Inhibition of furin by polyarginine-containing peptides: Nanomolar inhibition by nona-D-arginine

Journal of Biological Chemistry

Volumn 279, Issue 35, 2004, Pages 36788-36794

  Kacprzak, Magdalena M ^a   Peinado, Juan E ^a   Than, Manuel E ^b   Appel, Jon ^c   Henrich, Stefan ^b   Lipkind, Gregory ^d   Houghten, Richard A ^c   Bode, Wolfram ^b   Lindberg, Iris ^a  

^a LOUISIANA STATE UNIV HLTH SCI C   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BINDING ENERGY; METABOLISM; PATHOLOGY; PROTEINS; TOXIC MATERIALS; VIRUSES;

PATHOGENIC TOXINS; PEPTIDES; POLYARGININE; VIRAL PROLIFERATION;

ENZYME INHIBITION;

DEXTRO ARGININE; FURIN; HEXAPEPTIDE; PEPTIDE LIBRARY; POLYARGININE; SYNTHETIC PEPTIDE;

ANIMAL CELL; ANTHRAX; ARTICLE; CELL STRAIN; CELL STRAIN RAW 264 7; COMBINATORIAL CHEMISTRY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; DRUG SCREENING; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; ELECTRICITY; EMBRYO; HUMAN; HUMAN CELL; IC 50; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXEMIA; TOXICITY;

ALANINE; ANIMALS; ANTIGENS, BACTERIAL; ARGININE; BACTERIAL TOXINS; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FURIN; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; IONS; KINETICS; LYSINE; MICE; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ANIMALIA; ANTHRAX; MAMMALIA;

EID: 4344716372     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400484200     Document Type: Article

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