The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 5, 2006, Pages

  Moriyama, Maiko ^a,b   Fukuyama, Satoru ^c   Inoue, Hiromasa ^c   Matsumoto, Takafumi ^c   Sato, Takahiro ^a   Tanaka, Kentaro ^c,d   Kinjyo, Ichiko ^d   Kano, Tatsuhiko ^b   Yoshimura, Akihiko ^d   Kojima, Masayasu ^a  

^a KURUME UNIVERSITY   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Airway inflammation; Asthma models; Cell adhesion; Chemotaxis; Knockout mouse

Indexed keywords

CALCIUM; COLLAGEN TYPE 1; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROMEDIN U; NEUROPEPTIDE;

AIRWAY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CELL ADHESION; CELL FUNCTION; CELL LINE; CHEMOTAXIS; CHRONIC DISEASE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EOSINOPHIL; EOSINOPHILIA; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

ALLERGENS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CALCIUM SIGNALING; CELL ADHESION; EOSINOPHILIA; EOSINOPHILS; MACROPHAGES, ALVEOLAR; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPEPTIDES; RECEPTORS, NEUROTRANSMITTER;

EID: 33646539175     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00345.2005     Document Type: Article

References (26)

1. Aoki-Nagase T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita T, Ohga E, Nagai R, Kurihara H, and Ouchi Y. Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice. Am J Physiol Lung Cell Mol Physiol 283: L963-L970, 2002.
2. Borchers MT, Justice PJ, Ansay T, Mancino V, McGarry MP, Crosby J, Simon MI, Lee NA, and Lee JJ. Gq signaling is required for allergen-induced pulmonary eosinophilia. J Immunol 168: 3543-3549, 2002.
3. Brighton PJ, Szekeres PG, Wise A, and Willars GB. Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction. Mol Pharmacol 66: 154415-154456, 2004.
4. Fernandez EJ and Lolis E. Structure, function and inhibition of chemokines. Annu Rev Pharmacol Toxicol 42: 469-499, 2002.
5. Ferry X, Brehin S, Kamel R, and Landry Y. G protein-dependent activation of mast cell by peptides and basic secretagogues. Peptides 23: 1507-1515, 2002.
6. Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Habata Y, Hinuma S, Onda H, Nishimura O, and Fujino M. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J Biol Chem 275: 21068-21074, 2000.
7. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, and Kojima M. Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 10: 1067-1073, 2004.
8. Hedrick JA, Morse K, Shan L, Qiao X, Pang L, Wang S, Laz T, Gustafson EL, Bayne M, and Monsma FJ Jr. Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol Pharmacol 58: 870-875, 2000.
9. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, and Liu Q. Indentification of receptors for neuromedin U and its role in feeding. Nature 406: 70-74, 2000.
10. Inoue H, Kato R, Fukuyama S, Nonami A, Taniguchi K, Matsumoto K, Nakano T, Tsuda M, Matsumura M, Kubo M, Ishikawa F, Moon BG, Takatsu K, Nakanishi Y, and Yoshimura A. Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. J Exp Med 201: 73-82, 2005.
11. Johnson EN, Appelbaum ER, Carptenter DC, Cox RF, Disa J, Foley JJ, Ghosh SK, Naselsky DP, Pullen MA, Sarau HM, Scheff SR, Steplewski KM, Zaks-Zilberman M, and Aiyar N. Neuromedin U elicits cytokine release in murine Th2-type T cell clone D10. G41. J Immunol 173: 7230-7238, 2004.
12. Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, and Alam R. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95: 1911-1917, 2000.
13. Kibe A, Inoue H, Fukuyama S, Machida K, Matsumoto K, Koto H, Ikegami T, Aizawa H, and Hara N. Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. Am J Respir Crit Care Med 67: 50-56, 2003.
14. Levite M, Cahalon L, Hershkoviz R, Steinmann L, and Lider O. Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin. J Immunol 160: 993-1000, 1998.
15. Minamino N, Kangawa K, and Matsuo H. Neuromedin U-8 and U-25; novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem Biophys Res Commun 130: 1078-1085, 1985.
16. Moriyama M, Furue H, Katafuchi T, Teranishi H, Sato T, Kano T, Kojima M, and Yoshimura M. Presynaptic modulation by neuromedin U of sensory synaptic transmission in rat spinal dorsal horn neurones. J Physiol 559: 707-713, 2004.
17. Moriyama M, Sato T, Inoue H, Fukuyama S, Teranishi H, Kangawa K, Kano T, Yoshimura A, and Kojima M. The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. J Exp Med 202: 217-224, 2005.
18. Nakahara K, Kojima M, Hanada R, Egi Y, Ida T, Miyazato M, Kangawa K, and Murakami N. Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice. Biochem Biophys Res Commun 323: 615-620, 2004.
19. Naveilhan P, Hassani H, Lucas G, Blakeman KH, Hao JX, Xu XJ, Wiesenfeld-Hallin Z, Thoren P, and Ernfors P. Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Nature 409: 513-517, 2001.
20. Ohtsuka S, Takaki S, Iseki S, Miyoshi K, Nakagata N, Kataoka Y, Yoshida N, Takatsu K, and Yoshimura A. SH2-B is required for both male and female reproduction. Mol Cell Biol 22: 3066-3077, 2002.
21. Rothenberg ME, MacLean JA, Pearlman E, Luster AD, and Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med 185: 785-790, 1997.
22. Sasaki A, Taketomi T, Wakioka T, Kato R, and Yoshimura A. Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation. J Biol Chem 276: 36804-36808, 2002.
23. Senyshyn J, Baumgartner RA, and Beaven MA. Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway. J Immunol 160: 5136-5144, 1998.
24. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 17: 255-281, 1999.
25. Yuan Q, Austen KF, Friend DS, Heidtman M, and Boyce JA. Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1). J Exp Med 186: 313-323, 1997.
26. Zimmermann N, Daugherty BL, Stark JM, and Rothenberg ME. Molecular analysis of CCR-3 events in eosinophilic cells. J Immunol 164: 1055-1064, 2000.