New substrate analoque inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: Part 1

Medicinal Chemistry

Volumn 2, Issue 4, 2006, Pages 349-361

  Schweinitz, Andrea ^a   Stürzebecher, Anne ^a   Stürzebecher, Uta ^b   Schuster, Oliver ^c   Stürzebecher, Jörg ^b   Steinmetzer, Torsten ^a  

^a Curacyte Chemistry GmbH   (Germany)

^b Klinikum der Universitat Jena   (Germany)

^c Curacyte Discovery GmbH   (Germany)

Author keywords

Anticoagulants; Antithrombotics; Factor Xa; Protease inhibitor

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; AMIDE; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; FONDAPARINUX; N [2 (5 AMIDINO 2 HYDROXYPHENOXY) 3,5 DIFLUORO 6 [3 (1 METHYL 1H 2 IMIDAZOLIN 2 YL)PHENOXY] 4 PYRIDINYL] N METHYLGLYCINE; PLASMINOGEN ACTIVATOR INHIBITOR; PROTHROMBIN; THROMBIN INHIBITOR; THROMBOPLASTIN; XIMELAGATRAN; BENZYL DERIVATIVE; BLOOD CLOTTING FACTOR 5; PROTHROMBINASE COMPLEX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CLEARANCE; DRUG DESIGN; DRUG ELIMINATION; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; DRUG WITHDRAWAL; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER DYSFUNCTION; NONHUMAN; ORTHOPEDIC SURGERY; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT; THIN LAYER CHROMATOGRAPHY; VENOUS THROMBOEMBOLISM; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; HALF LIFE TIME; INTRAVENOUS DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTICOAGULANTS; BENZYL COMPOUNDS; BLOOD COAGULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR V; FACTOR XA; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RESEARCH SUPPORT, NON-U.S. GOV'T; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33746140038     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606777724040     Document Type: Article

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