메뉴 건너뛰기




Volumn 7, Issue FEB, 2016, Pages

T-cell immunity to influenza in older adults: A pathophysiological framework for development of more effective vaccines

Author keywords

Antibody; Cell mediated immunity; Immunosenescence; Influenza; Vaccination

Indexed keywords

INFLUENZA VACCINE; INTERLEUKIN 10;

EID: 84961653804     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00041     Document Type: Article
Times cited : (104)

References (106)
  • 2
    • 4444361767 scopus 로고    scopus 로고
    • Influenza and the winter increase in mortality in the United States, 1959-1999
    • Reichert TA, Simonsen L, Sharma A, Pardo SA, Fedson DS, Miller MA. Influenza and the winter increase in mortality in the United States, 1959-1999. Am J Epidemiol (2004) 160(5):492-502. doi:10.1093/aje/kwh227.
    • (2004) Am J Epidemiol , vol.160 , Issue.5 , pp. 492-502
    • Reichert, T.A.1    Simonsen, L.2    Sharma, A.3    Pardo, S.A.4    Fedson, D.S.5    Miller, M.A.6
  • 3
    • 0034716325 scopus 로고    scopus 로고
    • Impact of respiratory virus infections on persons with chronic underlying conditions
    • Glezen WP, Greenberg SB, Atmar RL, Piedra PA, Couch RB. Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA (2000) 283(4):499-505. doi:10.1001/jama.283.4.499.
    • (2000) JAMA , vol.283 , Issue.4 , pp. 499-505
    • Glezen, W.P.1    Greenberg, S.B.2    Atmar, R.L.3    Piedra, P.A.4    Couch, R.B.5
  • 4
    • 4544332903 scopus 로고    scopus 로고
    • Influenza-associated hospitalizations in the United States
    • Thompson WW, Shay DK, Weintraub E, Brammer L, Bridges CB, Cox NJ, et al. Influenza-associated hospitalizations in the United States. JAMA (2004) 292(11):1333-40. doi:10.1001/jama.292.11.1333.
    • (2004) JAMA , vol.292 , Issue.11 , pp. 1333-1340
    • Thompson, W.W.1    Shay, D.K.2    Weintraub, E.3    Brammer, L.4    Bridges, C.B.5    Cox, N.J.6
  • 5
    • 0037425564 scopus 로고    scopus 로고
    • Mortality associated with influenza and respiratory syncytial virus in the United States
    • Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA (2003) 289(2):179-86. doi:10.1001/jama.289.2.179.
    • (2003) JAMA , vol.289 , Issue.2 , pp. 179-186
    • Thompson, W.W.1    Shay, D.K.2    Weintraub, E.3    Brammer, L.4    Cox, N.5    Anderson, L.J.6
  • 6
    • 84863426446 scopus 로고    scopus 로고
    • Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study
    • Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet (2012) 380(9836):37-43. doi:10.1016/S0140-6736(12)60240-2.
    • (2012) Lancet , vol.380 , Issue.9836 , pp. 37-43
    • Barnett, K.1    Mercer, S.W.2    Norbury, M.3    Watt, G.4    Wyke, S.5    Guthrie, B.6
  • 7
    • 1142273123 scopus 로고    scopus 로고
    • Development and validation of a clinical prediction rule for hospitalization due to pneumonia or influenza or death during influenza epidemics among community-dwelling elderly persons
    • Hak E, Wei F, Nordin J, Mullooly J, Poblete S, Nichol KL. Development and validation of a clinical prediction rule for hospitalization due to pneumonia or influenza or death during influenza epidemics among community-dwelling elderly persons. J Infect Dis (2004) 189(3):450-8. doi:10.1086/381165.
    • (2004) J Infect Dis , vol.189 , Issue.3 , pp. 450-458
    • Hak, E.1    Wei, F.2    Nordin, J.3    Mullooly, J.4    Poblete, S.5    Nichol, K.L.6
  • 8
    • 0032559779 scopus 로고    scopus 로고
    • A study of the impact of influenza on the functional status of frail older people
    • Barker WH, Borisute H, Cox C. A study of the impact of influenza on the functional status of frail older people. Arch Intern Med (1998) 158(6):645-50. doi:10.1001/archinte.158.6.645.
    • (1998) Arch Intern Med , vol.158 , Issue.6 , pp. 645-650
    • Barker, W.H.1    Borisute, H.2    Cox, C.3
  • 9
    • 17644392071 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection in elderly and high-risk adults
    • Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med (2005) 352(17):1749-59. doi:10.1056/NEJMoa043951.
    • (2005) N Engl J Med , vol.352 , Issue.17 , pp. 1749-1759
    • Falsey, A.R.1    Hennessey, P.A.2    Formica, M.A.3    Cox, C.4    Walsh, E.E.5
  • 10
    • 0031043248 scopus 로고    scopus 로고
    • Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled
    • Ferrucci L, Guralnik JM, Pahor M, Corti MC, Havlik RJ. Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled. JAMA (1997) 277(9):728-34.
    • (1997) JAMA , vol.277 , Issue.9 , pp. 728-734
    • Ferrucci, L.1    Guralnik, J.M.2    Pahor, M.3    Corti, M.C.4    Havlik, R.J.5
  • 11
    • 0027973478 scopus 로고
    • The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial
    • Govaert TM, Thijs CT, Masurel N, Sprenger MJ, Dinant GJ, Knottnerus JA. The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial. JAMA (1994) 272(21):1661-5.
    • (1994) JAMA , vol.272 , Issue.21 , pp. 1661-1665
    • Govaert, T.M.1    Thijs, C.T.2    Masurel, N.3    Sprenger, M.J.4    Dinant, G.J.5    Knottnerus, J.A.6
  • 12
    • 77952316050 scopus 로고    scopus 로고
    • Sensitivity analyses to estimate the potential impact of unmeasured confounding in causal research
    • Groenwold RH, Nelson DB, Nichol KL, Hoes AW, Hak E. Sensitivity analyses to estimate the potential impact of unmeasured confounding in causal research. Int J Epidemiol (2010) 39(1):107-17. doi:10.1093/ije/dyp332.
    • (2010) Int J Epidemiol , vol.39 , Issue.1 , pp. 107-117
    • Groenwold, R.H.1    Nelson, D.B.2    Nichol, K.L.3    Hoes, A.W.4    Hak, E.5
  • 13
    • 0023851017 scopus 로고
    • Efficacy of sequential annual vaccination with inactivated influenza virus vaccine
    • Keitel WA, Cate TR, Couch RB. Efficacy of sequential annual vaccination with inactivated influenza virus vaccine. Am J Epidemiol (1988) 127(2):353-64.
    • (1988) Am J Epidemiol , vol.127 , Issue.2 , pp. 353-364
    • Keitel, W.A.1    Cate, T.R.2    Couch, R.B.3
  • 14
    • 0029096040 scopus 로고
    • Reduction in mortality associated with influenza vaccine during 1989-90 epidemic
    • Ahmed AE, Nicholson KG, Nguyen-Van-Tam JS. Reduction in mortality associated with influenza vaccine during 1989-90 epidemic. Lancet (1995) 346(8975):591-5. doi:10.1016/S0140-6736(95)91434-X.
    • (1995) Lancet , vol.346 , Issue.8975 , pp. 591-595
    • Ahmed, A.E.1    Nicholson, K.G.2    Nguyen-Van-Tam, J.S.3
  • 15
    • 7244229602 scopus 로고    scopus 로고
    • Annual revaccination against influenza and mortality risk in community-dwelling elderly persons
    • Voordouw AC, Sturkenboom MC, Dieleman JP, Stijnen T, Smith DJ, van der Lei J, et al. Annual revaccination against influenza and mortality risk in community-dwelling elderly persons. JAMA (2004) 292(17):2089-95. doi:10.1001/jama.292.17.2089.
    • (2004) JAMA , vol.292 , Issue.17 , pp. 2089-2095
    • Voordouw, A.C.1    Sturkenboom, M.C.2    Dieleman, J.P.3    Stijnen, T.4    Smith, D.J.5    van der Lei, J.6
  • 17
    • 79956110208 scopus 로고    scopus 로고
    • Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey
    • Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ (2011) 183(8):E487-94. doi:10.1503/cmaj.101271.
    • (2011) CMAJ , vol.183 , Issue.8 , pp. E487-E494
    • Rockwood, K.1    Song, X.2    Mitnitski, A.3
  • 19
    • 34548847744 scopus 로고    scopus 로고
    • Mortality benefits of influenza vaccination in elderly people: an ongoing controversy
    • Simonsen L, Taylor RJ, Viboud C, Miller MA, Jackson LA. Mortality benefits of influenza vaccination in elderly people: an ongoing controversy. Lancet Infect Dis (2007) 7(10):658-66. doi:10.1016/S1473-3099(07)70236-0.
    • (2007) Lancet Infect Dis , vol.7 , Issue.10 , pp. 658-666
    • Simonsen, L.1    Taylor, R.J.2    Viboud, C.3    Miller, M.A.4    Jackson, L.A.5
  • 20
    • 48149110000 scopus 로고    scopus 로고
    • Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study
    • Jackson ML, Nelson JC, Weiss NS, Neuzil KM, Barlow W, Jackson LA. Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study. Lancet (2008) 372(9636):398-405. doi:10.1016/S0140-6736(08)61160-5.
    • (2008) Lancet , vol.372 , Issue.9636 , pp. 398-405
    • Jackson, M.L.1    Nelson, J.C.2    Weiss, N.S.3    Neuzil, K.M.4    Barlow, W.5    Jackson, L.A.6
  • 22
    • 84887607325 scopus 로고    scopus 로고
    • Cochrane re-arranged: support for policies to vaccinate elderly people against influenza
    • Beyer WE, McElhaney J, Smith DJ, Monto AS, Nguyen-Van-Tam JS, Osterhaus AD. Cochrane re-arranged: support for policies to vaccinate elderly people against influenza. Vaccine (2013) 31(50):6030-3. doi:10.1016/j.vaccine.2013.09.063.
    • (2013) Vaccine , vol.31 , Issue.50 , pp. 6030-6033
    • Beyer, W.E.1    McElhaney, J.2    Smith, D.J.3    Monto, A.S.4    Nguyen-Van-Tam, J.S.5    Osterhaus, A.D.6
  • 24
    • 19944392873 scopus 로고    scopus 로고
    • Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
    • Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev (2005) 126(2):351-61.
    • (2005) Mech Ageing Dev , vol.126 , Issue.2 , pp. 351-361
    • Franceschi, C.1    Olivieri, F.2    Marchegiani, F.3    Cardelli, M.4    Cavallone, L.5    Capri, M.6
  • 25
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev (2007) 128(1):92-105. doi:10.1016/j.mad.2006.11.016.
    • (2007) Mech Ageing Dev , vol.128 , Issue.1 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5    Sevini, F.6
  • 26
    • 1642329318 scopus 로고    scopus 로고
    • Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
    • Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol (2004) 59(3):255-63. doi:10.1093/gerona/59.3.M255.
    • (2004) J Gerontol , vol.59 , Issue.3 , pp. 255-263
    • Fried, L.P.1    Ferrucci, L.2    Darer, J.3    Williamson, J.D.4    Anderson, G.5
  • 27
    • 34548393607 scopus 로고    scopus 로고
    • Frailty: an emerging research and clinical paradigm-issues and controversies
    • Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, et al. Frailty: an emerging research and clinical paradigm-issues and controversies. J Gerontol (2007) 62(7):731-7. doi:10.1093/gerona/62.7.731.
    • (2007) J Gerontol , vol.62 , Issue.7 , pp. 731-737
    • Bergman, H.1    Ferrucci, L.2    Guralnik, J.3    Hogan, D.B.4    Hummel, S.5    Karunananthan, S.6
  • 28
    • 34247132167 scopus 로고    scopus 로고
    • Frailty in elderly people
    • Strandberg TE, Pitkala KH. Frailty in elderly people. Lancet (2007) 369(9570):1328-9. doi:10.1016/S0140-6736(07)60613-8.
    • (2007) Lancet , vol.369 , Issue.9570 , pp. 1328-1329
    • Strandberg, T.E.1    Pitkala, K.H.2
  • 29
    • 84908089693 scopus 로고    scopus 로고
    • Standard laboratory tests to identify older adults at increased risk of death
    • Howlett SE, Rockwood MR, Mitnitski A, Rockwood K. Standard laboratory tests to identify older adults at increased risk of death. BMC Med (2014) 12:171. doi:10.1186/s12916-014-0171-9.
    • (2014) BMC Med , vol.12 , pp. 171
    • Howlett, S.E.1    Rockwood, M.R.2    Mitnitski, A.3    Rockwood, K.4
  • 30
    • 34247578803 scopus 로고    scopus 로고
    • Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept
    • Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc (2007) 55(5):780-91. doi:10.1111/j.1532-5415.2007.01156.x.
    • (2007) J Am Geriatr Soc , vol.55 , Issue.5 , pp. 780-791
    • Inouye, S.K.1    Studenski, S.2    Tinetti, M.E.3    Kuchel, G.A.4
  • 31
    • 33646729036 scopus 로고    scopus 로고
    • Determinants of physical health in frail older people: the importance of self-efficacy
    • Stretton CM, Latham NK, Carter KN, Lee AC, Anderson CS. Determinants of physical health in frail older people: the importance of self-efficacy. Clin Rehabil (2006) 20(4):357-66. doi:10.1191/0269215506cr946oa.
    • (2006) Clin Rehabil , vol.20 , Issue.4 , pp. 357-366
    • Stretton, C.M.1    Latham, N.K.2    Carter, K.N.3    Lee, A.C.4    Anderson, C.S.5
  • 32
    • 75749143469 scopus 로고    scopus 로고
    • Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index
    • Rockwood K, Rockwood MR, Mitnitski A. Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index. J Am Geriatr Soc (2010) 58(2):318-23. doi:10.1111/j.1532-5415.2009.02667.x.
    • (2010) J Am Geriatr Soc , vol.58 , Issue.2 , pp. 318-323
    • Rockwood, K.1    Rockwood, M.R.2    Mitnitski, A.3
  • 33
    • 77950439322 scopus 로고    scopus 로고
    • Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation
    • Song X, Mitnitski A, Rockwood K. Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. J Am Geriatr Soc (2010) 58(4):681-7. doi:10.1111/j.1532-5415.2010.02764.x.
    • (2010) J Am Geriatr Soc , vol.58 , Issue.4 , pp. 681-687
    • Song, X.1    Mitnitski, A.2    Rockwood, K.3
  • 35
    • 84857910024 scopus 로고    scopus 로고
    • Relationship between functional ability in older people, immune system status, and intensity of response to CMV
    • Moro-Garcia MA, Alonso-Arias R, Lopez-Vazquez A, Suarez-Garcia FM, Solano-Jaurrieta JJ, Baltar J, et al. Relationship between functional ability in older people, immune system status, and intensity of response to CMV. Age (Dordr) (2012) 34(2):479-95. doi:10.1007/s11357-011-9240-6.
    • (2012) Age (Dordr) , vol.34 , Issue.2 , pp. 479-495
    • Moro-Garcia, M.A.1    Alonso-Arias, R.2    Lopez-Vazquez, A.3    Suarez-Garcia, F.M.4    Solano-Jaurrieta, J.J.5    Baltar, J.6
  • 36
    • 68149148869 scopus 로고    scopus 로고
    • Biomarkers of human immunosenescence: impact of cytomegalovirus infection
    • Derhovanessian E, Larbi A, Pawelec G. Biomarkers of human immunosenescence: impact of cytomegalovirus infection. Curr Opin Immunol (2009) 21(4):440-5. doi:10.1016/j.coi.2009.05.012.
    • (2009) Curr Opin Immunol , vol.21 , Issue.4 , pp. 440-445
    • Derhovanessian, E.1    Larbi, A.2    Pawelec, G.3
  • 37
    • 0035202615 scopus 로고    scopus 로고
    • Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
    • Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, O'Fallon WM, Weyand CM. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol (2001) 75(24):12182-7. doi:10.1128/JVI.75.24.12182-12187.2001.
    • (2001) J Virol , vol.75 , Issue.24 , pp. 12182-12187
    • Goronzy, J.J.1    Fulbright, J.W.2    Crowson, C.S.3    Poland, G.A.4    O'Fallon, W.M.5    Weyand, C.M.6
  • 38
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • Saurwein-Teissl M, Lung TL, Marx F, Gschosser C, Asch E, Blasko I, et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol (2002) 168(11):5893-9. doi:10.4049/jimmunol.168.11.5893.
    • (2002) J Immunol , vol.168 , Issue.11 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3    Gschosser, C.4    Asch, E.5    Blasko, I.6
  • 39
    • 14744281718 scopus 로고    scopus 로고
    • Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
    • Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Wurzner R, et al. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol (2005) 79(6):3675-83. doi:10.1128/JVI.79.6.3675-3683.2005.
    • (2005) J Virol , vol.79 , Issue.6 , pp. 3675-3683
    • Almanzar, G.1    Schwaiger, S.2    Jenewein, B.3    Keller, M.4    Herndler-Brandstetter, D.5    Wurzner, R.6
  • 42
    • 20444481012 scopus 로고    scopus 로고
    • Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women
    • Schmaltz HN, Fried LP, Xue QL, Walston J, Leng SX, Semba RD. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc (2005) 53(5):747-54. doi:10.1111/j.1532-5415.2005.53250.x.
    • (2005) J Am Geriatr Soc , vol.53 , Issue.5 , pp. 747-754
    • Schmaltz, H.N.1    Fried, L.P.2    Xue, Q.L.3    Walston, J.4    Leng, S.X.5    Semba, R.D.6
  • 43
    • 84875417243 scopus 로고    scopus 로고
    • Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation
    • Choi YS, Eto D, Yang JA, Lao C, Crotty S. Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation. J Immunol (2013) 190(7):3049-53. doi:10.4049/jimmunol.1203032.
    • (2013) J Immunol , vol.190 , Issue.7 , pp. 3049-3053
    • Choi, Y.S.1    Eto, D.2    Yang, J.A.3    Lao, C.4    Crotty, S.5
  • 44
    • 78650647731 scopus 로고    scopus 로고
    • TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism
    • Jones SC, Brahmakshatriya V, Huston G, Dibble J, Swain SL. TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism. J Immunol (2010) 185(11):6783-94. doi:10.4049/jimmunol.0901296.
    • (2010) J Immunol , vol.185 , Issue.11 , pp. 6783-6794
    • Jones, S.C.1    Brahmakshatriya, V.2    Huston, G.3    Dibble, J.4    Swain, S.L.5
  • 45
    • 84898783099 scopus 로고    scopus 로고
    • CD4 T cell defects in the aged: causes, consequences and strategies to circumvent
    • Zhang W, Brahmakshatriya V, Swain SL. CD4 T cell defects in the aged: causes, consequences and strategies to circumvent. Exp Gerontol (2014) 54:67-70. doi:10.1016/j.exger.2014.01.002.
    • (2014) Exp Gerontol , vol.54 , pp. 67-70
    • Zhang, W.1    Brahmakshatriya, V.2    Swain, S.L.3
  • 46
    • 84927750142 scopus 로고    scopus 로고
    • Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults
    • Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, et al. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis (2015) 211(7):1174-84. doi:10.1093/infdis/jiu573.
    • (2015) J Infect Dis , vol.211 , Issue.7 , pp. 1174-1184
    • Mohanty, S.1    Joshi, S.R.2    Ueda, I.3    Wilson, J.4    Blevins, T.P.5    Siconolfi, B.6
  • 47
    • 79851497888 scopus 로고    scopus 로고
    • Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age
    • Skowronski DM, Hottes TS, McElhaney JE, Janjua NZ, Sabaiduc S, Chan T, et al. Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age. J Infect Dis (2011) 203:158-67. doi:10.1093/infdis/jiq039.
    • (2011) J Infect Dis , vol.203 , pp. 158-167
    • Skowronski, D.M.1    Hottes, T.S.2    McElhaney, J.E.3    Janjua, N.Z.4    Sabaiduc, S.5    Chan, T.6
  • 48
    • 33646468500 scopus 로고    scopus 로고
    • T cell responses are better correlates of vaccine protection in the elderly
    • McElhaney JE, Xie D, Hager WD, Barry MB, Wang Y, Kleppinger A, et al. T cell responses are better correlates of vaccine protection in the elderly. J Immunol (2006) 176(10):6333-9. doi:10.4049/jimmunol.176.10.6333.
    • (2006) J Immunol , vol.176 , Issue.10 , pp. 6333-6339
    • McElhaney, J.E.1    Xie, D.2    Hager, W.D.3    Barry, M.B.4    Wang, Y.5    Kleppinger, A.6
  • 49
    • 84878449660 scopus 로고    scopus 로고
    • AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial
    • McElhaney JE, Beran J, Devaster JM, Esen M, Launay O, Leroux-Roels G, et al. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. Lancet Infect Dis (2013) 13(6):485-96. doi:10.1016/S1473-3099(13)70046-X.
    • (2013) Lancet Infect Dis , vol.13 , Issue.6 , pp. 485-496
    • McElhaney, J.E.1    Beran, J.2    Devaster, J.M.3    Esen, M.4    Launay, O.5    Leroux-Roels, G.6
  • 50
    • 84906232635 scopus 로고    scopus 로고
    • Efficacy of high-dose versus standard-dose influenza vaccine in older adults
    • DiazGranados CA, Dunning AJ, Kimmel M, Kirby D, Treanor J, Collins A, et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med (2014) 371(7):635-45. doi:10.1056/NEJMoa1315727.
    • (2014) N Engl J Med , vol.371 , Issue.7 , pp. 635-645
    • DiazGranados, C.A.1    Dunning, A.J.2    Kimmel, M.3    Kirby, D.4    Treanor, J.5    Collins, A.6
  • 51
    • 84914148387 scopus 로고    scopus 로고
    • Ageing and respiratory infections: the airway of ageing
    • Haq K, McElhaney JE. Ageing and respiratory infections: the airway of ageing. Immunol Lett (2014) 162(1 Pt B):323-8. doi:10.1016/j.imlet.2014.06.009.
    • (2014) Immunol Lett , vol.162 , Issue.1 , pp. 323-328
    • Haq, K.1    McElhaney, J.E.2
  • 52
    • 84900435086 scopus 로고    scopus 로고
    • Immunosenescence: influenza vaccination and the elderly
    • Haq K, McElhaney JE. Immunosenescence: influenza vaccination and the elderly. Curr Opin Immunol (2014) 29:38-42. doi:10.1016/j.coi.2014.03.008.
    • (2014) Curr Opin Immunol , vol.29 , pp. 38-42
    • Haq, K.1    McElhaney, J.E.2
  • 53
    • 84902273706 scopus 로고    scopus 로고
    • B cell function and influenza vaccine responses in healthy aging and disease
    • Frasca D, Blomberg BB. B cell function and influenza vaccine responses in healthy aging and disease. Curr Opin Immunol (2014) 29:112-8. doi:10.1016/j.coi.2014.05.008.
    • (2014) Curr Opin Immunol , vol.29 , pp. 112-118
    • Frasca, D.1    Blomberg, B.B.2
  • 54
    • 0029890233 scopus 로고    scopus 로고
    • In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue
    • Baumgarth N, Kelso A. In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue. J Virol (1996) 70(7):4411-8.
    • (1996) J Virol , vol.70 , Issue.7 , pp. 4411-4418
    • Baumgarth, N.1    Kelso, A.2
  • 55
    • 84864746073 scopus 로고    scopus 로고
    • Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms
    • McKinstry KK, Strutt TM, Kuang Y, Brown DM, Sell S, Dutton RW, et al. Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest (2012) 122(8):2847-56. doi:10.1172/JCI63689.
    • (2012) J Clin Invest , vol.122 , Issue.8 , pp. 2847-2856
    • McKinstry, K.K.1    Strutt, T.M.2    Kuang, Y.3    Brown, D.M.4    Sell, S.5    Dutton, R.W.6
  • 56
    • 0027941401 scopus 로고
    • Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection
    • Graham MB, Braciale VL, Braciale TJ. Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection. J Exp Med (1994) 180(4):1273-82. doi:10.1084/jem.180.4.1273.
    • (1994) J Exp Med , vol.180 , Issue.4 , pp. 1273-1282
    • Graham, M.B.1    Braciale, V.L.2    Braciale, T.J.3
  • 57
    • 84855890988 scopus 로고    scopus 로고
    • GLA-SE, a synthetic TLR4 agonist, enhances T cell responses to influenza vaccine in older adults
    • Behzad H, Huckriede A, Haynes L, Gentleman B, Coyle K, Wilschut JC, et al. GLA-SE, a synthetic TLR4 agonist, enhances T cell responses to influenza vaccine in older adults. J Infect Dis (2012) 205(3):466-73. doi:10.1093/infdis/jir769.
    • (2012) J Infect Dis , vol.205 , Issue.3 , pp. 466-473
    • Behzad, H.1    Huckriede, A.2    Haynes, L.3    Gentleman, B.4    Coyle, K.5    Wilschut, J.C.6
  • 58
    • 84946237693 scopus 로고    scopus 로고
    • The regulatory role of B cells in autoimmunity, infections and cancer: perspectives beyond IL10 production
    • Gorosito Serran M, Fiocca Vernengo F, Beccaria CG, Acosta Rodriguez EV, Montes CL, Gruppi A. The regulatory role of B cells in autoimmunity, infections and cancer: perspectives beyond IL10 production. FEBS Lett (2015) 589(22):3362-9. doi:10.1016/j.febslet.2015.08.048.
    • (2015) FEBS Lett , vol.589 , Issue.22 , pp. 3362-3369
    • Gorosito Serran, M.1    Fiocca Vernengo, F.2    Beccaria, C.G.3    Acosta Rodriguez, E.V.4    Montes, C.L.5    Gruppi, A.6
  • 60
    • 0344304396 scopus 로고    scopus 로고
    • CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
    • Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A (2003) 100(25):15053-8. doi:10.1073/pnas.2433717100.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.25 , pp. 15053-15058
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 61
    • 77951243991 scopus 로고    scopus 로고
    • Differential impact of ageing on cellular and humoral immunity to a persistent murine gamma-herpesvirus
    • Yager EJ, Kim IJ, Freeman ML, Lanzer KG, Burkum CE, Cookenham T, et al. Differential impact of ageing on cellular and humoral immunity to a persistent murine gamma-herpesvirus. Immun Ageing (2010) 7:3. doi:10.1186/1742-4933-7-3.
    • (2010) Immun Ageing , vol.7 , pp. 3
    • Yager, E.J.1    Kim, I.J.2    Freeman, M.L.3    Lanzer, K.G.4    Burkum, C.E.5    Cookenham, T.6
  • 62
    • 84885416699 scopus 로고    scopus 로고
    • Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans
    • Dolfi DV, Mansfield KD, Kurupati RK, Kannan S, Doyle SA, Ertl HC, et al. Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. PLoS One (2013) 8(10):e77164. doi:10.1371/journal.pone.0077164.
    • (2013) PLoS One , vol.8 , Issue.10
    • Dolfi, D.V.1    Mansfield, K.D.2    Kurupati, R.K.3    Kannan, S.4    Doyle, S.A.5    Ertl, H.C.6
  • 63
    • 84862776631 scopus 로고    scopus 로고
    • Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
    • Wilkinson TM, Li CK, Chui CS, Huang AK, Perkins M, Liebner JC, et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med (2012) 18(2):274-80. doi:10.1038/nm.2612.
    • (2012) Nat Med , vol.18 , Issue.2 , pp. 274-280
    • Wilkinson, T.M.1    Li, C.K.2    Chui, C.S.3    Huang, A.K.4    Perkins, M.5    Liebner, J.C.6
  • 64
    • 84887473368 scopus 로고    scopus 로고
    • Cellular immune correlates of protection against symptomatic pandemic influenza
    • Sridhar S, Begom S, Bermingham A, Hoschler K, Adamson W, Carman W, et al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med (2013) 19(10):1305-12. doi:10.1038/nm.3350.
    • (2013) Nat Med , vol.19 , Issue.10 , pp. 1305-1312
    • Sridhar, S.1    Begom, S.2    Bermingham, A.3    Hoschler, K.4    Adamson, W.5    Carman, W.6
  • 65
    • 0032212474 scopus 로고    scopus 로고
    • Cytokine production after influenza vaccination in a healthy elderly population
    • Bernstein ED, Gardner EM, Abrutyn E, Gross P, Murasko DM. Cytokine production after influenza vaccination in a healthy elderly population. Vaccine (1998) 16(18):1722-31. doi:10.1016/S0264-410X(98)00140-6.
    • (1998) Vaccine , vol.16 , Issue.18 , pp. 1722-1731
    • Bernstein, E.D.1    Gardner, E.M.2    Abrutyn, E.3    Gross, P.4    Murasko, D.M.5
  • 66
    • 0027402746 scopus 로고
    • Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine
    • Powers DC, Belshe RB. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J Infect Dis (1993) 167(3):584-92. doi:10.1093/infdis/167.3.584.
    • (1993) J Infect Dis , vol.167 , Issue.3 , pp. 584-592
    • Powers, D.C.1    Belshe, R.B.2
  • 67
    • 62749155684 scopus 로고    scopus 로고
    • Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults
    • McElhaney JE, Ewen C, Zhou X, Kane KP, Xie D, Hager WD, et al. Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine (2009) 27:2418-25. doi:10.1016/j.vaccine.2009.01.136.
    • (2009) Vaccine , vol.27 , pp. 2418-2425
    • McElhaney, J.E.1    Ewen, C.2    Zhou, X.3    Kane, K.P.4    Xie, D.5    Hager, W.D.6
  • 68
    • 77955665631 scopus 로고    scopus 로고
    • Clinical and immunologic predictors of influenza illness among vaccinated older adults
    • Shahid Z, Kleppinger A, Gentleman B, Falsey AR, McElhaney JE. Clinical and immunologic predictors of influenza illness among vaccinated older adults. Vaccine (2010) 28(38):6145-51. doi:10.1016/j.vaccine.2010.07.036.
    • (2010) Vaccine , vol.28 , Issue.38 , pp. 6145-6151
    • Shahid, Z.1    Kleppinger, A.2    Gentleman, B.3    Falsey, A.R.4    McElhaney, J.E.5
  • 69
    • 84926681491 scopus 로고    scopus 로고
    • Clinical effectiveness of split-virion versus subunit trivalent influenza vaccines in older adults
    • Talbot HK, Nian H, Zhu Y, Chen Q, Williams JV, Griffin MR. Clinical effectiveness of split-virion versus subunit trivalent influenza vaccines in older adults. Clin Infect Dis (2015) 60(8):1170-5. doi:10.1093/cid/civ019.
    • (2015) Clin Infect Dis , vol.60 , Issue.8 , pp. 1170-1175
    • Talbot, H.K.1    Nian, H.2    Zhu, Y.3    Chen, Q.4    Williams, J.V.5    Griffin, M.R.6
  • 70
    • 77957038309 scopus 로고    scopus 로고
    • The 6-minute walk is associated with frailty and predicts mortality in older adults with heart failure
    • Boxer R, Kleppinger A, Ahmad A, Annis K, Hager D, Kenny A. The 6-minute walk is associated with frailty and predicts mortality in older adults with heart failure. Congest Heart Fail (2010) 16(5):208-13. doi:10.1111/j.1751-7133.2010.00151.x.
    • (2010) Congest Heart Fail , vol.16 , Issue.5 , pp. 208-213
    • Boxer, R.1    Kleppinger, A.2    Ahmad, A.3    Annis, K.4    Hager, D.5    Kenny, A.6
  • 71
    • 84877812916 scopus 로고    scopus 로고
    • Frailty, inflammation, and immunity
    • Li H, Manwani B, Leng SX. Frailty, inflammation, and immunity. Aging Dis (2011) 2(6):466-73.
    • (2011) Aging Dis , vol.2 , Issue.6 , pp. 466-473
    • Li, H.1    Manwani, B.2    Leng, S.X.3
  • 72
    • 84862776821 scopus 로고    scopus 로고
    • The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
    • McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, et al. The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine (2012) 30(12):2060-7. doi:10.1016/j.vaccine.2012.01.015.
    • (2012) Vaccine , vol.30 , Issue.12 , pp. 2060-2067
    • McElhaney, J.E.1    Zhou, X.2    Talbot, H.K.3    Soethout, E.4    Bleackley, R.C.5    Granville, D.J.6
  • 73
    • 84907223820 scopus 로고    scopus 로고
    • Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly
    • Derhovanessian E, Maier AB, Hahnel K, McElhaney JE, Slagboom EP, Pawelec G. Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly. J Immunol (2014) 193(7):3624-31. doi:10.4049/jimmunol.1303361.
    • (2014) J Immunol , vol.193 , Issue.7 , pp. 3624-3631
    • Derhovanessian, E.1    Maier, A.B.2    Hahnel, K.3    McElhaney, J.E.4    Slagboom, E.P.5    Pawelec, G.6
  • 74
    • 84971231130 scopus 로고    scopus 로고
    • Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes
    • McElhaney JE, Garneau H, Camous X, Dupuis G, Pawelec G, Baehl S, et al. Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes. BMJ Open Diabetes Res Care (2015) 3(1):e000140. doi:10.1136/bmjdrc-2015-000140.
    • (2015) BMJ Open Diabetes Res Care , vol.3 , Issue.1
    • McElhaney, J.E.1    Garneau, H.2    Camous, X.3    Dupuis, G.4    Pawelec, G.5    Baehl, S.6
  • 75
    • 84943419230 scopus 로고    scopus 로고
    • Telomere length as an indicator of the robustness of B-and T-cell response to influenza in older adults
    • Najarro K, Nguyen H, Chen G, Xu M, Alcorta S, Yao X, et al. Telomere length as an indicator of the robustness of B-and T-cell response to influenza in older adults. J Infect Dis (2015) 212(8):1261-9. doi:10.1093/infdis/jiv202.
    • (2015) J Infect Dis , vol.212 , Issue.8 , pp. 1261-1269
    • Najarro, K.1    Nguyen, H.2    Chen, G.3    Xu, M.4    Alcorta, S.5    Yao, X.6
  • 76
    • 79951786443 scopus 로고    scopus 로고
    • Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans
    • Zhou X, McElhaney JE. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine (2011) 29(11):2169-77. doi:10.1016/j.vaccine.2010.12.029.
    • (2011) Vaccine , vol.29 , Issue.11 , pp. 2169-2177
    • Zhou, X.1    McElhaney, J.E.2
  • 77
    • 2942746461 scopus 로고    scopus 로고
    • Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine
    • Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, et al. Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine. J Immunol (2004) 173(1):673-81. doi:10.4049/jimmunol.173.1.673.
    • (2004) J Immunol , vol.173 , Issue.1 , pp. 673-681
    • Kang, I.1    Hong, M.S.2    Nolasco, H.3    Park, S.H.4    Dan, J.M.5    Choi, J.Y.6
  • 78
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol (2011) 29:621-63. doi:10.1146/annurev-immunol-031210-101400.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 79
    • 68149181484 scopus 로고    scopus 로고
    • Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells
    • Maue AC, Eaton SM, Lanthier PA, Sweet KB, Blumerman SL, Haynes L. Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J Immunol (2009) 182(10):6129-35. doi:10.4049/jimmunol.0804226.
    • (2009) J Immunol , vol.182 , Issue.10 , pp. 6129-6135
    • Maue, A.C.1    Eaton, S.M.2    Lanthier, P.A.3    Sweet, K.B.4    Blumerman, S.L.5    Haynes, L.6
  • 80
    • 79251521021 scopus 로고    scopus 로고
    • Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • Morita R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity (2011) 34(1):108-21. doi:10.1016/j.immuni.2010.12.012.
    • (2011) Immunity , vol.34 , Issue.1 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.E.3    Ranganathan, R.4    Bourdery, L.5    Zurawski, G.6
  • 81
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
    • Rasheed AU, Rahn HP, Sallusto F, Lipp M, Muller G. Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur J Immunol (2006) 36(7):1892-903. doi:10.1002/eji.200636136.
    • (2006) Eur J Immunol , vol.36 , Issue.7 , pp. 1892-1903
    • Rasheed, A.U.1    Rahn, H.P.2    Sallusto, F.3    Lipp, M.4    Muller, G.5
  • 82
    • 84875129611 scopus 로고    scopus 로고
    • Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination
    • Bentebibel SE, Lopez S, Obermoser G, Schmitt N, Mueller C, Harrod C, et al. Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Sci Transl Med (2013) 5(176):176ra32. doi:10.1126/scitranslmed.3005191.
    • (2013) Sci Transl Med , vol.5 , Issue.176
    • Bentebibel, S.E.1    Lopez, S.2    Obermoser, G.3    Schmitt, N.4    Mueller, C.5    Harrod, C.6
  • 83
    • 79956196930 scopus 로고    scopus 로고
    • CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses
    • Chevalier N, Jarrossay D, Ho E, Avery DT, Ma CS, Yu D, et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol (2011) 186(10):5556-68. doi:10.4049/jimmunol.1002828.
    • (2011) J Immunol , vol.186 , Issue.10 , pp. 5556-5568
    • Chevalier, N.1    Jarrossay, D.2    Ho, E.3    Avery, D.T.4    Ma, C.S.5    Yu, D.6
  • 84
    • 84907200998 scopus 로고    scopus 로고
    • Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults
    • Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, et al. Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. J Immunol (2014) 193(7):3528-37. doi:10.4049/jimmunol.1302503.
    • (2014) J Immunol , vol.193 , Issue.7 , pp. 3528-3537
    • Herati, R.S.1    Reuter, M.A.2    Dolfi, D.V.3    Mansfield, K.D.4    Aung, H.5    Badwan, O.Z.6
  • 85
    • 58849118836 scopus 로고    scopus 로고
    • Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    • Huehn J, Polansky JK, Hamann A. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol (2009) 9(2):83-9. doi:10.1038/nri2474.
    • (2009) Nat Rev Immunol , vol.9 , Issue.2 , pp. 83-89
    • Huehn, J.1    Polansky, J.K.2    Hamann, A.3
  • 86
    • 33845408098 scopus 로고    scopus 로고
    • High accumulation of T regulatory cells prevents the activation of immune responses in aged animals
    • Sharma S, Dominguez AL, Lustgarten J. High accumulation of T regulatory cells prevents the activation of immune responses in aged animals. J Immunol (2006) 177(12):8348-55. doi:10.4049/jimmunol.177.12.8348.
    • (2006) J Immunol , vol.177 , Issue.12 , pp. 8348-8355
    • Sharma, S.1    Dominguez, A.L.2    Lustgarten, J.3
  • 87
    • 3242787209 scopus 로고    scopus 로고
    • Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity
    • Mendez S, Reckling SK, Piccirillo CA, Sacks D, Belkaid Y. Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med (2004) 200(2):201-10. doi:10.1084/jem.20040298.
    • (2004) J Exp Med , vol.200 , Issue.2 , pp. 201-210
    • Mendez, S.1    Reckling, S.K.2    Piccirillo, C.A.3    Sacks, D.4    Belkaid, Y.5
  • 88
    • 84901430100 scopus 로고    scopus 로고
    • Aging is associated with increased regulatory T-cell function
    • Garg SK, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, et al. Aging is associated with increased regulatory T-cell function. Aging Cell (2014) 13(3):441-8. doi:10.1111/acel.12191.
    • (2014) Aging Cell , vol.13 , Issue.3 , pp. 441-448
    • Garg, S.K.1    Delaney, C.2    Toubai, T.3    Ghosh, A.4    Reddy, P.5    Banerjee, R.6
  • 89
    • 17144423893 scopus 로고    scopus 로고
    • The vascular depression hypothesis: the influence of age on the relationship between cerebrovascular risk factors and depressive symptoms in community dwelling elders
    • Mast BT, Azar AR, Murrell SA. The vascular depression hypothesis: the influence of age on the relationship between cerebrovascular risk factors and depressive symptoms in community dwelling elders. Aging Ment Health (2005) 9(2):146-52. doi:10.1080/13607860412331336832.
    • (2005) Aging Ment Health , vol.9 , Issue.2 , pp. 146-152
    • Mast, B.T.1    Azar, A.R.2    Murrell, S.A.3
  • 90
    • 85014178199 scopus 로고    scopus 로고
    • Institute of Medicine Committee on Qualifications of Biomarkers and Surrogate Endpoints in Chronic Disease. Washington, DC
    • Micheel CM, Ball JR. Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Institute of Medicine Committee on Qualifications of Biomarkers and Surrogate Endpoints in Chronic Disease. Washington, DC (2010). doi:10.17226/12869.
    • (2010) Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
    • Micheel, C.M.1    Ball, J.R.2
  • 91
    • 0030849677 scopus 로고    scopus 로고
    • The association of plasma IL-6 levels with functional disability in community-dwelling elderly
    • Cohen HJ, Pieper CF, Harris T, Rao KM, Currie MS. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol (1997) 52(4):M201-8. doi:10.1093/gerona/52A.4.M201.
    • (1997) J Gerontol , vol.52 , Issue.4 , pp. M201-M208
    • Cohen, H.J.1    Pieper, C.F.2    Harris, T.3    Rao, K.M.4    Currie, M.S.5
  • 92
    • 79955650634 scopus 로고    scopus 로고
    • The pro-and anti-inflammatory properties of the cytokine interleukin-6
    • Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro-and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta (2011) 1813(5):878-88. doi:10.1016/j.bbamcr.2011.01.034.
    • (2011) Biochim Biophys Acta , vol.1813 , Issue.5 , pp. 878-888
    • Scheller, J.1    Chalaris, A.2    Schmidt-Arras, D.3    Rose-John, S.4
  • 93
    • 84940004282 scopus 로고    scopus 로고
    • IL-6 and IGF-1 signaling within and between muscle and bone: how important is the mTOR pathway for bone metabolism?
    • Bakker AD, Jaspers RT. IL-6 and IGF-1 signaling within and between muscle and bone: how important is the mTOR pathway for bone metabolism? Curr Osteoporos Rep (2015) 13(3):131-9. doi:10.1007/s11914-015-0264-1.
    • (2015) Curr Osteoporos Rep , vol.13 , Issue.3 , pp. 131-139
    • Bakker, A.D.1    Jaspers, R.T.2
  • 94
    • 70350159156 scopus 로고    scopus 로고
    • Adolph distinguished lecture: muscle as an endocrine organ: IL-6 and other myokines
    • Pedersen BK, Edward F. Adolph distinguished lecture: muscle as an endocrine organ: IL-6 and other myokines. J Appl Physiol (1985) (2009) 107(4):1006-14. doi:10.1152/japplphysiol.00734.2009.
    • (2009) J Appl Physiol (1985) , vol.107 , Issue.4 , pp. 1006-1014
    • Pedersen, B.K.1    Edward, F.2
  • 96
    • 79952428226 scopus 로고    scopus 로고
    • IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage
    • Toth KG, McKay BR, De Lisio M, Little JP, Tarnopolsky MA, Parise G. IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage. PLoS One (2011) 6(3):e17392. doi:10.1371/journal.pone.0017392.
    • (2011) PLoS One , vol.6 , Issue.3
    • Toth, K.G.1    McKay, B.R.2    De Lisio, M.3    Little, J.P.4    Tarnopolsky, M.A.5    Parise, G.6
  • 98
    • 37449022587 scopus 로고    scopus 로고
    • Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy
    • Serrano AL, Baeza-Raja B, Perdiguero E, Jardi M, Munoz-Canoves P. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab (2008) 7(1):33-44. doi:10.1016/j.cmet.2007.11.011.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 33-44
    • Serrano, A.L.1    Baeza-Raja, B.2    Perdiguero, E.3    Jardi, M.4    Munoz-Canoves, P.5
  • 99
    • 84876196796 scopus 로고    scopus 로고
    • A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
    • Voorhees PM, Manges RF, Sonneveld P, Jagannath S, Somlo G, Krishnan A, et al. A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma. Br J Haematol (2013) 161(3):357-66. doi:10.1111/bjh.12266.
    • (2013) Br J Haematol , vol.161 , Issue.3 , pp. 357-366
    • Voorhees, P.M.1    Manges, R.F.2    Sonneveld, P.3    Jagannath, S.4    Somlo, G.5    Krishnan, A.6
  • 100
    • 55349138408 scopus 로고    scopus 로고
    • Exercise training and plasma C-reactive protein and interleukin-6 in elderly people
    • Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, et al. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc (2008) 56(11):2045-52. doi:10.1111/j.1532-5415.2008.01994.x.
    • (2008) J Am Geriatr Soc , vol.56 , Issue.11 , pp. 2045-2052
    • Nicklas, B.J.1    Hsu, F.C.2    Brinkley, T.J.3    Church, T.4    Goodpaster, B.H.5    Kritchevsky, S.B.6
  • 104
    • 33845215290 scopus 로고    scopus 로고
    • Role of T lymphocyte replicative senescence in vaccine efficacy
    • Effros RB. Role of T lymphocyte replicative senescence in vaccine efficacy. Vaccine (2007) 25(4):599-604. doi:10.1016/j.vaccine.2006.08.032.
    • (2007) Vaccine , vol.25 , Issue.4 , pp. 599-604
    • Effros, R.B.1
  • 105
    • 76749084244 scopus 로고    scopus 로고
    • The diagnosis of viral respiratory disease in older adults
    • Talbot HK, Falsey AR. The diagnosis of viral respiratory disease in older adults. Clin Infect Dis (2010) 50(5):747-51. doi:10.1086/650486.
    • (2010) Clin Infect Dis , vol.50 , Issue.5 , pp. 747-751
    • Talbot, H.K.1    Falsey, A.R.2
  • 106
    • 84938765995 scopus 로고    scopus 로고
    • Should clinical case definitions of influenza in hospitalized older adults include fever?
    • Falsey AR, Baran A, Walsh EE. Should clinical case definitions of influenza in hospitalized older adults include fever? Influenza Other Respir Viruses (2015) 9(Suppl 1):23-9. doi:10.1111/irv.12316.
    • (2015) Influenza Other Respir Viruses , vol.9 , pp. 23-29
    • Falsey, A.R.1    Baran, A.2    Walsh, E.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.