Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 40, 2017, Pages E8372-E8381

  Mills, Richard J ^a   Titmarsh, Drew M ^a   Koenig, Xaver ^a,b   Parker, Benjamin L ^c   Ryall, James G ^d   Quaife Ryan, Gregory A ^a   Voges, Holly K ^a   Hodson, Mark P ^a   Ferguson, Charles ^a   Drowley, Lauren ^e   Plowright, Alleyn T ^e   Needham, Elise J ^c   Wang, Qing Dong ^e   Gregorevic, Paul ^f   Xin, Mei ^g   Thomas, Walter G ^a   Parton, Robert G ^a   Nielsen, Lars K ^a   Launikonis, Bradley S ^a   James, David E ^c   Elliott, David A ^d,h   Porrello, Enzo R ^a,d,h   Hudson, James E ^a   more..

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ASTRAZENECA R AND D   (Sweden)

^f BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^g CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^h ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Heart development; Metabolism; Pluripotent stem cells; Regeneration; Tissue engineering

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE; GROWTH FACTOR; POTASSIUM CHANNEL HERG; TRANSCRIPTION FACTOR YAP1; BIOLOGICAL FACTOR;

ARTICLE; CARDIAC MUSCLE CELL; CARDIAC ORGANOID; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL MATURATION; CELL METABOLISM; CELL SCREENING; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE RESPONSE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLYCOLYSIS; HEART DEVELOPMENT; HEART TISSUE; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; MITOGENESIS; PLURIPOTENT STEM CELL; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEOMICS; STROMA CELL; TISSUE ENGINEERING; TISSUE REGENERATION; ADULT; ANIMAL; CELL CYCLE CHECKPOINT; CYTOLOGY; DNA DAMAGE; MALE; METABOLISM; ORGANOID; PHYSIOLOGY; REGENERATION; SPRAGUE DAWLEY RAT;

ADULT; ANIMALS; BIOLOGICAL FACTORS; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; DNA DAMAGE; HUMANS; MALE; MYOCYTES, CARDIAC; ORGANOIDS; PLURIPOTENT STEM CELLS; RATS, SPRAGUE-DAWLEY; REGENERATION;

EID: 85030257223     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1707316114     Document Type: Article

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