Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

Aging Cell

Volumn 10, Issue 5, 2011, Pages 868-878

  Harries, Lorna W ^a   Hernandez, Dena ^b   Henley, William ^c   Wood, Andrew R ^a   Holly, Alice C ^a   Bradley Smith, Rachel M ^a   Yaghootkar, Hanieh ^a   Dutta, Ambarish ^a   Murray, Anna ^a   Frayling, Timothy M ^a   Guralnik, Jack M ^b   Bandinelli, Stefania ^d   Singleton, Andrew ^b   Ferrucci, Luigi ^e   Melzer, David ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF PLYMOUTH   (United Kingdom)

^d Azienda Sanitaria di Firenze   (Italy)

^e HARBOR HOSPITAL   (United States)

Author keywords

Aging; Cell senescence; Gene expression; MRNA processing; Predictive model

Indexed keywords

BIOLOGICAL MARKER; CD27 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; ENDOSIALIN; LEUCINE; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; PROTEIN LRRN3; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; CELL AGING; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE PROBE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION; REAL TIME POLYMERASE CHAIN REACTION; RNA PROCESSING;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ALTERNATIVE SPLICING; BIOLOGICAL MARKERS; COHORT STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOME, HUMAN; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ISOFORMS; RNA, MESSENGER;

EID: 80052803450     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00726.x     Document Type: Article

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