-
1
-
-
84908459245
-
Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma
-
Cheng, D. et al. Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma. Am. J. Respir. Crit. Care Med. 190, 639-648 (2014).
-
(2014)
Am. J. Respir. Crit. Care Med.
, vol.190
, pp. 639-648
-
-
Cheng, D.1
-
2
-
-
84922857734
-
IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells
-
Huang, Y. et al. IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells. Nat. Immunol. 16, 161-169 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 161-169
-
-
Huang, Y.1
-
3
-
-
61349089164
-
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
-
Gudbjartsson, D. F. et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat. Genet. 41, 342-347 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 342-347
-
-
Gudbjartsson, D.F.1
-
4
-
-
84896343916
-
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation
-
Halim, T. Y. et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40, 425-435 (2014).
-
(2014)
Immunity
, vol.40
, pp. 425-435
-
-
Halim, T.Y.1
-
5
-
-
84890825282
-
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis
-
Salimi, M. et al. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J. Exp. Med. 210, 2939-2950 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 2939-2950
-
-
Salimi, M.1
-
6
-
-
75749122181
-
Innate production of T(H)2 cytokines by adipose tissueassociated c-Kit+Sca-1+ lymphoid cells
-
Moro, K. et al. Innate production of T(H)2 cytokines by adipose tissueassociated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540-544 (2010).
-
(2010)
Nature
, vol.463
, pp. 540-544
-
-
Moro, K.1
-
7
-
-
77951817855
-
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
-
Neill, D. R. et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370 (2010).
-
(2010)
Nature
, vol.464
, pp. 1367-1370
-
-
Neill, D.R.1
-
8
-
-
79959380307
-
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
-
Chang, Y. J. et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat. Immunol. 12, 631-638 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 631-638
-
-
Chang, Y.J.1
-
9
-
-
85027948313
-
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
-
Monticelli, L. A. et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol. 12, 1045-1054 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1045-1054
-
-
Monticelli, L.A.1
-
10
-
-
85017360311
-
Scaling single-cell genomics from phenomenology to mechanism
-
Tanay, A. & Regev, A. Scaling single-cell genomics from phenomenology to mechanism. Nature 541, 331-338 (2017).
-
(2017)
Nature
, vol.541
, pp. 331-338
-
-
Tanay, A.1
Regev, A.2
-
11
-
-
84994860357
-
Revealing the vectors of cellular identity with single-cell genomics
-
Wagner, A., Regev, A. & Yosef, N. Revealing the vectors of cellular identity with single-cell genomics. Nat. Biotechnol. 34, 1145-1160 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 1145-1160
-
-
Wagner, A.1
Regev, A.2
Yosef, N.3
-
12
-
-
84949252174
-
Single-cell genomics unveils critical regulators of Th17 cell pathogenicity
-
Gaublomme, J. T. et al. Single-cell genomics unveils critical regulators of Th17 cell pathogenicity. Cell 163, 1400-1412 (2015).
-
(2015)
Cell
, vol.163
, pp. 1400-1412
-
-
Gaublomme, J.T.1
-
13
-
-
84980325679
-
Div-Seq: Single-nucleus RNA-seq reveals dynamics of rare adult newborn neurons
-
Habib, N. et al. Div-Seq: single-nucleus RNA-seq reveals dynamics of rare adult newborn neurons. Science 353, 925-928 (2016).
-
(2016)
Science
, vol.353
, pp. 925-928
-
-
Habib, N.1
-
14
-
-
84983741021
-
Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics
-
Shekhar, K. et al. Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics. Cell 166, 1308-1323.e30 (2016).
-
(2016)
Cell
, vol.166
, pp. 1308-1323e30
-
-
Shekhar, K.1
-
15
-
-
84983780960
-
The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome
-
Gury-BenAri, M. et al. The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome. Cell 166, 1231-1246.e13 (2016).
-
(2016)
Cell
, vol.166
, pp. 1231-1246e13
-
-
Gury-BenAri, M.1
-
16
-
-
84962062339
-
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation
-
Monticelli, L. A. et al. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat. Immunol. 17, 656-665 (2016).
-
(2016)
Nat. Immunol.
, vol.17
, pp. 656-665
-
-
Monticelli, L.A.1
-
17
-
-
84923436228
-
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
-
Robinette, M. L. et al. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat. Immunol. 16, 306-317 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 306-317
-
-
Robinette, M.L.1
-
18
-
-
84958078627
-
The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
-
Björklund, A. K. et al. The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing. Nat. Immunol. 17, 451-460 (2016).
-
(2016)
Nat. Immunol.
, vol.17
, pp. 451-460
-
-
Björklund, A.K.1
-
19
-
-
84956599311
-
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
-
Kowalczyk, M. S. et al. Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res. 25, 1860-1872 (2015).
-
(2015)
Genome Res.
, vol.25
, pp. 1860-1872
-
-
Kowalczyk, M.S.1
-
20
-
-
84963614956
-
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
-
Tirosh, I. et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189-196 (2016).
-
(2016)
Science
, vol.352
, pp. 189-196
-
-
Tirosh, I.1
-
21
-
-
85006488344
-
Perturb-Seq: Dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens
-
Dixit, A. et al. Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens. Cell 167, 1853-1866.e17 (2016).
-
(2016)
Cell
, vol.167
, pp. 1853-1853e17
-
-
Dixit, A.1
-
22
-
-
85009446777
-
Massively parallel digital transcriptional profiling of single cells
-
Zheng, G. X. et al. Massively parallel digital transcriptional profiling of single cells. Nat. Commun. 8, 14049 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 14049
-
-
Zheng, G.X.1
-
23
-
-
84887101406
-
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
-
Picelli, S. et al. Smart-seq2 for sensitive full-length transcriptome profiling in single cells. Nat. Methods 10, 1096-1098 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 1096-1098
-
-
Picelli, S.1
-
24
-
-
33646539175
-
The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia
-
Moriyama, M. et al. The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. Am. J. Physiol. Lung Cell. Mol. Physiol. 290, L971-L977 (2006).
-
(2006)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.290
, pp. L971-L977
-
-
Moriyama, M.1
-
25
-
-
0033798358
-
Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U
-
Hedrick, J. A. et al. Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol. Pharmacol. 58, 870-875 (2000).
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 870-875
-
-
Hedrick, J.A.1
-
26
-
-
0034617215
-
Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3
-
Szekeres, P. G. et al. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J. Biol. Chem. 275, 20247-20250 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20247-20250
-
-
Szekeres, P.G.1
-
27
-
-
0034671543
-
Identification of a novel neuromedin U receptor subtype expressed in the central nervous system
-
Shan, L. et al. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. J. Biol. Chem. 275, 39482-39486 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39482-39486
-
-
Shan, L.1
-
28
-
-
84937519445
-
Silencing nociceptor neurons reduces allergic airway inflammation
-
Talbot, S. et al. Silencing nociceptor neurons reduces allergic airway inflammation. Neuron 87, 341-354 (2015).
-
(2015)
Neuron
, vol.87
, pp. 341-354
-
-
Talbot, S.1
-
29
-
-
84885572626
-
Type 2 innate lymphoid cells control eosinophil homeostasis
-
Nussbaum, J. C. et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502, 245-248 (2013).
-
(2013)
Nature
, vol.502
, pp. 245-248
-
-
Nussbaum, J.C.1
-
30
-
-
85009461545
-
The nervous system of airways and its remodeling in inflammatory lung diseases
-
Audrit, K. J., Delventhal, L., Aydin, Ö. & Nassenstein, C. The nervous system of airways and its remodeling in inflammatory lung diseases. Cell Tissue Res. 367, 571-590 (2017).
-
(2017)
Cell Tissue Res.
, vol.367
, pp. 571-590
-
-
Audrit, K.J.1
Delventhal, L.2
Aydin, Ö.3
Nassenstein, C.4
-
31
-
-
33749353731
-
Direct evidence for a critical role of CD30 in the development of allergic asthma
-
Polte, T., Behrendt, A. K. & Hansen, G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J. Allergy Clin. Immunol. 118, 942-948 (2006).
-
(2006)
J. Allergy Clin. Immunol.
, vol.118
, pp. 942-948
-
-
Polte, T.1
Behrendt, A.K.2
Hansen, G.3
-
32
-
-
84887110394
-
Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2
-
Schuliga, M. et al. Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2. Am. J. Respir. Cell Mol. Biol. 49, 751-758 (2013).
-
(2013)
Am. J. Respir. Cell Mol. Biol.
, vol.49
, pp. 751-758
-
-
Schuliga, M.1
-
33
-
-
33745056264
-
Soluble CD30 serum levels in atopic dermatitis and bronchial asthma and its relationship with disease severity in pediatric age
-
Heshmat, N. M. & El-Hadidi, E. S. Soluble CD30 serum levels in atopic dermatitis and bronchial asthma and its relationship with disease severity in pediatric age. Pediatr. Allergy Immunol. 17, 297-303 (2006).
-
(2006)
Pediatr. Allergy Immunol.
, vol.17
, pp. 297-303
-
-
Heshmat, N.M.1
El-Hadidi, E.S.2
-
34
-
-
2542555049
-
Analysis of gene expressions of T cells from children with acute exacerbations of asthma
-
Katsunuma, T. et al. Analysis of gene expressions of T cells from children with acute exacerbations of asthma. Int. Arch. Allergy Immunol. 134, 29-33 (2004).
-
(2004)
Int. Arch. Allergy Immunol.
, vol.134
, pp. 29-33
-
-
Katsunuma, T.1
-
35
-
-
66749090518
-
Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma
-
Sekigawa, T. et al. Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma. Clin. Exp. Allergy 39, 972-981 (2009).
-
(2009)
Clin. Exp. Allergy
, vol.39
, pp. 972-981
-
-
Sekigawa, T.1
-
36
-
-
84938915304
-
Nuclear receptor Nur77 attenuates airway inflammation in mice by suppressing NF-B activity in lung epithelial cells
-
Kurakula, K. et al. Nuclear receptor Nur77 attenuates airway inflammation in mice by suppressing NF-B activity in lung epithelial cells. J. Immunol. 195, 1388-1398 (2015).
-
(2015)
J. Immunol.
, vol.195
, pp. 1388-1398
-
-
Kurakula, K.1
-
37
-
-
85020227250
-
Gene expression correlated with severe asthma characteristics reveals heterogeneous mechanisms of severe disease
-
Modena, B. D. et al. Gene expression correlated with severe asthma characteristics reveals heterogeneous mechanisms of severe disease. Am. J. Respir. Crit. Care Med. 195, 1449-1463 (2017).
-
(2017)
Am. J. Respir. Crit. Care Med.
, vol.195
, pp. 1449-1463
-
-
Modena, B.D.1
-
38
-
-
84908374296
-
Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
-
Beale, J. et al. Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Sci. Transl. Med. 6, 256ra134 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 256ra134
-
-
Beale, J.1
-
39
-
-
84954286513
-
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
-
von Moltke, J., Ji, M., Liang, H. E. & Locksley, R. M. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529, 221-225 (2016).
-
(2016)
Nature
, vol.529
, pp. 221-225
-
-
Von Moltke, J.1
Ji, M.2
Liang, H.E.3
Locksley, R.M.4
-
40
-
-
84954561117
-
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
-
Gerbe, F. et al. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529, 226-230 (2016).
-
(2016)
Nature
, vol.529
, pp. 226-230
-
-
Gerbe, F.1
-
41
-
-
84958767810
-
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
-
Howitt, M. R. et al. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351, 1329-1333 (2016).
-
(2016)
Science
, vol.351
, pp. 1329-1333
-
-
Howitt, M.R.1
-
42
-
-
84895527785
-
Chemosensory functions for pulmonary neuroendocrine cells
-
Gu, X. et al. Chemosensory functions for pulmonary neuroendocrine cells. Am. J. Respir. Cell Mol. Biol. 50, 637-646 (2014).
-
(2014)
Am. J. Respir. Cell Mol. Biol.
, vol.50
, pp. 637-646
-
-
Gu, X.1
-
43
-
-
84957840670
-
Pulmonary neuroendocrine cells function as airway sensors to control lung immune response
-
Branchfield, K. et al. Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science 351, 707-710 (2016).
-
(2016)
Science
, vol.351
, pp. 707-710
-
-
Branchfield, K.1
-
44
-
-
33646593151
-
Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice
-
Prendergast, C. E., Morton, M. F., Figueroa, K. W., Wu, X. & Shankley, N. P. Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice. Br. J. Pharmacol. 147, 886-896 (2006).
-
(2006)
Br. J. Pharmacol.
, vol.147
, pp. 886-896
-
-
Prendergast, C.E.1
Morton, M.F.2
Figueroa, K.W.3
Wu, X.4
Shankley, N.P.5
-
45
-
-
84986285632
-
A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells
-
Singer, M. et al. A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells. Cell 166, 1500-1511.e9 (2016).
-
(2016)
Cell
, vol.166
, pp. 1500-1511e9
-
-
Singer, M.1
-
46
-
-
73349109145
-
Th1 Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
-
Jäger, A., Dardalhon, V., Sobel, R. A., Bettelli, E. & Kuchroo, V. K. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183, 7169-7177 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 7169-7177
-
-
Jäger, A.1
Dardalhon, V.2
Sobel, R.A.3
Bettelli, E.4
Kuchroo, V.K.5
-
47
-
-
84929151009
-
Spatial reconstruction of single-cell gene expression data
-
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F. & Regev, A. Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol. 33, 495-502 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 495-502
-
-
Satija, R.1
Farrell, J.A.2
Gennert, D.3
Schier, A.F.4
Regev, A.5
-
50
-
-
84966283954
-
Near-optimal probabilistic RNA-seq quantification
-
Bray, N. L., Pimentel, H., Melsted, P. & Pachter, L. Near-optimal probabilistic RNA-seq quantification. Nat. Biotechnol. 34, 525-527 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 525-527
-
-
Bray, N.L.1
Pimentel, H.2
Melsted, P.3
Pachter, L.4
-
51
-
-
85010908291
-
Differential analyses for RNA-seq: Transcript-level estimates improve gene-level inferences
-
Soneson, C., Love, M. I. & Robinson, M. D. Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences. F1000 Res. 4, 1521 (2015).
-
(2015)
F1000 Res.
, vol.4
, pp. 1521
-
-
Soneson, C.1
Love, M.I.2
Robinson, M.D.3
|