Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Genome Research

Volumn 25, Issue 12, 2015, Pages 1860-1872

  Kowalczyk, Monika S ^a   Tirosh, Itay ^a   Heckl, Dirk ^b   Rao, Tata Nageswara ^c,d   Dixit, Atray ^a   Haas, Brian J ^a   Schneider, Rebekka K ^b   Wagers, Amy J ^c,d,e,f   Ebert, Benjamin L ^b   Regev, Aviv ^a,f  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Harvard University   (United States)

^d JOSLIN DIABETES CENTER   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL POPULATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; SINGLE CELL ANALYSIS; AGE; ANIMAL; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; BIOLOGY; CELL AGING; CLUSTER ANALYSIS; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; MULTIPOTENT STEM CELL; PHENOTYPE; PROCEDURES; SEQUENCE ANALYSIS;

BIOLOGICAL MARKER; TRANSCRIPTOME;

AGE FACTORS; ANIMALS; BIOMARKERS; CELL AGING; CELL CYCLE; CELL DIFFERENTIATION; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MICE; MODELS, BIOLOGICAL; MULTIPOTENT STEM CELLS; ORGAN SPECIFICITY; PHENOTYPE; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

EID: 84956599311     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.192237.115     Document Type: Article

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