Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 29, 2014, Pages 10678-10683

  Wu, Sen ^a   Wu, Yuanyuan ^b   Zhang, Xi ^a   Capecchi, Mario R ^b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHIMERA; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; EPISOME; EXPRESSION VECTOR; FEMALE; GENE EXPRESSION; GERM LINE; MALE; MOUSE; NONHUMAN; PLASMID; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; SOMATIC CELL; TRANSGENE;

ANIMALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GENETIC VECTORS; GERM CELLS; INDUCED PLURIPOTENT STEM CELLS; MICE; PLASMIDS; TRANSGENES;

EID: 84904662494     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409933111     Document Type: Article

References (33)

1. Yamanaka S (2009) A fresh look at iPS cells. Cell 137(1):13-17.
2. Hanna JH, Saha K, Jaenisch R (2010) Pluripotency and cellular reprogramming: Facts, hypotheses, unresolved issues. Cell 143(4):508-525.
3. Hacein-Bey-Abina S, et al. (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302(5644):415-419. (Pubitemid 37296260)
4. Okita K, Yamanaka S (2011) Induced pluripotent stem cells: Opportunities and challenges. Philos Trans R Soc Lond B Biol Sci 366(1575):2198-2207.
5. Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448(7151):313-317. (Pubitemid 47080336)
6. Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S (2008) Generation of mouse induced pluripotent stem cells without viral vectors. Science 322(5903):949-953.
7. Kaji K, et al. (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458(7239):771-775.
8. Yusa K, Rad R, Takeda J, Bradley A (2009) Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 6(5):363-369.
9. Woltjen K, et al. (2009) piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458(7239):766-770.
10. Yu J, et al. (2009) Human induced pluripotent stem cells free of vector and transgene sequences. Science 324(5928):797-801.
11. Okita K, et al. (2011) A more efficient method to generate integration-free human iPS cells. Nat Methods 8(5):409-412.
12. Jia F, et al. (2010) A nonviral minicircle vector for deriving human iPS cells. Nat Methods 7(3):197-199.
13. Hiratsuka M, et al. (2011) Integration-free iPS cells engineered using human artificial chromosome vectors. PLoS ONE 6(10):e25961.
14. Zhou H, et al. (2009) Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4(5):381-384.
15. Kim D, et al. (2009) Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 4(6):472-476.
16. Anokye-Danso F, et al. (2011) Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8(4):376-388.
17. Miyoshi N, et al. (2011) Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 8(6):633-638.
18. Warren L, et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7(5):618-630.
19. Hou P, et al. (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341(6146):651-654.
20. Guo G, Smith A (2010) A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development 137(19):3185-3192.
21. Szabó PE, Hübner K, Schöler H, Mann JR (2002) Allele-specific expression of imprinted genes in mouse migratory primordial germ cells. Mech Dev 115(1-2):157-160. (Pubitemid 34615682)
22. Silva J, et al. (2008) Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 6(10):e253.
23. Marks H, et al. (2012) The transcriptional and epigenomic foundations of ground state pluripotency. Cell 149(3):590-604.
24. Ying QL, et al. (2008) The ground state of embryonic stem cell self-renewal. Nature 453(7194):519-523.
25. George SH, et al. (2007) Developmental and adult phenotyping directly from mutant embryonic stem cells. Proc Natl Acad Sci USA 104(11):4455-4460. (Pubitemid 47186247)
26. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC (1993) Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 90(18):8424-8428. (Pubitemid 23277681)
27. Lee J, et al. (2012) Activation of innate immunity is required for efficient nuclear reprogramming. Cell 151(3):547-558.
28. Capecchi MR (2005) Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 6(6):507-512.
29. Buehr M, et al. (2008) Capture of authentic embryonic stem cells from rat blastocysts. Cell 135(7):1287-1298.
30. Li P, et al. (2008) Germline competent embryonic stem cells derived from rat blastocysts. Cell 135(7):1299-1310.
31. Tachibana M, et al. (2012) Generation of chimeric rhesus monkeys. Cell 148(1-2):285-295.
32. Nagy A, Gertsenstein M, Vintersten K, Behringer RR (2002) Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY), 3rd Ed, p 800.
33. Poueymirou WT, et al. (2007) F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat Biotechnol 25(1):91-99. (Pubitemid 46091512)