Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice

British Journal of Pharmacology

Volumn 147, Issue 8, 2006, Pages 886-896

  Prendergast, Clodagh E ^a,b   Morton, Magda F ^a   Figueroa, Katherine W ^a,c   Wu, Xiaodong ^a   Shankley, Nigel P ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Neuromedin U; NMU1 receptor knockout mouse; Smooth muscle contraction; Species differences

Indexed keywords

NEUROMEDIN U; NEUROMEDIN U 23; NEUROMEDIN U 9; NEUROMEDIN U RECEPTOR; NEUROMEDIN U1 RECEPTOR; NEUROMEDIN U2 RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOASSAY; BLADDER CONTRACTION; ELECTROSTIMULATION; FEMALE; GALLBLADDER; GUINEA PIG; ILEUM; IN VITRO STUDY; INTESTINE CONTRACTION; ISOLATED ORGAN; KNOCKOUT MOUSE; LOWER ESOPHAGUS SPHINCTER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CONTRACTION; SPECIES DIFFERENCE; STOMACH FUNDUS; UTERUS CONTRACTION; VAS DEFERENS;

ANIMALS; FEMALE; GUINEA PIGS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROTRANSMITTER;

EID: 33646593151     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706677     Document Type: Article

References (35)

1. AUGOOD, S.J., KEAST, J.R. & EMSON, P.C. (1988). Distribution and characterization of neuromedin U-like immunoreactivity in rat brain and intestine and in guinea pig intestine. Regul. Pept., 20, 281-292.
2. BALLESTA, J., CARLEI, F., BISHOP, A.E., STEEL, J.H., GIBSON, S.J., FAHEY, M., HENNESSEY, R., DOMIN, J., BLOOM, S.R. & POLAK, J.M. (1988). Occurrence and developmental pattern of neuromedin U-immunoreactive nerves in the gastrointestinal tract and brain of the rat. Neuroscience, 25, 797-816.
3. BENITO-ORFILA, M.A., DOMIN, J., NANDHA, K.A. & BLOOM, S.R. (1991). The motor effect of neuromedin U on rat stomach in vitro. Eur. J. Pharmacol., 193, 329-333.
4. BOCKMAN, C.S., ABEL, P.W., HICKS, J.W. & CONLON, J.M. (1989). Evidence that neuromedin U may regulate gut motility in reptiles but not in mammals. Eur. J. Pharmacol., 171, 255-257.
5. BRIGHTON, P.J., SZEKERES, P.G. & WILLARS, G.B. (2004a). Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol. Rev., 56, 231-248.
6. BRIGHTON, P.J., SZEKERES, P.G., WISE, A. & WILLARS, G.B. (2004b). Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction. Mol. Pharm., 66, 1544-1556.
7. BROWN, D.R. & QUITO, F.L. (1988). Neuromedin U octapeptide alters ion transport in porcine jejunum. Eur. J. Pharmacol., 155, 159-162.
8. CAO, C.Q., YU, X.H., DRAY, A., FILOSA, A. & PERKINS, M.N. (2003). A pro-nociceptive role of neuromedin U in adult mice. Pain, 104, 609-616.
9. CHU, C., JIN, Q., KUNITAKE, T., KATO, K., NABEKURA, T., NAKAZATO, M., KANGAWA, K. & KANNAN, H. (2002). Cardiovascular actions of central neuromedin U in conscious rats. Regul. Pept., 105, 29-34.
10. CONLON, J.M., DOMIN, J., THIM, L., DIMARZO, V., MORRIS, H.R. & BLOOM, S.R. (1988). Primary structure of neuromedin U from the rat. J. Neurochem., 51, 988-991.
11. DOMIN, J., GHATEI, M.A., CHOHAN, P. & BLOOM, S.R. (1987). Neuromedin U - a study of its distribution in the rat. Peptides, 8, 779-784.
12. FUJII, R., HOSOYA, M., FUKUSUMI, S., KAWAMATA, Y., HABATA, Y., HINUMA, S., ONDA, H., NISHIMURA, O. & FUJINO, M. (2000). Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J. Biol. Chem., 275, 21068-21074.
13. FUNES, S., HEDRICK, J.A., YANG, S., LIXIN, S., BAYNE, M., MONSMA, F.J. & GUSTAFSON, E.L. (2002). Cloning and characterization of murine neuromedin U receptors. Peptides, 23, 1607-1615.
14. FURNESS, J.B., POMPOLO, S., MURPHY, R. & GIRAUD, A. (1989). Projections of neurons with neuromedin U-like immunoreactivity in the small intestine of the guinea-pig. Cell Tissue Res., 257, 415-422.
15. GAN, L., FALZONE, T.L., ZHANG, K., RUBINSTEIN, M., BALDESSARINI, R.J. & TARAZI, F.I. (2004). Enhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout mice. J. Mol. Neurosci., 22, 167-178.
16. GARDINER, S.M., COMPTON, A.M. & BENNETT, T. (1990a). Differential effects of neuropeptides on celiac and superior mesenteric blood flows in conscious rats. Regul. Pept., 29, 215-227.
17. GARDINER, S.M., COMPTON, A.M., BENNETT, T., DOMIN, J. & BLOOM, S.R. (1990b). Regional hemodynamic effects of neuromedin U in conscious rats. Am. J. Physiol., 258, R32-R38.
18. GUAN, X.M., YU, H., JIANG, Q., VAN DER PLOEG, L.H. & LIU, J. (2001). Distribution of neuromedin U receptor subtype 2 mRNA in the rat brain. Gene Expr. Patterns, 1, 1-4.
19. HANADA, R., NAKAZATO, M., MURAKAMI, N., SAKIHARA, S., YOSHIMATSU, H., TOSHINAI, K., HANADA, T., SUDA, T., KANGAWA, K., MATSUKURA, S. & SAKATA, T. (2001). A role for neuromedin U in stress response. Biochem. Biophys. Res. Commun., 289, 225-228.
20. HEDRICK, J.A., MORSE, K., SHAN, L., QIAO, X., PANG, L., WANG, S., LAZ, T., GUSTAFSON, E.L., BAYNE, M. & MONSMA JR, F.J. (2000). Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol. Pharmacol., 58, 870-875.
21. HOSOYA, M., MORIYA, T., KAWAMATA, Y., OHKUBO, S., FUJII, R., MATSUI, H., SHINTANI, Y., KUKUSUMI, S., HABATA, Y., HINUMA, S., ONDA, H., NISHIMURA, O. & FUJINO, M. (2000). Identification and functional characterization of a novel subtype of neuromedin U receptor. J. Biol. Chem., 275, 29528-29532.
22. HOWARD, A.D., WANG, R., PONG, S-S., MELLIN, T.N., STRACK, A., GUAN, X-M., ZENG, Z., WILLIAMS, D.L., FEIGHNER, S.D., NUNES, C.N., MURPHY, B., STAIR, J.N., YU, H. & JIANG, Q. (2000). Identification of receptors for neuromedin U and its role in feeding. Nature, 406, 70-74.
23. HUTCHINSON, D.S., EVANS, B.A. & SUMMERS, R.J. (2001). beta(1)-Adrenoceptors compensate for beta(3)-adrenoceptors in ileum from beta(3)-adrenoceptor knockout mice. Br. J. Pharmacol., 132, 433-442.
24. MAGGI, C.A., PATACCHINI, R., GIULIANI, S., TURINI, D., BARBANTI, G., ROVERO, P. & MELI, A. (1990). Motor response of the human isolated small intestine and urinary bladder to porcine neuromedin U-8. Br. J. Pharmacol., 99, 186-188.
25. MINAMINO, N., KANGAWA, K. & MATSUO, H. (1985). Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem. Biophys. Res. Commun., 130, 1078-1085.
26. MURPHY, R., TURNER, C.A., FURNESS, J.B., PARKER, L. & GIRAUD, A. (1990). Isolation and microsequence analysis of a novel form of neuromedin U from guinea pig small intestine. Peptides, 11, 613-617.
27. NAKAZATO, M., HANADA, R., MURAKAMI, N., DATE, Y., MONDAL, M.S., KOJIMA, M., YOSHIMATSU, H., KANGAWA, K. & MATSUKURA, S. (2000). Central effects of neuromedin U in the regulation of energy homeostasis. Biochem. Biophys. Res. Commun., 277, 191-194.
28. RADDATZ, R., WILSON, A.E., ARTYMYSHYN, R., BONINI, J.A., BOROWSKY, B., BOTEJU, L.W., ZHOU, S., KOURANOVA, E.V., NAGORNY, R., GUEVARRA, M.S., DAI, M., LERMAN, G.S., VAYSSE, P.J., BRANCHEK, T.A., GERALD, C., FORRAY, C. & ADHAM, N. (2000). Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J. Biol. Chem., 275, 32452-32459.
29. SAKURA, N., OHTA, S., UCHIDA, Y., KUROSAWA, K., OKIMURA, K. & HASHIMOTO, T. (1991). Structure-activity relationships of rat neuromedin U for smooth muscle contraction. Chem. Pharm. Bull. (Tokyo), 39, 2016-2020.
30. SHAN, L., QIAO, X., CRONA, J.H., BEHAN, J., WANG, S., LAZ, T., BAYNE, M., GUSTAFSON, E.L., MONOSMA, F.J.J. & HEDRICK, J.A. (2000). Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. J. Biol. Chem., 275, 39482-39486.
31. SUMI, S., INOUE, K., KOGIRE, M., DOI, R., TAKAORI, K., SUZUKI, T., YAJIMA, H. & TOBE, T. (1987). Effect of synthetic neuromedin U-8 and U-25, novel peptides identified in porcine spinal cord, on splanchnic circulation in dogs. Life Sci., 41, 1585-1590.
32. SZEKERES, P.G., MUIR, A.I., SPINAGE, L.D., MILLER, J.E., BUTLER, S.I., SMITH, A., RENNIE, G.I., MURDOCK, P.R., FITZGERALD, L.R., WU, H.-L., MCMILLAN, L.J., GUERRERA, S., VAWTER, L., ELSHOURBAGY, N.A., MOONEY, J.L., BERGSMA, D.J., WILSON, S. & CHAMBERS, J.K. (2000). Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J. Biol. Chem., 275, 20247-20250.
33. WESTFALL, T.D., MCCAFFERTY, G.P., PULLEN, M., GRUVER, S., SULPIZIO, A.C., AIYAR, V.N., JYOTI, D., CONTINO, L.C., MANNAN, I.J. & HIEBLE, J.P. (2002). Characterization of neuromedin U effects in canine smooth muscle. J. Pharmacol. Exp. Ther., 301, 987-992.
34. WREN, A.M., SMALL, C.J., ABBOTT, C.R., JETHWA, P.H., KENNEDY, A.R., MURPHY, K.G., STANLEY, S.A., ZOLLNER, A.N., GHATEI, M.A. & BLOOM, S.R. (2002). Hypothalamic actions of neuromedin U. Endocrinology, 143, 4227-4234.
35. YU, X.H., CAO, C.Q., MENNICKEN, F., PUMA, C., DRAY, A., O'DONNELL, D., AHMAD, S. & PERKINS, M. (2003). Pronociceptive effects of neuromedin u in rat. Neuroscience, 120, 467-474.