Novel Furin Inhibitors with Potent Anti-infectious Activity

ChemMedChem

Volumn 10, Issue 7, 2015, Pages 1218-1231

  Hardes, Kornelia ^a   Becker, Gero L ^a   Lu, Yinghui ^a   Dahms, Sven O ^b   Köhler, Susanne ^c   Beyer, Wolfgang ^c   Sandvig, Kirsten ^d   Yamamoto, Hiroyuki ^e   Lindberg, Iris ^e   Walz, Lisa ^f   Vonmessling, Veronika ^f   Than, Manuel E ^b   Garten, Wolfgang ^a   Steinmetzer, Torsten ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c UNIVERSITY OF HOHENHEIM   (Germany)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f PAUL EHRLICH INSTITUT   (Germany)

Author keywords

antiviral agents; crystal structure analysis; furin; inhibitors; proprotein convertases

Indexed keywords

4 AMINOMETHYL PHENYLACETYL ARGINYL TERT LEUCYL ARGINYL 4 AMIDINOBENZYLAMIDE 4 TRIFLUOROACETIC ACID; 4 GUANIDINOMETHYL PHENYLACETYL ARGINYL TERT LEUCYL ARGINYL 4 AMIDINOBENZYLAMIDE 4 TRIFLUOROACETIC ACID; ANTHRAX TOXIN; ANTIINFECTIVE AGENT; DIPHTHERIA TOXIN; FURIN; FURIN INHIBITOR; PEPTIDOMIMETIC AGENT; SERINE PROTEINASE INHIBITOR; SHIGA TOXIN; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; ENZYME INHIBITOR; FURIN PROTEIN, HUMAN;

ANIMAL CELL; ANTHRAX; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; AVIAN INFLUENZA VIRUS; CANINE DISTEMPER VIRUS; CONTROLLED STUDY; CORYNEBACTERIUM DIPHTHERIAE; CRYSTALLIZATION; CYTOPATHOGENIC EFFECT; DIPHTHERIA; DRUG POTENCY; HUMAN; HUMAN CELL; INFLUENZA VIRUS A H5N1; INFLUENZA VIRUS A H7N1; INHIBITION CONSTANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; VERO CELL LINE; VIRUS INHIBITION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; INFLUENZA A VIRUS; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; DISTEMPER VIRUS, CANINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FURIN; HUMANS; INFLUENZA A VIRUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84933502451     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201500103     Document Type: Article

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