Mice lacking CCAAT/enhancer-binding protein-α show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs

Cell and Tissue Research

Volumn 306, Issue 1, 2001, Pages 57-63

  Sugahara, Kazuhiro ^a   Iyama, Ken Ichi ^b   Kimura, Tatsuya ^b   Sano, Kimihiko ^c   Darlington, Gretchen J ^e   Akiba, Tsuguno ^d   Takiguchi, Masaki ^d  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c KOBE UNIVERSITY   (Japan)

^d CHIBA UNIVERSITY   (Japan)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Alveolar type II cells; Gene regulation; In situ hybridization; Lung injury; Mutant mice (C EBP deficient); Wound healing

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; MESSENGER RNA; SURFACTANT PROTEIN A; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG; LUNG ALVEOLUS CELL TYPE 2; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIVISION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; PROTEOLIPIDS; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEIN A; PULMONARY SURFACTANT-ASSOCIATED PROTEINS; PULMONARY SURFACTANTS; RNA, MESSENGER;

ANIMALIA;

EID: 0034813831     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410100420     Document Type: Article

References (28)

1. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response
2. Evidence for posttranscriptional regulation of C/EBPα and C/EBPβ isoform expression during the lipopolysaccharide-mediated acute-phase response
3. Tissue-specific expression, developmental regulation, and genetic mapping of the encoding CCAAT/enhancer-binding protein
4. Transcription factor C/EBPd in fetal lung: Developmental regulation and effects of cyclic adenosine 3′,5′-monophosphate and glucocorticoids
5. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
6. C/EBPα and C/EBPδ activate the Clara cell secretory protein gene through interaction with two adjacent C/EBP-binding sites
7. The role of C/EBP genes in adipocyte differentiation
8. Transcription factors and liver-specific genes
9. cDNA and deduced amino acid sequence for the rat hydrophobic pulmonary surfactant-associated protein, SP-B
10. Nucleotide and deduced amino acid sequence of the hydrophobic surfactant protein SP-C for the rat: Expression in alveolar type II cells and homology with SP-C from other species
11. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer-binding protein α
12. Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse
13. The role of pancreatic insulin secretion in neonatal glucoregulation. I. Healthy term and preterm infants
14. Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPα knockout mice
15. Pulmonary surfactant apoprotein: A structure and modulation of surfactant secretion by rat alveolar type II cells
16. The leucine zipper: A hypothetical structure common to a new class of DNA-binding proteins
17. Biological role of the CCAAT/enhancer-binding protein family of transcription factors
18. Correlation of expression of transcription factor C/EBPα and surfactant protein genes in lung cells
19. Alveolar type II cells
20. Isolation and sequence of a cDNA clone for the rat pulmonary surfactant-associated protein (PSP-A)
21. Differential expression of surfactant protein SP-A, SP-B, and SP-C mRNAs in rats with streptozotocin-induced diabetes demonstrated by in situ hybridization
22. Keratinocyte growth factor increase mRNAs for SP-A and SP-B in adult rat alveolar type II cells in culture
23. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury
24. Differential expression of the transcription factor, C/EBPα, β, and δ in lung injury and fibrosis in rats
25. Double intratracheal instillation of keratinocyte growth factor prevents bleomycin-induced lung fibrosis in rats
26. Differential expression of CCAAT/enhancer-binding protein (C/EBP) family in rat alveolar epithelial cell proliferation and in acute lung injury
27. The C/EBP family of transcription factors in the liver and other organs
28. Impaired energy homeostasis in C/EBPα knockout mice