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Volumn 6, Issue , 2016, Pages

Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC MUSCLE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DEVICES; DRUG DEVELOPMENT; DRUG EFFECTS; HIGH THROUGHPUT SCREENING; HUMAN; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PROCEDURES; REPRODUCIBILITY; SIGNAL TRANSDUCTION; STANDARDS;

EID: 84964683465     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24637     Document Type: Article
Times cited : (54)

References (54)
  • 1
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K. et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell 131, 861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 2
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson, J. A. et al. Embryonic Stem Cell Lines Derived from Human Blastocysts. Science 282, 1145-1147 (1998).
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1
  • 3
    • 84862907693 scopus 로고    scopus 로고
    • Production of de novo cardiomyocytes: Human pluripotent stem cell differentiation and direct reprogramming
    • Burridge, Paul W., Keller, G., Gold, Joseph D. & Wu, Joseph C. Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming. Cell Stem Cell 10, 16-28 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 16-28
    • Burridge Paul, W.1    Keller, G.2    Gold Joseph, D.3    Wu Joseph, C.4
  • 4
    • 84905242471 scopus 로고    scopus 로고
    • Chemically defined generation of human cardiomyocytes
    • Burridge, P. W. et al. Chemically defined generation of human cardiomyocytes. Nat. Methods 11, 855-860 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 855-860
    • Burridge, P.W.1
  • 5
    • 84880678710 scopus 로고    scopus 로고
    • Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays
    • Harris, K. et al. Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Functional Preclinical Safety Assays. Toxicol. Sci. 134, 412-426 (2013).
    • (2013) Toxicol. Sci. , vol.134 , pp. 412-426
    • Harris, K.1
  • 6
    • 0037205320 scopus 로고    scopus 로고
    • Cardiomyocyte cell cycle regulation
    • Pasumarthi, K. B. S. & Field, L. J. Cardiomyocyte Cell Cycle Regulation. Circ. Res. 90, 1044-1054 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 1044-1054
    • Pasumarthi, K.B.S.1    Field, L.J.2
  • 7
    • 79952065525 scopus 로고    scopus 로고
    • Transient regenerative potential of the neonatal mouse heart
    • Porrello, E. R. et al. Transient Regenerative Potential of the Neonatal Mouse Heart. Science 331, 1078-1080 (2011).
    • (2011) Science , vol.331 , pp. 1078-1080
    • Porrello, E.R.1
  • 8
    • 84911417634 scopus 로고    scopus 로고
    • Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation
    • Senyo, S. E., Lee, R. T. & Kuhn, B. Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation. Stem Cell Res. 13, 532-541 (2014).
    • (2014) Stem Cell Res. , vol.13 , pp. 532-541
    • Senyo, S.E.1    Lee, R.T.2    Kuhn, B.3
  • 9
    • 84951787837 scopus 로고    scopus 로고
    • Regulatory aspects of small molecule drugs for heart regeneration
    • Rodgers, K., Papinska, A. & Mordwinkin, N. Regulatory aspects of small molecule drugs for heart regeneration. Adv. Drug Del. Rev. 96, 245-252 (2016).
    • (2016) Adv. Drug Del. Rev. , vol.96 , pp. 245-252
    • Rodgers, K.1    Papinska, A.2    Mordwinkin, N.3
  • 10
    • 84940747959 scopus 로고    scopus 로고
    • Harnessing the induction of cardiomyocyte proliferation for cardiac regenerative medicine
    • Sharma, A., Zhang, Y. & Wu, S. M. Harnessing the Induction of Cardiomyocyte Proliferation for Cardiac Regenerative Medicine. Curr. Treat. Options Cardiovasc. Med. 17, 1-12 (2015).
    • (2015) Curr. Treat. Options Cardiovasc. Med. , vol.17 , pp. 1-12
    • Sharma, A.1    Zhang, Y.2    Wu, S.M.3
  • 11
    • 84872081347 scopus 로고    scopus 로고
    • In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration
    • Choi, W. -Y. et al. In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development 140, 660-666 (2013).
    • (2013) Development , vol.140 , pp. 660-666
    • Choi, W.-Y.1
  • 12
    • 34547691243 scopus 로고    scopus 로고
    • Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
    • Kuhn, B. et al. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat. Med. 13, 962-969 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 962-969
    • Kuhn, B.1
  • 13
    • 27644455693 scopus 로고    scopus 로고
    • Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway
    • McDevitt, T. C., Laflamme, M. A. & Murry, C. E. Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway. J. Mol. Cell. Cardiol. 39, 865-873 (2005).
    • (2005) J. Mol. Cell. Cardiol. , vol.39 , pp. 865-873
    • McDevitt, T.C.1    Laflamme, M.A.2    Murry, C.E.3
  • 14
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • Bersell, K., Arab, S., Haring, B. & Kuhn, B. Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury. Cell 138, 257-270 (2009).
    • (2009) Cell , vol.138 , pp. 257-270
    • Bersell, K.1    Arab, S.2    Haring, B.3    Kuhn, B.4
  • 15
    • 33750298315 scopus 로고    scopus 로고
    • FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction
    • Engel, F. B., Hsieh, P. C. H., Lee, R. T. & Keating, M. T. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc. Natl. Acad. Sci. USA 103, 15546-15551 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 15546-15551
    • Engel, F.B.1    Hsieh, P.C.H.2    Lee, R.T.3    Keating, M.T.4
  • 16
    • 77449131670 scopus 로고    scopus 로고
    • G-CSF promotes the proliferation of developing cardiomyocytes in vivo and in derivation from ESCs and iPSCs
    • Shimoji, K. et al. G-CSF Promotes the Proliferation of Developing Cardiomyocytes In Vivo and in Derivation from ESCs and iPSCs. Cell Stem Cell 6, 227-237 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 227-237
    • Shimoji, K.1
  • 17
    • 79955405757 scopus 로고    scopus 로고
    • Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size
    • Heallen, T. et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332, 458-461 (2011).
    • (2011) Science , vol.332 , pp. 458-461
    • Heallen, T.1
  • 18
    • 33748702122 scopus 로고    scopus 로고
    • The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes
    • Tseng, A. -S., Engel, F. B. & Keating, Mark T. The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Chem. Biol. 13, 957-963 (2006).
    • (2006) Chem. Biol. , vol.13 , pp. 957-963
    • Tseng, A.-S.1    Engel, F.B.2    Keating, M.T.3
  • 19
    • 84892377400 scopus 로고    scopus 로고
    • Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells
    • Uosaki, H. et al. Identification of Chemicals Inducing Cardiomyocyte Proliferation in Developmental Stage-Specific Manner With Pluripotent Stem Cells. Circ. Cardiovasc. Genet. 6, 624-633 (2013).
    • (2013) Circ. Cardiovasc. Genet. , vol.6 , pp. 624-633
    • Uosaki, H.1
  • 20
    • 84873417297 scopus 로고    scopus 로고
    • Arrayed cellular environments for stem cells and regenerative medicine
    • Titmarsh, D. M., Chen, H., Wolvetang, E. J. & Cooper-White, J. J. Arrayed cellular environments for stem cells and regenerative medicine. Biotechnol. J. 8, 167-179 (2013).
    • (2013) Biotechnol. J. , vol.8 , pp. 167-179
    • Titmarsh, D.M.1    Chen, H.2    Wolvetang, E.J.3    Cooper-White, J.J.4
  • 21
    • 33644648070 scopus 로고    scopus 로고
    • Microfluidic arays for logarithmically perfused embryonic stem cell culture
    • Kim, L., Vahey, M. D., Lee, H. -Y. & Voldman, J. Microfluidic arays for logarithmically perfused embryonic stem cell culture. Lab Chip 6, 394-406 (2006).
    • (2006) Lab Chip , vol.6 , pp. 394-406
    • Kim, L.1    Vahey, M.D.2    Lee, H.-Y.3    Voldman, J.4
  • 22
    • 33845761551 scopus 로고    scopus 로고
    • A high-throughput microfluidic real-time gene expression living cell array
    • King, K. R. et al. A high-throughput microfluidic real-time gene expression living cell array. Lab Chip 7, 77-85 (2006).
    • (2006) Lab Chip , vol.7 , pp. 77-85
    • King, K.R.1
  • 23
    • 34249821066 scopus 로고    scopus 로고
    • Micro-bioreactor array for controlling cellular microenvironments
    • Figallo, E. et al. Micro-bioreactor array for controlling cellular microenvironments. Lab Chip 7, 710-719 (2007).
    • (2007) Lab Chip , vol.7 , pp. 710-719
    • Figallo, E.1
  • 24
    • 59649114748 scopus 로고    scopus 로고
    • An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells
    • Kamei, K. -i. et al. An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells. Lab Chip 9, 555-563 (2009).
    • (2009) Lab Chip , vol.9 , pp. 555-563
    • Kamei, K.-I.1
  • 25
    • 79952256268 scopus 로고    scopus 로고
    • 3-Dimensional cell culture for on-chip differentiation of stem cells in embryoid body
    • Kim, C. et al. 3-Dimensional cell culture for on-chip differentiation of stem cells in embryoid body. Lab Chip 11, 874-882 (2011).
    • (2011) Lab Chip , vol.11 , pp. 874-882
    • Kim, C.1
  • 26
    • 78650334218 scopus 로고    scopus 로고
    • Microenvironment array chip for cell culture environment screening
    • Hattori, K., Sugiura, S. & Kanamori, T. Microenvironment array chip for cell culture environment screening. Lab Chip 11, 212-214 (2010).
    • (2010) Lab Chip , vol.11 , pp. 212-214
    • Hattori, K.1    Sugiura, S.2    Kanamori, T.3
  • 27
    • 84892718887 scopus 로고    scopus 로고
    • Concise review: Microfluidic technology platforms: Poised to accelerate development and translation of stem cell-derived therapies
    • Titmarsh, D. M., Chen, H., Glass, N. R. & Cooper-White, J. J. Concise Review: Microfluidic Technology Platforms: Poised to Accelerate Development and Translation of Stem Cell-Derived Therapies. Stem Cells Transl. Med. 3, 81-90 (2014).
    • (2014) Stem Cells Transl. Med. , vol.3 , pp. 81-90
    • Titmarsh, D.M.1    Chen, H.2    Glass, N.R.3    Cooper-White, J.J.4
  • 28
    • 0037131390 scopus 로고    scopus 로고
    • Microfluidic large-scale integration
    • Thorsen, T., Maerkl, S. J. & Quake, S. R. Microfluidic Large-Scale Integration. Science 298, 580-584 (2002).
    • (2002) Science , vol.298 , pp. 580-584
    • Thorsen, T.1    Maerkl, S.J.2    Quake, S.R.3
  • 29
    • 45849087630 scopus 로고    scopus 로고
    • High throughput gene expression measurement with real time PCR in a microfluidic dynamic array
    • Spurgeon, S. L., Jones, R. C. & Ramakrishnan, R. High Throughput Gene Expression Measurement with Real Time PCR in a Microfluidic Dynamic Array. Plos One 3, e1662 (2008).
    • (2008) Plos One , vol.3 , pp. e1662
    • Spurgeon, S.L.1    Jones, R.C.2    Ramakrishnan, R.3
  • 30
    • 79959830458 scopus 로고    scopus 로고
    • High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays
    • Lecault, V. et al. High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nat. Methods 8, 581-U593 (2011).
    • (2011) Nat. Methods , vol.8 , pp. 581-U593
    • Lecault, V.1
  • 31
    • 37349089680 scopus 로고    scopus 로고
    • Gene transfer and protein dynamics in stem cells uing single cell electroporation in a microfluidic device
    • Valero, A. et al. Gene transfer and protein dynamics in stem cells uing single cell electroporation in a microfluidic device. Lab Chip 8, 62-67 (2008).
    • (2008) Lab Chip , vol.8 , pp. 62-67
    • Valero, A.1
  • 32
    • 84867322318 scopus 로고    scopus 로고
    • Spatiotemporally controlled deliever of soluble factors for stem cell differentiation
    • Kawada, J., Kimura, H., Akutsu, H., Sakai, Y. & Fujii, T. Spatiotemporally controlled deliever of soluble factors for stem cell differentiation. Lab Chip 12, 4508-4515 (2012).
    • (2012) Lab Chip , vol.12 , pp. 4508-4515
    • Kawada, J.1    Kimura, H.2    Akutsu, H.3    Sakai, Y.4    Fujii, T.5
  • 33
    • 17144398875 scopus 로고    scopus 로고
    • Human neural stem cell growth and differentiation in a gradient-generating microfluidic device
    • Chung, B. G. et al. Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip 5, 401-406 (2005).
    • (2005) Lab Chip , vol.5 , pp. 401-406
    • Chung, B.G.1
  • 34
    • 36348984356 scopus 로고    scopus 로고
    • A pneumatic micro cell chip for the differentiation of human mesenchymal stem cells under mechanical stimulation
    • Sim, W. Y. et al. A pneumatic micro cell chip for the differentiation of human mesenchymal stem cells under mechanical stimulation. Lab Chip 7, 1775-1782 (2007).
    • (2007) Lab Chip , vol.7 , pp. 1775-1782
    • Sim, W.Y.1
  • 35
    • 84861535388 scopus 로고    scopus 로고
    • Label-free enrichment of functional cardiomyocytes using microfluidic deterministic lateral flow displacement
    • Zhang, B., Green, J. V., Murthy, S. K. & Radisic, M. Label-Free Enrichment of Functional Cardiomyocytes Using Microfluidic Deterministic Lateral Flow Displacement. Plos One 7, e37619 (2012).
    • (2012) Plos One , vol.7 , pp. e37619
    • Zhang, B.1    Green, J.V.2    Murthy, S.K.3    Radisic, M.4
  • 36
    • 84882260099 scopus 로고    scopus 로고
    • Hydrogel-coated microfluidic channels for cardiomyocyte culture
    • Annabi, N. et al. Hydrogel-coated microfluidic channels for cardiomyocyte culture. Lab Chip 13, 3569-3577 (2013).
    • (2013) Lab Chip , vol.13 , pp. 3569-3577
    • Annabi, N.1
  • 37
    • 84860527213 scopus 로고    scopus 로고
    • A microflabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues
    • Boudou, T. et al. A Microflabricated Platform to measure and Manipulate the Mechanics of Engineered Cardiac Microtissues. Tissue Eng. Part A 18, 910-919 (2012).
    • (2012) Tissue Eng. Part A , vol.18 , pp. 910-919
    • Boudou, T.1
  • 38
    • 84870911361 scopus 로고    scopus 로고
    • Label-free electrophysiological cytometry for stem cell-derived cardiomyocyte clusters
    • Myers, F. B., Zarins, C. K., Abilez, O. J. & Lee, L. P. Label-free electrophysiological cytometry for stem cell-derived cardiomyocyte clusters. Lab Chip 13, 220-228 (2013).
    • (2013) Lab Chip , vol.13 , pp. 220-228
    • Myers, F.B.1    Zarins, C.K.2    Abilez, O.J.3    Lee, L.P.4
  • 39
    • 84871593878 scopus 로고    scopus 로고
    • Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation
    • Titmarsh, D. M. et al. Microbioreactor Arrays for Full Factorial Screening of Exogenous and Paracrine Factors in Human Embryonic Stem Cell Differentiation. Plos One 7, e52405 (2012).
    • (2012) Plos One , vol.7 , pp. e52405
    • Titmarsh, D.M.1
  • 40
    • 84879756725 scopus 로고    scopus 로고
    • Full factorial screening of human embryonic stem cell maintenance with multiplexed microbioreactor arrays
    • Titmarsh, D. M., Ovchinnikov, D. A., Wolvetang, E. J. & Cooper-White, J. J. Full factorial screening of human embryonic stem cell maintenance with multiplexed microbioreactor arrays. Biotechnol. J. 8, 822-834 (2013).
    • (2013) Biotechnol. J. , vol.8 , pp. 822-834
    • Titmarsh, D.M.1    Ovchinnikov, D.A.2    Wolvetang, E.J.3    Cooper-White, J.J.4
  • 41
    • 84893498597 scopus 로고    scopus 로고
    • Microbioreactor array screening of wnt modulators and microenvironmental factors in osteogenic differentiation of mesenchymal progenitor cells
    • Frith, J. E., Titmarsh, D. M., Padmanabhan, H. & Cooper-White, J. J. Microbioreactor Array Screening of Wnt Modulators and Microenvironmental Factors in Osteogenic Differentiation of Mesenchymal Progenitor Cells. Plos One 8, e82931 (2013).
    • (2013) Plos One , vol.8 , pp. e82931
    • Frith, J.E.1    Titmarsh, D.M.2    Padmanabhan, H.3    Cooper-White, J.J.4
  • 42
    • 44349170450 scopus 로고    scopus 로고
    • The ground state of embryonic stem cell self-renewal
    • Ying, Q. -L. et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519-523 (2008).
    • (2008) Nature , vol.453 , pp. 519-523
    • Ying, Q.-L.1
  • 43
    • 33645211374 scopus 로고    scopus 로고
    • Purmorphamine activates the Hedgehog pathway by targeting Smoothened
    • Sinha, S. & Chen, J. K. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat. Chem. Biol. 2, 29-30 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 29-30
    • Sinha, S.1    Chen, J.K.2
  • 44
    • 77950788166 scopus 로고    scopus 로고
    • Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions
    • Kamei, K. -i. et al. Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab Chip 10, 1113-1119 (2010).
    • (2010) Lab Chip , vol.10 , pp. 1113-1119
    • Kamei, K.-I.1
  • 45
    • 39449127641 scopus 로고    scopus 로고
    • Combinatorial signaling microenvironments for studying stem cell fate
    • Flaim, C. J., Teng, D., Chien, S. & Bhatia, S. N. Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev. 17, 29-39 (2008).
    • (2008) Stem Cells Dev. , vol.17 , pp. 29-39
    • Flaim, C.J.1    Teng, D.2    Chien, S.3    Bhatia, S.N.4
  • 46
    • 84876570848 scopus 로고    scopus 로고
    • Concise review: Maturation phases of human pluripotent stem cell-derived cardiomyocytes
    • Robertson, C., Tran, D. D. & George, S. C. Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells 31, 829-837 (2013).
    • (2013) Stem Cells , vol.31 , pp. 829-837
    • Robertson, C.1    Tran, D.D.2    George, S.C.3
  • 47
    • 80052816865 scopus 로고    scopus 로고
    • Targeting GSK-3 family members in the heart: A very sharp double-edged sword
    • Cheng, H., Woodgett, J., Maamari, M. & Force, T. Targeting GSK-3 family members in the heart: A very sharp double-edged sword. J. Mol. Cell. Cardiol. 51, 607-613 (2011).
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 607-613
    • Cheng, H.1    Woodgett, J.2    Maamari, M.3    Force, T.4
  • 48
    • 84928938582 scopus 로고    scopus 로고
    • ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation
    • DUva, G. et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat. Cell Biol. 17, 627-638 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 627-638
    • Duva, G.1
  • 49
    • 84863560929 scopus 로고    scopus 로고
    • Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
    • Lian, X. et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc. Natl. Acad. Sci. USA 109, E1848-E1857 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. E1848-E1857
    • Lian, X.1
  • 50
    • 0032403465 scopus 로고    scopus 로고
    • Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)
    • Duffy, D. C., McDonald, J. C., Schueller, O. J. A. & Whitesides, G. M. Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). Anal. Chem. 70, 4974-4984 (1998).
    • (1998) Anal. Chem. , vol.70 , pp. 4974-4984
    • Duffy, D.C.1    McDonald, J.C.2    Schueller, O.J.A.3    Whitesides, G.M.4
  • 51
    • 84874913500 scopus 로고    scopus 로고
    • Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology
    • Briggs, J. A. et al. Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology. Stem Cells 31, 467-478 (2013).
    • (2013) Stem Cells , vol.31 , pp. 467-478
    • Briggs, J.A.1
  • 53
    • 33845792555 scopus 로고    scopus 로고
    • CellProfiler: Image analysis software for identifying and quantifying cell phenotypes
    • Carpenter, A. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).
    • (2006) Genome Biol. , vol.7 , pp. R100
    • Carpenter, A.1
  • 54
    • 79954500285 scopus 로고    scopus 로고
    • Improved structure, function and compatibility for CellProfiler: Modular high-throughput image analysis software
    • Kamentsky, L. et al. Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics 27, 1179-1180 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 1179-1180
    • Kamentsky, L.1


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