Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases

Journal of Biological Chemistry

Volumn 287, Issue 26, 2012, Pages 21992-22003

  Becker, Gero L ^a   Lu, Yinghui ^a   Hardes, Kornelia ^a   Strehlow, Boris ^a   Levesque, Christine ^b   Lindberg, Iris ^c   Sandvig, Kirsten ^d   Bakowsky, Udo ^a   Day, Robert ^b   Garten, Wolfgang ^a   Steinmetzer, Torsten ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; VIRUSES;

ANTI-VIRAL EFFECTS; IMPROVED ACTIVITIES; INFECTIOUS DISEASE; MADIN-DARBY CANINE KIDNEY CELLS; PROPROTEIN CONVERTASE FURIN; PROTECTIVE EFFECTS; TRYPSIN-LIKE SERINE PROTEASE; VIRUS PROPAGATION;

DISEASES;

24 [4 (GUANIDOMETHYL)PHENYLACETYLARGINYLVALYLARGINYL 4 AMIDINOBENZYLAMIDE]; 3 (GUANIDINOMETHYL)PHENYLACETYL; 4 (GUANIDINOMETHYL)PHENYLACETYL; FURIN; FURIN INHIBITOR; HEMAGGLUTININ; PHENYLACETYLARGINYLVALYLARGINYL 4 AMIDINOBENZYLAMIDE; SERINE PROTEINASE INHIBITOR; SHIGA TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL PROTECTION; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; FOWL PLAGUE VIRUS; IC 50; IN VITRO STUDY; INFLUENZA VIRUS A H7N1; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN INTERACTION; STRUCTURE ANALYSIS; TOXIN SYNTHESIS; VIROGENESIS; VIRUS INFECTION;

EID: 84862644095     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.332643     Document Type: Article

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