Cyclin D3 maintains growth-inhibitory activity of C/EBPα by stabilizing C/EBPα-cdk2 and C/EBPα-Brm complexes

Molecular and Cellular Biology

Volumn 26, Issue 7, 2006, Pages 2570-2582

  Wang, Guo Li ^a   Shi, Xiurong ^a   Salisbury, Elizabeth ^a   Sun, Yuxiang ^a   Albrecht, Jeffrey H ^b   Smith, Roy G ^a   Timchenko, Nikolai A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C EBPALPHA BRM PROTEIN COMPLEX; C EBPALPHA CDK2 PROTEIN COMPLEX; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PROTEIN; PROTEIN C EBPALPHA; SERINE; UNCLASSIFIED DRUG;

ADIPOCYTE; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; LIVER; LIVER RESECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

3T3-L1 CELLS; AGING; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLINS; GROWTH INHIBITORS; HEPATECTOMY; LIVER; MICE; MOLECULAR WEIGHT; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ISOFORMS; SERINE; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 33645226613     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.26.7.2570-2582.2006     Document Type: Article

References (27)

1. 1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation. Oncogene 17:1027-1037.
2. Cenciarelli, C., F. De Santa, P. L. Puri, E. Mattei, L. Ricci, F. Bucci, A. Felsani, and M. Caruso. 1999. Critical role played by cyclin D3 in the MyoD-mediated arrest of cell cycle during myoblasts differentiation. Mol. Cell. Biol. 19:5203-5217.
3. Conboy, I. M., M. J. Conboy, A. J. Wagers, E. R. Girma, I. L. Weisman, and T. A. Rando. 2005. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 43:760-764.
4. de La Serna, I. L., K. Roy, K. A. Carlson, and A. N. Imbalzano. 2001. MyoD can induce Cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes. J. Biol. Chem. 276:41486-41491.
5. Doglioni, C., C. Chiarelli, E. Macri, A. P. Dei Tos, E. Meggiolaro, P. Dalla Palma, and M. Barbaresch. 1998. Cyclin D3 expression in normal, reactive and neoplastic tissues. J. Pathol. 185:159-166.
6. Fausto, N. 2000. Liver regeneration. J. Hepatol. 32:19-31.
7. Flodby, P. C., H. Barlow, L. Kalefjord, L. Ahrlund-Richer, and K. G. Xanthopolous. 1996. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/Enhancer binding protein α. J. Biol. Chem. 271:24753-24760.
8. 1/S phase transition in fibroblasts. J. Biol. Chem. 273:14958-14961.
9. Iakova, P., S. S. Awad, and N. A. Timchenko. 2003. Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest. Cell 113:495-506.
10. Mahony, D., D. A. Parry, and E. Lees. 1998. Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. Oncogene 16:603-611.
11. Muller, C., C. F. Calkhoven, X. Sha, and A. Leutz. 2004. C/EBPα requires a SWI/SNF complex for proliferation arrest. J. Biol. Chem. 279:7353-7358.
12. Nelsen, C. J., D. G. Rickheim, N. A. Timchenko, M. W. Stanley, and J. H. Albrecht. 2001. Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo. Cancer Res. 61:8564-8668.
13. Pederson, T. A., E. Kowenz-Leutz, A. Leutz, and C. Nerlov. 2001. Cooperation between C/EBPα, TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes Dev. 15:3208-3216.
14. Porse, B. T., T. A. Pederson, X. Xu, B. Lindbergh, U. M. Wewer, L. Fris-Hansen, and C. Nerlov. 2001. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell 107:247-258.
15. Reichert, M., and D. Eick. 1999. Analysis of cell cycle arrest in adipocyte differentiation. Oncogene 18:459-466.
16. Rickheim, D. G., C. J. Nelsen, J. T. Fassett, N. A. Timchenko, L. K. Hansen, and J. H. Albrecht. 2002. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology 36:30-38.
17. Sarruf, D. A., I. Iankova, A. Abella, S. Assou, S. Miard, and L. Fajas. 2005. Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor γ. Mol. Cell. Biol. 25:9985-9995.
18. Shao, D., and M. A. Lazar. 1997. Peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation. J. Biol. Chem. 272:21473-21478.
19. Timchenko, N. A., T. E. Harris, M. Wilde, T. A. Bilyeu, B. L. Burgess-Beusse, M. J. Finegold, and G. J. Darlington. 1997. CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol. Cell. Biol. 17:7353-7361.
20. Timchenko, N. A., M. Wilde, and G. J. Darlington. 1999. C/EBP alpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol. Cell. Biol. 19:2936-2945.
21. Timchenko, N. A., M. Wilde, P. Iakova, J. H. Albrecht, and G. J. Darlington. 1999. E2F/p107 and E2F/p130 complexes are regulated by C/EBPα in 3T3-L1 adipocytes. Nucleic Acids Res. 27:3621-3630.
22. Wang, G.-L., P. Iakova, M. Wilde, S. S. Awad, and N. A. Timchenko. 2004. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity. Genes Dev. 18:912-925.
23. Wang, G.-L., and N. A. Timchenko. 2005. Dephosphorylated C/EBPα accelerates cell proliferation through sequestering retinoblastoma protein. Mol. Cell. Biol. 25:1325-1338.
24. Wang, H., P. Iakova, M. Wilde, A. Welm, T. Goode, W. J. Roesler, and N. A. Timchenko. 2001. C/EBPα arrests cell proliferation through direct inhibition of cdk2 and cdk4. Mol. Cell 8:817-828.
25. Wang, H., T. Goode, P. Iakova, J. H. Albrecht, and N. A. Timchenko. 2002. C/EBPα triggers proteasome-dependent degradation of cdk4 during growth arrest. EMBO J. 21:930-941.
26. 1 cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation. EMBO J. 18:6983-6993.
27. Zhang, J.-M., Q. Wei, X. Zhao, and B. M. Paterson. 1999. Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4. EMBO J. 18:926-933.