Alzheimer's disease in an Asian population
    • COI: 1:CAS:528:DC%2BC3sXnsVWmt7g%3D, PID: 23572399
    • Liu G, Zhang S, Cai Z, Ma G, Zhang L, Jiang Y, Feng R, Liao M et al (2013) PICALM gene rs3851179 polymorphism contributes to Alzheimer's disease in an Asian population. Neuromolecular Med 15:384–388
    • (2013) Neuromolecular Med , vol.15 , pp. 384-388
    • Liu, G.1    Zhang, S.2    Cai, Z.3    Ma, G.4    Zhang, L.5    Jiang, Y.6    Feng, R.7    Liao, M.8
  • 10
  • 11
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • COI: 1:STN:280:DyaK2svls1KjtA%3D%3D, PID: 9310563
    • Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 12
    • 0034823867 scopus 로고    scopus 로고
    • Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis
    • COI: 1:STN:280:DC%2BD3MrivFWisA%3D%3D, PID: 11576817
    • Sterne JA, Egger M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54:1046–1055
    • (2001) J Clin Epidemiol , vol.54 , pp. 1046-1055
    • Sterne, J.A.1    Egger, M.2
  • 13
    • 0036208313 scopus 로고    scopus 로고
    • Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy
    • PID: 11914301
    • Song F, Khan KS, Dinnes J, Sutton AJ (2002) Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Int J Epidemiol 31:88–95
    • (2002) Int J Epidemiol , vol.31 , pp. 88-95
    • Song, F.1    Khan, K.S.2    Dinnes, J.3    Sutton, A.J.4
  • 14
    • 84939599004 scopus 로고    scopus 로고
    • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
    • COI: 1:CAS:528:DC%2BC2cXht1ait7%2FP, PID: 25064009
    • Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E et al (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 46:989–993
    • (2014) Nat Genet , vol.46 , pp. 989-993
    • Nalls, M.A.1    Pankratz, N.2    Lill, C.M.3    Do, C.B.4    Hernandez, D.G.5    Saad, M.6    DeStefano, A.L.7    Kara, E.8
  • 15
    • 84859339977 scopus 로고    scopus 로고
    • Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database
    • COI: 1:CAS:528:DC%2BC38Xkslagsbg%3D, PID: 22438815
    • Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E et al (2012) Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database. PLoS Genet 8:e1002548
    • (2012) PLoS Genet , vol.8 , pp. 1002548
    • Lill, C.M.1    Roehr, J.T.2    McQueen, M.B.3    Kavvoura, F.K.4    Bagade, S.5    Schjeide, B.M.6    Schjeide, L.M.7    Meissner, E.8
  • 16
    • 84864066707 scopus 로고    scopus 로고
    • Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants
    • COI: 1:CAS:528:DC%2BC38XovFSqs7s%3D, PID: 22685416
    • Zou F, Chai HS, Younkin CS, Allen M, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN et al (2012) Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet 8:e1002707
    • (2012) PLoS Genet , vol.8 , pp. 1002707
    • Zou, F.1    Chai, H.S.2    Younkin, C.S.3    Allen, M.4    Crook, J.5    Pankratz, V.S.6    Carrasquillo, M.M.7    Rowley, C.N.8
  • 17
    • 84864026404 scopus 로고    scopus 로고
    • Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation
    • COI: 1:CAS:528:DC%2BC38XpvVWrtbc%3D, PID: 22761592
    • Dumitriu A, Latourelle JC, Hadzi TC, Pankratz N, Garza D, Miller JP, Vance JM, Foroud T et al (2012) Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation. PLoS Genet 8:e1002794
    • (2012) PLoS Genet , vol.8 , pp. 1002794
    • Dumitriu, A.1    Latourelle, J.C.2    Hadzi, T.C.3    Pankratz, N.4    Garza, D.5    Miller, J.P.6    Vance, J.M.7    Foroud, T.8
  • 20
  • 21
    • 84952065620 scopus 로고    scopus 로고
    • The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia
    • Roussos P, Katsel P, Fam P, Tan W, Purohit DP, Haroutunian V (2014) The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia. Alzheimers Dement
    • (2014) Alzheimers Dement
    • Roussos, P.1    Katsel, P.2    Fam, P.3    Tan, W.4    Purohit, D.P.5    Haroutunian, V.6
  • 22
    • 84979865800 scopus 로고    scopus 로고
    • Trem2 protein expression changes correlate with Alzheimer's disease neurodegenerative pathologies in post-mortem temporal cortices
    • Lue LF, Schmitz CT, Serrano G, Sue LI, Beach TG, Walker DG (2014) Trem2 protein expression changes correlate with Alzheimer's disease neurodegenerative pathologies in post-mortem temporal cortices. Brain Pathol
    • (2014) Bra
    • Lue, L.F.1    Schmitz, C.T.2    Serrano, G.3    Sue, L.I.4    Beach, T.G.5    Walker, D.G.6
  • 23
    • 84889650344 scopus 로고    scopus 로고
    • Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients
    • COI: 1:CAS:528:DC%2BC3sXhvVGrs7fP, PID: 24002183
    • Hu N, Tan MS, Yu JT, Sun L, Tan L, Wang YL, Jiang T (2014) Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients. J Alzheimers Dis 38:497–501
    • (2014) J Alzheimers Dis , vol.38 , pp. 497-501
    • Hu, N.1    Tan, M.S.2    Yu, J.T.3    Sun, L.4    Tan, L.5    Wang, Y.L.6    Jiang, T.7
  • 24
    • 84937468720 scopus 로고    scopus 로고
    • Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARgamma
    • Strobel S, Grunblatt E, Riederer P, Heinsen H, Arzberger T, Al-Sarraj S, Troakes C, Ferrer I et al (2015) Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARgamma. J Neural Transm
    • (2015) J Neural Transm
    • Strobel, S.1    Grunblatt, E.2    Riederer, P.3    Heinsen, H.4    Arzberger, T.5    Al-Sarraj, S.6    Troakes, C.7    Ferrer, I.8
  • 26
    • 84976462403 scopus 로고
    • Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort
    • Feng SJ, Nie K, Gan R, Huang J, Zhang YW, Wang LM, Zhao JH, Tang HM et al (1780) Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort. Neurobiol Aging 2014(35):e1711–1782
    • (1780) Neurobiol Aging , vol.2014 , Issue.35 , pp. 1711-e1782
    • Feng, S.J.1    Nie, K.2    Gan, R.3    Huang, J.4    Zhang, Y.W.5    Wang, L.M.6    Zhao, J.H.7    Tang, H.M.8
  • 27
    • 84942502247 scopus 로고    scopus 로고
    • Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population
    • Chen Y, Chen X, Guo X, Song W, Cao B, Wei Q, Ou R, Zhao B et al (2015) Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population. Neurol Sci
    • (2015) Neurol Sci
    • Chen, Y.1    Chen, X.2    Guo, X.3    Song, W.4    Cao, B.5    Wei, Q.6    Ou, R.7    Zhao, B.8
  • 28
    • 84898618563 scopus 로고    scopus 로고
    • Rare variant association testing by adaptive combination of p-values
    • PID: 24454922
    • Lin WY, Lou XY, Gao G, Liu N (2014) Rare variant association testing by adaptive combination of p-values. PLoS One 9:e85728
    • (2014) PLoS One , vol.9 , pp. 85728
    • Lin, W.Y.1    Lou, X.Y.2    Gao, G.3    Liu, N.4
  • 29
    • 84884635946 scopus 로고    scopus 로고
    • A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits
    • COI: 1:CAS:528:DC%2BC3sXhsVagtLnO, PID: 23966874
    • Clarke GM, Rivas MA, Morris AP (2013) A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits. PLoS Genet 9:e1003694
    • (2013) PLoS Genet , vol.9 , pp. 1003694
    • Clarke, G.M.1    Rivas, M.A.2    Morris, A.P.3
  • 30
    • 80051499915 scopus 로고    scopus 로고
    • Rare-variant association testing for sequencing data with the sequence kernel association test
    • COI: 1:CAS:528:DC%2BC3MXovF2mtLc%3D, PID: 21737059
    • Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X (2011) Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet 89:82–93
    • (2011) Am J Hum Genet , vol.89 , pp. 82-93
    • Wu, M.C.1    Lee, S.2    Cai, T.3    Li, Y.4    Boehnke, M.5    Lin, X.6
  • 31
    • 78650856517 scopus 로고    scopus 로고
    • GCTA: a tool for genome-wide complex trait analysis
    • COI: 1:CAS:528:DC%2BC3MXktVejtg%3D%3D, PID: 21167468
    • Yang J, Lee SH, Goddard ME, Visscher PM (2011) GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 88:76–82
    • (2011) Am J Hum Genet , vol.88 , pp. 76-82
    • Yang, J.1    Lee, S.H.2    Goddard, M.E.3    Visscher, P.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.