Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells

Antioxidants and Redox Signaling

Volumn 26, Issue 8, 2017, Pages 351-363

  Palmieri, Erika M ^a   Menga, Alessio ^b   Lebrun, Aurore ^c   Hooper, Douglas C ^c   Butterfield, D Allan ^d,e   Mazzone, Massimiliano ^f,g   Castegna, Alessandra ^a,b  

^a UNIVERSITY OF BARI   (Italy)

^b NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e UNIVERSITY OF KENTUCKY   (United States)

^f KU Leuven and University Hospitals Leuven and Leuven Cancer Institute   (Belgium)

^g DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

glutamine; glutamine synthetase; insulin resistance; microglia; neuroinflammation

Indexed keywords

BETA ACTIN; CHEMOKINE RECEPTOR CCR7; COLONY STIMULATING FACTOR RECEPTOR; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; METHIONINE SULFOXIMINE; NITRIC OXIDE; PROSTAGLANDIN E2; QUINOLINIC ACID; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; GLUCOSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE DELETION; GLUCOSE TRANSPORT; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INSULIN SENSITIVITY; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SPINAL CORD; TRANSCRIPTION REGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; DISEASE MODEL; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; METABOLOME; METABOLOMICS; NERVE CELL; PATHOLOGY; PROCEDURES;

ANIMALS; BIOMARKERS; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GLUCOSE; GLUTAMATE-AMMONIA LIGASE; INFLAMMATION; INSULIN; LIPOPOLYSACCHARIDES; METABOLOME; METABOLOMICS; MICE; MICE, KNOCKOUT; MICROGLIA; NEURONS; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; SPINAL CORD;

EID: 85014548002     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2016.6715     Document Type: Article

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