Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

Cell Stem Cell

Volumn 19, Issue 3, 2016, Pages 406-414

  Black, Joshua B ^a   Adler, Andrew F ^a   Wang, Hong Gang ^c   D'Ippolito, Anthony M ^b,c   Hutchinson, Hunter A ^a   Reddy, Timothy E ^b,c   Pitt, Geoffrey S ^c   Leong, Kam W ^a   Gersbach, Charles A ^a,b,c  

^a Duke University   (United States)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; GUIDE RNA; LENTIVIRUS VECTOR; MICROTUBULE ASSOCIATED PROTEIN 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN2; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR MYT1L; UNCLASSIFIED DRUG; GENETIC MARKER; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL FATE; CHROMATIN; COMPARATIVE STUDY; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; ECTOPIC EXPRESSION; EMBRYO; EPIGENETICS; FIBROBLAST; GENE LOCUS; GENE TARGETING; GENETIC ENGINEERING; MOUSE; NERVE CELL; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; STABLE EXPRESSION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENE VECTOR; GENETIC EPIGENESIS; GENETIC MARKER; GENETICS; HEK293 CELL LINE; HUMAN; LENTIVIRINAE; MAMMALIAN EMBRYO; METABOLISM;

ANIMALS; CELLS, CULTURED; CRISPR-CAS SYSTEMS; EMBRYO, MAMMALIAN; EPIGENESIS, GENETIC; FIBROBLASTS; GENETIC LOCI; GENETIC MARKERS; GENETIC VECTORS; HEK293 CELLS; HUMANS; LENTIVIRUS; MICE, INBRED C57BL; NEURONS; RNA, GUIDE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84981748049     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.07.001     Document Type: Article

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