메뉴 건너뛰기




Volumn 68, Issue 2, 2016, Pages 84-91

The role of immunosenescence in the development of age-related diseases

Author keywords

Chronic diseases; Immunosenescence; Inflammaging

Indexed keywords

GAMMA INTERFERON; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 84973154251     PISSN: 00348376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (228)

References (90)
  • 1
    • 84947552827 scopus 로고    scopus 로고
    • Biological theories of aging
    • Lipsky MS, King M. Biological theories of aging. Dis Mon. 2015;61:460-6.
    • (2015) Dis Mon , vol.61 , pp. 460-466
    • Lipsky, M.S.1    King, M.2
  • 4
    • 84900988267 scopus 로고    scopus 로고
    • Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
    • Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl l):S4-9.
    • (2014) J Gerontol a Biol Sci Med Sci , vol.69 , pp. S4-S9
    • Franceschi, C.1    Campisi, J.2
  • 5
    • 84971604217 scopus 로고    scopus 로고
    • Physiological geroscience: Targeting function to increase healthspan and achieve optimal longevity
    • Epub ahead of print
    • Seals DR, Justice JN, LaRocca TJ. Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol. 2015 [Epub ahead of print].
    • (2015) J Physiol
    • Seals, D.R.1    Justice, J.N.2    La Rocca, T.J.3
  • 6
    • 84910029849 scopus 로고    scopus 로고
    • Geroscience: Linking aging to chronic disease
    • Kennedy BK, Berger SL, Brunet A, et al. Geroscience: linking aging to chronic disease. Cell. 2014;159:709-13.
    • (2014) Cell , vol.159 , pp. 709-713
    • Kennedy, B.K.1    Berger, S.L.2    Brunet, A.3
  • 7
    • 84907857762 scopus 로고    scopus 로고
    • Translational geroscience: Emphasizing function to achieve optimal longevity
    • Seals DR, Melov S. Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY). 2014;6:718-30.
    • (2014) Aging (Albany NY) , vol.6 , pp. 718-730
    • Seals, D.R.1    Melov, S.2
  • 9
    • 84868193217 scopus 로고    scopus 로고
    • Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
    • Solana R, Tarazona R, Gayoso I, Lesur O, Dupuis G, Fulop T. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol. 2012;24:331-41.
    • (2012) Semin Immunol , vol.24 , pp. 331-341
    • Solana, R.1    Tarazona, R.2    Gayoso, I.3    Lesur, O.4    Dupuis, G.5    Fulop, T.6
  • 10
    • 84948972267 scopus 로고    scopus 로고
    • Paradoxical changes in innate immunity in aging: Recent progress and new directions
    • Montgomery RR, Shaw AC. Paradoxical changes in innate immunity in aging: recent progress and new directions. J Leukoc Biol. 2015;98:937-43.
    • (2015) J Leukoc Biol , vol.98 , pp. 937-943
    • Montgomery, R.R.1    Shaw, A.C.2
  • 12
    • 84890832543 scopus 로고    scopus 로고
    • From "truly naive" to "exhausted senescent" T cells: When markers predict functionality
    • Larbi A, Fulop T. From "truly naive" to "exhausted senescent" T cells: when markers predict functionality. Cytometry A. 2014;85:25-35.
    • (2014) Cytometry A , vol.85 , pp. 25-35
    • Larbi, A.1    Fulop, T.2
  • 13
    • 84955328973 scopus 로고    scopus 로고
    • From inflamm-aging to immuneparalysis: A slippery slope during aging for immune-adaptation
    • Epub ahead of print
    • Fulop T, Dupuis G, Baehl S, et al. From inflamm-aging to immuneparalysis: a slippery slope during aging for immune-adaptation. Biogerontology. 2015. [Epub ahead of print].
    • (2015) Biogerontology
    • Fulop, T.1    Dupuis, G.2    Baehl, S.3
  • 15
    • 84897889733 scopus 로고    scopus 로고
    • Innate immune responses in the neutrophils of community dwelling and nursing home elders
    • Juthani-Mehta M, Guo X, Shaw AC, et al. Innate immune responses in the neutrophils of community dwelling and nursing home elders. J Aging Sci. 2014;2.
    • (2014) J Aging Sci , pp. 2
    • Juthani-Mehta, M.1    Guo, X.2    Shaw, A.C.3
  • 16
    • 84976473119 scopus 로고    scopus 로고
    • Aging neutrophils
    • Visan I. Aging neutrophils. Nat Immunol. 2015;16:1113.
    • (2015) Nat Immunol , vol.16 , pp. 1113
    • Visan, I.1
  • 17
    • 84925652399 scopus 로고    scopus 로고
    • Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture
    • Baëhl S, Garneau H, Le Page A, et al. Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. Exp Gerontol. 2015;65:58-68.
    • (2015) Exp Gerontol , vol.65 , pp. 58-68
    • Baëhl, S.1    Garneau, H.2    Le Page, A.3
  • 18
    • 84924296718 scopus 로고    scopus 로고
    • Disorders of innate immunity in human ageing and effects of nutraceutical administration
    • Magrone T, Jirillo E. Disorders of innate immunity in human ageing and effects of nutraceutical administration. Endocr Metab Immune Disord Drug Targets. 2014;14:272-82.
    • (2014) Endocr Metab Immune Disord Drug Targets , vol.14 , pp. 272-282
    • Magrone, T.1    Jirillo, E.2
  • 19
    • 84904903325 scopus 로고    scopus 로고
    • Impaired neutrophil extracellular trap formation: A novel defect in the innate immune system of aged individuals
    • Hazeldine J, Harris P, Chappie IL, et al. Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell. 2014;13:690-8.
    • (2014) Aging Cell , vol.13 , pp. 690-698
    • Hazeldine, J.1    Harris, P.2    Chappie, I.L.3
  • 20
    • 84900395915 scopus 로고    scopus 로고
    • Expanding roles of neutrophils in aging hosts
    • Tseng CW, Liu GY. Expanding roles of neutrophils in aging hosts. Curr Opin Immunol. 2014;29:43-8.
    • (2014) Curr Opin Immunol , vol.29 , pp. 43-48
    • Tseng, C.W.1    Liu, G.Y.2
  • 21
    • 84897842773 scopus 로고    scopus 로고
    • Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging
    • Qian F, Guo X, Wang X, et al. Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging (Albany NY). 2014;6:131-9.
    • (2014) Aging (Albany NY) , vol.6 , pp. 131-139
    • Qian, F.1    Guo, X.2    Wang, X.3
  • 22
    • 33646580485 scopus 로고    scopus 로고
    • Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    • Fortin CF, Larbi A, Lesur O, Douziech N. Fulop T. Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. J Leukoc Biol. 2006;79:1061-72.
    • (2006) J Leukoc Biol , vol.79 , pp. 1061-1072
    • Fortin, C.F.1    Larbi, A.2    Lesur, O.3    Douziech, N.4    Fulop, T.5
  • 23
    • 84870239678 scopus 로고    scopus 로고
    • Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress
    • Khanfer R, Carroll D, Lord JM, Phillips AC. Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress. Int J Psychophysiol. 2012;86:238-44.
    • (2012) Int J Psychophysiol , vol.86 , pp. 238-244
    • Khanfer, R.1    Carroll, D.2    Lord, J.M.3    Phillips, A.C.4
  • 26
    • 84892640743 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: Toward targeted treatments for immunosenescence
    • Sapey E, Greenwood H, Walton G, et al. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood. 2014;123:239-48.
    • (2014) Blood , vol.123 , pp. 239-248
    • Sapey, E.1    Greenwood, H.2    Walton, G.3
  • 27
    • 84914100710 scopus 로고    scopus 로고
    • Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart
    • Linton PJ, Thoman ML. Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart. Immunol Lett. 2014;162:290-7.
    • (2014) Immunol Lett , vol.162 , pp. 290-297
    • Linton, P.J.1    Thoman, M.L.2
  • 28
    • 78651275576 scopus 로고    scopus 로고
    • Impaired functions of peripheral blood monocyte subpopulations in aged humans
    • Nyugen J, Agrawal S, Gollapudi S, Gupta S. Impaired functions of peripheral blood monocyte subpopulations in aged humans. J Clin Immunol. 2010;30:806-13.
    • (2010) J Clin Immunol , vol.30 , pp. 806-813
    • Nyugen, J.1    Agrawal, S.2    Gollapudi, S.3    Gupta, S.4
  • 29
    • 77953669656 scopus 로고    scopus 로고
    • Age-dependent alterations of monocyte subsets and monocyterelated chemokine pathways in healthy adults
    • Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F. Age-dependent alterations of monocyte subsets and monocyterelated chemokine pathways in healthy adults. BMC Immunol. 2010:11:30.
    • (2010) BMC Immunol , vol.11 , pp. 30
    • Seidler, S.1    Zimmermann, H.W.2    Bartneck, M.3    Trautwein, C.4    Tacke, F.5
  • 30
    • 84949495879 scopus 로고    scopus 로고
    • Aging impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 ligand
    • Zacca ER, Crespo Ml, Acland RP, et al. Aging impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 ligand. PLoS One. 2015;10:e0140672.
    • (2015) PLoS One , vol.10 , pp. e0140672
    • Zacca, E.R.1    Crespo, M.L.2    Acland, R.P.3
  • 31
    • 84939566590 scopus 로고    scopus 로고
    • Immunosenescence: Implications for response to infection and vaccination in older people
    • Pera A, Campos C, López N, et al. Immunosenescence: Implications for response to infection and vaccination in older people. Maturitas. 2015;82:50-5.
    • (2015) Maturitas , vol.82 , pp. 50-55
    • Pera, A.1    Campos, C.2    López, N.3
  • 32
    • 84903156812 scopus 로고    scopus 로고
    • Comparison of chosen activation markers of human monocytes/macrophages isolated from the peripheral blood of young and elderly volunteers
    • Suchy D, Łabuzek K, Bułdak Ł, Szkudlapski D, Okopień B. Comparison of chosen activation markers of human monocytes/macrophages isolated from the peripheral blood of young and elderly volunteers. Pharmacol Rep. 2014;66:759-65.
    • (2014) Pharmacol Rep , vol.66 , pp. 759-765
    • Suchy, D.1    Łabuzek, K.2    Bułdak, Ł.3    Szkudlapski, D.4    Okopień, B.5
  • 33
    • 84922213705 scopus 로고    scopus 로고
    • Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly
    • Verschoor CP, Loukov D, Naidoo A, et al. Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly. Mol Immunol. 2015;65:148-56.
    • (2015) Mol Immunol , vol.65 , pp. 148-156
    • Verschoor, C.P.1    Loukov, D.2    Naidoo, A.3
  • 34
    • 84888198684 scopus 로고    scopus 로고
    • Phagocyte dysfunction, tissue aging and degeneration
    • Li W. Phagocyte dysfunction, tissue aging and degeneration. Ageing Res Rev. 2013;12:1005-12.
    • (2013) Ageing Res Rev , vol.12 , pp. 1005-1012
    • Li, W.1
  • 35
    • 70349899283 scopus 로고    scopus 로고
    • The intestinal epithelial barrier: Does it become impaired with age?
    • Meier J, Sturm A. The intestinal epithelial barrier: does it become impaired with age? Dig Dis. 2009;27:240-5.
    • (2009) Dig Dis , vol.27 , pp. 240-245
    • Meier, J.1    Sturm, A.2
  • 36
    • 84924815374 scopus 로고    scopus 로고
    • Small intestinal permeability in older adults
    • Valentini L, Ramminger S, Haas V, et al. Small intestinal permeability in older adults. Physiol Rep. 2014;2:e00281.
    • (2014) Physiol Rep , vol.2 , pp. e00281
    • Valentini, L.1    Ramminger, S.2    Haas, V.3
  • 37
    • 0033911488 scopus 로고    scopus 로고
    • Inflamm-aging. An evolutionary perspective on immunosenescence
    • Franceschi C, Bonafè M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908:244-54.
    • (2000) Ann N Y Acad Sci , vol.908 , pp. 244-254
    • Franceschi, C.1    Bonafè, M.2    Valensin, S.3
  • 38
    • 77952302657 scopus 로고    scopus 로고
    • Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
    • Goto M. Inflammaging (inflammation + aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? Biosci Trends. 2008;2:218-30.
    • (2008) Biosci Trends , vol.2 , pp. 218-230
    • Goto, M.1
  • 39
    • 84885402793 scopus 로고    scopus 로고
    • The effect of age on thymic function
    • Palmer DB. The effect of age on thymic function. Front Immunol. 2013:4:316.
    • (2013) Front Immunol , vol.4 , pp. 316
    • Palmer, D.B.1
  • 40
    • 84898788764 scopus 로고    scopus 로고
    • Mechanisms shaping the naive T cell repertoire in the elderly - Thymic involution or peripheral homeostatic proliferation?
    • Qi Q, Zhang DW, Weyand CM, Goronzy JJ. Mechanisms shaping the naive T cell repertoire in the elderly - thymic involution or peripheral homeostatic proliferation? Exp Gerontol. 2014;54:71-4.
    • (2014) Exp Gerontol , vol.54 , pp. 71-74
    • Qi, Q.1    Zhang, D.W.2    Weyand, C.M.3    Goronzy, J.J.4
  • 41
    • 84898826928 scopus 로고    scopus 로고
    • Naive T cells: The crux of cellular immune aging?
    • Appay V, Sauce D. Naive T cells: the crux of cellular immune aging? Exp Gerontol. 2014;54:90-3.
    • (2014) Exp Gerontol , vol.54 , pp. 90-93
    • Appay, V.1    Sauce, D.2
  • 42
    • 84886033654 scopus 로고    scopus 로고
    • Human T cell aging and the impact of persistent viral infections
    • Fülöp T, Larbi A, Pawelec G. Human T cell aging and the impact of persistent viral infections. Front Immunol. 2013;4:271.
    • (2013) Front Immunol , vol.4 , pp. 271
    • Fülöp, T.1    Larbi, A.2    Pawelec, G.3
  • 43
    • 84898803220 scopus 로고    scopus 로고
    • Immunosenenescence: Role of cytomegalovirus
    • Pawelec G. Immunosenenescence: role of cytomegalovirus. Exp Gerontol. 2014;54:1-5.
    • (2014) Exp Gerontol , vol.54 , pp. 1-5
    • Pawelec, G.1
  • 44
    • 0037396188 scopus 로고    scopus 로고
    • Morbidity does not influence the T-cell immune risk phenotype in the elderly: Findings in the Swedish NONA Immune Study using sample selection protocols
    • Nilsson BO, Ernerudh J, Johansson B, et al. Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols. Mech Ageing Dev. 2003;124:469-76.
    • (2003) Mech Ageing Dev , vol.124 , pp. 469-476
    • Nilsson, B.O.1    Ernerudh, J.2    Johansson, B.3
  • 45
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study
    • Wikby A, Johansson B, Olsson J, Löfgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol. 2002;37:445-53.
    • (2002) Exp Gerontol , vol.37 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3    Löfgren, S.4    Nilsson, B.O.5    Ferguson, F.6
  • 46
    • 33645102374 scopus 로고    scopus 로고
    • Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
    • Larbi A, Dupuis G, Khalil A, Douziech N, Fortin C, Fulop T. Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging. Cell Signal. 2006;18:1017-30.
    • (2006) Cell Signal , vol.18 , pp. 1017-1030
    • Larbi, A.1    Dupuis, G.2    Khalil, A.3    Douziech, N.4    Fortin, C.5    Fulop, T.6
  • 47
    • 84919754842 scopus 로고    scopus 로고
    • Immunomodulatory role of high-density lipoproteins: Impact on immunosenescence
    • Larbi A, Fortin C, Dupuis G, Berrougui H, Khalil A, Fulop T. Immunomodulatory role of high-density lipoproteins: impact on immunosenescence. Age (Dordr). 2014:36:9712.
    • (2014) Age (Dordr) , vol.36 , pp. 9712
    • Larbi, A.1    Fortin, C.2    Dupuis, G.3    Berrougui, H.4    Khalil, A.5    Fulop, T.6
  • 49
    • 84868208626 scopus 로고    scopus 로고
    • Signaling pathways in aged T cells - A reflection of T cell differentiation, cell senescence and host environment
    • Goronzy JJ, Li G, Yu M, Weyand CM. Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment. Semin Immunol. 2012;24:365-72.
    • (2012) Semin Immunol , vol.24 , pp. 365-372
    • Goronzy, J.J.1    Li, G.2    Yu, M.3    Weyand, C.M.4
  • 50
    • 84892818946 scopus 로고    scopus 로고
    • Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
    • Le Page A, Fortin C, Garneau H, et al. Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly. Cell Commun Signal. 2014;12:2.
    • (2014) Cell Commun Signal , vol.12 , pp. 2
    • Le Page, A.1    Fortin, C.2    Garneau, H.3
  • 51
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li G, Yu M, Lee WW, et al. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med. 2012;18:1518-24.
    • (2012) Nat Med , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3
  • 52
    • 58149119644 scopus 로고    scopus 로고
    • Exploring the complex relations between inflammation and aging (inflamm-aging): Anti-inflamm-aging remodelling of inflamm-aging, from robustness to frailty
    • Giunta S. Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm-aging, from robustness to frailty. Inflamm Res. 2008;57:558-63.
    • (2008) Inflamm Res , vol.57 , pp. 558-563
    • Giunta, S.1
  • 53
    • 84896985687 scopus 로고    scopus 로고
    • Proinflammatory cytokines, aging, and age-related diseases
    • Michaud M, Balardy L, Moulis G, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013;14:877-82.
    • (2013) J Am Med Dir Assoc , vol.14 , pp. 877-882
    • Michaud, M.1    Balardy, L.2    Moulis, G.3
  • 54
    • 84900988267 scopus 로고    scopus 로고
    • Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
    • Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl l):S4-9.
    • (2014) J Gerontol a Biol Sci Med Sci , vol.69 , pp. S4-S9
    • Franceschi, C.1    Campisi, J.2
  • 55
  • 57
    • 84938751873 scopus 로고    scopus 로고
    • MTOR regulates the protumorigenic senescence-associated secretory phenotype by promoting IL1A translation
    • Laberge RM, Sun Y, Orjalo AV, et al. MTOR regulates the protumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049-61.
    • (2015) Nat Cell Biol , vol.17 , pp. 1049-1061
    • Laberge, R.M.1    Sun, Y.2    Orjalo, A.V.3
  • 58
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • Van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509:439-46.
    • (2014) Nature , vol.509 , pp. 439-446
    • Van Deursen, J.M.1
  • 59
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
    • Tchkonia T, Zhu Y, Van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest. 2013;123:966-72.
    • (2013) J Clin Invest , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 60
    • 84904746130 scopus 로고    scopus 로고
    • Inflamm-aging does not simply reflect increases in pro-inflammatory markers
    • Morrisette-Thomas V, Cohen AA, Fülöp T, et al. Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mech Ageing Dev. 2014;139:49-57.
    • (2014) Mech Ageing Dev , vol.139 , pp. 49-57
    • Morrisette-Thomas, V.1    Cohen, A.A.2    Fülöp, T.3
  • 61
    • 84896296917 scopus 로고    scopus 로고
    • Regulatory T cells and the immune aging process: A mini-review
    • Jagger A, Shimojima Y, Goronzy JJ, Weyand CM. Regulatory T cells and the immune aging process: a mini-review. Gerontology. 2014;60:130-7.
    • (2014) Gerontology , vol.60 , pp. 130-137
    • Jagger, A.1    Shimojima, Y.2    Goronzy, J.J.3    Weyand, C.M.4
  • 62
    • 84919800606 scopus 로고    scopus 로고
    • Ageing and myeloid-derived suppressor cells: Possible involvement in immunosenescence and age-related disease
    • Bueno V, Sant'Anna OA, Lord JM. Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease. Age (Dordr). 2014:36:9729.
    • (2014) Age (Dordr) , vol.36 , pp. 9729
    • Bueno, V.1    Sant'Anna, O.A.2    Lord, J.M.3
  • 63
    • 84875658458 scopus 로고    scopus 로고
    • Blood CD33 (+) HLA-DR (-) myeloid-derived suppressor cells are increased with age and a history of cancer
    • Verschoor CP, Johnstone J, Millar J, et al. Blood CD33 (+) HLA-DR (-) myeloid-derived suppressor cells are increased with age and a history of cancer. J Leukoc Biol. 2013;93:633-7.
    • (2013) J Leukoc Biol , vol.93 , pp. 633-637
    • Verschoor, C.P.1    Johnstone, J.2    Millar, J.3
  • 64
    • 84863930878 scopus 로고    scopus 로고
    • The innate immune system and aging: What is the contribution to immunosenescence?
    • Fiilop T, Fortin C, Lesur O, et al. The innate immune system and aging: What is the contribution to immunosenescence? Open Longevity Science. 2012;6:121-32.
    • (2012) Open Longevity Science , vol.6 , pp. 121-132
    • Fiilop, T.1    Fortin, C.2    Lesur, O.3
  • 66
    • 84939938448 scopus 로고    scopus 로고
    • The epigenetic memory of monocytes and macrophages as a novel drug target in atherosclerosis
    • Bekkering S, Joosten LA, Van Der Meer JW, Netea MG, Riksen NP. The epigenetic memory of monocytes and macrophages as a novel drug target in atherosclerosis. Clin Ther. 2015;37:914-23
    • (2015) Clin Ther , vol.37 , pp. 914-923
    • Bekkering, S.1    Joosten, L.A.2    Van Der Meer, J.W.3    Netea, M.G.4    Riksen, N.P.5
  • 68
    • 84867909516 scopus 로고    scopus 로고
    • Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
    • Kleinnijenhuis J, Quintin J, Preijers F, et al. Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci USA. 2012;109:17537-42.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 17537-17542
    • Kleinnijenhuis, J.1    Quintin, J.2    Preijers, F.3
  • 69
    • 84865119423 scopus 로고    scopus 로고
    • Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes
    • Quintin J, Saeed S, Martens JH, et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe. 2012;12:223-32.
    • (2012) Cell Host Microbe , vol.12 , pp. 223-232
    • Quintin, J.1    Saeed, S.2    Martens, J.H.3
  • 70
    • 84872522528 scopus 로고    scopus 로고
    • Latent enhancers activated by stimulation in differentiated cells
    • Ostuni R, Piccolo V, Barozzi I, et al. Latent enhancers activated by stimulation in differentiated cells. Cell. 2013;152:157-71.
    • (2013) Cell , vol.152 , pp. 157-171
    • Ostuni, R.1    Piccolo, V.2    Barozzi, I.3
  • 71
    • 84909578049 scopus 로고    scopus 로고
    • mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity
    • Cheng SC, Quintin J, Cramer RA, et al. mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345:1250684.
    • (2014) Science , vol.345 , pp. 1250684
    • Cheng, S.C.1    Quintin, J.2    Cramer, R.A.3
  • 72
    • 84907483941 scopus 로고    scopus 로고
    • Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
    • Saeed S, Quintin J, Kerstens HH, et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science. 2014;345:1251086.
    • (2014) Science , vol.345 , pp. 1251086
    • Saeed, S.1    Quintin, J.2    Kerstens, H.H.3
  • 74
    • 84928730412 scopus 로고    scopus 로고
    • Immune aging, dysmetabolism, and inflammation in neurological diseases
    • Deleidi M, Jäggle M, Rubino G. Immune aging, dysmetabolism, and inflammation in neurological diseases. Front Neurosci. 2015;9:172.
    • (2015) Front Neurosci , vol.9 , pp. 172
    • Deleidi, M.1    Jäggle, M.2    Rubino, G.3
  • 75
    • 84906230096 scopus 로고    scopus 로고
    • Increase of oxidation and inflammation in nervous and immune systems with aging and anxiety
    • Vida C, González EM, De La Fuente M. Increase of oxidation and inflammation in nervous and immune systems with aging and anxiety. Curr Pharm Des. 2014;20:4656-78.
    • (2014) Curr Pharm des , vol.20 , pp. 4656-4678
    • Vida, C.1    González, E.M.2    De La Fuente, M.3
  • 76
    • 84976511593 scopus 로고    scopus 로고
    • Microglia in Alzheimer's disease: A multifaceted relationship
    • Epub ahead of print
    • ElAli A, Rivest S. Microglia in Alzheimer's disease: A multifaceted relationship. Brain Behav Immun. 2015. [Epub ahead of print].
    • (2015) Brain Behav Immun
    • El Ali, A.1    Rivest, S.2
  • 77
    • 84929313637 scopus 로고    scopus 로고
    • NK cells are activated in amnestic mild cognitive impairment but not in mild Alzheimer's disease patients
    • Le Page A, Bourgade K, Lamoureux J, et al. NK cells are activated in amnestic mild cognitive impairment but not in mild alzheimer's disease patients. J Alzheimers Dis. 2015;46:93-107.
    • (2015) J Alzheimers Dis , vol.46 , pp. 93-107
    • Le Page, A.1    Bourgade, K.2    Lamoureux, J.3
  • 78
    • 67650921447 scopus 로고    scopus 로고
    • Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
    • Larbi A, Pawelec G, Witkowski JM, et al. Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease. J Alzheimers Dis. 2009;17:91-103.
    • (2009) J Alzheimers Dis , vol.17 , pp. 91-103
    • Larbi, A.1    Pawelec, G.2    Witkowski, J.M.3
  • 79
    • 84939433031 scopus 로고    scopus 로고
    • Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: The intersection between aging biology and personalized medicine
    • Wu IC, Lin CC, Hsiung CA. Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: the intersection between aging biology and personalized medicine. Biomedicine (Taipei). 2015;5:1.
    • (2015) Biomedicine (Taipei) , vol.5 , pp. 1
    • Wu, I.C.1    Lin, C.C.2    Hsiung, C.A.3
  • 80
    • 84971231130 scopus 로고    scopus 로고
    • Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes
    • McElhaney JE, Garneau H, Camous X, et al. Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes. BMJ Open Diabetes Res Care. 2015;3:e000140.
    • (2015) BMJ Open Diabetes Res Care , vol.3 , pp. e000140
    • McElhaney, J.E.1    Garneau, H.2    Camous, X.3
  • 81
    • 0142258704 scopus 로고    scopus 로고
    • Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects
    • Mori TA, Woodman RJ, Burke V, Puddey IB, Croft KD, Beilin LJ. Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. Free Radic Biol Med. 2003;35:772-81.
    • (2003) Free Radic Biol Med , vol.35 , pp. 772-781
    • Mori, T.A.1    Woodman, R.J.2    Burke, V.3    Puddey, I.B.4    Croft, K.D.5    Beilin, L.J.6
  • 82
    • 84925934623 scopus 로고    scopus 로고
    • Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease
    • Guarner V, Rubio-Ruiz ME. Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease. Interdiscip Top Gerontol. 2015;40:99-106.
    • (2015) Interdiscip Top Gerontol , vol.40 , pp. 99-106
    • Guarner, V.1    Rubio-Ruiz, M.E.2
  • 83
    • 84949552901 scopus 로고    scopus 로고
    • Inflammation, oxidative stress and renin angiotensin system in atherosclerosis
    • Husain K, Hernandez W, Ansari RA, Ferder L. Inflammation, oxidative stress and renin angiotensin system in atherosclerosis. World J Biol Chem. 2015;6:209-17.
    • (2015) World J Biol Chem , vol.6 , pp. 209-217
    • Husain, K.1    Hernandez, W.2    Ansari, R.A.3    Ferder, L.4
  • 84
    • 0035657709 scopus 로고    scopus 로고
    • Atherosclerosis as an autoimmune disease: An update
    • Wick G, Perschinka H, Millonig G. Atherosclerosis as an autoimmune disease: an update. Trends Immunol. 2001;22:665-9.
    • (2001) Trends Immunol , vol.22 , pp. 665-669
    • Wick, G.1    Perschinka, H.2    Millonig, G.3
  • 85
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-74.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 86
    • 84980321715 scopus 로고    scopus 로고
    • T cell senescence and cardiovascular diseases
    • Epub ahead of print
    • Yu HT, Park S, Shin EC, Lee WW. T cell senescence and cardiovascular diseases. Clin Exp Med. 2015. [Epub ahead of print].
    • (2015) Clin Exp Med
    • Yu, H.T.1    Park, S.2    Shin, E.C.3    Lee, W.W.4
  • 87
    • 1642463859 scopus 로고    scopus 로고
    • Inflammatory mediators in chronic heart failure: An overview
    • Anker SD, Von Haehling S. Inflammatory mediators in chronic heart failure: an overview. Heart. 2004;90:464-70.
    • (2004) Heart , vol.90 , pp. 464-470
    • Anker, S.D.1    Von Haehling, S.2
  • 88
    • 84903279433 scopus 로고    scopus 로고
    • Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease
    • Moro-García MA, Echeverría A, Galán-Artímez MC, et al. Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease. Int J Cardiol. 2014;174:590-9.
    • (2014) Int J Cardiol , vol.174 , pp. 590-599
    • Moro-García, M.A.1    Echeverría, A.2    Galán-Artímez, M.C.3
  • 90
    • 38149017709 scopus 로고    scopus 로고
    • Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure
    • Foldes G, Von Haehling S, Okonko DO, Jankowska EA, Poole-Wilson PA, Anker SD. Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure. Int J Cardiol. 2008;124:80-5.
    • (2008) Int J Cardiol , vol.124 , pp. 80-85
    • Foldes, G.1    Von Haehling, S.2    Okonko, D.O.3    Jankowska, E.A.4    Poole-Wilson, P.A.5    Anker, S.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.