-
1
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., Charpentier, E., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337 (2012), 816–821.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
Charpentier, E.6
-
2
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L., Ran, F.A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P.D., Wu, X., Jiang, W., Marraffini, L.A., Zhang, F., Multiplex genome engineering using CRISPR/Cas systems. Science 339 (2013), 819–823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
Habib, N.6
Hsu, P.D.7
Wu, X.8
Jiang, W.9
Marraffini, L.A.10
Zhang, F.11
-
3
-
-
84874617789
-
Efficient genome editing in zebrafish using a CRISPR-Cas system
-
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Tsai, S.Q., Sander, J.D., Peterson, R.T., Yeh, J.R., Joung, J.K., Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol. 31 (2013), 227–229.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 227-229
-
-
Hwang, W.Y.1
Fu, Y.2
Reyon, D.3
Maeder, M.L.4
Tsai, S.Q.5
Sander, J.D.6
Peterson, R.T.7
Yeh, J.R.8
Joung, J.K.9
-
4
-
-
84876575031
-
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
-
DiCarlo, J.E., Norville, J.E., Mali, P., Rios, X., Aach, J., Church, G.M., Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res. 41 (2013), 4336–4343.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 4336-4343
-
-
DiCarlo, J.E.1
Norville, J.E.2
Mali, P.3
Rios, X.4
Aach, J.5
Church, G.M.6
-
5
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
-
Wang, H., Yang, H., Shivalila, C.S., Dawlaty, M.M., Cheng, A.W., Zhang, F., Jaenisch, R., One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153 (2013), 910–918.
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
Yang, H.2
Shivalila, C.S.3
Dawlaty, M.M.4
Cheng, A.W.5
Zhang, F.6
Jaenisch, R.7
-
6
-
-
84884160273
-
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
Mali, P., Aach, J., Stranges, P.B., Esvelt, K.M., Moosburner, M., Kosuri, S., Yang, L., Church, G.M., CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. 31 (2013), 833–838.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 833-838
-
-
Mali, P.1
Aach, J.2
Stranges, P.B.3
Esvelt, K.M.4
Moosburner, M.5
Kosuri, S.6
Yang, L.7
Church, G.M.8
-
7
-
-
84860440653
-
RNA in defense: CRISPRs protect prokaryotes against mobile genetic elements
-
Jore, M.M., Brouns, S.J., van der Oost, J., RNA in defense: CRISPRs protect prokaryotes against mobile genetic elements. Cold Spring Harb. Perspect. Biol., 4, 2012, a003657.
-
(2012)
Cold Spring Harb. Perspect. Biol.
, vol.4
, pp. a003657
-
-
Jore, M.M.1
Brouns, S.J.2
van der Oost, J.3
-
8
-
-
84866859751
-
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
-
Gasiunas, G., Barrangou, R., Horvath, P., Siksnys, V., Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc. Natl. Acad. Sci. USA 109 (2012), E2579–E2586.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E2579-E2586
-
-
Gasiunas, G.1
Barrangou, R.2
Horvath, P.3
Siksnys, V.4
-
9
-
-
84896733529
-
Crystal structure of Cas9 in complex with guide RNA and target DNA
-
Nishimasu, H., Ran, F.A., Hsu, P.D., Konermann, S., Shehata, S.I., Dohmae, N., Ishitani, R., Zhang, F., Nureki, O., Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell 156 (2014), 935–949.
-
(2014)
Cell
, vol.156
, pp. 935-949
-
-
Nishimasu, H.1
Ran, F.A.2
Hsu, P.D.3
Konermann, S.4
Shehata, S.I.5
Dohmae, N.6
Ishitani, R.7
Zhang, F.8
Nureki, O.9
-
10
-
-
84884906690
-
RNA-guided gene activation by CRISPR-Cas9-based transcription factors
-
Perez-Pinera, P., Kocak, D.D., Vockley, C.M., Adler, A.F., Kabadi, A.M., Polstein, L.R., Thakore, P.I., Glass, K.A., Ousterout, D.G., Leong, K.W., et al. RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat. Methods 10 (2013), 973–976.
-
(2013)
Nat. Methods
, vol.10
, pp. 973-976
-
-
Perez-Pinera, P.1
Kocak, D.D.2
Vockley, C.M.3
Adler, A.F.4
Kabadi, A.M.5
Polstein, L.R.6
Thakore, P.I.7
Glass, K.A.8
Ousterout, D.G.9
Leong, K.W.10
-
11
-
-
84908352138
-
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
-
Gilbert, L.A., Horlbeck, M.A., Adamson, B., Villalta, J.E., Chen, Y., Whitehead, E.H., Guimaraes, C., Panning, B., Ploegh, H.L., Bassik, M.C., et al. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell 159 (2014), 647–661.
-
(2014)
Cell
, vol.159
, pp. 647-661
-
-
Gilbert, L.A.1
Horlbeck, M.A.2
Adamson, B.3
Villalta, J.E.4
Chen, Y.5
Whitehead, E.H.6
Guimaraes, C.7
Panning, B.8
Ploegh, H.L.9
Bassik, M.C.10
-
12
-
-
84880571335
-
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
-
Gilbert, L.A., Larson, M.H., Morsut, L., Liu, Z., Brar, G.A., Torres, S.E., Stern-Ginossar, N., Brandman, O., Whitehead, E.H., Doudna, J.A., et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154 (2013), 442–451.
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
Larson, M.H.2
Morsut, L.3
Liu, Z.4
Brar, G.A.5
Torres, S.E.6
Stern-Ginossar, N.7
Brandman, O.8
Whitehead, E.H.9
Doudna, J.A.10
-
13
-
-
84874687019
-
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
-
Qi, L.S., Larson, M.H., Gilbert, L.A., Doudna, J.A., Weissman, J.S., Arkin, A.P., Lim, W.A., Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152 (2013), 1173–1183.
-
(2013)
Cell
, vol.152
, pp. 1173-1183
-
-
Qi, L.S.1
Larson, M.H.2
Gilbert, L.A.3
Doudna, J.A.4
Weissman, J.S.5
Arkin, A.P.6
Lim, W.A.7
-
14
-
-
84920992414
-
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
-
Zalatan, J.G., Lee, M.E., Almeida, R., Gilbert, L.A., Whitehead, E.H., La Russa, M., Tsai, J.C., Weissman, J.S., Dueber, J.E., Qi, L.S., Lim, W.A., Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 160 (2015), 339–350.
-
(2015)
Cell
, vol.160
, pp. 339-350
-
-
Zalatan, J.G.1
Lee, M.E.2
Almeida, R.3
Gilbert, L.A.4
Whitehead, E.H.5
La Russa, M.6
Tsai, J.C.7
Weissman, J.S.8
Dueber, J.E.9
Qi, L.S.10
Lim, W.A.11
-
15
-
-
84908328232
-
A protein-tagging system for signal amplification in gene expression and fluorescence imaging
-
Tanenbaum, M.E., Gilbert, L.A., Qi, L.S., Weissman, J.S., Vale, R.D., A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell 159 (2014), 635–646.
-
(2014)
Cell
, vol.159
, pp. 635-646
-
-
Tanenbaum, M.E.1
Gilbert, L.A.2
Qi, L.S.3
Weissman, J.S.4
Vale, R.D.5
-
16
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann, S., Brigham, M.D., Trevino, A.E., Joung, J., Abudayyeh, O.O., Barcena, C., Hsu, P.D., Habib, N., Gootenberg, J.S., Nishimasu, H., et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517 (2015), 583–588.
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
Brigham, M.D.2
Trevino, A.E.3
Joung, J.4
Abudayyeh, O.O.5
Barcena, C.6
Hsu, P.D.7
Habib, N.8
Gootenberg, J.S.9
Nishimasu, H.10
-
17
-
-
84926521955
-
Highly efficient Cas9-mediated transcriptional programming
-
Chavez, A., Scheiman, J., Vora, S., Pruitt, B.W., Tuttle, M., P R Iyer, E., Lin, S., Kiani, S., Guzman, C.D., Wiegand, D.J., et al. Highly efficient Cas9-mediated transcriptional programming. Nat. Methods 12 (2015), 326–328.
-
(2015)
Nat. Methods
, vol.12
, pp. 326-328
-
-
Chavez, A.1
Scheiman, J.2
Vora, S.3
Pruitt, B.W.4
Tuttle, M.5
P R Iyer, E.6
Lin, S.7
Kiani, S.8
Guzman, C.D.9
Wiegand, D.J.10
-
18
-
-
84940450173
-
piggyBac-ing models and new therapeutic strategies
-
Woodard, L.E., Wilson, M.H., piggyBac-ing models and new therapeutic strategies. Trends Biotechnol. 33 (2015), 525–533.
-
(2015)
Trends Biotechnol.
, vol.33
, pp. 525-533
-
-
Woodard, L.E.1
Wilson, M.H.2
-
19
-
-
0024449118
-
Transposon mutagenesis of baculoviruses: analysis of Trichoplusia ni transposon IFP2 insertions within the FP-locus of nuclear polyhedrosis viruses
-
Cary, L.C., Goebel, M., Corsaro, B.G., Wang, H.G., Rosen, E., Fraser, M.J., Transposon mutagenesis of baculoviruses: analysis of Trichoplusia ni transposon IFP2 insertions within the FP-locus of nuclear polyhedrosis viruses. Virology 172 (1989), 156–169.
-
(1989)
Virology
, vol.172
, pp. 156-169
-
-
Cary, L.C.1
Goebel, M.2
Corsaro, B.G.3
Wang, H.G.4
Rosen, E.5
Fraser, M.J.6
-
20
-
-
23744479962
-
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
-
Ding, S., Wu, X., Li, G., Han, M., Zhuang, Y., Xu, T., Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell 122 (2005), 473–483.
-
(2005)
Cell
, vol.122
, pp. 473-483
-
-
Ding, S.1
Wu, X.2
Li, G.3
Han, M.4
Zhuang, Y.5
Xu, T.6
-
21
-
-
34347337601
-
Toward simpler and faster genome-wide mutagenesis in mice
-
Wu, S., Ying, G., Wu, Q., Capecchi, M.R., Toward simpler and faster genome-wide mutagenesis in mice. Nat. Genet. 39 (2007), 922–930.
-
(2007)
Nat. Genet.
, vol.39
, pp. 922-930
-
-
Wu, S.1
Ying, G.2
Wu, Q.3
Capecchi, M.R.4
-
22
-
-
85010635827
-
piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice
-
Xu, C., Qi, X., Du, X., Zou, H., Gao, F., Feng, T., Lu, H., Li, S., An, X., Zhang, L., et al. piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice. Proc. Natl. Acad. Sci. USA 114 (2017), 722–727.
-
(2017)
Proc. Natl. Acad. Sci. USA
, vol.114
, pp. 722-727
-
-
Xu, C.1
Qi, X.2
Du, X.3
Zou, H.4
Gao, F.5
Feng, T.6
Lu, H.7
Li, S.8
An, X.9
Zhang, L.10
-
23
-
-
69249138761
-
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells
-
Xue, H., Wu, S., Papadeas, S.T., Spusta, S., Swistowska, A.M., MacArthur, C.C., Mattson, M.P., Maragakis, N.J., Capecchi, M.R., Rao, M.S., et al. A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells 27 (2009), 1836–1846.
-
(2009)
Stem Cells
, vol.27
, pp. 1836-1846
-
-
Xue, H.1
Wu, S.2
Papadeas, S.T.3
Spusta, S.4
Swistowska, A.M.5
MacArthur, C.C.6
Mattson, M.P.7
Maragakis, N.J.8
Capecchi, M.R.9
Rao, M.S.10
-
24
-
-
84924219729
-
Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells
-
Douvaras, P., Wang, J., Zimmer, M., Hanchuk, S., O'Bara, M.A., Sadiq, S., Sim, F.J., Goldman, J., Fossati, V., Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells. Stem Cell Reports 3 (2014), 250–259.
-
(2014)
Stem Cell Reports
, vol.3
, pp. 250-259
-
-
Douvaras, P.1
Wang, J.2
Zimmer, M.3
Hanchuk, S.4
O'Bara, M.A.5
Sadiq, S.6
Sim, F.J.7
Goldman, J.8
Fossati, V.9
-
25
-
-
79955548121
-
OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation
-
Liu, Y., Jiang, P., Deng, W., OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation. Nat. Protoc. 6 (2011), 640–655.
-
(2011)
Nat. Protoc.
, vol.6
, pp. 640-655
-
-
Liu, Y.1
Jiang, P.2
Deng, W.3
-
26
-
-
84891959329
-
Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex
-
Dixit, R., Wilkinson, G., Cancino, G.I., Shaker, T., Adnani, L., Li, S., Dennis, D., Kurrasch, D., Chan, J.A., Olson, E.C., et al. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J. Neurosci. 34 (2014), 539–553.
-
(2014)
J. Neurosci.
, vol.34
, pp. 539-553
-
-
Dixit, R.1
Wilkinson, G.2
Cancino, G.I.3
Shaker, T.4
Adnani, L.5
Li, S.6
Dennis, D.7
Kurrasch, D.8
Chan, J.A.9
Olson, E.C.10
-
27
-
-
0032033009
-
The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons
-
Fode, C., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M., Goridis, C., Guillemot, F., The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 20 (1998), 483–494.
-
(1998)
Neuron
, vol.20
, pp. 483-494
-
-
Fode, C.1
Gradwohl, G.2
Morin, X.3
Dierich, A.4
LeMeur, M.5
Goridis, C.6
Guillemot, F.7
-
28
-
-
0033967842
-
A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
-
Fode, C., Ma, Q., Casarosa, S., Ang, S.L., Anderson, D.J., Guillemot, F., A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 14 (2000), 67–80.
-
(2000)
Genes Dev.
, vol.14
, pp. 67-80
-
-
Fode, C.1
Ma, Q.2
Casarosa, S.3
Ang, S.L.4
Anderson, D.J.5
Guillemot, F.6
-
29
-
-
84859882919
-
Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation
-
Hindley, C., Ali, F., McDowell, G., Cheng, K., Jones, A., Guillemot, F., Philpott, A., Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation. Development 139 (2012), 1718–1723.
-
(2012)
Development
, vol.139
, pp. 1718-1723
-
-
Hindley, C.1
Ali, F.2
McDowell, G.3
Cheng, K.4
Jones, A.5
Guillemot, F.6
Philpott, A.7
-
30
-
-
12144271676
-
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
-
Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L., Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev. 19 (2005), 282–294.
-
(2005)
Genes Dev.
, vol.19
, pp. 282-294
-
-
Lee, S.K.1
Lee, B.2
Ruiz, E.C.3
Pfaff, S.L.4
-
31
-
-
0032032016
-
neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia
-
Ma, Q., Chen, Z., del Barco Barrantes, I., de la Pompa, J.L., Anderson, D.J., neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20 (1998), 469–482.
-
(1998)
Neuron
, vol.20
, pp. 469-482
-
-
Ma, Q.1
Chen, Z.2
del Barco Barrantes, I.3
de la Pompa, J.L.4
Anderson, D.J.5
-
32
-
-
0003073157
-
Identification of neurogenin, a vertebrate neuronal determination gene
-
Ma, Q., Kintner, C., Anderson, D.J., Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87 (1996), 43–52.
-
(1996)
Cell
, vol.87
, pp. 43-52
-
-
Ma, Q.1
Kintner, C.2
Anderson, D.J.3
-
33
-
-
41549151113
-
Regulation of motor neuron specification by phosphorylation of neurogenin 2
-
Ma, Y.C., Song, M.R., Park, J.P., Henry Ho, H.Y., Hu, L., Kurtev, M.V., Zieg, J., Ma, Q., Pfaff, S.L., Greenberg, M.E., Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron 58 (2008), 65–77.
-
(2008)
Neuron
, vol.58
, pp. 65-77
-
-
Ma, Y.C.1
Song, M.R.2
Park, J.P.3
Henry Ho, H.Y.4
Hu, L.5
Kurtev, M.V.6
Zieg, J.7
Ma, Q.8
Pfaff, S.L.9
Greenberg, M.E.10
-
34
-
-
0035855786
-
Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons
-
Mizuguchi, R., Sugimori, M., Takebayashi, H., Kosako, H., Nagao, M., Yoshida, S., Nabeshima, Y., Shimamura, K., Nakafuku, M., Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31 (2001), 757–771.
-
(2001)
Neuron
, vol.31
, pp. 757-771
-
-
Mizuguchi, R.1
Sugimori, M.2
Takebayashi, H.3
Kosako, H.4
Nagao, M.5
Yoshida, S.6
Nabeshima, Y.7
Shimamura, K.8
Nakafuku, M.9
-
35
-
-
0035855795
-
Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
-
Novitch, B.G., Chen, A.I., Jessell, T.M., Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31 (2001), 773–789.
-
(2001)
Neuron
, vol.31
, pp. 773-789
-
-
Novitch, B.G.1
Chen, A.I.2
Jessell, T.M.3
-
36
-
-
78651235357
-
Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury
-
Perrin, F.E., Boniface, G., Serguera, C., Lonjon, N., Serre, A., Prieto, M., Mallet, J., Privat, A., Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. PLoS ONE, 5, 2010, e15914.
-
(2010)
PLoS ONE
, vol.5
, pp. e15914
-
-
Perrin, F.E.1
Boniface, G.2
Serguera, C.3
Lonjon, N.4
Serre, A.5
Prieto, M.6
Mallet, J.7
Privat, A.8
-
37
-
-
58449121331
-
Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis
-
Roybon, L., Deierborg, T., Brundin, P., Li, J.Y., Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. Eur. J. Neurosci. 29 (2009), 232–243.
-
(2009)
Eur. J. Neurosci.
, vol.29
, pp. 232-243
-
-
Roybon, L.1
Deierborg, T.2
Brundin, P.3
Li, J.Y.4
-
38
-
-
62849111110
-
Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis
-
Roybon, L., Hjalt, T., Stott, S., Guillemot, F., Li, J.Y., Brundin, P., Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis. PLoS ONE, 4, 2009, e4779.
-
(2009)
PLoS ONE
, vol.4
, pp. e4779
-
-
Roybon, L.1
Hjalt, T.2
Stott, S.3
Guillemot, F.4
Li, J.Y.5
Brundin, P.6
-
39
-
-
0035797449
-
Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
-
Scardigli, R., Schuurmans, C., Gradwohl, G., Guillemot, F., Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31 (2001), 203–217.
-
(2001)
Neuron
, vol.31
, pp. 203-217
-
-
Scardigli, R.1
Schuurmans, C.2
Gradwohl, G.3
Guillemot, F.4
-
40
-
-
0037062516
-
Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate
-
Zirlinger, M., Lo, L., McMahon, J., McMahon, A.P., Anderson, D.J., Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc. Natl. Acad. Sci. USA 99 (2002), 8084–8089.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8084-8089
-
-
Zirlinger, M.1
Lo, L.2
McMahon, J.3
McMahon, A.P.4
Anderson, D.J.5
-
41
-
-
84925235094
-
Rapid neurogenesis through transcriptional activation in human stem cells
-
Busskamp, V., Lewis, N.E., Guye, P., Ng, A.H., Shipman, S.L., Byrne, S.M., Sanjana, N.E., Murn, J., Li, Y., Li, S., et al. Rapid neurogenesis through transcriptional activation in human stem cells. Mol. Syst. Biol., 10, 2014, 760.
-
(2014)
Mol. Syst. Biol.
, vol.10
, pp. 760
-
-
Busskamp, V.1
Lewis, N.E.2
Guye, P.3
Ng, A.H.4
Shipman, S.L.5
Byrne, S.M.6
Sanjana, N.E.7
Murn, J.8
Li, Y.9
Li, S.10
-
42
-
-
84878849645
-
Rapid single-step induction of functional neurons from human pluripotent stem cells
-
Zhang, Y., Pak, C., Han, Y., Ahlenius, H., Zhang, Z., Chanda, S., Marro, S., Patzke, C., Acuna, C., Covy, J., et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron 78 (2013), 785–798.
-
(2013)
Neuron
, vol.78
, pp. 785-798
-
-
Zhang, Y.1
Pak, C.2
Han, Y.3
Ahlenius, H.4
Zhang, Z.5
Chanda, S.6
Marro, S.7
Patzke, C.8
Acuna, C.9
Covy, J.10
-
43
-
-
84901195977
-
Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells
-
Nissim, L., Perli, S.D., Fridkin, A., Perez-Pinera, P., Lu, T.K., Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells. Mol. Cell 54 (2014), 698–710.
-
(2014)
Mol. Cell
, vol.54
, pp. 698-710
-
-
Nissim, L.1
Perli, S.D.2
Fridkin, A.3
Perez-Pinera, P.4
Lu, T.K.5
-
44
-
-
84902204289
-
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
-
Tsai, S.Q., Wyvekens, N., Khayter, C., Foden, J.A., Thapar, V., Reyon, D., Goodwin, M.J., Aryee, M.J., Joung, J.K., Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat. Biotechnol. 32 (2014), 569–576.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 569-576
-
-
Tsai, S.Q.1
Wyvekens, N.2
Khayter, C.3
Foden, J.A.4
Thapar, V.5
Reyon, D.6
Goodwin, M.J.7
Aryee, M.J.8
Joung, J.K.9
-
45
-
-
84925262435
-
Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system
-
Xie, K., Minkenberg, B., Yang, Y., Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system. Proc. Natl. Acad. Sci. USA 112 (2015), 3570–3575.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 3570-3575
-
-
Xie, K.1
Minkenberg, B.2
Yang, Y.3
-
46
-
-
85005949914
-
Multiplex CRISPR/Cas9-based genome engineering enhanced by Drosha-mediated sgRNA-shRNA structure
-
Yan, Q., Xu, K., Xing, J., Zhang, T., Wang, X., Wei, Z., Ren, C., Liu, Z., Shao, S., Zhang, Z., Multiplex CRISPR/Cas9-based genome engineering enhanced by Drosha-mediated sgRNA-shRNA structure. Sci. Rep., 6, 2016, 38970.
-
(2016)
Sci. Rep.
, vol.6
, pp. 38970
-
-
Yan, Q.1
Xu, K.2
Xing, J.3
Zhang, T.4
Wang, X.5
Wei, Z.6
Ren, C.7
Liu, Z.8
Shao, S.9
Zhang, Z.10
-
47
-
-
84930812429
-
Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications
-
Sadahiro, T., Yamanaka, S., Ieda, M., Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. Circ. Res. 116 (2015), 1378–1391.
-
(2015)
Circ. Res.
, vol.116
, pp. 1378-1391
-
-
Sadahiro, T.1
Yamanaka, S.2
Ieda, M.3
-
48
-
-
84981748049
-
Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells
-
Black, J.B., Adler, A.F., Wang, H.G., D'Ippolito, A.M., Hutchinson, H.A., Reddy, T.E., Pitt, G.S., Leong, K.W., Gersbach, C.A., Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. Cell Stem Cell 19 (2016), 406–414.
-
(2016)
Cell Stem Cell
, vol.19
, pp. 406-414
-
-
Black, J.B.1
Adler, A.F.2
Wang, H.G.3
D'Ippolito, A.M.4
Hutchinson, H.A.5
Reddy, T.E.6
Pitt, G.S.7
Leong, K.W.8
Gersbach, C.A.9
-
49
-
-
84923798099
-
A CRISPR/Cas9-based system for reprogramming cell lineage specification
-
Chakraborty, S., Ji, H., Kabadi, A.M., Gersbach, C.A., Christoforou, N., Leong, K.W., A CRISPR/Cas9-based system for reprogramming cell lineage specification. Stem Cell Reports 3 (2014), 940–947.
-
(2014)
Stem Cell Reports
, vol.3
, pp. 940-947
-
-
Chakraborty, S.1
Ji, H.2
Kabadi, A.M.3
Gersbach, C.A.4
Christoforou, N.5
Leong, K.W.6
-
50
-
-
84941047606
-
Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation
-
Balboa, D., Weltner, J., Eurola, S., Trokovic, R., Wartiovaara, K., Otonkoski, T., Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation. Stem Cell Reports 5 (2015), 448–459.
-
(2015)
Stem Cell Reports
, vol.5
, pp. 448-459
-
-
Balboa, D.1
Weltner, J.2
Eurola, S.3
Trokovic, R.4
Wartiovaara, K.5
Otonkoski, T.6
-
51
-
-
84955589837
-
Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators
-
Wei, S., Zou, Q., Lai, S., Zhang, Q., Li, L., Yan, Q., Zhou, X., Zhong, H., Lai, L., Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Sci. Rep., 6, 2016, 19648.
-
(2016)
Sci. Rep.
, vol.6
, pp. 19648
-
-
Wei, S.1
Zou, Q.2
Lai, S.3
Zhang, Q.4
Li, L.5
Yan, Q.6
Zhou, X.7
Zhong, H.8
Lai, L.9
-
52
-
-
78650467973
-
Open chromatin in pluripotency and reprogramming
-
Gaspar-Maia, A., Alajem, A., Meshorer, E., Ramalho-Santos, M., Open chromatin in pluripotency and reprogramming. Nat. Rev. Mol. Cell Biol. 12 (2011), 36–47.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 36-47
-
-
Gaspar-Maia, A.1
Alajem, A.2
Meshorer, E.3
Ramalho-Santos, M.4
-
53
-
-
73849086119
-
PiggyBac transposon-based inducible gene expression in vivo after somatic cell gene transfer
-
Saridey, S.K., Liu, L., Doherty, J.E., Kaja, A., Galvan, D.L., Fletcher, B.S., Wilson, M.H., PiggyBac transposon-based inducible gene expression in vivo after somatic cell gene transfer. Mol. Ther. 17 (2009), 2115–2120.
-
(2009)
Mol. Ther.
, vol.17
, pp. 2115-2120
-
-
Saridey, S.K.1
Liu, L.2
Doherty, J.E.3
Kaja, A.4
Galvan, D.L.5
Fletcher, B.S.6
Wilson, M.H.7
-
54
-
-
48249130858
-
Chromosomal transposition of PiggyBac in mouse embryonic stem cells
-
Wang, W., Lin, C., Lu, D., Ning, Z., Cox, T., Melvin, D., Wang, X., Bradley, A., Liu, P., Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA 105 (2008), 9290–9295.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9290-9295
-
-
Wang, W.1
Lin, C.2
Lu, D.3
Ning, Z.4
Cox, T.5
Melvin, D.6
Wang, X.7
Bradley, A.8
Liu, P.9
-
55
-
-
84904662494
-
Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells
-
Wu, S., Wu, Y., Zhang, X., Capecchi, M.R., Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells. Proc. Natl. Acad. Sci. USA 111 (2014), 10678–10683.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 10678-10683
-
-
Wu, S.1
Wu, Y.2
Zhang, X.3
Capecchi, M.R.4
-
56
-
-
79952138028
-
A hyperactive piggyBac transposase for mammalian applications
-
Yusa, K., Zhou, L., Li, M.A., Bradley, A., Craig, N.L., A hyperactive piggyBac transposase for mammalian applications. Proc. Natl. Acad. Sci. USA 108 (2011), 1531–1536.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 1531-1536
-
-
Yusa, K.1
Zhou, L.2
Li, M.A.3
Bradley, A.4
Craig, N.L.5
-
57
-
-
85047687015
-
Seamless genome editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon
-
Yusa, K., Seamless genome editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon. Nat. Protoc. 8 (2013), 2061–2078.
-
(2013)
Nat. Protoc.
, vol.8
, pp. 2061-2078
-
-
Yusa, K.1
-
58
-
-
84875260104
-
The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites
-
Li, M.A., Pettitt, S.J., Eckert, S., Ning, Z., Rice, S., Cadiñanos, J., Yusa, K., Conte, N., Bradley, A., The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites. Mol. Cell. Biol. 33 (2013), 1317–1330.
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 1317-1330
-
-
Li, M.A.1
Pettitt, S.J.2
Eckert, S.3
Ning, Z.4
Rice, S.5
Cadiñanos, J.6
Yusa, K.7
Conte, N.8
Bradley, A.9
-
59
-
-
67349270900
-
Enzymatic assembly of DNA molecules up to several hundred kilobases
-
Gibson, D.G., Young, L., Chuang, R.Y., Venter, J.C., Hutchison, C.A. 3rd, Smith, H.O., Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 6 (2009), 343–345.
-
(2009)
Nat. Methods
, vol.6
, pp. 343-345
-
-
Gibson, D.G.1
Young, L.2
Chuang, R.Y.3
Venter, J.C.4
Hutchison, C.A.5
Smith, H.O.6
-
60
-
-
84887010498
-
Genome engineering using the CRISPR-Cas9 system
-
Ran, F.A., Hsu, P.D., Wright, J., Agarwala, V., Scott, D.A., Zhang, F., Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8 (2013), 2281–2308.
-
(2013)
Nat. Protoc.
, vol.8
, pp. 2281-2308
-
-
Ran, F.A.1
Hsu, P.D.2
Wright, J.3
Agarwala, V.4
Scott, D.A.5
Zhang, F.6
-
61
-
-
84862908206
-
Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus
-
Macarthur, C.C., Xue, H., Van Hoof, D., Lieu, P.T., Dudas, M., Fontes, A., Swistowski, A., Touboul, T., Seerke, R., Laurent, L.C., et al. Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus. Stem Cells Dev. 21 (2012), 191–205.
-
(2012)
Stem Cells Dev.
, vol.21
, pp. 191-205
-
-
Macarthur, C.C.1
Xue, H.2
Van Hoof, D.3
Lieu, P.T.4
Dudas, M.5
Fontes, A.6
Swistowski, A.7
Touboul, T.8
Seerke, R.9
Laurent, L.C.10
-
62
-
-
84983121994
-
Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System
-
Li, S., Xue, H., Wu, J., Rao, M.S., Kim, D.H., Deng, W., Liu, Y., Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System. Stem Cells Dev. 24 (2015), 2925–2942.
-
(2015)
Stem Cells Dev.
, vol.24
, pp. 2925-2942
-
-
Li, S.1
Xue, H.2
Wu, J.3
Rao, M.S.4
Kim, D.H.5
Deng, W.6
Liu, Y.7
-
63
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (2001), 402–408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
64
-
-
84904705701
-
Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells
-
Chen, C., Jiang, P., Xue, H., Peterson, S.E., Tran, H.T., McCann, A.E., Parast, M.M., Li, S., Pleasure, D.E., Laurent, L.C., et al. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat. Commun., 5, 2014, 4430.
-
(2014)
Nat. Commun.
, vol.5
, pp. 4430
-
-
Chen, C.1
Jiang, P.2
Xue, H.3
Peterson, S.E.4
Tran, H.T.5
McCann, A.E.6
Parast, M.M.7
Li, S.8
Pleasure, D.E.9
Laurent, L.C.10
|