The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications

Journal of Biological Chemistry

Volumn 281, Issue 41, 2006, Pages 30561-30572

  Benjannet, Suzanne ^a   Rhainds, David ^a   Hamelin, Josée ^a   Nassoury, Nasha ^a   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; HUMAN PLASMA; POST-TRANSLATIONAL MODIFICATIONS;

AMINO ACIDS; BIODEGRADATION; BIOLOGICAL MEMBRANES; MOLECULAR BIOLOGY; MUTAGENESIS;

ENZYMES;

FURIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE PCSK9; PROTEINASE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOSOME; GOLGI COMPLEX; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IMMUNOFLUORESCENCE; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; FEMALE; FURIN; HUMANS; LIPOPROTEINS, LDL; MALE; MOLECULAR SEQUENCE DATA; MUTATION; PROPROTEIN CONVERTASE 5; PROTEIN PROCESSING, POST-TRANSLATIONAL; SERINE ENDOPEPTIDASES; TRANS-GOLGI NETWORK;

EID: 33750090075     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606495200     Document Type: Article

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