The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: The Swedish HEXA immune study

Age

Volumn 35, Issue 3, 2013, Pages 985-991

  Strindhall, J ^a   Skog, M ^b   Ernerudh, J ^b   Bengner, M ^c   Lofgren S ^c   Matussek, A ^c   Nilsson, B O ^c   Wikby, A ^a  

^a JÖNKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c RYHOV COUNTY HOSPITAL   (Sweden)

Author keywords

Age; Gender; Immune profile; Immunosenescence; T lymphocytes

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

AGED; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4 CD8 RATIO; CD4 LYMPHOCYTE PERCENTAGE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EFFECTOR CELL; FEMALE; GERIATRIC ASSESSMENT; HIGH RISK POPULATION; HUMAN; IMMUNE STATUS; INFECTION RISK; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MORBIDITY; MORTALITY; PREVALENCE; RISK ASSESSMENT; SURVIVAL PREDICTION; T LYMPHOCYTE SUBPOPULATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNITY, CELLULAR; MALE; MORBIDITY; RETROSPECTIVE STUDIES; SWEDEN;

EID: 84880571275     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9400-3     Document Type: Article

References (21)

1. Amadori A, Zamarchi R, De Silvestro G, Forza G, Cavatton G, Danieli GA, Clementi M, Chieco-Bianchi L (1995) Genetic control of the CD4/CD8 T cell ratio in humans. Nat Med 1(12):1279-1283
2. Aspinall R, Pitts D, Lapenna A, Mitchell WA (2010) Immunity in the elderly: the role of the thymus. J Comp Pathol 142:S111-S115
3. Clementi M, Forabosco P, Amadori A, Zamarchi R, De Silvestro G, Di Gianantonio E, Chieco-Bianchi L, Tenconi R (1999) CD4 and CD8 T lymphocyte inheritance. Evidence for major autosomal recessive genes. Hum Genet 105:337-342
4. Effros RB (2007) Telomerase induction in T cells: a cure for aging and disease? Exp Gerontol 42(5):416-420
5. Ferguson F, Wikby A, Maxson P, Olsson J, Johansson B (1995) Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol Biol Sci 50A:B378-B382
6. Huppert FA, Pinto EM, Morgan K, Brayne C (2003) Survival in a population sample is predicted by proportions of lymphocyte subsets. Mech Ageing Dev 124:449-451
7. Lang PO, Govind S, Michel JP, Aspinall R, Mitchell WA (2011) Immunosenescence: implications for vaccination programmes in adults. Maturitas 68:322-330
8. Nilsson BO, Ernerudh J, Johansson B, Evrin PE, Löfgren S, Ferguson F, Wikby A (2003) Morbidity does not influence the T cell immune risk phenotype in the elderly: findings in the Swedish NONA immune study using sample selection protocols. Mech Ageing Dev 124:469-476
9. Olsson J, Wikby A, Johannson B, Löfgren S, Nilsson BO, Ferguson F (2000) Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in very old: Swedish longitudinal OCTO immune study. Mech Ageing Dev 121:187-201
10. Ouyang Q, Wagner WM, Wikby A, Walter S, Aubert G, Dodi AI, Travers P, Pawelec G (2003) Large numbers of dysfunctional CD8+ T-lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 23:247-257
11. Pawelec G, Ferguson F, Wikby A (2001) The SENIEUR protocol after 16 years. Mech Ageing Dev 122:132-134
12. Pawelec G, Larbi A, Derhovanessian E (2010) Senescence of the human immune system. J Comp Pathol 142:39-44
13. Reker-Hadrup S, Strindhall J, Kollgaard T, Seremet T, Johannson B, Pawelec G, thor Straten P, Wikby A (2006) Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and increased number of dysfunctional cytomegalovirus-specific T cells in the elderly. J Immunol 176:2645-2653
14. Saule P, Trauet J, Dutriez V, Lekeux V, Dessaint JP, Labalette M (2006) Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment. Mec Ageing Dev 127:274-281
15. Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE (2011) Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in United States. PLoS One 6(2):e16103
16. Spaulding CS, Guo W, Effros RB (1999) Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol 34:633-644
17. Stowe RP, Kozlova EV, Yetman DL, Walling DM, Goodwin JS, Glaser R (2007) Chronic herpes virus reactivation occurs in aging. Exp Gerontol 42:563-570
18. Strandberg TE, Pitkala KH, Tilvis RS (2009) Cytomegalovirus antibody level and mortality among community-dwelling older adults with stable cardiovascular disease. JAMA 301(4):380-382
19. Wikby A, Maxson P, Olsson J, Johansson B, Ferguson F (1998) Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev 102:187-198
20. Wikby A, Johansson B, Olsson J, Löfgren S, Nilsson BO, Ferguson F (2002) Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 37:445-453
21. Wikby A, Månsson I, Johansson B, Strindhall J, Nilsson SE (2008) The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 200-100 years of age. Biogerontology 9:299-308