IL-25-responsive, lineage-negative KLRG1 hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells

Nature Immunology

Volumn 16, Issue 2, 2015, Pages 161-169

  Huang, Yuefeng ^a   Guo, Liying ^a   Qiu, Jin ^a   Chen, Xi ^a   Hu Li, Jane ^a   Siebenlist, Ulrich ^a   Williamson, Peter R ^a   Urban, Joseph F ^b   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b BELTSVILLE HUMAN NUTRITION RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 25; INTERLEUKIN 33; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 7 RECEPTOR; KLRG1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CELL POPULATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE LYMPHOID CELL; LYMPHOID CELL; MOUSE; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; TH17 CELL; ANIMAL; CANDIDIASIS; CELL LINEAGE; CYTOLOGY; GENE DELETION; GENETICS; IMMUNOLOGY; LEUKOCYTE; LUNG; LYMPHOCYTE; METABOLISM; NIPPOSTRONGYLUS; PATHOLOGY; STRONGYLE INFECTION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CANDIDA ALBICANS; CANDIDIASIS; CELL LINEAGE; GENE DELETION; INFLAMMATION; INTERLEUKIN-17; LEUKOCYTES; LUNG; LYMPHOCYTES; MICE; NIPPOSTRONGYLUS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-7; STRONGYLIDA INFECTIONS;

EID: 84922857734     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3078     Document Type: Article

References (29)

1. Walker, J.A., Barlow, J.L. & McKenzie, A.N. Innate lymphoid cells-how did we miss them?. Nat. Rev. Immunol. 13, 75-87 (2013
2. Spits, H. & Cupedo, T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu. Rev. Immunol. 30, 647-675 (2012
3. Spits, H., et al. Innate lymphoid cells-A proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013
4. Moro, K., et al. Innate production of TH2 cytokines by adipose tissue-Associated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540-544 (2010
5. Neill, D.R., et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370 (2010
6. Price, A.E., et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl. Acad. Sci. USA 107, 11489-11494 (2010
7. Saenz, S.A., et al. IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses. Nature 464, 1362-1366 (2010
8. Saenz, S.A., et al. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. J. Exp. Med. 210, 1823-1837 (2013
9. Fallon, P.G., et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105-1116 (2006
10. Chang, Y.J., et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat. Immunol. 12, 631-638 (2011
11. Motomura, Y., et al. Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40, 758-771 (2014
12. Salimi, M., et al. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J. Exp. Med. 210, 2939-2950 (2013
13. Monticelli, L.A., et al. Innate lymphoid cells promote lung-Tissue homeostasis after infection with influenza virus. Nat. Immunol. 12, 1045-1054 (2011
14. McHedlidze, T., et al. Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity 39, 357-371 (2013
15. Nussbaum, J.C., et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502, 245-248 (2013
16. Wilhelm, C., et al. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat. Immunol. 12, 1071-1077 (2011
17. Magri, G., et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat. Immunol. 15, 354-364 (2014
18. Boos, M.D., Yokota, Y., Eberl, G. & Kee, B.L. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J. Exp. Med. 204, 1119-1130 (2007
19. Hoyler, T., et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37, 634-648 (2012
20. Yagi, R., et al. The transcription factor GATA3 is critical for the development of all IL-7Ra-expressing innate lymphoid cells. Immunity 40, 378-388 (2014
21. Wong, S.H., et al. Transcription factor RORa is critical for nuocyte development. Nat. Immunol. 13, 229-236 (2012
22. Yang, Q., et al. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity 38, 694-704 (2013
23. Spooner, C.J., et al. Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nat. Immunol. 14, 1229-1236 (2013
24. Hwang, Y.Y. & McKenzie, A.N. Innate lymphoid cells in immunity and disease. Adv. Exp. Med. Biol. 785, 9-26 (2013
25. Mjösberg, J.M., et al. Human IL-25- And IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat. Immunol. 12, 1055-1062 (2011
26. Guo, L., et al. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. USA 106, 13463-13468 (2009
27. Licona-Limón, P., Kim, L.K., Palm, N.W. & Flavell, R.A. TH2, allergy and group 2 innate lymphoid cells. Nat. Immunol. 14, 536-542 (2013
28. Gladiator, A., Wangler, N., Trautwein-Weidner, K. & LeibundGut-Landmann, S. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. J. Immunol. 190, 521-525 (2013
29. OShea, J.J. & Paul, W.E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327, 1098-1102 (2010