Erratum: Structural studies revealed active site distortions of human furin by a small molecule inhibitor (ACS Chemical Biology (2017) 12 (1211-1216) DOI: 10.1021/acschembio.6b01110);Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor

ACS Chemical Biology

Volumn 12, Issue 5, 2017, Pages 1211-1216

  Dahms, Sven O ^a,c   Jiao, Guan Sheng ^b,d   Than, Manuel E ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b Hawaii Biotech Inc   (United States)

^c UNIVERSITY OF SALZBURG   (Austria)

^d MedChem ShortCut LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; ENZYME INHIBITOR; SERINE PROTEINASE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RACEMIC MIXTURE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; HUMAN; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FURIN; HUMANS; PROPROTEIN CONVERTASES;

EID: 85019551170     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.7b00633     Document Type: Erratum

References (29)

1. Artenstein, A. W. and Opal, S. M. (2011) Proprotein convertases in health and disease N. Engl. J. Med. 365, 2507-2518 10.1056/NEJMra1106700
2. Thomas, G. (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease Nat. Rev. Mol. Cell Biol. 3, 753-766 10.1038/nrm934
3. Basak, A. (2005) Inhibitors of proprotein convertases J. Mol. Med. 83, 844-855 10.1007/s00109-005-0710-0
4. Seidah, N. G. and Prat, A. (2012) The biology and therapeutic targeting of the proprotein convertases Nat. Rev. Drug Discovery 11, 367-383 10.1038/nrd3699
5. Garten, W., Hallenberger, S., Ortmann, D., Schafer, W., Vey, M., Angliker, H., Shaw, E., and Klenk, H. D. (1994) Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones Biochimie 76, 217-225 10.1016/0300-9084(94)90149-X
6. Kacprzak, M. M., Peinado, J. R., Than, M. E., Appel, J., Henrich, S., Lipkind, G., Houghten, R. A., Bode, W., and Lindberg, I. (2004) Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine J. Biol. Chem. 279, 36788-36794 10.1074/jbc.M400484200
7. Levesque, C., Couture, F., Kwiatkowska, A., Desjardins, R., Guerin, B., Neugebauer, W. A., and Day, R. (2015) PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation Oncotarget 6, 3680-3693 10.18632/oncotarget.2918
8. Hardes, K., Becker, G. L., Lu, Y., Dahms, S. O., Kohler, S., Beyer, W., Sandvig, K., Yamamoto, H., Lindberg, I., Walz, L., von Messling, V., Than, M. E., Garten, W., and Steinmetzer, T. (2015) Novel Furin Inhibitors with Potent Anti-infectious Activity ChemMedChem 10, 1218-1231 10.1002/cmdc.201500103
9. Becker, G. L., Sielaff, F., Than, M. E., Lindberg, I., Routhier, S., Day, R., Lu, Y., Garten, W., and Steinmetzer, T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics J. Med. Chem. 53, 1067-1075 10.1021/jm9012455
10. Lu, Y., Hardes, K., Dahms, S. O., Bottcher-Friebertshauser, E., Steinmetzer, T., Than, M. E., Klenk, H. D., and Garten, W. (2015) Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells Antiviral Res. 120, 89-100 10.1016/j.antiviral.2015.05.006
11. Jiao, G. S., Cregar, L., Wang, J., Millis, S. Z., Tang, C., O'Malley, S., Johnson, A. T., Sareth, S., Larson, J., and Thomas, G. (2006) Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine Proc. Natl. Acad. Sci. U. S. A. 103, 19707-19712 10.1073/pnas.0606555104
12. Komiyama, T., Coppola, J. M., Larsen, M. J., van Dort, M. E., Ross, B. D., Day, R., Rehemtulla, A., and Fuller, R. S. (2009) Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules J. Biol. Chem. 284, 15729-15738 10.1074/jbc.M901540200
13. Ramos-Molina, B., Lick, A. N., Blanco, E. H., Posada-Salgado, J. A., Martinez-Mayorga, K., Johnson, A. T., Jiao, G. S., and Lindberg, I. (2015) Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays Biochem. Pharmacol. 96, 107-118 10.1016/j.bcp.2015.05.008
14. Sielaff, F., Than, M. E., Bevec, D., Lindberg, I., and Steinmetzer, T. (2011) New furin inhibitors based on weakly basic amidinohydrazones Bioorg. Med. Chem. Lett. 21, 836-840 10.1016/j.bmcl.2010.11.092
15. Scamuffa, N., Sfaxi, F., Ma, J., Lalou, C., Seidah, N., Calvo, F., and Khatib, A. M. (2014) Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis Carcinogenesis 35, 528-536 10.1093/carcin/bgt345
16. Zhu, J., Declercq, J., Roucourt, B., Ghassabeh, G. H., Meulemans, S., Kinne, J., David, G., Vermorken, A. J., Van de Ven, W. J., Lindberg, I., Muyldermans, S., and Creemers, J. W. (2012) Generation and characterization of non-competitive furin-inhibiting nanobodies Biochem. J. 448, 73-82 10.1042/BJ20120537
17. Henrich, S., Cameron, A., Bourenkov, G. P., Kiefersauer, R., Huber, R., Lindberg, I., Bode, W., and Than, M. E. (2003) The crystal structure of the proprotein processing proteinase furin explains its stringent specificity Nat. Struct. Biol. 10, 520-526 10.1038/nsb941
18. Dahms, S. O., Hardes, K., Becker, G. L., Steinmetzer, T., Brandstetter, H., and Than, M. E. (2014) X-ray Structures of Human Furin in Complex with Competitive Inhibitors ACS Chem. Biol. 9, 1113-1118 10.1021/cb500087x
19. Holyoak, T., Kettner, C. A., Petsko, G. A., Fuller, R. S., and Ringe, D. (2004) Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases Biochemistry 43, 2412-2421 10.1021/bi035849h
20. Dahms, S. O., Arciniega, M., Steinmetzer, T., Huber, R., and Than, M. E. (2016) Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism Proc. Natl. Acad. Sci. U. S. A. 113, 11196-11201 10.1073/pnas.1613630113
21. Henrich, S., Lindberg, I., Bode, W., and Than, M. E. (2005) Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity J. Mol. Biol. 345, 211-227 10.1016/j.jmb.2004.10.050
22. Mueller, U., Darowski, N., Fuchs, M. R., Forster, R., Hellmig, M., Paithankar, K. S., Puhringer, S., Steffien, M., Zocher, G., and Weiss, M. S. (2012) Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin J. Synchrotron Radiat. 19, 442-449 10.1107/S0909049512006395
23. Kabsch, W. (2010) Xds Acta Crystallogr., Sect. D: Biol. Crystallogr. 66, 125-132 10.1107/S0907444909047337
24. Winn, M. D., Ballard, C. C., Cowtan, K. D., Dodson, E. J., Emsley, P., Evans, P. R., Keegan, R. M., Krissinel, E. B., Leslie, A. G., McCoy, A., McNicholas, S. J., Murshudov, G. N., Pannu, N. S., Potterton, E. A., Powell, H. R., Read, R. J., Vagin, A., and Wilson, K. S. (2011) Overview of the CCP4 suite and current developments Acta Crystallogr., Sect. D: Biol. Crystallogr. 67, 235-242 10.1107/S0907444910045749
25. Emsley, P., Lohkamp, B., Scott, W. G., and Cowtan, K. (2010) Features and development of Coot Acta Crystallogr., Sect. D: Biol. Crystallogr. 66, 486-501 10.1107/S0907444910007493
26. Adams, P. D., Afonine, P. V., Bunkoczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L. W., Kapral, G. J., Grosse-Kunstleve, R. W., McCoy, A. J., Moriarty, N. W., Oeffner, R., Read, R. J., Richardson, D. C., Richardson, J. S., Terwilliger, T. C., and Zwart, P. H. (2010) PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr., Sect. D: Biol. Crystallogr. 66, 213-221 10.1107/S0907444909052925
27. Schuttelkopf, A. W. and van Aalten, D. M. (2004) PRODRG: a tool for high-throughput crystallography of protein-ligand complexes Acta Crystallogr., Sect. D: Biol. Crystallogr. 60, 1355-1363 10.1107/S0907444904011679
28. Turk, D. (2013) MAIN software for density averaging, model building, structure refinement and validation Acta Crystallogr., Sect. D: Biol. Crystallogr. 69, 1342-1357 10.1107/S0907444913008408
29. Brunger, A. T. (2007) Version 1.2 of the Crystallography and NMR system Nat. Protoc. 2, 2728-2733 10.1038/nprot.2007.406