메뉴 건너뛰기




Volumn 75, Issue 8, 2018, Pages 1339-1348

The TET enzymes

Author keywords

5hmC; Cancer; DNA methylation; EMT; Gene regulation; Hypoxia

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARATE DEPENDENT DIOXYGENASE; 5 METHYLCYTOSINE; CITRIC ACID; DIOXYGENASE; ENZYME; FUMARIC ACID; SUCCINIC ACID; TEN ELEVEN TRANSLOCATION ENZYME; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ONCOPROTEIN;

EID: 85035142480     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-017-2721-8     Document Type: Review
Times cited : (54)

References (94)
  • 2
    • 0037099537 scopus 로고    scopus 로고
    • LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
    • COI: 1:CAS:528:DC%2BD38XlsV2lsbs%3D, PID: 12124344
    • Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y (2002) LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res 62:4075–4080
    • (2002) Cancer Res , vol.62 , pp. 4075-4080
    • Ono, R.1    Taki, T.2    Taketani, T.3    Taniwaki, M.4    Kobayashi, H.5    Hayashi, Y.6
  • 3
    • 0037350661 scopus 로고    scopus 로고
    • TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)
    • COI: 1:CAS:528:DC%2BD3sXitFentbY%3D, PID: 12646957
    • Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR (2003) TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia 17:637–641
    • (2003) Leukemia , vol.17 , pp. 637-641
    • Lorsbach, R.B.1    Moore, J.2    Mathew, S.3    Raimondi, S.C.4    Mukatira, S.T.5    Downing, J.R.6
  • 4
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • COI: 1:CAS:528:DC%2BD1MXlslWnurk%3D, PID: 19372393
    • Kriaucionis S, Heintz N (2009) The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324:929–930
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 5
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • COI: 1:CAS:528:DC%2BC3cXovFCntro%3D, PID: 20639862
    • Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466:1129–1133
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D’Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 7
    • 50649120554 scopus 로고    scopus 로고
    • Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets
    • COI: 1:CAS:528:DC%2BD1cXhtVGnsbfK, PID: 19160570
    • Myllyharju J (2008) Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets. Ann Med 40:402–417
    • (2008) Ann Med , vol.40 , pp. 402-417
    • Myllyharju, J.1
  • 10
    • 84877778628 scopus 로고    scopus 로고
    • Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules
    • COI: 1:CAS:528:DC%2BC3sXot1ygtr0%3D, PID: 23690950
    • Liu N, Wang M, Deng W, Schmidt CS, Qin W, Leonhardt H, Spada F (2013) Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules. PLoS One 8:e62755
    • (2013) PLoS One , vol.8
    • Liu, N.1    Wang, M.2    Deng, W.3    Schmidt, C.S.4    Qin, W.5    Leonhardt, H.6    Spada, F.7
  • 14
    • 84928231344 scopus 로고    scopus 로고
    • Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT)
    • COI: 1:CAS:528:DC%2BC2MXjtlGjtbY%3D, PID: 25568311
    • Bauer C, Gobel K, Nagaraj N, Colantuoni C, Wang M, Muller U, Kremmer E, Rottach A, Leonhardt H (2015) Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). J Biol Chem 290:4801–4812
    • (2015) J Biol Chem , vol.290 , pp. 4801-4812
    • Bauer, C.1    Gobel, K.2    Nagaraj, N.3    Colantuoni, C.4    Wang, M.5    Muller, U.6    Kremmer, E.7    Rottach, A.8    Leonhardt, H.9
  • 16
    • 0031616949 scopus 로고    scopus 로고
    • Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases
    • COI: 1:CAS:528:DyaK1cXmsV2nsbs%3D, PID: 9559057
    • Kivirikko KI, Pihlajaniemi T (1998) Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases. Adv Enzymol Relat Areas Mol Biol 72:325–398
    • (1998) Adv Enzymol Relat Areas Mol Biol , vol.72 , pp. 325-398
    • Kivirikko, K.I.1    Pihlajaniemi, T.2
  • 17
    • 23444447955 scopus 로고    scopus 로고
    • Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
    • COI: 1:CAS:528:DC%2BD2MXntlWiu70%3D, PID: 15941769
    • Hirsila M, Koivunen P, Xu L, Seeley T, Kivirikko KI, Myllyharju J (2005) Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. FASEB J 19:1308–1310
    • (2005) FASEB J , vol.19 , pp. 1308-1310
    • Hirsila, M.1    Koivunen, P.2    Xu, L.3    Seeley, T.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 22
    • 84930572740 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine in cancer: significance in diagnosis and therapy
    • COI: 1:CAS:528:DC%2BC2MXlvVKjtL8%3D, PID: 25892122
    • Vasanthakumar A, Godley LA (2015) 5-Hydroxymethylcytosine in cancer: significance in diagnosis and therapy. Cancer Genet 208:167–177
    • (2015) Cancer Genet , vol.208 , pp. 167-177
    • Vasanthakumar, A.1    Godley, L.A.2
  • 23
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • COI: 1:CAS:528:DC%2BC3MXhtV2jt7nN, PID: 21778364
    • Ito Shinsuke, Shen Li, Dai Qing, Wu Susan C, Collins Leonard B, Swenberg James A, He Chuan, Zhang Yi (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333:1300–1303
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 24
    • 84886035297 scopus 로고    scopus 로고
    • A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
    • PID: 24156278
    • Iurlaro M, Ficz G, Oxley D, Raiber E, Bachman M, Booth MJ, Andrews S, Balasubramanian S, Reik W (2013) A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol 14:R119
    • (2013) Genome Biol , vol.14 , pp. R119
    • Iurlaro, M.1    Ficz, G.2    Oxley, D.3    Raiber, E.4    Bachman, M.5    Booth, M.J.6    Andrews, S.7    Balasubramanian, S.8    Reik, W.9
  • 28
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • COI: 1:CAS:528:DC%2BC3MXmslOgsLY%3D, PID: 21576262
    • Deaton AM, Bird A (2011) CpG islands and the regulation of transcription. Genes Dev 25:1010–1022
    • (2011) Genes Dev , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 29
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • COI: 1:CAS:528:DC%2BD2sXis12ju7k%3D, PID: 17320506
    • Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128:683–692
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 31
    • 85021329167 scopus 로고    scopus 로고
    • TET family dioxygenases and DNA demethylation in stem cells and cancers
    • COI: 1:CAS:528:DC%2BC2sXksVCmu7c%3D, PID: 28450733
    • An J, Rao A, Ko M (2017) TET family dioxygenases and DNA demethylation in stem cells and cancers. Exp Mol Med 49:e323
    • (2017) Exp Mol Med , vol.49
    • An, J.1    Rao, A.2    Ko, M.3
  • 32
    • 84962886326 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an independent unfavorable prognostic factor for esophageal squamous cell carcinoma
    • PID: 27050164
    • Shi X, Yu Y, Luo M, Zhang Z, Shi S, Feng X, Chen Z, He J (2016) Loss of 5-hydroxymethylcytosine is an independent unfavorable prognostic factor for esophageal squamous cell carcinoma. PLoS One 11:e0153100
    • (2016) PLoS One , vol.11
    • Shi, X.1    Yu, Y.2    Luo, M.3    Zhang, Z.4    Shi, S.5    Feng, X.6    Chen, Z.7    He, J.8
  • 33
    • 85009726405 scopus 로고    scopus 로고
    • Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis
    • PID: 27911867
    • Chen Z, Shi X, Guo L, Li Y, Luo M, He J (2017) Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis. Oncotarget 8:1944–1952
    • (2017) Oncotarget , vol.8 , pp. 1944-1952
    • Chen, Z.1    Shi, X.2    Guo, L.3    Li, Y.4    Luo, M.5    He, J.6
  • 34
    • 84967190687 scopus 로고    scopus 로고
    • Low level of 5-hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer
    • PID: 27313688
    • Liao Y, Gu J, Wu Y, Long X, Ge DI, Xu J, Ding J (2016) Low level of 5-hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer. Oncol Lett 11:3753–3760
    • (2016) Oncol Lett , vol.11 , pp. 3753-3760
    • Liao, Y.1    Gu, J.2    Wu, Y.3    Long, X.4    Ge, D.I.5    Xu, J.6    Ding, J.7
  • 35
    • 84864053192 scopus 로고    scopus 로고
    • Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma
    • COI: 1:CAS:528:DC%2BC38XhtFSksLbM, PID: 22829908
    • Orr BA, Haffner MC, Nelson WG, Yegnasubramanian S, Eberhart CG (2012) Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. PLoS One 7:e41036
    • (2012) PLoS One , vol.7
    • Orr, B.A.1    Haffner, M.C.2    Nelson, W.G.3    Yegnasubramanian, S.4    Eberhart, C.G.5
  • 36
    • 85007564500 scopus 로고    scopus 로고
    • Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance
    • Van Damme M, Crompot E, Meuleman N, Maerevoet M, Mineur P, Bron D, Lagneaux L, Stamatopoulos B (2016) Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance. Clin Epigenet 8:132
    • (2016) Clin Epigenet , vol.8 , pp. 132
    • Van Damme, M.1    Crompot, E.2    Meuleman, N.3    Maerevoet, M.4    Mineur, P.5    Bron, D.6    Lagneaux, L.7    Stamatopoulos, B.8
  • 40
    • 84895810190 scopus 로고    scopus 로고
    • The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
    • COI: 1:CAS:528:DC%2BC3sXhvFCqtrnO, PID: 24220273
    • Solary E, Bernard OA, Tefferi A, Fuks F, Vainchenker W (2014) The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases. Leukemia 28:485–496
    • (2014) Leukemia , vol.28 , pp. 485-496
    • Solary, E.1    Bernard, O.A.2    Tefferi, A.3    Fuks, F.4    Vainchenker, W.5
  • 41
    • 84855718050 scopus 로고    scopus 로고
    • TET2 and DNMT3A mutations in human T-cell lymphoma
    • COI: 1:CAS:528:DC%2BC38XhtVKiuro%3D, PID: 22216861
    • Couronne L, Bastard C, Bernard OA (2012) TET2 and DNMT3A mutations in human T-cell lymphoma. N Engl J Med 366:95–96
    • (2012) N Engl J Med , vol.366 , pp. 95-96
    • Couronne, L.1    Bastard, C.2    Bernard, O.A.3
  • 50
    • 85004065577 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: master regulators of cancer progression
    • PID: 28741521
    • Schito L, Semenza GL (2016) Hypoxia-inducible factors: master regulators of cancer progression. Trends Cancer 2:758–770
    • (2016) Trends Cancer , vol.2 , pp. 758-770
    • Schito, L.1    Semenza, G.L.2
  • 52
    • 85017474086 scopus 로고    scopus 로고
    • Novel epigenetic controlling of hypoxia pathway related to overexpression and promoter hypomethylation of TET1 and TET2 in RPE cells
    • COI: 1:CAS:528:DC%2BC2sXlvFCnsro%3D, PID: 28252217
    • Alivand MR, Soheili ZS, Pornour M, Solali S, Sabouni F (2017) Novel epigenetic controlling of hypoxia pathway related to overexpression and promoter hypomethylation of TET1 and TET2 in RPE cells. J Cell Biochem 118:3193–3204
    • (2017) J Cell Biochem , vol.118 , pp. 3193-3204
    • Alivand, M.R.1    Soheili, Z.S.2    Pornour, M.3    Solali, S.4    Sabouni, F.5
  • 54
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • COI: 1:CAS:528:DC%2BC38XhtVegs7zM, PID: 22677546
    • Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL (2012) Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 26:1326–1338
    • (2012) Genes Dev , vol.26 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5    Zhu, H.6    Liu, L.7    Liu, Y.8    Yang, C.9    Xu, Y.10    Zhao, S.11    Ye, D.12    Xiong, Y.13    Guan, K.L.14
  • 56
    • 84925503908 scopus 로고    scopus 로고
    • Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells
    • COI: 1:CAS:528:DC%2BC2cXitFamsrjL, PID: 25487152
    • Carey BW, Finley LW, Cross JR, Allis CD, Thompson CB (2015) Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518:413–416
    • (2015) Nature , vol.518 , pp. 413-416
    • Carey, B.W.1    Finley, L.W.2    Cross, J.R.3    Allis, C.D.4    Thompson, C.B.5
  • 61
    • 84855710482 scopus 로고    scopus 로고
    • Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
    • PID: 22238332
    • Andronesi OC, Kim GS, Gerstner E, Batchelor T, Tzika AA, Fantin VR, Vander Heiden MG, Sorensen AG (2012) Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med 4:116ra4
    • (2012) Sci Transl Med , vol.4 , pp. 116ra4
    • Andronesi, O.C.1    Kim, G.S.2    Gerstner, E.3    Batchelor, T.4    Tzika, A.A.5    Fantin, V.R.6    Vander Heiden, M.G.7    Sorensen, A.G.8
  • 65
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
    • PID: 12788921
    • Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J (2003) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278:30772–30780
    • (2003) J Biol Chem , vol.278 , pp. 30772-30780
    • Hirsila, M.1    Koivunen, P.2    Gunzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 67
  • 68
    • 38149075003 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury
    • COI: 1:CAS:528:DC%2BD1cXhs12htL0%3D, PID: 18178798
    • Hill P, Shukla D, Tran MG, Aragones J, Cook HT, Carmeliet P, Maxwell PH (2008) Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 19:39–46
    • (2008) J Am Soc Nephrol , vol.19 , pp. 39-46
    • Hill, P.1    Shukla, D.2    Tran, M.G.3    Aragones, J.4    Cook, H.T.5    Carmeliet, P.6    Maxwell, P.H.7
  • 73
    • 84947770106 scopus 로고    scopus 로고
    • Loss of the epigenetic mark, 5-hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma
    • PID: 26462027
    • Lee JJ, Cook M, Mihm MC, Xu S, Zhan Q, Wang TJ, Murphy GF, Lian CG (2015) Loss of the epigenetic mark, 5-hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma. Oncotarget 6:37995
    • (2015) Oncotarget , vol.6 , pp. 37995
    • Lee, J.J.1    Cook, M.2    Mihm, M.C.3    Xu, S.4    Zhan, Q.5    Wang, T.J.6    Murphy, G.F.7    Lian, C.G.8
  • 77
    • 84997190994 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine expression in proliferative nodules arising within congenital nevi allows differentiation from malignant melanoma
    • COI: 1:CAS:528:DC%2BC28XhsVOqsL7E, PID: 27456754
    • Pavlova O, Fraitag S, Hohl D (2016) 5-Hydroxymethylcytosine expression in proliferative nodules arising within congenital nevi allows differentiation from malignant melanoma. J Investig Dermatol 136:2453–2461
    • (2016) J Investig Dermatol , vol.136 , pp. 2453-2461
    • Pavlova, O.1    Fraitag, S.2    Hohl, D.3
  • 79
    • 85006198802 scopus 로고    scopus 로고
    • Decreased 5-Hydroxymethylcytosine (5-hmC) predicts poor prognosis in early-stage laryngeal squamous cell carcinoma
    • PID: 27294001
    • Zhang Y, Wu K, Shao Y, Sui F, Yang Q, Shi B, Hou P, Ji M (2016) Decreased 5-Hydroxymethylcytosine (5-hmC) predicts poor prognosis in early-stage laryngeal squamous cell carcinoma. Am J Cancer Res 6:1089–1098
    • (2016) Am J Cancer Res , vol.6 , pp. 1089-1098
    • Zhang, Y.1    Wu, K.2    Shao, Y.3    Sui, F.4    Yang, Q.5    Shi, B.6    Hou, P.7    Ji, M.8
  • 83
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    • COI: 1:CAS:528:DC%2BD2sXhsFKgsrY%3D, PID: 17182618
    • Koivunen P, Hirsila M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J (2007) Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem 282:4524–4532
    • (2007) J Biol Chem , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsila, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 84
    • 33749410367 scopus 로고    scopus 로고
    • The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases
    • COI: 1:CAS:528:DC%2BD28XpvFantLc%3D, PID: 16885164
    • Koivunen P, Hirsila M, Kivirikko KI, Myllyharju J (2006) The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. J Biol Chem 281:28712–28720
    • (2006) J Biol Chem , vol.281 , pp. 28712-28720
    • Koivunen, P.1    Hirsila, M.2    Kivirikko, K.I.3    Myllyharju, J.4
  • 85
    • 33846315497 scopus 로고    scopus 로고
    • Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
    • COI: 1:CAS:528:DC%2BD28XhtlShsLfE, PID: 16952279
    • Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ (2007) Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J 401:227–234
    • (2007) Biochem J , vol.401 , pp. 227-234
    • Ehrismann, D.1    Flashman, E.2    Genn, D.N.3    Mathioudakis, N.4    Hewitson, K.S.5    Ratcliffe, P.J.6    Schofield, C.J.7
  • 86
    • 0030962028 scopus 로고    scopus 로고
    • Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase
    • COI: 1:CAS:528:DyaK2sXitlOisb4%3D, PID: 9135134
    • Myllyharju J, Kivirikko KI (1997) Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase. EMBO J 16:1173–1180
    • (1997) EMBO J , vol.16 , pp. 1173-1180
    • Myllyharju, J.1    Kivirikko, K.I.2
  • 87
    • 0017347136 scopus 로고
    • Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme
    • COI: 1:CAS:528:DyaE2sXhvVGisrg%3D, PID: 192269
    • Berg RA, Kishida Y, Sakakibara S, Prockop DJ (1977) Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme. Biochemistry 16:1615–1621
    • (1977) Biochemistry , vol.16 , pp. 1615-1621
    • Berg, R.A.1    Kishida, Y.2    Sakakibara, S.3    Prockop, D.J.4
  • 88
    • 1642315195 scopus 로고    scopus 로고
    • Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
    • COI: 1:CAS:528:DC%2BD2cXitlKls7w%3D, PID: 14701857
    • Koivunen P, Hirsila M, Gunzler V, Kivirikko KI, Myllyharju J (2004) Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 279:9899–9904
    • (2004) J Biol Chem , vol.279 , pp. 9899-9904
    • Koivunen, P.1    Hirsila, M.2    Gunzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 89
    • 85018461057 scopus 로고    scopus 로고
    • The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
    • COI: 1:CAS:528:DC%2BC2sXit1GjtQ%3D%3D, PID: 28051298
    • Hancock RL, Masson N, Dunne K, Flashman E, Kawamura A (2017) The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations. ACS Chem Biol 12:1011–1019
    • (2017) ACS Chem Biol , vol.12 , pp. 1011-1019
    • Hancock, R.L.1    Masson, N.2    Dunne, K.3    Flashman, E.4    Kawamura, A.5
  • 91
    • 28244466886 scopus 로고    scopus 로고
    • Repair of methylation damage in DNA and RNA by mammalian AlkB homologues
    • COI: 1:CAS:528:DC%2BD2MXht1emsrfK, PID: 16174769
    • Lee DH, Jin SG, Cai S, Chen Y, Pfeifer GP, O’Connor TR (2005) Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. J Biol Chem 280:39448–39459
    • (2005) J Biol Chem , vol.280 , pp. 39448-39459
    • Lee, D.H.1    Jin, S.G.2    Cai, S.3    Chen, Y.4    Pfeifer, G.P.5    O’Connor, T.R.6
  • 92
    • 0021765030 scopus 로고
    • The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion
    • COI: 1:CAS:528:DyaL2cXmsVSrsw%3D%3D, PID: 6321169
    • Majamaa K, Hanauske-Abel HM, Gunzler V, Kivirikko KI (1984) The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion. Eur J Biochem 138:239–245
    • (1984) Eur J Biochem , vol.138 , pp. 239-245
    • Majamaa, K.1    Hanauske-Abel, H.M.2    Gunzler, V.3    Kivirikko, K.I.4
  • 93
    • 0017697003 scopus 로고
    • Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates
    • COI: 1:CAS:528:DyaE1cXitlWl, PID: 200424
    • Tuderman L, Myllyla R, Kivirikko KI (1977) Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates. Eur J Biochem 80:341–348
    • (1977) Eur J Biochem , vol.80 , pp. 341-348
    • Tuderman, L.1    Myllyla, R.2    Kivirikko, K.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.