C/EBPα-induced miR-100 expression suppresses tumor metastasis and growth by targeting ZBTB7A in gastric cancer

Cancer Letters

Volumn 369, Issue 2, 2015, Pages 376-385

  Shi, Duan Bo ^a   Wang, Ya Wen ^a   Xing, Ai Yan ^a   Gao, Ji Wei ^a   Zhang, Hui ^a   Guo, Xiang Yu ^a   Gao, Peng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

C EBP ; Gastric cancer; Metastasis; MiR 100; ZBTB7A

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; MICRORNA 100; TUMOR PROTEIN; UNCLASSIFIED DRUG; ZBTB7A PROTEIN; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN; DNA BINDING PROTEIN; MICRORNA; TRANSCRIPTION FACTOR; ZBTB7A PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER PROGNOSIS; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STOMACH CANCER; TUMOR INVASION; GENETIC TRANSFECTION; GENETICS; METABOLISM; METASTASIS; PATHOLOGY; STOMACH TUMOR;

CCAAT-ENHANCER-BINDING PROTEINS; CELL PROLIFERATION; DNA-BINDING PROTEINS; HUMANS; MICRORNAS; NEOPLASM METASTASIS; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84945275255     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2015.08.029     Document Type: Article

References (39)

1. Lai E.C. Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat. Genet 2002, 30(4):363-364.
2. Ma L., Teruya-Feldstein J., Weinberg R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449(7163):682-688.
3. Elyakim E., Sitbon E., Faerman A., et al. hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. Cancer Res 2010, 70(20):8077-8087.
4. Bandres E., Bitarte N., Arias F., et al. microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. Clin. Cancer Res 2009, 15(7):2281-2290.
5. Xu Y., Zhao F., Wang Z., et al. MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. Oncogene 2012, 31(11):1398-1407.
6. Wang Y.W., Shi D.B., Chen X., et al. Clinicopathological significance of microRNA-214 in gastric cancer and its effect on cell biological behaviour. PLoS ONE 2014, 9(3):e91307.
7. Parkin D.M., Bray F., Ferlay J., et al. Global cancer statistics, 2002. CA Cancer J. Clin 2005, 55(2):74-108.
8. Gao P., Xing A.Y., Zhou G.Y., et al. The molecular mechanism of microRNA-145 to suppress invasion-metastasis cascade in gastric cancer. Oncogene 2013, 32(4):491-501.
9. Tie J., Pan Y., Zhao L., et al. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 2010, 6(3):e1000879.
10. Doghman M., El W.A., Cardinaud B., et al. Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Res 2010, 70(11):4666-4675.
11. Nagaraja A.K., Creighton C.J., Yu Z., et al. A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer. Mol. Endocrinol 2010, 24(2):447-463.
12. Zheng Y.S., Zhang H., Zhang X.J., et al. MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene 2012, 31(1):80-92.
13. Hashimoto Y., Akiyama Y., Otsubo T., et al. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis 2010, 31(5):777-784.
14. Nakada C., Matsuura K., Tsukamoto Y., et al. Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c. J. Pathol 2008, 216(4):418-427.
15. Gao P., Wong C.C., Tung E.K., et al. Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. J. Hepatol 2011, 54(6):1177-1184.
16. Maeda T., Hobbs R.M., Merghoub T., et al. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature 2005, 433(7023):278-285.
17. Jiang L., Siu M.K., Wong O.G., et al. Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers. Mol. Cancer 2010, 9:318.
18. Gotte M., Mohr C., Koo C.Y., et al. miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. Oncogene 2010, 29(50):6569-6580.
19. Thiele S., Rauner M., Goettsch C., et al. Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates. J. Cell. Biochem 2011, 112(6):1593-1600.
20. Suzuki M., Kato-Nakano M., Kawamoto S., et al. Therapeutic antitumor efficacy of monoclonal antibody against Claudin-4 for pancreatic and ovarian cancers. Cancer Sci 2009, 100(9):1623-1630.
21. Regalo G., Resende C., Wen X., et al. C/EBPα expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis. Lab. Invest 2010, 90:1132-1139.
22. Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6(4):259-269.
23. Chen D., Sun Y., Yuan Y., et al. miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet 2014, 10(2):e1004177.
24. Fang F., Yang L., Tao Y., Qin W. FBI-1 promotes cell proliferation and enhances resistance to chemotherapy of hepatocellular carcinoma in vitro and in vivo. Cancer 2012, 118(1):134-146.
25. Zhang Y.Q., Xiao C.X., Lin B.Y., et al. Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells. PLoS ONE 2013, 8(7):e68981.
26. Zu X., Ma J., Liu H., et al. Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression. Breast Cancer Res 2011, 13(2):R26.
27. Wang G., Lunardi A., Zhang J., et al. Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion. Nat. Genet 2013, 45(7):739-746.
28. Liu X.S., Haines J.E., Mehanna E.K., et al. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev 2014, 28(17):1917-1928.
29. Syrigos K.N., Karayiannakis A., Syrigou E.I., et al. Abnormal expression of p120 correlates with poor survival in patients with bladder cancer. Eur. J. Cancer 1998, 34(13):2037-2040.
30. Xing A.Y., Wang Y.W., Su Z.X., et al. Catenin-δ1, negatively regulated by miR-145, promotes tumour aggressiveness in gastric cancer. J. Pathol 2015, 236(1):53-64.
31. Liu Y., Wang Y., Zhang Y., et al. Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer. Lung Cancer 2009, 63(3):375-382.
32. Mann K.M., Ward J.M., Yew C.C., et al. Sleeping beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc. Natl. Acad. Sci. U.S.A. 2012, 109(16):5934-5941.
33. Gupta J., del Barco Barrantes I., Igea A., et al. Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Cancer Cell 2014, 25(4):484-500.
34. von Frowein J., Pagel P., Kappler R., et al. MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma. Hepatology 2011, 53(3):833-842.
35. Birkenmeier E.H., Gwynn B., Howard S., et al. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev 1989, 3(8):1146-1156.
36. Bennett K.L., Hackanson B., Smith L.T., et al. Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma. Cancer Res 2007, 67(10):4657-4664.
37. Halmos B., Huettner C.S., Kocher O., et al. Down-regulation and antiproliferative role of C/EBPalpha in lung cancer. Cancer Res 2002, 62(2):528-534.
38. Takai N., Kawamata N., Walsh C.S., et al. Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Mol. Cancer Res 2005, 3(5):261-269.
39. Radomska H.S., Basseres D.S., Zheng R., et al. Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J. Exp. Med 2006, 203(2):371-381.