Measuring the burden of treatment for chronic disease: Implications of a scoping review of the literature

BMC Medical Research Methodology

Volumn 17, Issue 1, 2017, Pages

  Sav, Adem ^a,d   Salehi, Asiyeh ^b   Mair, Frances S ^c   McMillan, Sara S ^b  

^a AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d NONE   (Australia)

Author keywords

Burden of medication; Burden of treatment; Chronic disease; Cost of illness; Time burden; Treatment experience; Workload burden

Indexed keywords

CHRONIC DISEASE; COST OF ILLNESS; HUMAN;

CHRONIC DISEASE; COST OF ILLNESS; HUMANS;

EID: 85029308562     PISSN: None     EISSN: 14712288     Source Type: Journal    
DOI: 10.1186/s12874-017-0411-8     Document Type: Review

References (118)

1. World Health Organization: Noncommunicable diseases. In: Media Centre. Edited by Organization WH. Geneva, Switzerland: World Health Organization; 2017.
2. Gallacher K, May CR, Montori VM, Mair FS. Understanding patients' experiences of treatment burden in chronic heart failure using normalization process theory. Ann Fam Med. 2011;9(3):235-43. 239p
3. Sav A, Whitty JA, McMillan SS, Kendall E, Kelly F, King MA, Wheeler AJ. Treatment burden and chronic illness: who is at most risk. Patient - Patient-Centered Outcomes Res. 2016;9(6):559-69.
4. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 380(9836):37-43.
5. Mair FS, May CR. Thinking about the burden of treatment. BMJ: British Medical Journal. 2014;349
6. Tran VT, Montori VM, Eton DT, Baruch D, Falissard B, Ravaud P. Development and description of measurement properties of an instrument to assess treatment burden among patients with multiple chronic conditions. BMC Med. 2012;10
7. May C, Montori VM, Mair FS. We need minimally disruptive medicine. BMJ. 2009;339
8. Sav A, King MA, Whitty JA, Kendall E, McMillan SS, Kelly F, Hunter B, Wheeler AJ. Burden of treatment for chronic illness: a concept analysis and review of the literature. Health Expectations. 2015;18(3):312-24. 313p
9. Tran VT, Harrington M, Montori VM, Barnes C, Wicks P, Ravaud P. Adaptation and validation of the Treatment Burden Questionnaire (TBQ) in English using an internet platform. BMC Med. 2014;12(1):109.
10. Demain S, Gonçalves AC, Areia C, Oliveira R, Marcos AJ, Marques A, Parmar R, Hunt K. Living with, managing and minimising treatment burden in long term conditions: A systematic review of qualitative research. PLoS One. 2015;10(5):e0125457.
11. Sav A, Kendall E, McMillan SS, Kelly F, Whitty JA, King MA, Wheeler AJ. You say treatment, I say hard work: treatment burden among people with chronic illness and their carers in Australia. Health Soc Care Community. 2013;21(6):665-74. 610p
12. Colquhoun HL, Levac D, O'Brien KK, Straus S, Tricco AC, Perrier L, Kastner M, Moher D. Scoping reviews: time for clarity in definition, methods, and reporting. J Clin Epidemiol. 2014;67(12):1291-4.
13. Tricco AC, Lillie E, Zarin W, O'Brien K, Colquhoun H, Kastner M, Levac D, Ng C, Sharpe JP, Wilson K, et al. A scoping review on the conduct and reporting of scoping reviews. BMC Med Res Methodol. 2016;16:15.
14. H. A, L. OM: Scoping studies: towards a methodological framework. Int J Soc Res Methodol 2005, 8(1):19-32.
15. Davis K, Drey N, Gould D. What are scoping studies? A review of the nursing literature. Int J Nurs Stud. 2009;46(10):1386-400.
16. Levac D, Colquhoun H, O'Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69.
17. Singh A, Harford J, Schuch HS, Watt RG, Peres MA. Theoretical basis and explanation for the relationship between area-level social inequalities and population oral health outcomes - a scoping review. SSM - Population Health. 2016;2:451-62.
18. Vijan S, Sussman JB, Yudkin JS, Hayward RA. Effect of patients' risks and preferences on health gains with plasma glucose level lowering in type 2 diabetes mellitus. JAMA Intern Med. 2014;174(8):1227-34.
19. Brod M, Valensi P, Shaban JA, Bushnell DM, Christensen TL. Patient treatment satisfaction after switching to NovoMix® 30 (BIAsp 30) in the IMPROVE™ study: an analysis of the influence of prior and current treatment factors. Qual Life Res. 2010;19(9):1285-93.
20. Lucas JS, Behan L, Dunn Galvin A, Alpern A, Morris AM, Carroll MP, Knowles MR, Leigh MW, Quittner AL. A quality-of-life measure for adults with primary ciliary dyskinesia: QOL-PCD. Eur Respir J. 2015;46(2):375-83.
21. Tran V-T, Barnes C, Montori VM, Falissard B, Ravaud P. Taxonomy of the burden of treatment: a multi-country web-based qualitative study of patients with chronic conditions. BMC Med. 2015;13(1):115-115. 111p
22. Baylor CR, Yorkston KM, Eadie TL, Maronian NC. The psychosocial consequences of BOTOX injections for spasmodic dysphonia: a qualitative study of patients' experiences. J Voice. 2007;21(2):231-47. 217p
23. Gallacher KI, Batty GD, McLean G, Mercer SW, Guthrie B, May CR, Langhorne P, Mair FS. Stroke, multimorbidity and polypharmacy in a nationally representative sample of 1,424,378 patients in Scotland: implications for treatment burden. BMC Med. 2014;12(1):151-151. 151p
24. Sav A, McMillan SS, Kelly F, Kendall E, Whitty JA, King MA, Wheeler AJ. Treatment burden among people with chronic illness: what are consumer health organizations saying. Chronic Illness. 2013;9(3):220-32.
25. Eton DT, Ramalho de Oliveira D, Egginton JS, Ridgeway JL, Odell L, May CR, Montori VM. building a measurement framework of burden of treatment in complex patients with chronic conditions: a qualitative study. Patient Relat Outcome Measures. 2012;3:39-49.
26. Eton DT, Ridgeway JL, Egginton JS, Tiedje K, Linzer M, Boehm DH, Poplau S, Ramalho de Oliveira D, Odell L, Montori VM, et al. finalizing a measurement framework for the burden of treatment in complex patients with chronic conditions. Patient Relat Outcome Measures. 2015;6:117-26.
27. Kahn LS, Vest BM, Madurai N, Singh R, York TRM, Cipparone CW, Reilly S, Malik KS, Fox CH. Chronic kidney disease (CKD) treatment burden among low-income primary care patients. Chronic Illn. 2015;11(3):171-83.
28. Karamanidou C, Weinman J, Horne R. A qualitative study of treatment burden among haemodialysis recipients. J Health Psychol. 2014;19(4):556-69.
29. Ridgeway JL, Egginton JS, Tiedje K, Linzer M, Boehm D, Poplau S, de Oliveira DR, Odell L, Montori VM, Eton DT. Factors that lessen the burden of treatment in complex patients with chronic conditions: a qualitative study. Patient Preference Adherence. 2014;8:339-51.
30. Eton DT, Yost KJ, Lai JS, Ridgeway JL, Egginton JS, Rosedahl JK, Linzer M, Boehm DH, Thakur A, Poplau S, et al. Development and validation of the patient experience with treatment and self-management (PETS): a patient-reported measure of treatment burden. Qual Life Res. 2016:1-15.
31. Nordyke RJ, Chang C-H, Chiou C-F, Wallace JF, Yao B, Schwartzberg LS. Validation of a patient satisfaction questionnaire for anemia treatment, the PSQ-an. Health Qual Life Outcomes. 2006;4:28-28.
32. Henry DH, Viswanathan HN, Elkin EP, Traina S, Wade S, Cella D. Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S. Support Care Cancer. 2008;16(7):791-801.
33. Bohlen K, Scoville E, Shippee ND, May CR, Montori VM. Overwhelmed Patients: A videographic analysis of how patients with type 2 diabetes and clinicians articulate and address treatment burden during clinical encounters. Diab Care. 2012;35(1):47-9. 43p
34. Jordan S, Philpin S, Warring J, Cheung WY, Williams J. Percutaneous endoscopic gastrostomies: the burden of treatment from a patient perspective. J Adv Nurs. 2006;56(3):270-81.
35. Atkinson MJ, Sinha A, Hass SL, Colman SS, Kumar RN, Brod M, Rowland CR. Validation of a general measure of treatment satisfaction, the treatment satisfaction questionnaire for medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes. 2004;2(1):12.
36. Alpern AN, Brumback LC, Ratjen F, Rosenfeld M, Davis SD, Quittner AL. Initial evaluation of the parent cystic fibrosis questionnaire-revised (CFQ-R) in infants and young children. J Cyst Fibros. 2015;14(3):403-11.
37. Beek L, Schappin R, Gooskens R, Huisman J, Jongmans M. Surviving a brain tumor in childhood: impact on family functioning in adolescence. Psycho-Oncology. 2015;24(1):89-94.
38. Brod M, Christensen T, Bushnell D. Maximizing the value of validation findings to better understand treatment satisfaction issues for diabetes. Qual Life Res. 2007;16(6):1053-63.
39. Brod M, Christensen T, Hammer M, Busk AK, Bushnell DM. Examining the ability to detect change using the TRIM-diabetes and TRIM-diabetes device measures. Qual Life Res. 2011;20(9):1513-8.
40. Colombo C, Daccò V, Alicandro G, Loi S, Mazzi S, Lucioni C, Ravasio R. Cost of cystic fibrosis: analysis of treatment costs in a specialized center in northern Italy. Adv Ther. 2013;30(2):165-75. 111p
41. Garg S, Bailey T, Deluzio T, Pollom D. Preference for a new prefilled insulin pen compared with the original pen. Curr Med Res Opin. 2011;27(12):2323-33. 2311p
42. Grootscholten C, Snoek FJ, Bijl M, van Houwelingen HC, Derksen RHW, Berden JHM. Health-related quality of life and treatment burden in patients with proliferative lupus nephritis treated with cyclophosphamide or azathioprine/methylprednisolone in a randomized controlled trial. J Rheumatol. 2007;34(8):1699-707. 1699p
43. Hanke WC, Norlin JM, Mark Knudsen K, Larsson T, Stone S. Quality of life in treatment of AK: treatment burden of ingenol mebutate gel is small and short lasting. J Dermatol Treat. 2016;27(5):450-5.
44. Janssen DJ, Spruit MA, Schols JM, Wouters EF. A call for high-quality advance care planning in outpatients with severe COPD or chronic heart failure. CHEST. 2011;139(5):1081-8. 1088p
45. Kent EE, Forsythe LP, Yabroff KR, Weaver KE, de Moor JS, Rodriguez JL, Rowland JH: Are survivors who report cancer-related financial problems more likely to forgo or delay medical care? Cancer (0008543X) 2013, 119(20):3710-3717 3718p.
46. Leung E, Warde P, Jewett M, Panzarella T, O'Malley M, Sweet J, Moore M, Sturgeon J, Gospodarowicz M, Chung P. Treatment burden in stage i seminoma: a comparison of surveillance and adjuvant radiation therapy. BJU Int. 2013;112(8):1088-95.
47. Liu JY, Woloshin S, Laycock WS, Rothstein RI, Finlayson SRG, Schwartz LM. Symptoms and treatment burden of gastroesophageal reflux disease: validating the GERD assessment scales. Arch Intern Med. 2004;164(18):2058-64.
48. Ovayolu Ö, Ovayolu N, Ae D, Özkaya M. The Challenge of Diabetes in the Elderly and Affecting Factors. Holist Nurs Pract. 2015;29(5):272-9. 278p
49. Schmittdiel JA, Raebel MA, Dyer W, Xu S, Goodrich GK, Schroeder EB, Segal JB, Connor PJ O', Nichols GA, Lawrence JM, et al. Prescription medication burden in patients with newly diagnosed diabetes: a SUrveillance, PREvention, and ManagEment of Diabetes Mellitus (SUPREME-DM) study. J Am Pharm Assoc (2003). 2014;54(4):374-82. 379p
50. Shah S, Akbari M, Vanga R, Kelly CP, Hansen J, Theethira T, Tariq S, Dennis M, Leffler DA. Patient perception of treatment burden is high in celiac disease compared with other common conditions. Am J Gastroenterol. 2014;109(9):1304-11.
51. Dewulf J, Vermeulen F, Wanyama S, Thomas M, Proesmans M, Dupont L, De Boeck K. Treatment burden in patients with at least one class IV or v CFTR mutation. Pediatr Pulmonol. 2015;50(12):1230-6.
52. Groeneveld IF, Sosa ES, Pérez M, Fiuza-Luces C, Gonzalez-Saiz L, Gallardo C, López-Mojares LM, Ruiz JR, Lucia A. Health-related quality of life of Spanish children with cystic fibrosis. Qual Life Res. 2012;21(10):1837-45.
53. Havermans T, Vreys M, Proesmans M, De Boeck C. Assessment of agreement between parents and children on health-related quality of life in children with cystic fibrosis. Child Care Health Dev. 2006;32(1):1-7.
54. Henry B, Aussage P, Grosskopf C, Goehrs J-M. Development of the cystic fibrosis questionnaire (CFQ) for assessing quality of life in pediatric and adult patients. Qual Life Res. 2003;12(1):63-76.
55. McCullough AR, Tunney MM, Quittner AL, Elborn JS, Bradley JM, Hughes CM. Treatment adherence and health outcomes in patients with bronchiectasis. BMC Pulm Med. 2014:14(1).
56. Modi AC, Quittner AL. Validation of a disease-specific measure of health-related quality of life for children with cystic fibrosis. J Pediatr Psychol. 2003;28(8):535-46.
57. Sawicki GS, Rasouliyan L, McMullen AH, Wagener JS, McColley SA, Pasta DJ, Quittner AL. Longitudinal assessment of health-related quality of life in an observational cohort of patients with cystic fibrosis. Pediatr Pulmonol. 2011;46(1):36-44.
58. Blanch-Hartigan D, Chawla N, Beckjord EI, Forsythe LP, de Moor JS, Hesse BW, Arora NK. Cancer survivors' receipt of treatment summaries and implications for patient-centered communication and quality of care. Patient Educ Couns. 2015;98(10):1274-9.
59. Duclos M, Dejager S, Postel-Vinay N, di Nicola S, Quéré S, Fiquet B: Physical activity in patients with type 2 diabetes and hypertension - insights into motivations and barriers from the MOBILE study. Vasc Health Risk Manag 2015, 11:361-371 311p.
60. Fraser SDS, Roderick PJ, May CR, McIntyre N, McIntyre C, Fluck RJ, Shardlow A, Taal MW. The burden of comorbidity in people with chronic kidney disease stage 3: a cohort study. BMC Nephrology. 2015;16:193-03. 111p
61. Hock R, Kinsman A, Ortaglia A. Examining treatment adherence among parents of children with autism spectrum disorder. Disabil Health J. 2015;8(3):407-13.
62. Olveira C, Olveira G, Espildora F, Giron RM, Muñoz G, Quittner AL, Martinez-Garcia MA. Validation of a quality of life questionnaire for bronchiectasis: psychometric analyses of the Spanish QOL-B-V3.0. Qual Life Res. 2014;23(4):1279-92.
63. Robertson J, Doran E, Henry DA, Salkeld G. Prescription medicines: decision-making preferences of patients who receive different levels of public subsidy. Health Expect. 2014;17(1):15-26. 12p
64. Wolff J, Boyd C, Wolff JL, Boyd CM. A Look at Person- and Family-Centered Care Among Older Adults: Results from a National Survey [corrected]. JGIM. 2015;30(10):1497-504. 1498p
65. Dill EJ, Dawson R, Sellers DE, Robinson WM, Sawicki GS. Longitudinal trends in health-related quality of life in adults with cystic fibrosis. CHEST. 2013;144(3):981-9. 989p
66. Drabe N, Steinert H, Moergeli H, Weidt S, Strobel K, Jenewein J. Perception of treatment burden, psychological distress, and fatigue in thyroid cancer patients and their partners - effects of gender, role, and time since diagnosis. Psycho-Oncology. 2016;25:203-9.
67. Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346(14):1061-6.
68. Ziaian T, Sawyer MG, Reynolds KE, Carbone JA, Clark JJ, Baghurst PA, Couper JJ, Kennedy D, Martin AJ, Staugas RE, et al. Treatment burden and health-related quality of life of children with diabetes, cystic fibrosis and asthma. J Paediatr Child Health. 2006;42(10):596-600.
69. Avisar A, Lavie-Ajayi M. The burden of treatment: listening to stories of adolescents with ADHD about stimulant medication use. Ethical Hum Psychol Psychiatry: Int J Crit Inq. 2014;16(1):37-50.
70. Fried TR, Bradley EH. What matters to seriously ill older persons making end-of-life treatment decisions?: A qualitative study. J Palliat Med. 2003;6(2):237-44. 238p
71. Hyland ME, Whalley B, Jones RC, Masoli M. A qualitative study of the impact of severe asthma and its treatment showing that treatment burden is neglected in existing asthma assessment scales. Qual Life Res. 2015;24(3):631-9.
72. Sawicki GS, Heller KS, Demars N, Robinson WM. Motivating adherence among adolescents with cystic fibrosis: youth and parent perspectives. Pediatr Pulmonol. 2015;50(2):127-36.
73. Tunnicliffe DJ, Singh-Grewal D, Chaitow J, Mackie F, Manolios N, Lin M-W, O'Neill SG, Ralph AF, Craig JC, Tong A. Lupus means sacrifices: perspectives of adolescents and young adults with systemic lupus Erythematosus. Arthritis Care Res. 2016;68(6):828-37.
74. Yorke J, Armstrong I, Bundock S. Impact of living with pulmonary hypertension: a qualitative exploration. Nursing Health Sci. 2014;16(4):454-60.
75. Hogan A, Bonney M-A, Brien J-A, Karamy R, Aslani P. Factors affecting nebulised medicine adherence in adult patients with cystic fibrosis: a qualitative study. Int J Clin Pharm. 2015;37(1):86-93. 88p
76. Singer JP, Chen J, Katz PP, Blanc PD, Kagawa-Singer M, Stewart AL. Defining novel health-related quality of life domains in lung transplantation: a qualitative analysis. Qual Life Res. 2015;24(6):1521-33. 1513p
77. Levinson M, Mills A, Oldroyd J, Gellie A, Barrett J, Staples M, Stephenson G. The impact of intensive care in a private hospital on patients aged 80 and over: health-related quality of life, functional status and burden versus benefit. Intern Med J. 2016;46(6):694-702.
78. Quittner AL, Marciel KK, Salathe MA, O'Donnell AE, Gotfried MH, Ilowite JS, Metersky ML, Flume PA, Lewis SA, McKevitt M, et al. A preliminary quality of life questionnaire-bronchiectasis: a patient-reported outcome measure for bronchiectasis. CHEST. 2014;146(2):437-48. 412p
79. Moock J, Hessel F, Ziegeler D, Kubiak T, Kohlmann T. Development and testing of the insulin treatment experience questionnaire (ITEQ). The Patient: Patient-Centered Outcomes Res. 2010;3(1):45-58.
80. Fried TR, Bradley EH, Towle VR. Assessment of patient preferences: integrating treatments and outcomes. J Gerontol B Psychol Sci Soc Sci. 2002;57B(6):S348-54. 341p
81. Barrett-Lee P, Bloomfield D, Dougherty L, Harries M, Laing R, Patel H, Walker M. An audit to determine the time taken to administer intravenous bisphosphonate infusions in patients diagnosed with metastatic breast cancer to bone in a hospital setting. Curr Med Res Opin. 2007;23(7):1575-82. 1578p
82. Benner JS, Chapman RH, Petrilla AA, Tang SSK, Rosenberg N, Schwartz JS. Association between prescription burden and medication adherence in patients initiating antihypertensive and lipid-lowering therapy. Am J Health-Sys Pharm. 2009;66(16):1471-7. 1477p
83. Black JA, Long GH, Sharp SJ, Kuznetsov L, Boothby CE, Griffin SJ, Simmons RK. Change in cardio-protective medication and health-related quality of life after diagnosis of screen-detected diabetes: Results from the ADDITION-Cambridge cohort. Diab Res Clin Pract. 2015;109(1):170-7. 178p
84. Blome C, Gosau R, Radtke MA, Reich K, Rustenbach SJ, Spehr C, Thaçi D, Augustin M. Patient-relevant treatment goals in psoriasis. Arch Dermatol Res. 2016;308(2):69-78.
85. Broom R, Du H, Clemons M, Eton D, Dranitsaris G, Simmons C, Ooi W, Cella D. Switching breast cancer patients with progressive bone metastases to third-generation bisphosphonates: measuring impact using the Functional Assessment of Cancer Therapy-Bone Pain. J Pain Symptom Manage. 2009;38(2):244-57. 214p
86. Brose LS, Bradley C. Psychometric development of the Retinopathy Treatment Satisfaction Questionnaire (RetTSQ). Psychol Health Med. 2009;14(6):740-54. 715p
87. Burcu M, Alexander GC, Ng X, Harrington D. Construct Validity and Factor Structure of Survey-based Assessment of Cost-related Medication Burden. Med Care. 2015;53(2):199-206. 198p
88. De Smedt RHE, Haaijer-Ruskamp FM, Groenier KH, van der Meer K, Jaarsma T. Perceived adverse drug events in heart failure: patients' perceptions and related factors. J Cardiovasc Nurs. 2011;26(3):250-60. 211p
89. Eiser C, Upton P. Costs of caring for a child with cancer: a questionnaire survey. Child Care Health Dev. 2007;33(4):455-9.
90. Foltz R, Huefner JC. The subjective experience of being medicated in troubled youth: a sample from residential treatment. J Child Fam Stud. 2014;23(4):752-63.
91. Garfield LD, Dixon D, Nowotny P, Lotrich FE, Pollock BG, Kristjansson SD, Doré PM, Lenze EJ. Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial. Am J Geriat Psychiatry. 2014;22(10):971-9. 979p
92. Lau DT, Mercaldo ND, Shega JW, Rademaker A, Weintraub S. Functional decline associated with polypharmacy and potentially inappropriate medications in community-dwelling older adults with dementia. Am J Alzheimers Dis Other Demen. 2011;26(8):606-15.
93. Lundy E, McMullan D, McShane P, Williams M, Watson M, White C. Polypharmacy and Drug Omissions across Hospices in Northern Ireland. J Palliat Med. 2013;16(11):1446-9. 1444p
94. Miller JE, Nugent CN, Russell LB. Which components of medical homes reduce the time burden on families of children with special health care needs. Health Serv Res. 2015;50(2):440-61. 422p
95. Miller JE, Nugent CN, Russell LB. Risk factors for family time burdens providing and arranging health care for children with special health care needs: lessons from nonproportional odds models. Soc Sci Res. 2015;52:602-14.
96. Mofizul Islam M, McRae IS, Yen L, Jowsey T, Valderas JM. Time spent on health-related activities by senior Australians with chronic diseases: what is the role of multimorbidity and comorbidity? Aust N Z J Public Health. 2015;39(3):277-83.
97. Passik SD, Kirsh KL, Rosenfeld B, McDonald MV, Theobald DE. The changeable nature of patients' fears regarding chemotherapy: implications for palliative care. J Pain Symptom Manage. 2001;21(2):113-20. 118p
98. Peeters L, Sibille A, Anrys B, Oyen C, Dooms C, Nackaerts K, Wauters I, Vansteenkiste J. Maintenance therapy for advanced non-small-cell lung cancer: a pilot study on patients' perceptions. J Thorac Oncol. 2012;7(8):1291-5. 1295p
99. Robertson TA, Cooke CE, Wang J, Shaya FT, Lee HY. Effect of medication burden on persistent use of lipid-lowering drugs among patients with hypertension. Am J Manag Care. 2008;14(11):710-6. 717p
100. Voorham J, Haaijer-Ruskamp FM, Wolffenbuttel BHR, Stolk RP, Denig P. Cardiometabolic treatment decisions in patients with type 2 diabetes: the role of repeated measurements and medication burden. Qual Saf Health Care. 2010;19(5):411-5. 415p
101. Wright KD, Asmundson GJG. Brief report: factor structure of the childhood illness attitude scales (CIAS). J Pediatr Psychol. 2005;30(2):213-8.
102. Zan H, Scharff R. The Heterogeneity in Financial and Time Burden of Caregiving to Children with Chronic Conditions. Matern Child Health J. 2015;19(3):615-25. 611p
103. Zeber JE, Miller AL, Copeland LA, McCarthy JF, Zivin K, Valenstein M, Greenwald D, Kilbourne AM. Medication adherence, ethnicity, and the influence of multiple psychosocial and financial barriers. Adm Policy Ment Health Ment Health Serv Res. 2011;38(2):86-95.
104. Bower P, Harkness E, Macdonald W, Coventry P, Bundy C, Moss-Morris R. Illness representations in patients with multimorbid long-term conditions: Qualitative study. Psychol Health. 2012;27(10):1211-26. 1216p
105. Janke EA, Ramirez ML, Haltzman B, Fritz M, Kozak AT. Patient's Experience with comorbidity management in primary care: a qualitative study of comorbid pain and obesity. Prim Health Care Res Dev. 2016;17(1):33-41.
106. Johnston S, Noble H. Factors influencing patients with stage 5 chronic kidney disease to opt for conservative management: a practitioner research study. J Clin Nurs. 2012;21(9/10):1215-22. 1218p
107. Lourens M. An exploration of Xhosa speaking patients' understanding of cancer treatment and its influence on their treatment experience. J Psychosoc Oncol. 2013;31(1):103-21.
108. Obeidat RF, Dickerson SS, Homish GG, Alqaissi NM, Lally RM. Controlling fear: Jordanian women's perceptions of the diagnosis and surgical treatment of early-stage breast cancer. Cancer Nurs. 2013;36(6):484-92.
109. Salter ML, Kumar K, Law AH, Gupta N, Marks K, Balhara K, McAdams-DeMarco MA, Taylor LA, Segev DL. Perceptions about hemodialysis and transplantation among African American adults with end-stage renal disease: inferences from focus groups. BMC Nephrol. 2015;16(1):49-49. 41p
110. Shahid S, Finn L, Bessarab D, Thompson SC. Nowhere to room. nobody told them: logistical and cultural impediments to Aboriginal peoples' participation in cancer treatment. Aust Health Rev. 2011;35(2):235-41. 237p
111. Stajduhar KI, Neithercut J, Chu E, Pham P, Rohde J, Sicotte A, Young K: Thyroid cancer: patients' experiences of receiving iodine-131 therapy. Oncology Nursing Forum 2000, 27(8):1213-1218 1216p.
112. Taylor RM, Franck LS, Dhawan A, Gibson F. The stories of young people living with a liver transplant. Qual Health Res. 2010;20(8):1076-90.
113. Tjia J, Givens JL, Karlawish JH, Okoli-Umeweni A, Barg FK. Beneath the surface: discovering the unvoiced concerns of older adults with Type 2 diabetes mellitus. Health Educ Res. 2008;23(1):40-52. 13p
114. Clark JA, Bokhour BG, Inui TS, Silliman RA, Talcott JA. Measuring patients' perceptions of the outcomes of treatment for early prostate cancer. Med Care. 2003;41(8):923-36. 914p
115. Tijerina MS. Psychosocial factors influencing Mexican-American women's adherence with hemodialysis treatment. Soc Work Health Care. 2006;43(1):57-74. 18p
116. Shippee ND, Shah ND, May CR, Mair FS, Montori VM. Cumulative complexity: a functional, patient-centered model of patient complexity can improve research and practice. J Clin Epidemiol. 2012;65(10):1041-51.
117. Baatiema L, De-Graft Aikins A, Sav A, Mnatzaganian G, Chan KYC, Somerset S. Barriers to evidence-based acute stroke care in Ghana: a qualitative study on the perspectives of stroke care professionals. BMJ Open Under Rev.
118. Morrison A, Polisena J, Husereau D, Moulton K, Clark M, Fiander M, Mierzwinski-Urban M, Clifford T, Hutton B, Rabb D. The effect of English-language restriction on systematic review-based meta-analyses: a systematic review of empirical studies. Int J Technol Assess Health Care. 2012;28(2):138-44.