Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase

Aging

Volumn 6, Issue 11, 2014, Pages 957-974

  Bektas, Arsun ^a   Zhang, Yongqing ^a   Lehmann, Elin ^a   Wood, William H ^a   Becker, Kevin G ^a   Madara, Karen ^a   Ferrucci, Luigi ^a   Sen, Ranjan ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

CD4+ T cells; Gene expression; Human aging; NF B; PI3K

Indexed keywords

AUTACOID; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; RAPAMYCIN;

ADULT; AGE; AGED; AGING; ANTAGONISTS AND INHIBITORS; CD4+ T LYMPHOCYTE; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; SIGNAL TRANSDUCTION; VERY ELDERLY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; FEMALE; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION, GENETIC;

EID: 84920281589     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100705     Document Type: Article

References (49)

1. Bruunsgaard H and Pedersen BK. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003; 23:15-39.
2. Ferrucci L, Corsi A, Lauretani F, Bandinelli S, Bartali B, Taub DD, Guralnik JM and Longo DL. The origins of age-related proinflammatory state. Blood. 2005; 105:2294-2299.
3. Pawelec G. Hallmarks of human "immunosenescence": adaptation or dysregulation? Immunity & ageing: I & A. 2012; 9:15.
4. Goronzy JJ and Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nature immunology. 2013; 14:428-436.
5. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B and Wikby A. Human immunosenescence: is it infectious? Immunol Rev. 2005; 205:257-268.
6. Lindstrom TM and Robinson WH. Rheumatoid arthritis: a role for immunosenescence? J Am Geriatr Soc. 2010; 58:1565-1575.
7. Ginaldi L, Loreto MF, Corsi MP, Modesti M and De Martinis M. Immunosenescence and infectious diseases. Microbes Infect. 2001; 3:851-857.
8. Derhovanessian E, Solana R, Larbi A and Pawelec G. Immunity, ageing and cancer. Immunity & ageing: I & A. 2008; 5:11.
9. Ferrucci L, Guralnik JM, Pahor M, Corti MC and Havlik RJ. Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled. JAMA: the journal of the American Medical Association. 1997; 277:728-734.
10. Nichol KL. Influenza vaccination in the elderly: impact on hospitalisation and mortality. Drugs Aging. 2005; 22: 495-515.
11. Brubaker AL, Palmer JL and Kovacs EJ. Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models. Aging and disease. 2011; 2:346-360.
12. Ratts RB and Weng NP. Homeostasis of lymphocytes and monocytes in frequent blood donors. Frontiers in immunology. 2012; 3:271.
13. Li G, Yu M, Lee WW, Tsang M, Krishnan E, Weyand CM and Goronzy JJ. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nature medicine. 2012; 18:1518-1524.
14. Mirza N, Pollock K, Hoelzinger DB, Dominguez AL and Lustgarten J. Comparative kinetic analyses of gene profiles of naive CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations. Aging cell. 2011; 10:853-867.
15. Cao JN, Gollapudi S, Sharman EH, Jia Z and Gupta S. Agerelated alterations of gene expression patterns in human CD8+ T cells. Aging cell. 2010; 9:19-31.
16. Remondini D, Salvioli S, Francesconi M, Pierini M, Mazzatti DJ, Powell JR, Zironi I, Bersani F, Castellani G and Franceschi C. Complex patterns of gene expression in human T cells during in vivo aging. Molecular bioSystems. 2010; 6:1983-1992.
17. Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, Guralnik JM, Bandinelli S, Singleton A, et al. Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging cell. 2011; 10:868-878.
18. Kim SY and Volsky DJ. PAGE: parametric analysis of gene set enrichment. BMC Bioinformatics. 2005; 6:144.
19. Tilstra JS, Clauson CL, Niedernhofer LJ and Robbins PD. NFkappaB in Aging and Disease. Aging and disease. 2011; 2:449-465.
20. Lombardi L, Ciana P, Cappellini C, Trecca D, Guerrini L, Migliazza A, Maiolo AT and Neri A. Structural and functional characterization of the promoter regions of the NFKB2 gene. Nucleic acids research. 1995; 23:2328-2336.
21. Bren GD, Solan NJ, Miyoshi H, Pennington KN, Pobst LJ and Paya CV. Transcription of the RelB gene is regulated by NFkappaB. Oncogene. 2001; 20:7722-7733.
22. Bonizzi G and Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends in immunology. 2004; 25:280-288.
23. Dorfman JR and Germain RN. MHC-dependent survival of naive T cells? A complicated answer to a simple question. Microbes Infect. 2002; 4:547-554.
24. Morgan MJ and Liu ZG. Crosstalk of reactive oxygen species and NF-kappaB signaling. Cell research. 2011; 21:103-115.
25. Chen J, Liu Y, Liu H, Hermonat PL and Mehta JL. Molecular dissection of angiotensin II-activated human LOX-1 promoter. Arteriosclerosis, thrombosis, and vascular biology. 2006; 26:1163-1168.
26. Xu S, Liu Z, Huang Y, Le K, Tang F, Huang H, Ogura S, Little PJ, Shen X and Liu P. Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-kappaB activation. Translational research: the journal of laboratory and clinical medicine. 2012; 160:114-124.
27. Kenyon CJ. The genetics of ageing. Nature. 2010; 464:504-512.
28. Ayyadevara S, Alla R, Thaden JJ and Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3Knull mutants. Aging cell. 2008; 7:13-22.
29. Sharp ZD and Bartke A. Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. The journals of gerontology Series A, Biological sciences and medical sciences. 2005; 60:293-300.
30. Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R and Fontana L. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging cell. 2013; 12:645-651.
31. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009; 460:392-395.
32. Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, et al. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging cell. 2013. 13:468-477.
33. Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N and Larsson O. Translational control of immune responses: from transcripts to translatomes. Nature immunology. 2014; 15:503-511.
34. Trifunovic A and Larsson NG. Mitochondrial dysfunction as a cause of ageing. Journal of internal medicine. 2008; 263:167-178.
35. Lin K, Dorman JB, Rodan A and Kenyon C. daf-16: An HNF-3/forkhead family member that can function to double the lifespan of Caenorhabditis elegans. Science. 1997; 278:1319-1322.
36. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA and Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997; 389:994-999.
37. Hwangbo DS, Gershman B, Tu MP, Palmer M and Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature. 2004; 429:562-566.
38. Bartke A. Pleiotropic effects of growth hormone signaling in aging. Trends in endocrinology and metabolism: TEM. 2011; 22:437-442.
39. Lorenzini A, Salmon AB, Lerner C, Torres C, Ikeno Y, Motch S, McCarter R and Sell C. Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span. The journals of gerontology Series A, Biological sciences and medical sciences. 2014; 69:410-419.
40. Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH, 3rd, Becker KG, Perez VI and Richardson A. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PloS one. 2014; 9:e83988.
41. Blagosklonny MV. Answering the ultimate question "what is the proximal cause of aging?". Aging. 2012; 4:861-877.
42. Gems D and de la Guardia Y. Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction? Antioxidants & redox signaling. 2013; 19:321-329.
43. Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV and Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell Cycle. 2009; 8:1888-1895.
44. Demidenko ZN, Shtutman M and Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle. 2009; 8:1896-1900.
45. Oeckinghaus A, Hayden MS and Ghosh S. Crosstalk in NFkappaB signaling pathways. Nature immunology. 2011; 12:695-708.
46. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J and Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature. 2004; 429:883-891.
47. Rodwell GE, Sonu R, Zahn JM, Lund J, Wilhelmy J, Wang L, Xiao W, Mindrinos M, Crane E, Segal E, Myers BD, Brooks JD, Davis RW, et al. A transcriptional profile of aging in the human kidney. PLoS biology. 2004; 2:e427.
48. Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E and Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes & development. 2007; 21:3244-3257.
49. Bektas A, Zhang Y, Wood WH, 3rd, Becker KG, Madara K, Ferrucci L and Sen R. Age-associated alterations in inducible gene transcription in human CD4+ T lymphocytes. Aging. 2013; 5:18-36.