Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes

Journal of Biological Chemistry

Volumn 291, Issue 8, 2016, Pages 4256-4265

  Laukka, Tuomas ^a   Mariani, Christopher J ^b,c   Ihantola, Tuukka ^a   Cao, John Z ^b,c   Hokkanen, Juho ^d   Kaelin, William G ^e,f   Godley, Lucy A ^b,c   Koivunen, Peppi ^a  

^a UNIVERSITY OF OULU   (Finland)

^b SECTION OF HEMATOLOGY ONCOLOGY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d Admescope Ltd   (Finland)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYMES; GENES; STABILIZATION; TRANSCRIPTION;

2-OXOGLUTARATE-DEPENDENT DIOXYGENASE; 5-HYDROXYMETHYLCYTOSINE; ACUTE MYELOID LEUKEMIA; DIFFERENTIAL EFFECT; EPIGENETIC REGULATION; HYPOXIA-INDUCIBLE FACTORS; NEUROBLASTOMA CELLS; SUCCINATE DEHYDROGENASE;

GENE EXPRESSION;

5 HYDROXYMETHYLCYTOSINE; DIOXYGENASE; FUMARIC ACID; HYPOXIA INDUCIBLE FACTOR; SUCCINIC ACID; TEN ELEVEN TRANSLOCATION 1 PROTEIN; TEN ELEVEN TRANSLOCATION 2 PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; FUMARIC ACID DERIVATIVE; MIXED FUNCTION OXIDASE; ONCOPROTEIN; TET1 PROTEIN, HUMAN; TET3 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; IN VITRO STUDY; PRIORITY JOURNAL; ACUTE MYELOID LEUKEMIA; ANIMAL; BIOSYNTHESIS; CELL HYPOXIA; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; MUTATION; NEUROBLASTOMA; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; DIOXYGENASES; DNA-BINDING PROTEINS; FUMARATES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MIXED FUNCTION OXYGENASES; MUTATION; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS; SUCCINIC ACID;

EID: 84964614586     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.688762     Document Type: Article

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