Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Cell Reports

Volumn 20, Issue 7, 2017, Pages 1654-1666

  Palmieri, Erika M ^a,b   Menga, Alessio ^c,d,e   Martín Pérez, Rosa ^d,e   Quinto, Annamaria ^c   Riera Domingo, Carla ^d,e   De Tullio, Giacoma ^c   Hooper, Douglas C ^f   Lamers, Wouter H ^g,h,i   Ghesquière, Bart ^j,k   McVicar, Daniel W ^b   Guarini, Attilio ^c   Mazzone, Massimiliano ^d,e   Castegna, Alessandra ^a,c  

^a UNIVERSITY OF BARI   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e KU Leuven and University Hospitals Leuven and Leuven Cancer Institute   (Belgium)

^f THOMAS JEFFERSON UNIVERSITY   (United States)

^g MAASTRICHT UNIVERSITY   (Netherlands)

^h TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

ⁱ UNIVERSITY OF AMSTERDAM   (Netherlands)

^j Vesalius Research Center   (Belgium)

^k Metabolomics Expertise Center   (Belgium)

more..

Author keywords

glutamine; glutamine synthetase; HIF1 ; IL 10; macrophages; metabolic rewiring; metastasis; starvation; succinate

Indexed keywords

GLUTAMATE AMMONIA LIGASE; GLUTAMINE; METHIONINE SULFOXIMINE; SUCCINIC ACID; TAMOXIFEN; ENZYME INHIBITOR; GLUCOSE; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IL10 PROTEIN, MOUSE; INTERLEUKIN 10;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOACCUMULATION; CANCER CHEMOTHERAPY; CELL MOTILITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE DELETION; GENE TARGETING; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INTRACELLULAR MEMBRANE; LEWIS CARCINOMA; MACROPHAGE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; ANIMAL; CELL DIFFERENTIATION; CELL MOTION; CHRONIC LYMPHATIC LEUKEMIA; DEFICIENCY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG TUMOR; METABOLISM; MONOCYTE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PRIMARY CELL CULTURE; SECONDARY; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR CELL LINE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GLUCOSE; GLUTAMATE-AMMONIA LIGASE; GLUTAMINE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-10; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LUNG NEOPLASMS; MACROPHAGES; METHIONINE SULFOXIMINE; MICE; MICE, KNOCKOUT; MONOCYTES; NEOVASCULARIZATION, PATHOLOGIC; PRIMARY CELL CULTURE; SUCCINIC ACID; T-LYMPHOCYTES, CYTOTOXIC;

EID: 85027849350     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.07.054     Document Type: Article

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