Optimization of Substrate-Analogue Furin Inhibitors

ChemMedChem

Volumn 12, Issue 23, 2017, Pages 1953-1968

  Ivanova, Teodora ^a   Hardes, Kornelia ^a   Kallis, Stephanie ^b,c   Dahms, Sven O ^d,e   Than, Manuel E ^d   Künzel, Sebastian ^f   Böttcher Friebertshäuser, Eva ^a   Lindberg, Iris ^g   Jiao, Guan Sheng ^h,i   Bartenschlager, Ralf ^b,c   Steinmetzer, Torsten ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Heidelberg   (Germany)

^d FRITZ LIPMANN INSTITUTE   (Germany)

^e UNIVERSITY OF SALZBURG   (Austria)

^f Hochschule Ansbach   (Germany)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^h Hawaii Biotech Inc   (United States)

ⁱ MedChem ShortCut LLC   (United States)

Author keywords

antiviral activity; enzyme kinetics; furin inhibitors; proprotein convertases; toxicity

Indexed keywords

2 FLUORO 4 (HYDROXYMETHYL)BENZONITRILE; 4 (AMINOMETHYL) 2 FLUOROBENZIMIDAMIDE; 4 (AMINOMETHYL)BENZOHYDRAZONAMIDE; 4 (GUANIDINOMETHYL)PHENYLACETYL ARGINYL TERTLEUCYL ARGINYL 4 AMIDINOBENZYLAMIDE; 6 (AMINOMETHYL)BENZO[D]ISOXAZOL 3 AMINE; BENZYL (4 CARBAMOHYDRAZONOYLBENZYL)CARBAMATE; BENZYL 4 CYANOBENZYLCARBAMATE; BIS BOC 4 (AMIDOMETHYL) 2 FLUOROBENZONITRILE; BIS BOC 6 (AMIDOMETHYL)BENZO[D]ISOXAZOL 3 AMINE; FURIN INHIBITOR DERIVATIVE; INFLUENZA VIRUS HEMAGGLUTININ; METHYL 4 CYANO 3 FLUOROBENZOATE; MI 1148; SERINE PROTEINASE INHIBITOR; TERT BUTYL 4 CARBAMIMIDOYL 3 FLUOROBENZYLCARBAMATE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; ENZYME INHIBITOR; FURIN; FURIN PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ACUTE TOXICITY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CANINE DISTEMPER VIRUS; CARBOXY TERMINAL SEQUENCE; CELL VIABILITY; CHIKUNGUNYA VIRUS; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DENGUE VIRUS; DENGUE VIRUS 2; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS; HUH-7 CELL LINE; HUMAN; HUMAN CELL; IC50; INFLUENZA A VIRUS (H5N1); INFLUENZA A VIRUS (H7N1); MALE; MOUSE; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SEMLIKI FOREST VIRUS; STEADY STATE; VERO C1008 CELL LINE; VIRUS REPLICATION; WEST NILE VIRUS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYME SPECIFICITY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; DENGUE VIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FURIN; HEK293 CELLS; HUMANS; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; WEST NILE VIRUS;

EID: 85034108494     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201700596     Document Type: Article

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