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Volumn 102, Issue 4, 2017, Pages 977-988

Human T cell immunosenescence and inflammation in aging

Author keywords

Immune dysregulation; Inflamm aging; NF B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MICRORNA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 85030718149     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.3RI0716-335R     Document Type: Review
Times cited : (205)

References (129)
  • 1
    • 84924006883 scopus 로고    scopus 로고
    • Mechanisms of development of multimorbidity in the elderly
    • Barnes, P. J. (2015) Mechanisms of development of multimorbidity in the elderly. Eur. Respir. J. 45, 790-806.
    • (2015) Eur. Respir. J , vol.45 , pp. 790-806
    • Barnes, P.J.1
  • 15
    • 33644826101 scopus 로고    scopus 로고
    • Macrophages in human visceral adipose tissue: Increased accumulation in obesity and a source of resistin and visfatin
    • Curat, C. A., Wegner, V., Sengenès, C., Miranville, A., Tonus, C., Busse, R., Bouloumié, A. (2006) Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia 49, 744-747.
    • (2006) Diabetologia , vol.49 , pp. 744-747
    • Curat, C.A.1    Wegner, V.2    Sengenès, C.3    Miranville, A.4    Tonus, C.5    Busse, R.6    Bouloumié, A.7
  • 19
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn, O., Olefsky, J. M. (2012) The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 18, 363-374.
    • (2012) Nat. Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 22
    • 84949237262 scopus 로고    scopus 로고
    • Metabolism: Inflammation keeps old mice healthy
    • Maillard, I., Saltiel, A. R. (2015) Metabolism: inflammation keeps old mice healthy. Nature 528, 44-46.
    • (2015) Nature , vol.528 , pp. 44-46
    • Maillard, I.1    Saltiel, A.R.2
  • 23
    • 68949196898 scopus 로고    scopus 로고
    • Redox regulation of nuclear posttranslational modifications during NF-kappaB activation
    • Gloire, G., Piette, J. (2009) Redox regulation of nuclear posttranslational modifications during NF-kappaB activation. Antioxid. Redox Signal. 11, 2209-2222.
    • (2009) Antioxid. Redox Signal , vol.11 , pp. 2209-2222
    • Gloire, G.1    Piette, J.2
  • 24
    • 0034450123 scopus 로고    scopus 로고
    • Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors
    • Zhang, G., Ghosh, S. (2000) Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J. Endotoxin Res. 6, 453-457.
    • (2000) J. Endotoxin Res , vol.6 , pp. 453-457
    • Zhang, G.1    Ghosh, S.2
  • 25
    • 79955017452 scopus 로고    scopus 로고
    • P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
    • Freund, A., Patil, C. K., Campisi, J. (2011) p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J. 30, 1536-1548.
    • (2011) EMBO J , vol.30 , pp. 1536-1548
    • Freund, A.1    Patil, C.K.2    Campisi, J.3
  • 26
    • 70350125106 scopus 로고    scopus 로고
    • Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    • Orjalo, A. V., Bhaumik, D., Gengler, B. K., Scott, G. K., Campisi, J. (2009) Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc. Natl. Acad. Sci. USA 106, 17031-17036.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 17031-17036
    • Orjalo, A.V.1    Bhaumik, D.2    Gengler, B.K.3    Scott, G.K.4    Campisi, J.5
  • 27
    • 84939548808 scopus 로고    scopus 로고
    • Microglia in Alzheimer’s disease: A multifaceted relationship
    • ElAli, A., Rivest, S. (2016) Microglia in Alzheimer’s disease: a multifaceted relationship. Brain Behav. Immun. 55, 138-150.
    • (2016) Brain Behav. Immun , vol.55 , pp. 138-150
    • Elali, A.1    Rivest, S.2
  • 29
    • 84973154251 scopus 로고    scopus 로고
    • The role of immunosenescence in the development of age-related diseases
    • Fulop, T., Dupuis, G., Witkowski, J. M., Larbi, A. (2016) The role of immunosenescence in the development of age-related diseases. Rev. Invest. Clin. 68, 84-91.
    • (2016) Rev. Invest. Clin , vol.68 , pp. 84-91
    • Fulop, T.1    Dupuis, G.2    Witkowski, J.M.3    Larbi, A.4
  • 32
    • 85017184321 scopus 로고    scopus 로고
    • The immunology of atherosclerosis
    • Gisterå, A., Hansson, G. K. (2017) The immunology of atherosclerosis. Nat. Rev. Nephrol. 13, 368-380.
    • (2017) Nat. Rev. Nephrol , vol.13 , pp. 368-380
    • Gisterå, A.1    Hansson, G.K.2
  • 33
    • 0035657709 scopus 로고    scopus 로고
    • Atherosclerosis as an autoimmune disease: An update
    • Wick, G., Perschinka, H., Millonig, G. (2001) Atherosclerosis as an autoimmune disease: an update. Trends Immunol. 22, 665-669.
    • (2001) Trends Immunol , vol.22 , pp. 665-669
    • Wick, G.1    Perschinka, H.2    Millonig, G.3
  • 34
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby, P. (2002) Inflammation in atherosclerosis. Nature 420, 868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 35
    • 84937131109 scopus 로고    scopus 로고
    • T cell senescence and cardiovascular diseases
    • Yu, H. T., Park, S., Shin, E. C., Lee, W. W. (2016) T cell senescence and cardiovascular diseases. Clin. Exp. Med. 16, 257-263.
    • (2016) Clin. Exp. Med , vol.16 , pp. 257-263
    • Yu, H.T.1    Park, S.2    Shin, E.C.3    Lee, W.W.4
  • 40
    • 34447319921 scopus 로고    scopus 로고
    • No immune risk profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study
    • Strindhall, J., Nilsson, B. O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B., Wikby, A. (2007) No immune risk profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp. Gerontol. 42, 753-761.
    • (2007) Exp. Gerontol. , vol.42 , pp. 753-761
    • Strindhall, J.1    Nilsson, B.O.2    Löfgren, S.3    Ernerudh, J.4    Pawelec, G.5    Johansson, B.6    Wikby, A.7
  • 41
    • 84856641109 scopus 로고    scopus 로고
    • NF-κB, the first quarter-century: Remarkable progress and outstanding questions
    • Hayden, M. S., Ghosh, S. (2012) NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 26, 203-234.
    • (2012) Genes Dev , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 42
    • 80051988785 scopus 로고    scopus 로고
    • Hierarchies of NF-κB target-gene regulation
    • Smale, S. T. (2011) Hierarchies of NF-κB target-gene regulation. Nat. Immunol. 12, 689-694.
    • (2011) Nat. Immunol , vol.12 , pp. 689-694
    • Smale, S.T.1
  • 43
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau, O., Tschopp, J. (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 46
    • 46749093740 scopus 로고    scopus 로고
    • Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines
    • Huang, M. C., Liao, J. J., Bonasera, S., Longo, D. L., Goetzl, E. J. (2008) Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 22, 2142-2150.
    • (2008) FASEB J , vol.22 , pp. 2142-2150
    • Huang, M.C.1    Liao, J.J.2    Bonasera, S.3    Longo, D.L.4    Goetzl, E.J.5
  • 47
    • 33745145485 scopus 로고    scopus 로고
    • Differential sensitivity of naive and memory subsets of human CD8+ T cells to TNF-alphainduced apoptosis
    • Gupta, S., Su, H., Bi, R., Gollapudi, S. (2006) Differential sensitivity of naive and memory subsets of human CD8+ T cells to TNF-alphainduced apoptosis. J. Clin. Immunol. 26, 193-203.
    • (2006) J. Clin. Immunol , vol.26 , pp. 193-203
    • Gupta, S.1    Su, H.2    Bi, R.3    Gollapudi, S.4
  • 48
    • 13544258066 scopus 로고    scopus 로고
    • Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans
    • Gupta, S., Bi, R., Kim, C., Chiplunkar, S., Yel, L., Gollapudi, S. (2005) Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans. Cell Death Differ. 12, 177-183.
    • (2005) Cell Death Differ , vol.12 , pp. 177-183
    • Gupta, S.1    Bi, R.2    Kim, C.3    Chiplunkar, S.4    Yel, L.5    Gollapudi, S.6
  • 49
    • 84920281589 scopus 로고    scopus 로고
    • Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase
    • Bektas, A., Zhang, Y., Lehmann, E., Wood III W. H., Becker, K. G., Madara, K., Ferrucci, L., Sen, R. (2014) Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase. Aging (Albany NY) 6, 957-969.
    • (2014) Aging (Albany NY) , vol.6 , pp. 957-969
    • Bektas, A.1    Zhang, Y.2    Lehmann, E.3    Wood, W.H.4    Becker, K.G.5    Madara, K.6    Ferrucci, L.7    Sen, R.8
  • 50
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-kappaB activity
    • Adler, A. S., Sinha, S., Kawahara, T. L., Zhang, J. Y., Segal, E., Chang, H. Y. (2007) Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 21, 3244-3257.
    • (2007) Genes Dev , vol.21 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 52
    • 84874801912 scopus 로고    scopus 로고
    • Answering the ultimate question “what is the proximal cause of aging?”
    • Blagosklonny, M. V. (2012) Answering the ultimate question “what is the proximal cause of aging?”. Aging (Albany NY) 4, 861-877.
    • (2012) Aging (Albany NY) , vol.4 , pp. 861-877
    • Blagosklonny, M.V.1
  • 53
    • 84879513284 scopus 로고    scopus 로고
    • Alternative perspectives on aging in Caenorhabditis elegans: Reactive oxygen species or hyperfunction?
    • Gems, D., de la Guardia, Y. (2013) Alternative perspectives on aging in Caenorhabditis elegans: reactive oxygen species or hyperfunction? Antioxid. Redox Signal. 19, 321-329.
    • (2013) Antioxid. Redox Signal , vol.19 , pp. 321-329
    • Gems, D.1    De La Guardia, Y.2
  • 54
    • 84874798024 scopus 로고    scopus 로고
    • What is the proximal cause of aging? Front
    • Zimniak, P. (2012) What is the proximal cause of aging? Front. Genet. 3, 189.
    • (2012) Genet , vol.3 , pp. 189
    • Zimniak, P.1
  • 56
    • 0034746363 scopus 로고    scopus 로고
    • The 39 untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR
    • Dean, J. L., Wait, R., Mahtani, K. R., Sully, G., Clark, A. R., Saklatvala, J. (2001) The 39 untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol. Cell. Biol. 21, 721-730.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 721-730
    • Dean, J.L.1    Wait, R.2    Mahtani, K.R.3    Sully, G.4    Clark, A.R.5    Saklatvala, J.6
  • 57
    • 60749124122 scopus 로고    scopus 로고
    • The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
    • Hao, S., Baltimore, D. (2009) The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat. Immunol. 10, 281-288.
    • (2009) Nat. Immunol , vol.10 , pp. 281-288
    • Hao, S.1    Baltimore, D.2
  • 58
    • 84880361099 scopus 로고    scopus 로고
    • RNA splicing regulates the temporal order of TNF-induced gene expression
    • Hao, S., Baltimore, D. (2013) RNA splicing regulates the temporal order of TNF-induced gene expression. Proc. Natl. Acad. Sci. USA 110, 11934-11939.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 11934-11939
    • Hao, S.1    Baltimore, D.2
  • 59
    • 84876535364 scopus 로고    scopus 로고
    • Understanding immunosenescence to improve responses to vaccines
    • Goronzy, J. J., Weyand, C. M. (2013) Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 14, 428-436.
    • (2013) Nat. Immunol , vol.14 , pp. 428-436
    • Goronzy, J.J.1    Weyand, C.M.2
  • 60
    • 84864927213 scopus 로고    scopus 로고
    • Hallmarks of human “immunosenescence”: Adaptation or dysregulation?
    • Pawelec, G. (2012) Hallmarks of human “immunosenescence”: adaptation or dysregulation? Immun. Ageing 9, 15.
    • (2012) Immun. Ageing , vol.9 , pp. 15
    • Pawelec, G.1
  • 61
    • 84939566590 scopus 로고    scopus 로고
    • Immunosenescence: Implications for response to infection and vaccination in older people
    • Pera, A., Campos, C., López, N., Hassouneh, F., Alonso, C., Tarazona, R., Solana, R. (2015) Immunosenescence: implications for response to infection and vaccination in older people. Maturitas 82, 50-55.
    • (2015) Maturitas , vol.82 , pp. 50-55
    • Pera, A.1    Campos, C.2    López, N.3    Hassouneh, F.4    Alonso, C.5    Tarazona, R.6    Solana, R.7
  • 62
  • 64
  • 65
    • 0031043248 scopus 로고    scopus 로고
    • Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled
    • Ferrucci, L., Guralnik, J. M., Pahor, M., Corti, M. C., Havlik, R. J. (1997) Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled. JAMA 277, 728-734.
    • (1997) JAMA , vol.277 , pp. 728-734
    • Ferrucci, L.1    Guralnik, J.M.2    Pahor, M.3    Corti, M.C.4    Havlik, R.J.5
  • 66
    • 84961653804 scopus 로고    scopus 로고
    • T-Cell immunity to influenza in older adults: A pathophysiological framework for development of more effective vaccines
    • McElhaney, J. E., Kuchel, G. A., Zhou, X., Swain, S. L., Haynes, L. (2016) T-Cell immunity to influenza in older adults: a pathophysiological framework for development of more effective vaccines. Front. Immunol. 7, 41.
    • (2016) Front. Immunol , vol.7 , pp. 41
    • McElhaney, J.E.1    Kuchel, G.A.2    Zhou, X.3    Swain, S.L.4    Haynes, L.5
  • 67
    • 22344457082 scopus 로고    scopus 로고
    • Influenza vaccination in the elderly: Impact on hospitalisation and mortality
    • Nichol, K. L. (2005) Influenza vaccination in the elderly: impact on hospitalisation and mortality. Drugs Aging 22, 495-515.
    • (2005) Drugs Aging , vol.22 , pp. 495-515
    • Nichol, K.L.1
  • 68
    • 84869721270 scopus 로고    scopus 로고
    • [package insert], Accessed March 19, 2017
    • Merck Sharp & Dohme. ZOSTAVAX (zoster vaccine, live) [package insert]. Available at: https://www.fda.gov/downloads/biologicsbloodvaccines/vaccines/approvedproducts/ucm132831.pdf. Accessed March 19, 2017.
    • ZOSTAVAX (Zoster Vaccine, Live)
  • 74
    • 79952847690 scopus 로고    scopus 로고
    • Aging and immune function: Molecular mechanisms to interventions
    • Ponnappan, S., Ponnappan, U. (2011) Aging and immune function: molecular mechanisms to interventions. Antioxid. Redox Signal. 14, 1551-1585.
    • (2011) Antioxid. Redox Signal , vol.14 , pp. 1551-1585
    • Ponnappan, S.1    Ponnappan, U.2
  • 76
    • 10744223612 scopus 로고    scopus 로고
    • Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: A contribution to understand the relationship between inflammation and immunosenescence
    • Zanni, F., Vescovini, R., Biasini, C., Fagnoni, F., Zanlari, L., Telera, A., Di Pede, P., Passeri, G., Pedrazzoni, M., Passeri, M., Franceschi, C., Sansoni, P. (2003) Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp. Gerontol. 38, 981-987.
    • (2003) Exp. Gerontol , vol.38 , pp. 981-987
    • Zanni, F.1    Vescovini, R.2    Biasini, C.3    Fagnoni, F.4    Zanlari, L.5    Telera, A.6    Di Pede, P.7    Passeri, G.8    Pedrazzoni, M.9    Passeri, M.10    Franceschi, C.11    Sansoni, P.12
  • 77
    • 67649407892 scopus 로고    scopus 로고
    • CD28(-) T cells: Their role in the age-associated decline of immune function
    • Weng, N. P., Akbar, A. N., Goronzy, J. (2009) CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 30, 306-312.
    • (2009) Trends Immunol , vol.30 , pp. 306-312
    • Weng, N.P.1    Akbar, A.N.2    Goronzy, J.3
  • 79
    • 84874215345 scopus 로고    scopus 로고
    • Homeostasis of lymphocytes and monocytes in frequent blood donors
    • Ratts, R. B., Weng, N. P. (2012) Homeostasis of lymphocytes and monocytes in frequent blood donors. Front. Immunol. 3, 271.
    • (2012) Front. Immunol , vol.3 , pp. 271
    • Ratts, R.B.1    Weng, N.P.2
  • 80
    • 84928473003 scopus 로고    scopus 로고
    • Naive T cell maintenance and function in human aging
    • Goronzy, J. J., Fang, F., Cavanagh, M. M., Qi, Q., Weyand, C. M. (2015) Naive T cell maintenance and function in human aging. J. Immunol. 194, 4073-4080.
    • (2015) J. Immunol , vol.194 , pp. 4073-4080
    • Goronzy, J.J.1    Fang, F.2    Cavanagh, M.M.3    Qi, Q.4    Weyand, C.M.5
  • 81
    • 0028837645 scopus 로고
    • Reference intervals for human peripheral blood lymphocyte subpopulations from ‘healthy’ young and aged subjects
    • Stulnig, T., Maczek, C., Böck, G., Majdic, O., Wick, G. (1995) Reference intervals for human peripheral blood lymphocyte subpopulations from ‘healthy’ young and aged subjects. Int. Arch. Allergy Immunol. 108, 205-210.
    • (1995) Int. Arch. Allergy Immunol , vol.108 , pp. 205-210
    • Stulnig, T.1    Maczek, C.2    Böck, G.3    Majdic, O.4    Wick, G.5
  • 84
    • 33847675339 scopus 로고    scopus 로고
    • Immune remodeling: Lessons from repertoire alterations during chronological aging and in immune-mediated disease
    • Vallejo, A. N. (2007) Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease. Trends Mol. Med. 13, 94-102.
    • (2007) Trends Mol. Med , vol.13 , pp. 94-102
    • Vallejo, A.N.1
  • 85
    • 84924074940 scopus 로고    scopus 로고
    • Defining Th-cell subsets in a classical and tissue-specific manner: Examples from the skin
    • Eyerich, S., Zielinski, C. E. (2014) Defining Th-cell subsets in a classical and tissue-specific manner: examples from the skin. Eur. J. Immunol. 44, 3475-3483.
    • (2014) Eur. J. Immunol , vol.44 , pp. 3475-3483
    • Eyerich, S.1    Zielinski, C.E.2
  • 86
    • 84948430058 scopus 로고    scopus 로고
    • Functional and phenotypic plasticity of CD4(+) T cell subsets
    • Caza, T., Landas, S. (2015) Functional and phenotypic plasticity of CD4(+) T cell subsets. BioMed Res. Int. 2015, 521957.
    • (2015) Biomed Res. Int
    • Caza, T.1    Landas, S.2
  • 87
    • 0032524973 scopus 로고    scopus 로고
    • Altered cytokine production in the elderly
    • Rink, L., Cakman, I., Kirchner, H. (1998) Altered cytokine production in the elderly. Mech. Ageing Dev. 102, 199-209.
    • (1998) Mech. Ageing Dev , vol.102 , pp. 199-209
    • Rink, L.1    Cakman, I.2    Kirchner, H.3
  • 88
    • 84891760313 scopus 로고    scopus 로고
    • How T follicular helper cells and the germinal centre response change with age
    • Linterman, M. A. (2014) How T follicular helper cells and the germinal centre response change with age. Immunol. Cell Biol. 92, 72-79.
    • (2014) Immunol. Cell Biol , vol.92 , pp. 72-79
    • Linterman, M.A.1
  • 89
    • 84884964160 scopus 로고    scopus 로고
    • The Th17/Treg balance is disturbed during aging
    • Schmitt, V., Rink, L., Uciechowski, P. (2013) The Th17/Treg balance is disturbed during aging. Exp. Gerontol. 48, 1379-1386.
    • (2013) Exp. Gerontol , vol.48 , pp. 1379-1386
    • Schmitt, V.1    Rink, L.2    Uciechowski, P.3
  • 90
    • 79955955068 scopus 로고    scopus 로고
    • Impact of age on T cell signaling: A general defect or specific alterations?
    • Larbi, A., Pawelec, G., Wong, S. C., Goldeck, D., Tai, J. J., Fulop, T. (2011) Impact of age on T cell signaling: a general defect or specific alterations? Ageing Res. Rev. 10, 370-378.
    • (2011) Ageing Res. Rev , vol.10 , pp. 370-378
    • Larbi, A.1    Pawelec, G.2    Wong, S.C.3    Goldeck, D.4    Tai, J.J.5    Fulop, T.6
  • 92
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li, G., Yu, M., Lee, W. W., Tsang, M., Krishnan, E., Weyand, C. M., Goronzy, J. J. (2012) Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat. Med. 18, 1518-1524.
    • (2012) Nat. Med , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3    Tsang, M.4    Krishnan, E.5    Weyand, C.M.6    Goronzy, J.J.7
  • 94
    • 76249100899 scopus 로고    scopus 로고
    • Agerelated alterations of gene expression patterns in human CD8+ T cells
    • Cao, J. N., Gollapudi, S., Sharman, E. H., Jia, Z., Gupta, S. (2010) Agerelated alterations of gene expression patterns in human CD8+ T cells. Aging Cell 9, 19-31.
    • (2010) Aging Cell , vol.9 , pp. 19-31
    • Cao, J.N.1    Gollapudi, S.2    Sharman, E.H.3    Jia, Z.4    Gupta, S.5
  • 98
    • 84930821357 scopus 로고    scopus 로고
    • Regulatory T cell identity: Formation and maintenance
    • Li, X., Zheng, Y. (2015) Regulatory T cell identity: formation and maintenance. Trends Immunol. 36, 344-353.
    • (2015) Trends Immunol , vol.36 , pp. 344-353
    • Li, X.1    Zheng, Y.2
  • 99
    • 84896296917 scopus 로고    scopus 로고
    • Regulatory T cells and the immune aging process: A mini-review
    • Jagger, A., Shimojima, Y., Goronzy, J. J., Weyand, C. M. (2014) Regulatory T cells and the immune aging process: a mini-review. Gerontology 60, 130-137.
    • (2014) Gerontology , vol.60 , pp. 130-137
    • Jagger, A.1    Shimojima, Y.2    Goronzy, J.J.3    Weyand, C.M.4
  • 100
    • 77955498156 scopus 로고    scopus 로고
    • Regulatory T cells: Roles of T cell receptor for their development and function
    • Ohkura, N., Sakaguchi, S. (2010) Regulatory T cells: roles of T cell receptor for their development and function. Semin. Immunopathol. 32, 95-106.
    • (2010) Semin. Immunopathol , vol.32 , pp. 95-106
    • Ohkura, N.1    Sakaguchi, S.2
  • 101
    • 84883773405 scopus 로고    scopus 로고
    • IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels
    • Raynor, J., Sholl, A., Plas, D. R., Bouillet, P., Chougnet, C. A., Hildeman, D. A. (2013) IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels. Front. Immunol. 4, 161.
    • (2013) Front. Immunol , vol.4 , pp. 161
    • Raynor, J.1    Sholl, A.2    Plas, D.R.3    Bouillet, P.4    Chougnet, C.A.5    Hildeman, D.A.6
  • 104
    • 84860887914 scopus 로고    scopus 로고
    • Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells
    • Sun, L., Hurez, V. J., Thibodeaux, S. R., Kious, M. J., Liu, A., Lin, P., Murthy, K., Pandeswara, S., Shin, T., Curiel, T. J. (2012) Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. Aging Cell 11, 509-519.
    • (2012) Aging Cell , vol.11 , pp. 509-519
    • Sun, L.1    Hurez, V.J.2    Thibodeaux, S.R.3    Kious, M.J.4    Liu, A.5    Lin, P.6    Murthy, K.7    Pandeswara, S.8    Shin, T.9    Curiel, T.J.10
  • 105
    • 67650705116 scopus 로고    scopus 로고
    • Aging and human CD4(+) regulatory T cells
    • Hwang, K. A., Kim, H. R., Kang, I. (2009) Aging and human CD4(+) regulatory T cells. Mech. Ageing Dev. 130, 509-517.
    • (2009) Mech. Ageing Dev , vol.130 , pp. 509-517
    • Hwang, K.A.1    Kim, H.R.2    Kang, I.3
  • 106
    • 57149108306 scopus 로고    scopus 로고
    • The frequency of regulatory CD3+CD8+CD282 CD25+ T lymphocytes in human peripheral blood increases with age
    • Simone, R., Zicca, A., Saverino, D. (2008) The frequency of regulatory CD3+CD8+CD282 CD25+ T lymphocytes in human peripheral blood increases with age. J. Leukoc. Biol. 84, 1454-1461.
    • (2008) J. Leukoc. Biol , vol.84 , pp. 1454-1461
    • Simone, R.1    Zicca, A.2    Saverino, D.3
  • 108
    • 84964301308 scopus 로고    scopus 로고
    • T cell responses to cytomegalovirus
    • Klenerman, P., Oxenius, A. (2016) T cell responses to cytomegalovirus. Nat. Rev. Immunol. 16, 367-377.
    • (2016) Nat. Rev. Immunol , vol.16 , pp. 367-377
    • Klenerman, P.1    Oxenius, A.2
  • 109
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood Tlymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study
    • Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B. O., Ferguson, F. G. (2000) Age-related change in peripheral blood Tlymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 121, 187-201.
    • (2000) Mech. Ageing Dev. , vol.121 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3    Löfgren, S.4    Nilsson, B.O.5    Ferguson, F.G.6
  • 110
    • 84954290764 scopus 로고    scopus 로고
    • The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence
    • Bauer, M. E., Fuente, Mde. L. (2016) The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence. Mech. Ageing Dev. 158, 27-37.
    • (2016) Mech. Ageing Dev , vol.158 , pp. 27-37
    • Bauer, M.E.1    Fuente, M.L.2
  • 111
    • 33745451585 scopus 로고    scopus 로고
    • The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning
    • Wikby, A., Nilsson, B. O., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F., Johansson, B. (2006) The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech. Ageing Dev. 127, 695-704.
    • (2006) Mech. Ageing Dev , vol.127 , pp. 695-704
    • Wikby, A.1    Nilsson, B.O.2    Forsey, R.3    Thompson, J.4    Strindhall, J.5    Löfgren, S.6    Ernerudh, J.7    Pawelec, G.8    Ferguson, F.9    Johansson, B.10
  • 112
    • 84880571275 scopus 로고    scopus 로고
    • The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: The Swedish HEXA immune study
    • Strindhall, J., Skog, M., Ernerudh, J., Bengner, M., Löfgren, S., Matussek, A., Nilsson, B. O., Wikby, A. (2013) The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study. Age (Dordr.) 35, 985-991.
    • (2013) Age (Dordr.) , vol.35 , pp. 985-991
    • Strindhall, J.1    Skog, M.2    Ernerudh, J.3    Bengner, M.4    Löfgren, S.5    Matussek, A.6    Nilsson, B.O.7    Wikby, A.8
  • 113
    • 84864718204 scopus 로고    scopus 로고
    • Cytomegalovirus, aging, and HIV: A perfect storm
    • Barrett, L., Fowke, K. R., Grant, M. D. (2012) Cytomegalovirus, aging, and HIV: a perfect storm. AIDS Rev. 14, 159-167.
    • (2012) AIDS Rev , vol.14 , pp. 159-167
    • Barrett, L.1    Fowke, K.R.2    Grant, M.D.3
  • 114
    • 85017562243 scopus 로고    scopus 로고
    • HIV-associated cellular senescence: A contributor to accelerated aging
    • Cohen, J., Torres, C. (2016) HIV-associated cellular senescence: a contributor to accelerated aging. Ageing Res. Rev. 36, 117-124.
    • (2016) Ageing Res. Rev , vol.36 , pp. 117-124
    • Cohen, J.1    Torres, C.2
  • 115
    • 84878085003 scopus 로고    scopus 로고
    • Accelerated aging in HIV/AIDS: Novel biomarkers of senescent human CD8+ T cells
    • Chou, J. P., Ramirez, C. M., Wu, J. E., Effros, R. B. (2013) Accelerated aging in HIV/AIDS: novel biomarkers of senescent human CD8+ T cells. PLoS One 8, e64702.
    • (2013) Plos One , vol.8
    • Chou, J.P.1    Ramirez, C.M.2    Wu, J.E.3    Effros, R.B.4
  • 117
    • 84990929557 scopus 로고    scopus 로고
    • Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression
    • Mudd, J. C., Brenchley, J. M. (2016) Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression. J. Infect. Dis. 214 (Suppl 2), S58-S66.
    • (2016) J. Infect. Dis , vol.214 , pp. S58-S66
    • Mudd, J.C.1    Brenchley, J.M.2
  • 119
    • 84901258066 scopus 로고    scopus 로고
    • Contribution of intestinal barrier damage, microbial translocation and HIV-1 infection status to an inflammaging signature
    • Steele, A. K., Lee, E. J., Vestal, B., Hecht, D., Dong, Z., Rapaport, E., Koeppe, J., Campbell, T. B., Wilson, C. C. (2014) Contribution of intestinal barrier damage, microbial translocation and HIV-1 infection status to an inflammaging signature. PLoS One 9, e97171.
    • (2014) Plos One , vol.9
    • Steele, A.K.1    Lee, E.J.2    Vestal, B.3    Hecht, D.4    Dong, Z.5    Rapaport, E.6    Koeppe, J.7    Campbell, T.B.8    Wilson, C.C.9
  • 122
    • 84908142376 scopus 로고    scopus 로고
    • MicroRNAs in Tfh cells: Micromanaging inflammaging
    • Yu, D. (2014) MicroRNAs in Tfh cells: micromanaging inflammaging. Immunity 41, 509-511.
    • (2014) Immunity , vol.41 , pp. 509-511
    • Yu, D.1
  • 125
    • 84882450447 scopus 로고    scopus 로고
    • Omics technologies and the study of human ageing
    • Valdes, A. M., Glass, D., Spector, T. D. (2013) Omics technologies and the study of human ageing. Nat. Rev. Genet. 14, 601-607.
    • (2013) Nat. Rev. Genet , vol.14 , pp. 601-607
    • Valdes, A.M.1    Glass, D.2    Spector, T.D.3
  • 128
    • 84883826522 scopus 로고    scopus 로고
    • T cell aging: A review of the transcriptional changes determined from genome-wide analysis
    • Chen, G., Lustig, A., Weng, N. P. (2013) T cell aging: a review of the transcriptional changes determined from genome-wide analysis. Front. Immunol. 4, 121.
    • (2013) Front. Immunol , vol.4 , pp. 121
    • Chen, G.1    Lustig, A.2    Weng, N.P.3


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