In vivo evidence that furin from hepatocytes inactivates PCSK9

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4257-4263

  Essalmani, Rachid ^a   Susan Resiga, Delia ^a   Chamberland, Ann ^a   Abifadel, Marianne ^c   Creemers, John W ^b   Boileau, Catherine ^c   Seidah, Nabil G ^a   Prat, Annik ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL HOMEOSTASIS; COMPOUND EFFECT; CONVERTASES; EX-VIVO; HEPATOCYTES; IN-VIVO; MEMBRANE-BOUND; MOUSE PLASMA; MRNA LEVEL; OVER-EXPRESSION; PRIMARY HEPATOCYTES; RECEPTOR PROTEINS;

GENES;

NUCLEIC ACIDS;

ARGININE; FERRIC UPTAKE REGULATOR; FURIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE PC5; PROPROTEIN CONVERTASE PC6A; PROPROTEIN CONVERTASE PCSK9; SERINE PROTEINASE; UNCLASSIFIED DRUG; FURIN PROTEIN, HUMAN; PCSK9 PROTEIN, HUMAN; PCSK9 PROTEIN, MOUSE;

AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DIVISION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GENE INACTIVATION; GENE OVEREXPRESSION; HETEROZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; AMINO ACID SUBSTITUTION; ANIMAL; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; LIVER; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

AMINO ACID SUBSTITUTION; ANIMALS; ENZYME ACTIVATION; FURIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; HUMANS; LIVER; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; RECEPTORS, LDL; SERINE ENDOPEPTIDASES;

EID: 79953022875     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.192104     Document Type: Article

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