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Volumn 36, Issue 37, 2017, Pages 5221-5230

A tumor suppressor role for C/EBPα in solid tumors: More than fat and blood

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA;

EID: 85031695785     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2017.151     Document Type: Review
Times cited : (76)

References (147)
  • 1
    • 21644462493 scopus 로고    scopus 로고
    • Molecular stop signs: Regulation of cell-cycle arrest by C/EBP transcription factors
    • Johnson PF. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci 2005; 118: 2545-2555.
    • (2005) J Cell Sci , vol.118 , pp. 2545-2555
    • Johnson, P.F.1
  • 2
    • 0030021836 scopus 로고    scopus 로고
    • DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family
    • Osada S, Yamamoto H, Nishihara T, Imagawa M. DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family. J Biol Chem 1996; 271: 3891-3896.
    • (1996) J Biol Chem , vol.271 , pp. 3891-3896
    • Osada, S.1    Yamamoto, H.2    Nishihara, T.3    Imagawa, M.4
  • 3
    • 0037082508 scopus 로고    scopus 로고
    • Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
    • Gombart AF, Hofmann W-K, Kawano S, Takeuchi S, Krug U, Kwok SH et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood 2002; 99: 1332-1340.
    • (2002) Blood , vol.99 , pp. 1332-1340
    • Gombart, A.F.1    Hofmann, W.-K.2    Kawano, S.3    Takeuchi, S.4    Krug, U.5    Kwok, S.H.6
  • 4
    • 0038350876 scopus 로고    scopus 로고
    • Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha
    • Miller M, Shuman JD, Sebastian T, Dauter Z, Johnson PF. Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha. J Biol Chem 2003; 278: 15178-15184.
    • (2003) J Biol Chem , vol.278 , pp. 15178-15184
    • Miller, M.1    Shuman, J.D.2    Sebastian, T.3    Dauter, Z.4    Johnson, P.F.5
  • 5
    • 0022508422 scopus 로고
    • Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene
    • Graves BJ, Johnson PF, McKnight SL. Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene. Cell 1986; 44: 565-576.
    • (1986) Cell , vol.44 , pp. 565-576
    • Graves, B.J.1    Johnson, P.F.2    McKnight, S.L.3
  • 6
    • 0033869876 scopus 로고    scopus 로고
    • Translational control of C/EBPalpha and C/EBPbeta isoform expression
    • Calkhoven CF, Müller C, Leutz A. Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes Dev 2000; 14: 1920-1932.
    • (2000) Genes Dev , vol.14 , pp. 1920-1932
    • Calkhoven, C.F.1    Müller, C.2    Leutz, A.3
  • 7
    • 0025936177 scopus 로고
    • A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
    • Descombes P, Schibler U. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 1991; 67: 569-579.
    • (1991) Cell , vol.67 , pp. 569-579
    • Descombes, P.1    Schibler, U.2
  • 8
    • 0027420920 scopus 로고
    • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: Transcriptional activator lacking antimitotic activity
    • Lin FT, MacDougald OA, Diehl AM, Lane MD. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. Proc Natl Acad Sci USA 1993; 90: 9606-9610.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9606-9610
    • Lin, F.T.1    MacDougald, O.A.2    Diehl, A.M.3    Lane, M.D.4
  • 9
    • 0027214319 scopus 로고
    • CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials
    • Ossipow V, Descombes P, Schibler U. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc Natl Acad Sci USA 1993; 90: 8219-8223.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8219-8223
    • Ossipow, V.1    Descombes, P.2    Schibler, U.3
  • 10
    • 0029156782 scopus 로고
    • CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells
    • Nerlov C, Ziff EB. CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells. EMBO J 1995; 14: 4318-4328.
    • (1995) EMBO J , vol.14 , pp. 4318-4328
    • Nerlov, C.1    Ziff, E.B.2
  • 11
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo
    • Porse BT, Pedersen TA, Xu X, Lindberg B, Wewer UM, Friis-Hansen L et al. E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 2001; 107: 247-258.
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1    Pedersen, T.A.2    Xu, X.3    Lindberg, B.4    Wewer, U.M.5    Friis-Hansen, L.6
  • 12
    • 77950647654 scopus 로고    scopus 로고
    • Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes
    • Zaragoza K, Bégay V, Schuetz A, Heinemann U, Leutz A. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol Cell Biol 2010; 30: 2293-2304.
    • (2010) Mol Cell Biol , vol.30 , pp. 2293-2304
    • Zaragoza, K.1    Bégay, V.2    Schuetz, A.3    Heinemann, U.4    Leutz, A.5
  • 13
    • 0142214647 scopus 로고    scopus 로고
    • The amino terminal and E2F interaction domains are critical for C/EBP alphamediated induction of granulopoietic development of hematopoietic cells
    • D'Alo' F, Johansen LM, Nelson EA, Radomska HS, Evans EK, Zhang P et al. The amino terminal and E2F interaction domains are critical for C/EBP alphamediated induction of granulopoietic development of hematopoietic cells. Blood 2003; 102: 3163-3171.
    • (2003) Blood , vol.102 , pp. 3163-3171
    • D'Alo, F.1    Johansen, L.M.2    Nelson, E.A.3    Radomska, H.S.4    Evans, E.K.5    Zhang, P.6
  • 14
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, Schnittger S et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet 2001; 27: 263-270.
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3    Radomska, H.S.4    Narravula, S.5    Schnittger, S.6
  • 15
    • 78650975508 scopus 로고    scopus 로고
    • Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: Lessons from clinical data and BMT models
    • Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K et al. Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models. Blood 2011; 117: 221-233.
    • (2011) Blood , vol.117 , pp. 221-233
    • Kato, N.1    Kitaura, J.2    Doki, N.3    Komeno, Y.4    Watanabe-Okochi, N.5    Togami, K.6
  • 16
    • 84892550999 scopus 로고    scopus 로고
    • C/EBPα: Critical at the origin of leukemic transformation
    • Roe J-S, Vakoc CR. C/EBPα: critical at the origin of leukemic transformation. J Exp Med 2014; 211: 1-4.
    • (2014) J Exp Med , vol.211 , pp. 1-4
    • Roe, J.-S.1    Vakoc, C.R.2
  • 17
    • 84912143436 scopus 로고    scopus 로고
    • C/EBP transcription factors in human squamous cell carcinoma: Selective changes in expression of isoforms correlate with the neoplastic state
    • Anand S, Ebner J, Warren CB, Raam MS, Piliang M, Billings SD et al. C/EBP transcription factors in human squamous cell carcinoma: selective changes in expression of isoforms correlate with the neoplastic state. PLoS One 2014; 9: e112073.
    • (2014) PLoS One , vol.9 , pp. e112073
    • Anand, S.1    Ebner, J.2    Warren, C.B.3    Raam, M.S.4    Piliang, M.5    Billings, S.D.6
  • 18
    • 34250332520 scopus 로고    scopus 로고
    • Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma
    • Bennett KL, Hackanson B, Smith LT, Morrison CD, Lang JC, Schuller DE et al. Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma. Cancer Res 2007; 67: 4657-4664.
    • (2007) Cancer Res , vol.67 , pp. 4657-4664
    • Bennett, K.L.1    Hackanson, B.2    Smith, L.T.3    Morrison, C.D.4    Lang, J.C.5    Schuller, D.E.6
  • 19
    • 34047263219 scopus 로고    scopus 로고
    • Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade
    • Datta J, Majumder S, Kutay H, Motiwala T, Frankel W, Costa R et al. Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade. Cancer Res 2007; 67: 2736-2746.
    • (2007) Cancer Res , vol.67 , pp. 2736-2746
    • Datta, J.1    Majumder, S.2    Kutay, H.3    Motiwala, T.4    Frankel, W.5    Costa, R.6
  • 21
    • 77955507119 scopus 로고    scopus 로고
    • C/EBPalpha is upregulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation
    • 643.e1-4
    • Lu G-D, Leung CH-W, Yan B, Tan CM-Y, Low SY, Aung MO et al. C/EBPalpha is upregulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation. Gastroenterology 2010; 139: 632-643, 643.e1-4.
    • (2010) Gastroenterology , vol.139 , pp. 632-643
    • Lu, G.-D.1    Ch-W, L.2    Yan, B.3    Cm-Y, T.4    Low, S.Y.5    Aung, M.O.6
  • 22
    • 33644958558 scopus 로고    scopus 로고
    • Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer
    • Tada Y, Brena RM, Hackanson B, Morrison C, Otterson GA, Plass C. Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. J Natl Cancer Inst 2006; 98: 396-406.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 396-406
    • Tada, Y.1    Brena, R.M.2    Hackanson, B.3    Morrison, C.4    Otterson, G.A.5    Plass, C.6
  • 23
    • 33747331632 scopus 로고    scopus 로고
    • Down regulation of PSA by C/EBPalpha is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell line
    • Yin H, Radomska HS, Tenen DG, Glass J. Down regulation of PSA by C/EBPalpha is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell line. BMC Cancer 2006; 6: 158.
    • (2006) BMC Cancer , vol.6 , pp. 158
    • Yin, H.1    Radomska, H.S.2    Tenen, D.G.3    Glass, J.4
  • 24
    • 84856777602 scopus 로고    scopus 로고
    • Restoration of C/EBPα in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis
    • Wu Y V, Okada T, DeCarolis P, Socci N, O'Connor R, Geha RC et al. Restoration of C/EBPα in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis. Genes Chromosom Cancer 2012; 51: 313-327.
    • (2012) Genes Chromosom Cancer , vol.51 , pp. 313-327
    • Wu, Y.V.1    Okada, T.2    DeCarolis, P.3    Socci, N.4    O'Connor, R.5    Geha, R.C.6
  • 25
    • 0029746172 scopus 로고    scopus 로고
    • Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha
    • Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, Xanthopoulos KG. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem 1996; 271: 24753-24760.
    • (1996) J Biol Chem , vol.271 , pp. 24753-24760
    • Flodby, P.1    Barlow, C.2    Kylefjord, H.3    Ahrlund-Richter, L.4    Xanthopoulos, K.G.5
  • 26
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    • Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci USA 1997; 94: 569-574.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 569-574
    • Zhang, D.E.1    Zhang, P.2    Wang, N.D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 28
    • 33746861562 scopus 로고    scopus 로고
    • C/EBPalpha: A tumour suppressor in multiple tissues?
    • Schuster MB, Porse BT. C/EBPalpha: a tumour suppressor in multiple tissues? Biochim Biophys Acta 2006; 1766: 88-103.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 88-103
    • Schuster, M.B.1    Porse, B.T.2
  • 29
    • 0031837472 scopus 로고    scopus 로고
    • Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in skin neoplasms
    • Oh HS, Smart RC. Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in skin neoplasms. J Invest Dermatol 1998; 110: 939-945.
    • (1998) J Invest Dermatol , vol.110 , pp. 939-945
    • Oh, H.S.1    Smart, R.C.2
  • 30
    • 0024711273 scopus 로고
    • Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein
    • Birkenmeier EH, Gwynn B, Howard S, Jerry J, Gordon JI, Landschulz WH et al. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev 1989; 3: 1146-1156.
    • (1989) Genes Dev , vol.3 , pp. 1146-1156
    • Birkenmeier, E.H.1    Gwynn, B.2    Howard, S.3    Jerry, J.4    Gordon, J.I.5    Landschulz, W.H.6
  • 31
    • 0028889290 scopus 로고
    • Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)
    • Antonson P, Xanthopoulos KG. Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha). Biochem Biophys Res Commun 1995; 215: 106-113.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 106-113
    • Antonson, P.1    Xanthopoulos, K.G.2
  • 32
    • 0029121366 scopus 로고
    • PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene
    • Hohaus S, Petrovick MS, Voso MT, Sun Z, Zhang DE, Tenen DG. PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol Cell Biol 1995; 15: 5830-5845.
    • (1995) Mol Cell Biol , vol.15 , pp. 5830-5845
    • Hohaus, S.1    Petrovick, M.S.2    Voso, M.T.3    Sun, Z.4    Zhang, D.E.5    Tenen, D.G.6
  • 33
    • 55749095056 scopus 로고    scopus 로고
    • PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
    • Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A et al. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 2008; 22: 2941-2952.
    • (2008) Genes Dev , vol.22 , pp. 2941-2952
    • Lefterova, M.I.1    Zhang, Y.2    Steger, D.J.3    Schupp, M.4    Schug, J.5    Cristancho, A.6
  • 34
    • 0032125697 scopus 로고    scopus 로고
    • Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1
    • McNagny KM, Sieweke MH, Döderlein G, Graf T, Nerlov C. Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1. EMBO J 1998; 17: 3669-3680.
    • (1998) EMBO J , vol.17 , pp. 3669-3680
    • McNagny, K.M.1    Sieweke, M.H.2    Döderlein, G.3    Graf, T.4    Nerlov, C.5
  • 35
    • 0034502513 scopus 로고    scopus 로고
    • C/EBP alpha and TTF-1 synergistically transactivate the Clara cell secretory protein gene
    • Cassel TN, Suske G, Nord M. C/EBP alpha and TTF-1 synergistically transactivate the Clara cell secretory protein gene. Ann N Y Acad Sci 2000; 923: 300-302.
    • (2000) Ann N y Acad Sci , vol.923 , pp. 300-302
    • Cassel, T.N.1    Suske, G.2    Nord, M.3
  • 36
    • 0035529053 scopus 로고    scopus 로고
    • Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
    • Pedersen TA, Kowenz-Leutz E, Leutz A, Nerlov C. Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes Dev 2001; 15: 3208-3216.
    • (2001) Genes Dev , vol.15 , pp. 3208-3216
    • Pedersen, T.A.1    Kowenz-Leutz, E.2    Leutz, A.3    Nerlov, C.4
  • 37
    • 0035844209 scopus 로고    scopus 로고
    • MacDougald OA. P300 coactivates the adipogenic transcription factor CCAAT/enhancer-binding protein alpha
    • Erickson RL, Hemati N, Ross SE, MacDougald OA. p300 coactivates the adipogenic transcription factor CCAAT/enhancer-binding protein alpha. J Biol Chem 2001; 276: 16348-16355.
    • (2001) J Biol Chem , vol.276 , pp. 16348-16355
    • Erickson, R.L.1    Hemati, N.2    Ross, S.E.3
  • 38
    • 0034785786 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein alpha assembles essential cooperating factors in common subnuclear domains
    • Schaufele F, Enwright JF, Wang X, Teoh C, Srihari R, Erickson R et al. CCAAT/enhancer binding protein alpha assembles essential cooperating factors in common subnuclear domains. Mol Endocrinol 2001; 15: 1665-1676.
    • (2001) Mol Endocrinol , vol.15 , pp. 1665-1676
    • Schaufele, F.1    Enwright, J.F.2    Wang, X.3    Teoh, C.4    Srihari, R.5    Erickson, R.6
  • 40
    • 84940592833 scopus 로고    scopus 로고
    • Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
    • Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y et al. Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Nat Cell Biol 2015; 17: 1099-1111.
    • (2015) Nat Cell Biol , vol.17 , pp. 1099-1111
    • Wang, Q.A.1    Tao, C.2    Jiang, L.3    Shao, M.4    Ye, R.5    Zhu, Y.6
  • 41
    • 0032555932 scopus 로고    scopus 로고
    • Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis
    • Zhang P, Iwama A, Datta MW, Darlington GJ, Link DC, Tenen DG. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis. J Exp Med 1998; 188: 1173-1184.
    • (1998) J Exp Med , vol.188 , pp. 1173-1184
    • Zhang, P.1    Iwama, A.2    Datta, M.W.3    Darlington, G.J.4    Link, D.C.5    Tenen, D.G.6
  • 42
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol 1998; 18: 4301-4314.
    • (1998) Mol Cell Biol , vol.18 , pp. 4301-4314
    • Radomska, H.S.1    Huettner, C.S.2    Zhang, P.3    Cheng, T.4    Scadden, D.T.5    Tenen, D.G.6
  • 43
    • 0030024112 scopus 로고    scopus 로고
    • CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
    • Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM et al. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 1996; 16: 1231-1240.
    • (1996) Mol Cell Biol , vol.16 , pp. 1231-1240
    • Zhang, D.E.1    Hetherington, C.J.2    Meyers, S.3    Rhoades, K.L.4    Larson, C.J.5    Chen, H.M.6
  • 44
    • 10344230611 scopus 로고    scopus 로고
    • Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha
    • Zhang P, Iwasaki-Arai J, Iwasaki H, Fenyus ML, Dayaram T, Owens BM et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 2004; 21: 853-863.
    • (2004) Immunity , vol.21 , pp. 853-863
    • Zhang, P.1    Iwasaki-Arai, J.2    Iwasaki, H.3    Fenyus, M.L.4    Dayaram, T.5    Owens, B.M.6
  • 46
    • 2342544921 scopus 로고    scopus 로고
    • C/EBPalpha mutations in acute myeloid leukaemias
    • Nerlov C. C/EBPalpha mutations in acute myeloid leukaemias. Nat Rev Cancer 2004; 4: 394-400.
    • (2004) Nat Rev Cancer , vol.4 , pp. 394-400
    • Nerlov, C.1
  • 47
    • 84874261272 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein-α suppresses lung tumor development in mice through the p38α MAP kinase pathway
    • Sato A, Yamada N, Ogawa Y, Ikegami M. CCAAT/enhancer-binding protein-α suppresses lung tumor development in mice through the p38α MAP kinase pathway. PLoS One 2013; 8: e57013.
    • (2013) PLoS One , vol.8 , pp. e57013
    • Sato, A.1    Yamada, N.2    Ogawa, Y.3    Ikegami, M.4
  • 49
    • 31344444129 scopus 로고    scopus 로고
    • Respiratory failure due to differentiation arrest and expansion of alveolar cells following lungspecific loss of the transcription factor C/EBPalpha in mice
    • Bassères DS, Levantini E, Ji H, Monti S, Elf S, Dayaram T et al. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lungspecific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 2006; 26: 1109-1123.
    • (2006) Mol Cell Biol , vol.26 , pp. 1109-1123
    • Bassères, D.S.1    Levantini, E.2    Ji, H.3    Monti, S.4    Elf, S.5    Dayaram, T.6
  • 50
    • 0032525340 scopus 로고    scopus 로고
    • C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
    • Seagroves TN, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington GJ et al. C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev 1998; 12: 1917-1928.
    • (1998) Genes Dev , vol.12 , pp. 1917-1928
    • Seagroves, T.N.1    Krnacik, S.2    Raught, B.3    Gay, J.4    Burgess-Beusse, B.5    Darlington, G.J.6
  • 51
    • 65849375498 scopus 로고    scopus 로고
    • Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival
    • Tseng H-H, Hwang Y-H, Yeh K-T, Chang J-G, Chen Y-L, Yu H-S. Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival. J Cancer Res Clin Oncol 2009; 135: 241-247.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 241-247
    • Tseng, H.-H.1    Hwang, Y.-H.2    Yeh, K.-T.3    Chang, J.-G.4    Chen, Y.-L.5    Yu, H.-S.6
  • 52
    • 0036618423 scopus 로고    scopus 로고
    • Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas
    • Tomizawa M, Wang Y-Q, Ebara M, Saisho H, Watanabe K, Nakagawara A et al. Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas. Int J Mol Med 2002; 9: 597-600.
    • (2002) Int J Mol Med , vol.9 , pp. 597-600
    • Tomizawa, M.1    Wang, Y.-Q.2    Ebara, M.3    Saisho, H.4    Watanabe, K.5    Nakagawara, A.6
  • 53
    • 13444271570 scopus 로고    scopus 로고
    • Diminished expression of C/EBPalpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBPalpha in carcinoma cells inhibits proliferation
    • Shim M, Powers KL, Ewing SJ, Zhu S, Smart RC. Diminished expression of C/EBPalpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBPalpha in carcinoma cells inhibits proliferation. Cancer Res 2005; 65: 861-867.
    • (2005) Cancer Res , vol.65 , pp. 861-867
    • Shim, M.1    Powers, K.L.2    Ewing, S.J.3    Zhu, S.4    Smart, R.C.5
  • 54
    • 33847676808 scopus 로고    scopus 로고
    • Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: A correlative study of E3590
    • Costa DB, Li S, Kocher O, Feins RH, Keller SM, Schiller JH et al. Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: a correlative study of E3590. Lung Cancer 2007; 56: 97-103.
    • (2007) Lung Cancer , vol.56 , pp. 97-103
    • Costa, D.B.1    Li, S.2    Kocher, O.3    Feins, R.H.4    Keller, S.M.5    Schiller, J.H.6
  • 55
    • 84903265648 scopus 로고    scopus 로고
    • Down-regulation of the expression of CCAAT/enhancer binding protein α gene in cervical squamous cell carcinoma
    • Pan Z, Zheng W, Zhang J, Gao R, Li D, Guo X et al. Down-regulation of the expression of CCAAT/enhancer binding protein α gene in cervical squamous cell carcinoma. BMC Cancer 2014; 14: 417.
    • (2014) BMC Cancer , vol.14 , pp. 417
    • Pan, Z.1    Zheng, W.2    Zhang, J.3    Gao, R.4    Li, D.5    Guo, X.6
  • 56
    • 84945275255 scopus 로고    scopus 로고
    • C/EBPα-induced MIR-100 expression suppresses tumor metastasis and growth by targeting ZBTB7A in gastric cancer
    • Shi D-B, Wang Y-W, Xing A-Y, Gao J-W, Zhang H, Guo X-Y et al. C/EBPα-induced miR-100 expression suppresses tumor metastasis and growth by targeting ZBTB7A in gastric cancer. Cancer Lett 2015; 369: 376-385.
    • (2015) Cancer Lett , vol.369 , pp. 376-385
    • Shi, D.-B.1    Wang, Y.-W.2    Xing, A.-Y.3    Gao, J.-W.4    Zhang, H.5    Guo, X.-Y.6
  • 58
    • 0344837364 scopus 로고    scopus 로고
    • Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: A possible prognostic marker
    • Tomizawa M, Watanabe K, Saisho H, Nakagawara A, Tagawa M. Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. Anticancer Res 2003; 23: 351-354.
    • (2003) Anticancer Res , vol.23 , pp. 351-354
    • Tomizawa, M.1    Watanabe, K.2    Saisho, H.3    Nakagawara, A.4    Tagawa, M.5
  • 59
    • 13444269762 scopus 로고    scopus 로고
    • An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
    • Roepman P, Wessels LFA, Kettelarij N, Kemmeren P, Miles AJ, Lijnzaad P et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet 2005; 37: 182-186.
    • (2005) Nat Genet , vol.37 , pp. 182-186
    • Roepman, P.1    Wessels, L.F.A.2    Kettelarij, N.3    Kemmeren, P.4    Miles, A.J.5    Lijnzaad, P.6
  • 60
    • 84901404889 scopus 로고    scopus 로고
    • MIR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma
    • Wang C, Ren R, Hu H, Tan C, Han M, Wang X et al. MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma. Chin J Cancer Res 2014; 26: 17-29.
    • (2014) Chin J Cancer Res , vol.26 , pp. 17-29
    • Wang, C.1    Ren, R.2    Hu, H.3    Tan, C.4    Han, M.5    Wang, X.6
  • 63
    • 34547123572 scopus 로고    scopus 로고
    • Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis
    • Loomis KD, Zhu S, Yoon K, Johnson PF, Smart RC. Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis. Cancer Res 2007; 67: 6768-6776.
    • (2007) Cancer Res , vol.67 , pp. 6768-6776
    • Loomis, K.D.1    Zhu, S.2    Yoon, K.3    Johnson, P.F.4    Smart, R.C.5
  • 64
    • 84867333038 scopus 로고    scopus 로고
    • Yin Yang-1 suppresses differentiation of hepatocellular carcinoma cells through the downregulation of CCAAT/enhancer-binding protein alpha
    • Zhang S, Jiang T, Feng L, Sun J, Lu H, Wang Q et al. Yin Yang-1 suppresses differentiation of hepatocellular carcinoma cells through the downregulation of CCAAT/enhancer-binding protein alpha. J Mol Med 2012; 90: 1069-1077.
    • (2012) J Mol Med , vol.90 , pp. 1069-1077
    • Zhang, S.1    Jiang, T.2    Feng, L.3    Sun, J.4    Lu, H.5    Wang, Q.6
  • 65
    • 59649124191 scopus 로고    scopus 로고
    • The tumour necrosis factor-alphamediated suppression of the CCAAT/enhancer binding protein-alpha gene transcription in hepatocytes involves inhibition of autoregulation
    • Foka P, Singh NN, Salter RC, Ramji DP. The tumour necrosis factor-alphamediated suppression of the CCAAT/enhancer binding protein-alpha gene transcription in hepatocytes involves inhibition of autoregulation. Int J Biochem Cell Biol 2009; 41: 1189-1197.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1189-1197
    • Foka, P.1    Singh, N.N.2    Salter, R.C.3    Ramji, D.P.4
  • 66
    • 34249807348 scopus 로고    scopus 로고
    • P38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    • Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M et al. p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet 2007; 39: 750-758.
    • (2007) Nat Genet , vol.39 , pp. 750-758
    • Ventura, J.J.1    Tenbaum, S.2    Perdiguero, E.3    Huth, M.4    Guerra, C.5    Barbacid, M.6
  • 67
    • 84865262075 scopus 로고    scopus 로고
    • Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/MIR-17-92 axis
    • Oeztuerk-Winder F, Guinot A, Ochalek A, Ventura J-J. Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis. EMBO J 2012; 31: 3431-3441.
    • (2012) EMBO J , vol.31 , pp. 3431-3441
    • Oeztuerk-Winder, F.1    Guinot, A.2    Ochalek, A.3    Ventura, J.-J.4
  • 68
    • 48749105025 scopus 로고    scopus 로고
    • Expression and subcellular localization of the CCAAT/enhancer binding protein alpha in relation to postnatal development and malignancy of the prostate
    • Zhang J, Wilkinson JE, Gonit M, Keck R, Selman S, Ratnam M. Expression and subcellular localization of the CCAAT/enhancer binding protein alpha in relation to postnatal development and malignancy of the prostate. Prostate 2008; 68: 1206-1214.
    • (2008) Prostate , vol.68 , pp. 1206-1214
    • Zhang, J.1    Wilkinson, J.E.2    Gonit, M.3    Keck, R.4    Selman, S.5    Ratnam, M.6
  • 69
    • 58149469248 scopus 로고    scopus 로고
    • Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells
    • Kumagai T, Akagi T, Desmond JC, Kawamata N, Gery S, Imai Y et al. Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells. Int J Cancer 2009; 124: 827-833.
    • (2009) Int J Cancer , vol.124 , pp. 827-833
    • Kumagai, T.1    Akagi, T.2    Desmond, J.C.3    Kawamata, N.4    Gery, S.5    Imai, Y.6
  • 70
    • 76349104599 scopus 로고    scopus 로고
    • C/EBPalpha redirects androgen receptor signaling through a unique bimodal interaction
    • Zhang J, Gonit M, Salazar MD, Shatnawi A, Shemshedini L, Trumbly R et al. C/EBPalpha redirects androgen receptor signaling through a unique bimodal interaction. Oncogene 2010; 29: 723-738.
    • (2010) Oncogene , vol.29 , pp. 723-738
    • Zhang, J.1    Gonit, M.2    Salazar, M.D.3    Shatnawi, A.4    Shemshedini, L.5    Trumbly, R.6
  • 71
    • 33746576757 scopus 로고    scopus 로고
    • The CCAAT enhancer-binding protein-alpha negatively regulates the transactivation of androgen receptor in prostate cancer cells
    • Chattopadhyay S, Gong E-Y, Hwang M, Park E, Lee HJ, Hong CY et al. The CCAAT enhancer-binding protein-alpha negatively regulates the transactivation of androgen receptor in prostate cancer cells. Mol Endocrinol 2006; 20: 984-995.
    • (2006) Mol Endocrinol , vol.20 , pp. 984-995
    • Chattopadhyay, S.1    Gong, E.-Y.2    Hwang, M.3    Park, E.4    Lee, H.J.5    Hong, C.Y.6
  • 75
    • 0034282535 scopus 로고    scopus 로고
    • Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering
    • Girard L, Zöchbauer-Müller S, Virmani AK, Gazdar AF, Minna JD. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 2000; 60: 4894-4906.
    • (2000) Cancer Res , vol.60 , pp. 4894-4906
    • Girard, L.1    Zöchbauer-Müller, S.2    Virmani, A.K.3    Gazdar, A.F.4    Minna, J.D.5
  • 76
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293: 1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 79
    • 0035049323 scopus 로고    scopus 로고
    • Methylation in the p53 promoter is a supplementary route to breast carcinogenesis: Correlation between CpG methylation in the p53 promoter and the mutation of the p53 gene in the progression from ductal carcinoma in situ to invasive ductal carcinoma
    • Kang JH, Kim SJ, Noh DY, Park IA, Choe KJ, Yoo OJ et al. Methylation in the p53 promoter is a supplementary route to breast carcinogenesis: correlation between CpG methylation in the p53 promoter and the mutation of the p53 gene in the progression from ductal carcinoma in situ to invasive ductal carcinoma. Lab Invest 2001; 81: 573-579.
    • (2001) Lab Invest , vol.81 , pp. 573-579
    • Kang, J.H.1    Kim, S.J.2    Noh, D.Y.3    Park, I.A.4    Choe, K.J.5    Yoo, O.J.6
  • 80
    • 19244370208 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
    • Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 2000; 60: 2368-2371.
    • (2000) Cancer Res , vol.60 , pp. 2368-2371
    • Esteller, M.1    Toyota, M.2    Sanchez-Cespedes, M.3    Capella, G.4    Peinado, M.A.5    Watkins, D.N.6
  • 81
    • 84856807056 scopus 로고    scopus 로고
    • Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas
    • Taylor BS, DeCarolis PL, Angeles C V, Brenet F, Schultz N, Antonescu CR et al. Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas. Cancer Discov 2011; 1: 587-597.
    • (2011) Cancer Discov , vol.1 , pp. 587-597
    • Taylor, B.S.1    DeCarolis, P.L.2    Angeles, C.V.3    Brenet, F.4    Schultz, N.5    Antonescu, C.R.6
  • 82
    • 60549088321 scopus 로고    scopus 로고
    • Activator protein 2 alpha (AP2alpha) suppresses 42 kDa C/CAAT enhancer binding protein alpha (p42(C/EBPalpha)) in head and neck squamous cell carcinoma
    • Bennett KL, Romigh T, Arab K, Teresi RE, Tada Y, Eng C et al. Activator protein 2 alpha (AP2alpha) suppresses 42 kDa C/CAAT enhancer binding protein alpha (p42(C/EBPalpha)) in head and neck squamous cell carcinoma. Int J Cancer 2009; 124: 1285-1292.
    • (2009) Int J Cancer , vol.124 , pp. 1285-1292
    • Bennett, K.L.1    Romigh, T.2    Arab, K.3    Teresi, R.E.4    Tada, Y.5    Eng, C.6
  • 83
    • 78651331694 scopus 로고    scopus 로고
    • CEBPA methylation as a prognostic biomarker in patients with de novo acute myeloid leukemia
    • Lin T-C, Hou H, Chou W-C, Ou D-L, Yu S-L, Tien H-F et al. CEBPA methylation as a prognostic biomarker in patients with de novo acute myeloid leukemia. Leukemia 2011; 25: 32-40.
    • (2011) Leukemia , vol.25 , pp. 32-40
    • Lin, T.-C.1    Hou, H.2    Chou, W.-C.3    Ou, D.-L.4    Yu, S.-L.5    Tien, H.-F.6
  • 84
    • 0034813831 scopus 로고    scopus 로고
    • Mice lacking CCAAt/enhancer-binding protein-alpha show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs
    • Sugahara K, Iyama KI, Kimura T, Sano K, Darlington GJ, Akiba T et al. Mice lacking CCAAt/enhancer-binding protein-alpha show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs. Cell Tissue Res 2001; 306: 57-63.
    • (2001) Cell Tissue Res , vol.306 , pp. 57-63
    • Sugahara, K.1    Iyama, K.I.2    Kimura, T.3    Sano, K.4    Darlington, G.J.5    Akiba, T.6
  • 85
    • 0031940340 scopus 로고    scopus 로고
    • Lack of C/EBP alpha gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice [correction of rat] hepatocytes
    • Soriano HE, Kang DC, Finegold MJ, Hicks MJ, Wang ND, Harrison W et al. Lack of C/EBP alpha gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice [correction of rat] hepatocytes. Hepatology 1998; 27: 392-401.
    • (1998) Hepatology , vol.27 , pp. 392-401
    • Soriano, H.E.1    Kang, D.C.2    Finegold, M.J.3    Hicks, M.J.4    Wang, N.D.5    Harrison, W.6
  • 86
    • 10044222111 scopus 로고    scopus 로고
    • C/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes
    • Yoon K, Smart RC. C/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes. Mol Cell Biol 2004; 24: 10650-10660.
    • (2004) Mol Cell Biol , vol.24 , pp. 10650-10660
    • Yoon, K.1    Smart, R.C.2
  • 87
    • 79956039252 scopus 로고    scopus 로고
    • C/EBPα expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPα confers susceptibility to UVB-induced skin squamous cell carcinomas
    • Thompson EA, Zhu S, Hall JR, House JS, Ranjan R, Burr JA et al. C/EBPα expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPα confers susceptibility to UVB-induced skin squamous cell carcinomas. J Invest Dermatol 2011; 131: 1339-1346.
    • (2011) J Invest Dermatol , vol.131 , pp. 1339-1346
    • Thompson, E.A.1    Zhu, S.2    Hall, J.R.3    House, J.S.4    Ranjan, R.5    Burr, J.A.6
  • 88
    • 0029086784 scopus 로고
    • Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression
    • Raught B, Liao WS, Rosen JM. Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression. Mol Endocrinol 1995; 9: 1223-1232.
    • (1995) Mol Endocrinol , vol.9 , pp. 1223-1232
    • Raught, B.1    Liao, W.S.2    Rosen, J.M.3
  • 89
    • 70349652084 scopus 로고    scopus 로고
    • C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation
    • Lopez RG, Garcia-Silva S, Moore SJ, Bereshchenko O, Martinez-Cruz AB, Ermakova O et al. C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation. Nat Cell Biol 2009; 11: 1181-1190.
    • (2009) Nat Cell Biol , vol.11 , pp. 1181-1190
    • Lopez, R.G.1    Garcia-Silva, S.2    Moore, S.J.3    Bereshchenko, O.4    Martinez-Cruz, A.B.5    Ermakova, O.6
  • 90
    • 84883746123 scopus 로고    scopus 로고
    • C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades
    • Shi Y-C, Zhao H, Yin C, Zeng X, Zhang Q, Xu W-P et al. C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades. Dig Liver Dis 2013; 45: 844-851.
    • (2013) Dig Liver Dis , vol.45 , pp. 844-851
    • Shi, Y.-C.1    Zhao, H.2    Yin, C.3    Zeng, X.4    Zhang, Q.5    Xu, W.-P.6
  • 91
    • 0030022255 scopus 로고    scopus 로고
    • Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein
    • Watkins PJ, Condreay JP, Huber BE, Jacobs SJ, Adams DJ. Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein. Cancer Res 1996; 56: 1063-1067.
    • (1996) Cancer Res , vol.56 , pp. 1063-1067
    • Watkins, P.J.1    Condreay, J.P.2    Huber, B.E.3    Jacobs, S.J.4    Adams, D.J.5
  • 92
    • 28544438792 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma
    • Tan EH, Hooi SC, Laban M, Wong E, Ponniah S, Wee A et al. CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res 2005; 65: 10330-10337.
    • (2005) Cancer Res , vol.65 , pp. 10330-10337
    • Tan, E.H.1    Hooi, S.C.2    Laban, M.3    Wong, E.4    Ponniah, S.5    Wee, A.6
  • 93
    • 84963537517 scopus 로고    scopus 로고
    • C/EBPα short-activating RNA suppresses metastasis of hepatocellular carcinoma through inhibiting EGFR/β-catenin signaling mediated EMT
    • Huan H, Wen X, Chen X, Wu L, Liu W, Habib NA et al. C/EBPα short-activating RNA suppresses metastasis of hepatocellular carcinoma through inhibiting EGFR/β-catenin signaling mediated EMT. PLoS One 2016; 11: e0153117.
    • (2016) PLoS One , vol.11 , pp. e0153117
    • Huan, H.1    Wen, X.2    Chen, X.3    Wu, L.4    Liu, W.5    Habib, N.A.6
  • 94
    • 84894856234 scopus 로고    scopus 로고
    • Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo
    • Reebye V, Saetrom P, Mintz PJ, Huang K-W, Swiderski P, Peng L et al. Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology 2014; 59: 216-227.
    • (2014) Hepatology , vol.59 , pp. 216-227
    • Reebye, V.1    Saetrom, P.2    Mintz, P.J.3    Huang, K.-W.4    Swiderski, P.5    Peng, L.6
  • 95
    • 84973149548 scopus 로고    scopus 로고
    • Targeted delivery of C/EBPα -saRNA by pancreatic ductal adenocarcinoma (PDAC)-specific RNA aptamers Inhibits Tumor Growth in vivo
    • Yoon S, Huang K-W, Reebye V, Mintz P, Tien Y-W, Lai H-S et al. Targeted delivery of C/EBPα -saRNA by pancreatic ductal adenocarcinoma (PDAC)-specific RNA aptamers Inhibits Tumor Growth in vivo. Mol Ther 2016; 24: 1106-1116.
    • (2016) Mol Ther , vol.24 , pp. 1106-1116
    • Yoon, S.1    Huang, K.-W.2    Reebye, V.3    Mintz, P.4    Tien, Y.-W.5    Lai, H.-S.6
  • 96
    • 59149098239 scopus 로고    scopus 로고
    • CCAAT enhancer-binding protein alpha is a molecular target of 1, 25-dihydroxyvitamin D3 in MCF-7 breast cancer cells
    • Dhawan P, Wieder R, Weider R, Christakos S. CCAAT enhancer-binding protein alpha is a molecular target of 1, 25-dihydroxyvitamin D3 in MCF-7 breast cancer cells. J Biol Chem 2009; 284: 3086-3095.
    • (2009) J Biol Chem , vol.284 , pp. 3086-3095
    • Dhawan, P.1    Wieder, R.2    Weider, R.3    Christakos, S.4
  • 97
    • 32644451972 scopus 로고    scopus 로고
    • Regulation of the human p21 (waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor
    • Saramäki A, Banwell CM, Campbell MJ, Carlberg C. Regulation of the human p21 (waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor. Nucleic Acids Res 2006; 34: 543-554.
    • (2006) Nucleic Acids Res , vol.34 , pp. 543-554
    • Saramäki, A.1    Banwell, C.M.2    Campbell, M.J.3    Carlberg, C.4
  • 98
    • 78049506983 scopus 로고    scopus 로고
    • A novel GSK-3 beta-C/EBP alpha-MIR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma
    • Zeng C, Wang R, Li D, Lin X-J, Wei Q-K, Yuan Y et al. A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma. Hepatology 2010; 52: 1702-1712.
    • (2010) Hepatology , vol.52 , pp. 1702-1712
    • Zeng, C.1    Wang, R.2    Li, D.3    Lin, X.-J.4    Wei, Q.-K.5    Yuan, Y.6
  • 99
    • 0036668475 scopus 로고    scopus 로고
    • Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein
    • Kimura SH, Nojima H. Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein. Genes Cells 2002; 7: 869-880.
    • (2002) Genes Cells , vol.7 , pp. 869-880
    • Kimura, S.H.1    Nojima, H.2
  • 100
    • 67651007766 scopus 로고    scopus 로고
    • MIR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells
    • Fornari F, Gramantieri L, Giovannini C, Veronese A, Ferracin M, Sabbioni S et al. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 2009; 69: 5761-5767.
    • (2009) Cancer Res , vol.69 , pp. 5761-5767
    • Fornari, F.1    Gramantieri, L.2    Giovannini, C.3    Veronese, A.4    Ferracin, M.5    Sabbioni, S.6
  • 103
    • 3042662966 scopus 로고    scopus 로고
    • A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer
    • Halmos B, Bassères DS, Monti S, D'Aló F, Dayaram T, Ferenczi K et al. A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer. Cancer Res 2004; 64: 4137-4147.
    • (2004) Cancer Res , vol.64 , pp. 4137-4147
    • Halmos, B.1    Bassères, D.S.2    Monti, S.3    D'Aló, F.4    Dayaram, T.5    Ferenczi, K.6
  • 104
    • 18144386919 scopus 로고    scopus 로고
    • Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1
    • Murata K, Hattori M, Hirai N, Shinozuka Y, Hirata H, Kageyama R et al. Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol 2005; 25: 4262-4271.
    • (2005) Mol Cell Biol , vol.25 , pp. 4262-4271
    • Murata, K.1    Hattori, M.2    Hirai, N.3    Shinozuka, Y.4    Hirata, H.5    Kageyama, R.6
  • 105
    • 33645226613 scopus 로고    scopus 로고
    • Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalphacdk2 and C/EBPalpha-Brm complexes
    • Wang G-L, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG et al. Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalphacdk2 and C/EBPalpha-Brm complexes. Mol Cell Biol 2006; 26: 2570-2582.
    • (2006) Mol Cell Biol , vol.26 , pp. 2570-2582
    • Wang, G.-L.1    Shi, X.2    Salisbury, E.3    Sun, Y.4    Albrecht, J.H.5    Smith, R.G.6
  • 106
    • 0034740215 scopus 로고    scopus 로고
    • C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
    • Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ et al. C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell 2001; 8: 817-828.
    • (2001) Mol Cell , vol.8 , pp. 817-828
    • Wang, H.1    Iakova, P.2    Wilde, M.3    Welm, A.4    Goode, T.5    Roesler, W.J.6
  • 107
    • 77954964456 scopus 로고    scopus 로고
    • Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice
    • Wang G-L, Shi X, Haefliger S, Jin J, Major A, Iakova P et al. Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J Clin Invest 2010; 120: 2549-2562.
    • (2010) J Clin Invest , vol.120 , pp. 2549-2562
    • Wang, G.-L.1    Shi, X.2    Haefliger, S.3    Jin, J.4    Major, A.5    Iakova, P.6
  • 108
    • 1942466512 scopus 로고    scopus 로고
    • Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity
    • Wang G-L, Iakova P, Wilde M, Awad S, Timchenko NA. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev 2004; 18: 912-925.
    • (2004) Genes Dev , vol.18 , pp. 912-925
    • Wang, G.-L.1    Iakova, P.2    Wilde, M.3    Awad, S.4    Timchenko, N.A.5
  • 109
    • 13444263536 scopus 로고    scopus 로고
    • Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein
    • Wang G-L, Timchenko NA. Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein. Mol Cell Biol 2005; 25: 1325-1338.
    • (2005) Mol Cell Biol , vol.25 , pp. 1325-1338
    • Wang, G.-L.1    Timchenko, N.A.2
  • 110
    • 67049155471 scopus 로고    scopus 로고
    • In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and E2F and by activation of AKT
    • Yin H, Lowery M, Glass J. In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and E2F and by activation of AKT. Prostate 2009; 69: 1001-1016.
    • (2009) Prostate , vol.69 , pp. 1001-1016
    • Yin, H.1    Lowery, M.2    Glass, J.3
  • 111
    • 79960847407 scopus 로고    scopus 로고
    • Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα
    • Grandinetti KB, Stevens TA, Ha S, Salamone RJ, Walker JR, Zhang J et al. Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα. Oncogene 2011; 30: 3328-3335.
    • (2011) Oncogene , vol.30 , pp. 3328-3335
    • Grandinetti, K.B.1    Stevens, T.A.2    Ha, S.3    Salamone, R.J.4    Walker, J.R.5    Zhang, J.6
  • 112
    • 33751073965 scopus 로고    scopus 로고
    • Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia
    • Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H et al. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 2006; 10: 401-411.
    • (2006) Cancer Cell , vol.10 , pp. 401-411
    • Keeshan, K.1    He, Y.2    Wouters, B.J.3    Shestova, O.4    Xu, L.5    Sai, H.6
  • 113
    • 22244486994 scopus 로고    scopus 로고
    • The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
    • Higashitsuji H, Higashitsuji H, Itoh K, Sakurai T, Nagao T, Sumitomo Y et al. The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell 2005; 8: 75-87.
    • (2005) Cancer Cell , vol.8 , pp. 75-87
    • Higashitsuji, H.1    Higashitsuji, H.2    Itoh, K.3    Sakurai, T.4    Nagao, T.5    Sumitomo, Y.6
  • 114
    • 84874471740 scopus 로고    scopus 로고
    • Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expression
    • Kim YH, Kim J-H, Choi YW, Lim SK, Yim H, Kang SY et al. Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expression. Exp Mol Pathol 2013; 94: 360-365.
    • (2013) Exp Mol Pathol , vol.94 , pp. 360-365
    • Kim, Y.H.1    Kim, J.-H.2    Choi, Y.W.3    Lim, S.K.4    Yim, H.5    Kang, S.Y.6
  • 115
    • 79959434779 scopus 로고    scopus 로고
    • Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer
    • Li J, Knobloch TJ, Kresty LA, Zhang Z, Lang JC, Schuller DE et al. Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer. Anticancer Res 2011; 31: 2683-2692.
    • (2011) Anticancer Res , vol.31 , pp. 2683-2692
    • Li, J.1    Knobloch, T.J.2    Kresty, L.A.3    Zhang, Z.4    Lang, J.C.5    Schuller, D.E.6
  • 116
    • 85046915363 scopus 로고    scopus 로고
    • Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer
    • Tang S, Yang G, Meng Y, Du R, Li X, Fan R et al. Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer. Cancer Biol Ther 2010; 9: 88-95.
    • (2010) Cancer Biol Ther , vol.9 , pp. 88-95
    • Tang, S.1    Yang, G.2    Meng, Y.3    Du, R.4    Li, X.5    Fan, R.6
  • 117
    • 84874698046 scopus 로고    scopus 로고
    • RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG2 human hepatocellular carcinoma cell line: C-Myc silencing in hepatocellular carcinoma cell
    • Zhao Y, Jian W, Gao W, Zheng Y-X, Wang Y-K, Zhou Z-Q et al. RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG2 human hepatocellular carcinoma cell line: c-Myc silencing in hepatocellular carcinoma cell. Cancer Cell Int 2013; 13: 23.
    • (2013) Cancer Cell Int , vol.13 , pp. 23
    • Zhao, Y.1    Jian, W.2    Gao, W.3    Zheng, Y.-X.4    Wang, Y.-K.5    Zhou, Z.-Q.6
  • 119
    • 33845981503 scopus 로고    scopus 로고
    • Novel c-MYC target genes mediate differential effects on cell proliferation and migration
    • Cappellen D, Schlange T, Bauer M, Maurer F, Hynes NE. Novel c-MYC target genes mediate differential effects on cell proliferation and migration. EMBO Rep 2007; 8: 70-76.
    • (2007) EMBO Rep , vol.8 , pp. 70-76
    • Cappellen, D.1    Schlange, T.2    Bauer, M.3    Maurer, F.4    Hynes, N.E.5
  • 120
    • 35649014840 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    • Kim J, Gao P, Liu Y-C, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007; 27: 7381-7393.
    • (2007) Mol Cell Biol , vol.27 , pp. 7381-7393
    • Kim, J.1    Gao, P.2    Liu, Y.-C.3    Semenza, G.L.4    Dang, C.V.5
  • 121
    • 77649275464 scopus 로고    scopus 로고
    • MIR-9, a MYC/MYCNactivated microRNA, regulates E-cadherin and cancer metastasis
    • Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D et al. miR-9, a MYC/MYCNactivated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010; 12: 247-256.
    • (2010) Nat Cell Biol , vol.12 , pp. 247-256
    • Ma, L.1    Young, J.2    Prabhala, H.3    Pan, E.4    Mestdagh, P.5    Muth, D.6
  • 122
    • 72849130207 scopus 로고    scopus 로고
    • The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelialmesenchymal transition in human nasopharyngeal epithelial cells
    • Song L-B, Li J, Liao W-T, Feng Y, Yu C-P, Hu L-J et al. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelialmesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest 2009; 119: 3626-3636.
    • (2009) J Clin Invest , vol.119 , pp. 3626-3636
    • Song, L.-B.1    Li, J.2    Liao, W.-T.3    Feng, Y.4    Yu, C.-P.5    Hu, L.-J.6
  • 123
    • 79251589918 scopus 로고    scopus 로고
    • Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer
    • Guo B-H, Feng Y, Zhang R, Xu L-H, Li M-Z, Kung H-F et al. Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer 2011; 10: 10.
    • (2011) Mol Cancer , vol.10 , pp. 10
    • Guo, B.-H.1    Feng, Y.2    Zhang, R.3    Xu, L.-H.4    Li, M.-Z.5    Kung, H.-F.6
  • 124
    • 68349125561 scopus 로고    scopus 로고
    • Anchorageindependent cell growth signature identifies tumors with metastatic potential
    • Mori S, Chang JT, Andrechek ER, Matsumura N, Baba T, Yao G et al. Anchorageindependent cell growth signature identifies tumors with metastatic potential. Oncogene 2009; 28: 2796-2805.
    • (2009) Oncogene , vol.28 , pp. 2796-2805
    • Mori, S.1    Chang, J.T.2    Andrechek, E.R.3    Matsumura, N.4    Baba, T.5    Yao, G.6
  • 126
    • 57749113609 scopus 로고    scopus 로고
    • Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors
    • Jeon B-N, Yoo J-Y, Choi W-I, Lee C-E, Yoon H-G, Hur M-W. Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors. J Biol Chem 2008; 283: 33199-33210.
    • (2008) J Biol Chem , vol.283 , pp. 33199-33210
    • Jeon, B.-N.1    Yoo, J.-Y.2    Choi, W.-I.3    Lee, C.-E.4    Yoon, H.-G.5    Hur, M.-W.6
  • 127
    • 78049524086 scopus 로고    scopus 로고
    • The ARF tumor suppressor: Structure, functions and status in cancer
    • Ozenne P, Eymin B, Brambilla E, Gazzeri S. The ARF tumor suppressor: Structure, functions and status in cancer. Int J Cancer 2010; 127: 2239-2247.
    • (2010) Int J Cancer , vol.127 , pp. 2239-2247
    • Ozenne, P.1    Eymin, B.2    Brambilla, E.3    Gazzeri, S.4
  • 128
    • 35649023187 scopus 로고    scopus 로고
    • Tamoxifen induction of CCAAT enhancerbinding protein alpha is required for tamoxifen-induced apoptosis
    • Cheng J, Yu D V, Zhou J-H, Shapiro DJ. Tamoxifen induction of CCAAT enhancerbinding protein alpha is required for tamoxifen-induced apoptosis. J Biol Chem 2007; 282: 30535-30543.
    • (2007) J Biol Chem , vol.282 , pp. 30535-30543
    • Cheng, J.1    Yu, D.V.2    Zhou, J.-H.3    Shapiro, D.J.4
  • 129
    • 40949085122 scopus 로고    scopus 로고
    • Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines
    • Wang G-L, Shi X, Salisbury E, Timchenko NA. Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines. Exp Cell Res 2008; 314: 1626-1639.
    • (2008) Exp Cell Res , vol.314 , pp. 1626-1639
    • Wang, G.-L.1    Shi, X.2    Salisbury, E.3    Timchenko, N.A.4
  • 130
    • 85013270024 scopus 로고    scopus 로고
    • C/EBPα inhibits proliferation of breast cancer cells via a novel pathway of MIR-134/CREB
    • Zhang J, Ma Y, Wang S, Chen F, Gu Y. C/EBPα inhibits proliferation of breast cancer cells via a novel pathway of miR-134/CREB. Int J Clin Exp Pathol 2015; 8: 14472-14478.
    • (2015) Int J Clin Exp Pathol , vol.8 , pp. 14472-14478
    • Zhang, J.1    Ma, Y.2    Wang, S.3    Chen, F.4    Gu, Y.5
  • 131
    • 77956185062 scopus 로고    scopus 로고
    • A novel pathway regulates memory and plasticity via SIRT1 and MIR-134
    • Gao J, Wang W-Y, Mao Y-W, Gräff J, Guan J-S, Pan L et al. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 2010; 466: 1105-1109.
    • (2010) Nature , vol.466 , pp. 1105-1109
    • Gao, J.1    Wang, W.-Y.2    Mao, Y.-W.3    Gräff, J.4    Guan, J.-S.5    Pan, L.6
  • 132
    • 84978173498 scopus 로고    scopus 로고
    • Hsa-MIR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1
    • Sun C-C, Li S-J, Li D-J. Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1. Oncotarget 2016; 7: 35960-35978.
    • (2016) Oncotarget , vol.7 , pp. 35960-35978
    • Sun, C.-C.1    Li, S.-J.2    Li, D.-J.3
  • 133
    • 0036382940 scopus 로고    scopus 로고
    • Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer
    • Maass N, Biallek M, Rösel F, Schem C, Ohike N, Zhang M et al. Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer. Biochem Biophys Res Commun 2002; 297: 125-128.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 125-128
    • Maass, N.1    Biallek, M.2    Rösel, F.3    Schem, C.4    Ohike, N.5    Zhang, M.6
  • 134
    • 14044269508 scopus 로고    scopus 로고
    • Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition
    • Latha K, Zhang W, Cella N, Shi HY, Zhang M. Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition. Mol Cell Biol 2005; 25: 1737-1748.
    • (2005) Mol Cell Biol , vol.25 , pp. 1737-1748
    • Latha, K.1    Zhang, W.2    Cella, N.3    Shi, H.Y.4    Zhang, M.5
  • 135
    • 1642274517 scopus 로고    scopus 로고
    • Bax mediates the apoptosis-sensitizing effect of maspin
    • Liu J, Yin S, Reddy N, Spencer C, Sheng S. Bax mediates the apoptosis-sensitizing effect of maspin. Cancer Res 2004; 64: 1703-1711.
    • (2004) Cancer Res , vol.64 , pp. 1703-1711
    • Liu, J.1    Yin, S.2    Reddy, N.3    Spencer, C.4    Sheng, S.5
  • 136
    • 84867230539 scopus 로고    scopus 로고
    • Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer
    • Patrick BA, Jaiswal AK. Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer. Oncogene 2012; 31: 4362-4371.
    • (2012) Oncogene , vol.31 , pp. 4362-4371
    • Patrick, B.A.1    Jaiswal, A.K.2
  • 139
    • 12344315827 scopus 로고    scopus 로고
    • Stable expression of C/EBPalpha in prostate cancer cells down-regulates metallothionein and increases zinc-induced toxicity
    • Yin H, Smith M, Glass J. Stable expression of C/EBPalpha in prostate cancer cells down-regulates metallothionein and increases zinc-induced toxicity. Prostate 2005; 62: 209-216.
    • (2005) Prostate , vol.62 , pp. 209-216
    • Yin, H.1    Smith, M.2    Glass, J.3
  • 140
    • 79952118221 scopus 로고    scopus 로고
    • C/EBPalpha and C/EBPbeta are required for Sebocyte differentiation and stratified squamous differentiation in adult mouse skin
    • House JS, Zhu S, Ranjan R, Linder K, Smart RC. C/EBPalpha and C/EBPbeta are required for Sebocyte differentiation and stratified squamous differentiation in adult mouse skin. PLoS One 2010; 5: e9837.
    • (2010) PLoS One , vol.5 , pp. e9837
    • House, J.S.1    Zhu, S.2    Ranjan, R.3    Linder, K.4    Smart, R.C.5
  • 141
    • 0033624628 scopus 로고    scopus 로고
    • C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue
    • Chen SS, Chen JF, Johnson PF, Muppala V, Lee YH. C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol 2000; 20: 7292-7299.
    • (2000) Mol Cell Biol , vol.20 , pp. 7292-7299
    • Chen, S.S.1    Chen, J.F.2    Johnson, P.F.3    Muppala, V.4    Lee, Y.H.5
  • 142
    • 0038018480 scopus 로고    scopus 로고
    • Expression of the CCAAT/enhancer- binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: Correlations with clinicopathologic parameters and cell-cycle regulatory proteins
    • Milde-Langosch K, Löning T, Bamberger A-M. Expression of the CCAAT/enhancer- binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins. Breast Cancer Res Treat 2003; 79: 175-185.
    • (2003) Breast Cancer Res Treat , vol.79 , pp. 175-185
    • Milde-Langosch, K.1    Löning, T.2    Bamberger, A.-M.3
  • 143
    • 84919933440 scopus 로고    scopus 로고
    • C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVBinduced DNA damage to control the G1/S checkpoint
    • Hall JR, Bereman MS, Nepomuceno AI, Thompson EA, Muddiman DC, Smart RC. C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVBinduced DNA damage to control the G1/S checkpoint. Cell Cycle 2014; 13: 3602-3610.
    • (2014) Cell Cycle , vol.13 , pp. 3602-3610
    • Hall, J.R.1    Bereman, M.S.2    Nepomuceno, A.I.3    Thompson, E.A.4    Muddiman, D.C.5    Smart, R.C.6
  • 144
    • 33947719311 scopus 로고    scopus 로고
    • Reciprocal expression of CCAAT/enhancer binding proteins alpha and beta in hepatoblastomas and its prognostic significance
    • Tomizawa M, Horie H, Yamamoto H, Matsunaga T, Sasaki F, Hashizume K et al. Reciprocal expression of CCAAT/enhancer binding proteins alpha and beta in hepatoblastomas and its prognostic significance. Oncol Rep 2007; 17: 341-344.
    • (2007) Oncol Rep , vol.17 , pp. 341-344
    • Tomizawa, M.1    Horie, H.2    Yamamoto, H.3    Matsunaga, T.4    Sasaki, F.5    Hashizume, K.6
  • 145
    • 77955507119 scopus 로고    scopus 로고
    • C/EBPalpha is upregulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation
    • 643.e1
    • Lu G-D, CH-W Leung, Yan B, CM-Y Tan, Low SY, Aung MO et al. C/EBPalpha is upregulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation. Gastroenterology 2010; 139: 632-643 643.e1.
    • (2010) Gastroenterology , vol.139 , pp. 632-643
    • Lu, G.-D.1    Leung, C.2    Yan, B.3    Tan, C.M.-Y.4    Low, S.Y.5    Aung, M.O.6
  • 146
    • 84956896921 scopus 로고    scopus 로고
    • MIR-381 suppresses C/EBPα- dependent Cx43 expression in breast cancer cells
    • Ming J, Zhou Y, Du J, Fan S, Pan B, Wang Y et al. miR-381 suppresses C/EBPα- dependent Cx43 expression in breast cancer cells. Biosci Rep 2015; 35: e00266.
    • (2015) Biosci Rep , vol.35 , pp. e00266
    • Ming, J.1    Zhou, Y.2    Du, J.3    Fan, S.4    Pan, B.5    Wang, Y.6
  • 147
    • 58149457065 scopus 로고    scopus 로고
    • Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells
    • Adams BD, Claffey KP, White BA. Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells. Endocrinology 2009; 150: 14-23.
    • (2009) Endocrinology , vol.150 , pp. 14-23
    • Adams, B.D.1    Claffey, K.P.2    White, B.A.3


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