MiR-381 suppresses C/EBPα-dependent Cx43 expression in breast cancer cells

Bioscience Reports

Volumn 35, Issue 6, 2015, Pages

  Ming, Jia ^a   Zhou, Yan ^b   Du, Junze ^b   Fan, Shenghao ^a   Pan, Beibei ^a   Wang, Yinhuan ^a   Fan, Lingjun ^b   Jiang, Jun ^b  

^a THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

3' UTR; C EBP ; Cx43; MCF 7; MDA MB 231; MiR 381

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CONNEXIN 43; MICRORNA; MICRORNA 381; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN; MIRN381 MICRORNA, HUMAN;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CCAAT ENHANCER BINDING PROTEIN ALPHA GENE; CELL INVASION; CLINICAL ARTICLE; CONNEXIN 43 GENE; CONTROLLED STUDY; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG METASTASIS; MIGRATION INHIBITION; PROMOTER REGION; SITE DIRECTED MUTAGENESIS; UPREGULATION; BIOSYNTHESIS; BREAST TUMOR; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METASTASIS; PATHOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; CONNEXIN 43; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC;

EID: 84956896921     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20150167     Document Type: Article

References (40)

1. Parkin, D.M., Bray, F., Ferlay, J. and Pisani, P. (2005) Global cancer statistics, 2002. CA Cancer J. Clin. 55, 74-108 CrossRef PubMed
2. DeSantis, C., Ma, J., Bryan, L. and Jemal, A. (2014) Breast cancer statistics, 2013. CA Cancer J. Clin. 64, 52-62 CrossRef PubMed
3. Coughlin, S.S. and Ekwueme, D.U. (2009) Breast cancer as a global health concern. Cancer Epidemiol. 33, 315-318 CrossRef PubMed
4. Jemal, A., Center, M.M., DeSantis, C. and Ward, E.M. (2010) Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol. Biomarkers Prev. 19, 1893-1907 CrossRef PubMed
5. Defamie, N., Chepied, A. and Mesnil, M. (2014) Connexins, gap junctions and tissue invasion. FEBS Lett. 588, 1331-1338 CrossRef PubMed
6. McLachlan, E., Shao, Q. and Laird, D.W. (2007) Connexins and gap junctions in mammary gland development and breast cancer progression. J. Membr. Biol. 218, 107-121 CrossRef PubMed
7. Smyth, J.W. and Shaw, R.M. (2013) Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep. 5, 611-618 CrossRef PubMed
8. Vliagoftis, H., Ebeling, C., Ilarraza, R., Mahmudi-Azer, S., Abel, M., Adamko, D., Befus, A.D. and Moqbel, R. (2014) Connexin 43 expression on peripheral blood eosinophils: role of gap junctions in transendothelial migration. Biomed. Res. Int. 2014, 803257 CrossRef PubMed
9. Ryszawy, D., Sarna, M., Rak, M., Szpak, K., Kedracka-Krok, S., Michalik, M., Siedlar, M., Zuba-Surma, E., Burda, K., Korohoda, W. et al. (2014) Functional links between Snail-1 and Cx43 account for the recruitment of Cx43-positive cells into the invasive front of prostate cancer. Carcinogenesis 35, 1920-1930 CrossRef PubMed
10. Ming, J., Zhou, Y., Du, J., Fan, S., Pan, B., Wang, Y., Fan, L. and Jun, J. (2015) Identification of miR-200a as a novel suppressor of connexin-43 in breast cancer cells. Biosci. Rep. 35, e00251 CrossRef PubMed
11. Fu, Y., Jiang, B.Q., Wu, Y., Li, Z.D. and Zhuang, Z.G. (2013) [Hsa-miR-206 inhibits the migration and invasion of breast cancer by targeting Cx43]. Zhonghua Yi Xue Za Zhi 93, 2890-2894 PubMed
12. Villares, G.J., Dobroff, A.S., Wang, H., Zigler, M., Melnikova, V.O., Huang, L. and Bar-Eli, M. (2009) Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43. Cancer Res. 69, 6730-6737 CrossRef PubMed
13. Gao, F.H., Wang, Q., Wu, Y.L., Li, X., Zhao, K.W. and Chen, G.Q. (2007) c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochem. Biophys. Res. Commun. 356, 505-511 CrossRef PubMed
14. Schmidt, K. and de Wit, C. (2015) Keep calm and carry on: miR-1298 prevents up-regulation of Cx43 and secures a quiescent vascular smooth muscle cell. Cardiovasc. Res. 107, 407-409 CrossRef PubMed
15. Fellmann, C., Hoffmann, T., Sridhar, V., Hopfgartner, B., Muhar, M., Roth, M., Lai, D.Y., Barbosa, I.A., Kwon, J.S., Guan, Y. et al. (2013) An optimized microRNA backbone for effective single-copy RNAi. Cell Rep. 5, 1704-1713 CrossRef PubMed
16. Ghosh, T., Aprea, J., Nardelli, J., Engel, H., Selinger, C., Mombereau, C., Lemonnier, T., Moutkine, I., Schwendimann, L., Dori, M. et al. (2014) MicroRNAs establish robustness and adaptability of a critical gene network to regulate progenitor fate decisions during cortical neurogenesis. Cell Rep. 7, 1779-1788 CrossRef PubMed
17. Pollock, A., Bian, S., Zhang, C., Chen, Z. and Sun, T. (2014) Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway. Cell Rep. 7, 1184-1196 CrossRef PubMed
18. Benaich, N., Woodhouse, S., Goldie, S.J., Mishra, A., Quist, S.R. and Watt, F.M. (2014) Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis. Cell Rep. 9, 104-117 CrossRef PubMed
19. Schober, A., Nazari-Jahantigh, M. and Weber, C. (2015) MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis. Nat. Rev. Cardiol. 12, 361-374 CrossRef PubMed
20. Iorio, M.V., Ferracin, M., Liu, C.G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M. et al. (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65, 7065-7070 CrossRef PubMed
21. Gee, H.E., Camps, C., Buffa, F.M., Colella, S., Sheldon, H., Gleadle, J.M., Ragoussis, J. and Harris, A.L. (2008) MicroRNA-10b and breast cancer metastasis. Nature 455, E8-E9 CrossRef PubMed
22. Anderson, C., Catoe, H. and Werner, R. (2006) miR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res. 34, 5863-5871 CrossRef PubMed
23. Xu, Y., Ohms, S.J., Li, Z., Wang, Q., Gong, G., Hu, Y., Mao, Z., Shannon, M.F. and Fan, J.Y. (2013) Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. PLoS One 8, e82062 CrossRef PubMed
24. Lwin, Z.M., Guo, C., Salim, A., Yip, G.W., Chew, F.T., Nan, J., Thike, A.A., Tan, P.H. and Bay, B.H. (2010) Clinicopathological significance of calreticulin in breast invasive ductal carcinoma. Mod. Pathol. 23, 1559-1566 CrossRef PubMed
25. Miao, H., Zhang, Y., Lu, Z., Yu, L. and Gan, L. (2012) FOXO1 increases CCL20 to promote NF-κB-dependent lymphocyte chemotaxis. Mol. Endocrinol. 26, 423-437 CrossRef PubMed
26. Ghosh, S., Kumar, A., Tripathi, R.P. and Chandna, S. (2014) Connexin-43 regulates p38-mediated cell migration and invasion induced selectively in tumour cells by low doses of gamma-radiation in an ERK-1/2-independent manner. Carcinogenesis 35, 383-395 CrossRef PubMed
27. Forster, T., Rausch, V., Zhang, Y., Isayev, O., Heilmann, K., Schoensiegel, F., Liu, L., Nessling, M., Richter, K., Labsch, S. et al. (2014) Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication. Oncotarget 5, 1621-1634 CrossRef PubMed
28. Brockmeyer, P., Jung, K., Perske, C., Schliephake, H. and Hemmerlein, B. (2014) Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma. Int. J. Oncol. 45, 273-281 PubMed
29. Sirnes, S., Lind, G.E., Bruun, J., Fykerud, T.A., Mesnil, M., Lothe, R.A., Rivedal, E., Kolberg, M. and Leithe, E. (2015) Connexins in colorectal cancer pathogenesis. Int. J. Cancer 137, 1-11 CrossRef PubMed
30. Tang, B., Peng, Z.H., Yu, P.W., Yu, G., Qian, F., Zeng, D.Z., Zhao, Y.L., Shi, Y., Hao, Y.X. and Luo, H.X. (2013) Aberrant expression of Cx43 is associated with the peritoneal metastasis of gastric cancer and Cx43-mediated gap junction enhances gastric cancer cell diapedesis from peritoneal mesothelium. PLoS One 8, e74527 CrossRef PubMed
31. Yu, M., Zhang, C., Li, L., Dong, S., Zhang, N. and Tong, X. (2014) Cx43 reverses the resistance of A549 lung adenocarcinoma cells to cisplatin by inhibiting EMT. Oncol. Rep. 31, 2751-2758 PubMed
32. Rothschild, S.I., Tschan, M.P., Jaggi, R., Fey, M.F., Gugger, M. and Gautschi, O. (2012) MicroRNA-381 represses ID1 and is deregulated in lung adenocarcinoma. J. Thorac. Oncol. 7, 1069-1077 CrossRef PubMed
33. Tang, H., Liu, X., Wang, Z., She, X., Zeng, X., Deng, M., Liao, Q., Guo, X., Wang, R., Li, X. et al. (2011) Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth. Brain Res. 1390, 21-32 CrossRef PubMed
34. Chandrasekaran, C. and Gordon, J.I. (1993) Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein alpha expression in the gut epithelium of normal and transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 90, 8871-8875 CrossRef PubMed
35. Rapino, F., Robles, E.F., Richter-Larrea, J.A., Kallin, E.M., Martinez-Climent, J.A. and Graf, T. (2013) C/EBPα induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity. Cell Rep. 3, 1153-1163 CrossRef PubMed
36. Lu, H., Yu, Z., Liu, S., Cui, L., Chen, X. and Yao, R. (2015) CUGBP1 promotes cell proliferation and suppresses apoptosis via down-regulating C/EBPα in human non-small cell lung cancers. Med. Oncol. 32, 82 CrossRef PubMed
37. Xue, M., Li, X., Wu, W., Zhang, S., Wu, S., Li, Z. and Chen, W. (2014) Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein alpha contributes to bladder cancer cell growth and reduced apoptosis. Oncol. Rep. 31, 1993-2000 PubMed
38. Lu, G.D., Ang, Y.H., Zhou, J., Tamilarasi, J., Yan, B., Lim, Y.C., Srivastava, S., Salto-Tellez, M., Hui, K.M., Shen, H.M. et al. (2015) CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma. Hepatology 61, 965-978 CrossRef PubMed
39. Elzarrad, M.K., Haroon, A., Willecke, K., Dobrowolski, R., Gillespie, M.N. and Al-Mehdi, A.B. (2008) Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium. BMC Med. 6, 20 CrossRef PubMed
40. Granot, I. and Dekel, N. (1994) Phosphorylation and expression of connexin-43 ovarian gap junction protein are regulated by luteinizing hormone. J. Biol. Chem. 269, 30502-30509 PubMed